T Engel

Summary

Country: Germany

Publications

  1. ncbi request reprint Lowering of HDL cholesterol in post-menopausal women by tibolone is not associated with changes in cholesterol efflux capacity or paraoxonase activity
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Strasse 33, D 48129, Munster, Germany
    Atherosclerosis 159:433-9. 2001
  2. ncbi request reprint Association of serum apolipoprotein A-I (but not high-density lipoprotein cholesterol) with healed myocardial infarction in men independent of serum insulin and C-peptide
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Am J Cardiol 88:723-6. 2001
  3. ncbi request reprint ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages
    A von Eckardstein
    Institute of Clinical Chemistry and Laboratory Medicine, Central Laboratory, Westphalian Wilhelms University, D 48129 Munster, Germany
    FASEB J 15:1555-61. 2001
  4. ncbi request reprint High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 21:13-27. 2001
  5. ncbi request reprint Acceleration of reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Curr Opin Cardiol 15:348-54. 2000
  6. ncbi request reprint Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Curr Opin Lipidol 11:627-37. 2000
  7. ncbi request reprint Risk for diabetes mellitus in middle-aged Caucasian male participants of the PROCAM study: implications for the definition of impaired fasting glucose by the American Diabetes Association. Prospective Cardiovascular Münster
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    J Clin Endocrinol Metab 85:3101-8. 2000
  8. ncbi request reprint High density lipoproteins and reverse cholesterol transport: lessons from mutations
    A von Eckardstein
    Institut für Arterioskleroseforschung an der Universität Münster, Germany
    Atherosclerosis 137:S7-11. 1998
  9. ncbi request reprint Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Atherosclerosis 138:25-34. 1998
  10. ncbi request reprint Genomic sequence and structure of the human ABCG1 (ABC8) gene
    S Lorkowski
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat Munster, Germany
    Biochem Biophys Res Commun 280:121-31. 2001

