M Ludwig

Summary

Affiliation: Endokrinologikum Hamburg
Country: Germany

Publications

  1. ncbi request reprint The usefulness of a thyrotropin-releasing hormone stimulation test in subfertile female patients
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Hamburg, Germany
    Gynecol Endocrinol 23:226-30. 2007
  2. ncbi request reprint Is there an increased risk of malformations after assisted reproductive technologies?
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Lornsenstrasse 6, 22767 Hamburg, Germany
    Reprod Biomed Online 10:83-9. 2005
  3. ncbi request reprint Development of children born after IVF and ICSI
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Lornsenstrasse 6, 22767 Hamburg, Germany
    Reprod Biomed Online 9:10-2. 2004
  4. ncbi request reprint Does the addition of luteinizing hormone in ovarian stimulation protocols improve the outcome?
    Michael Ludwig
    Centre of Reproductive Medicine and Gynecologic Endocrinology, Endokrinologikum Hamburg, Hamburg, Germany
    Treat Endocrinol 2:305-13. 2003
  5. ncbi request reprint [Optimisation of possible success in an IVF program]
    M Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Hamburg
    Zentralbl Gynakol 126:368-72. 2004
  6. pmc Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples
    M Ludwig
    Endokrinologikum Hamburg, Hamburg, Germany
    J Med Genet 42:289-91. 2005
  7. ncbi request reprint Risk during pregnancy and birth after assisted reproductive technologies: an integral view of the problem
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Hamburg, Germany
    Semin Reprod Med 23:363-70. 2005
  8. ncbi request reprint Is women's health endangered by the German Embryo Protection Law?
    Michael Ludwig
    Centre for Reproductive Medicine and Gynaecologic Endocrinology, Endokrinologikum Hamburg, Lornsenstrasse 6, 22767 Hamburg, Germany
    Curr Womens Health Rep 3:349-50. 2003
  9. doi request reprint Assessment of vision and hearing in children conceived spontaneously and by ICSI: a prospective controlled, single-blinded follow-up study
    A K Ludwig
    Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Endokrinologikum Hamburg, Lornsenstr 4 6, 22767 Hamburg, Germany
    Reprod Biomed Online 20:391-7. 2010
  10. doi request reprint Can we sense ART? The blinded examiner is not blind-a problem with follow-up studies on children born after assisted reproduction
    Annika K Ludwig
    Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Endokrinologikum Hamburg, Germany
    Fertil Steril 92:950-2. 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint The usefulness of a thyrotropin-releasing hormone stimulation test in subfertile female patients
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Hamburg, Germany
    Gynecol Endocrinol 23:226-30. 2007
    ..However, its usefulness in daily clinical practice has not been proven, despite more than 30 years of use...
  2. ncbi request reprint Is there an increased risk of malformations after assisted reproductive technologies?
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Lornsenstrasse 6, 22767 Hamburg, Germany
    Reprod Biomed Online 10:83-9. 2005
    ..The latter seems to be suggested by retrospective studies. The different theories behind the increased risk of major malformations and the current database worldwide are described in this review...
  3. ncbi request reprint Development of children born after IVF and ICSI
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Lornsenstrasse 6, 22767 Hamburg, Germany
    Reprod Biomed Online 