Detail Information

Publications16

  1. ncbi request reprint Lowering of HDL cholesterol in post-menopausal women by tibolone is not associated with changes in cholesterol efflux capacity or paraoxonase activity
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Strasse 33, D 48129, Munster, Germany
    Atherosclerosis 159:433-9. 2001
    ..We conclude that changes in insulin do not contribute to the lowering of HDL cholesterol by tibolone. Despite decreased HDL cholesterol, putatively anti-atherogenic activities of HDL remained unchanged...
  2. ncbi request reprint Association of serum apolipoprotein A-I (but not high-density lipoprotein cholesterol) with healed myocardial infarction in men independent of serum insulin and C-peptide
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Am J Cardiol 88:723-6. 2001
    ..Thus, the combined measurement of apolipoprotein A-I and C-peptide may improve the identification of nondiabetic patients at increased risk for CHD...
  3. ncbi request reprint ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages
    A von Eckardstein
    Institute of Clinical Chemistry and Laboratory Medicine, Central Laboratory, Westphalian Wilhelms University, D 48129 Munster, Germany
    FASEB J 15:1555-61. 2001
    ..Inhibition of ABCA1 in HMDM prevented the occurrence of anti-apoE-immunoreactive granular structures in the plasma membrane. We conclude that ABCA1 and, to a lesser extent, ABC8 both promote secretion of apoE from human macrophages...
  4. ncbi request reprint High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 21:13-27. 2001
    ..Instead, the concentration of HDL subclasses, the mobilization of cellular lipids for efflux, and the kinetics of HDL metabolism are important determinants of RCT and the risk of atherosclerosis...
  5. ncbi request reprint Acceleration of reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Curr Opin Cardiol 15:348-54. 2000
    ..It is suggested, however, that the serum level of HDL cholesterol does not necessarily reflect the efficacy of reverse cholesterol transport...
  6. ncbi request reprint Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Curr Opin Lipidol 11:627-37. 2000
    ....
  7. ncbi request reprint Risk for diabetes mellitus in middle-aged Caucasian male participants of the PROCAM study: implications for the definition of impaired fasting glucose by the American Diabetes Association. Prospective Cardiovascular Münster
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    J Clin Endocrinol Metab 85:3101-8. 2000
    ..72 mmol/L glucose may help to reduce the previously reported discordance between impaired fasting glucose (American Diabetes Association) and impaired glucose tolerance (WHO) in diagnosis of the prediabetic state...
  8. ncbi request reprint High density lipoproteins and reverse cholesterol transport: lessons from mutations
    A von Eckardstein
    Institut für Arterioskleroseforschung an der Universität Münster, Germany
    Atherosclerosis 137:S7-11. 1998
    ..Apo E and gamma-LpE are of special interest for reverse cholesterol transport since macrophages can produce apo E...
  9. ncbi request reprint Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Atherosclerosis 138:25-34. 1998
    ..Moreover, the lack of alpha-LpA-I in TD plasma together with its failure to convert exogenous apo A-I into an alpha-migrating particle provide specific tests for the diagnosis of TD...
  10. ncbi request reprint Genomic sequence and structure of the human ABCG1 (ABC8) gene
    S Lorkowski
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat Munster, Germany
    Biochem Biophys Res Commun 280:121-31. 2001
    ..Nevertheless, both promoters responded in macrophages to stimulation by hydroxycholesterol and retinoic acid...
  11. ncbi request reprint Intrinsic sterol- and phosphatidylcholine transfer activities of 17 beta-hydroxysteroid dehydrogenase type IV
    U Seedorf
    Institut für Arterioskeleroseforschung, Zentrallaboratorium, Westfalische Wilhelms Universitat, Munster, Germany
    J Steroid Biochem Mol Biol 55:549-53. 1995
    ..We conclude that the 80 kDa type IV 17 beta-HSD represents a potentially multifunctional protein with intrinsic in vitro sterol and phospholipid transfer activity in addition to its enzymatic activity...
  12. ncbi request reprint Structure-activity studies of human sterol carrier protein 2
    U Seedorf
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Munster, Germany
    J Biol Chem 269:2613-8. 1994
    ..Circular dichroism results showed that Leu20 and Asp70 may serve to stabilize the overall fold, whereas residue 104 appears to play a role in the specific lipid binding and/or transfer activity of SCP2...
  13. pmc Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function
    U Seedorf
    Institute for Arteriosclerosis Research, Westfalian Wilhelms University, D 48129 M unster, Germany
    Genes Dev 12:1189-201. 1998
    ..These results corresponded to high-affinity binding of phytanoyl-CoA to the recombinant rat SCP2 protein, as well as high 3-ketopristanoyl-CoA thiolase activity of the recombinant rat SCPx protein...
  14. ncbi request reprint The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages
    T Engel
    Macrophage Metabolism, Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Domagkstrasse 3, 48149 Munster, Germany
    Biochem Biophys Res Commun 288:483-8. 2001
    ..6 kb in size on chromosome 11q23.3. Based on its structural features and an LXR/RXR-responsive regulation similar to the cellular lipid export protein ABCA1, we conclude that ABCG4 may be involved in macrophage lipid homeostasis...
  15. ncbi request reprint Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity
    U Seedorf
    Institut für Arterioskleroseforschung, Westfälischen Wilhelms Universität, Munster, Federal Republic of Germany
    J Biol Chem 269:21277-83. 1994
    ..These findings suggest that SCPx is a previously undescribed peroxisomal 3-ketoacyl-CoA thiolase (EC 2.3.1.16) with intrinsic sterol carrier and lipid transfer activity (suggested name: SCP2/3-oxoacyl-CoA thiolase)...
  16. ncbi request reprint Apolipoprotein E in macrophages and hepatocytes is eegraded via the proteasomal pathway
    C Wenner
    Institute of Arteriosclerosis Research, University of Munster, Germany
    Biochem Biophys Res Commun 282:608-14. 2001
    ..These studies provide strong evidence for proteasomal degradation of apoE in the two main cell types responsible for its production and indicate a possible new level of regulation of this important protein...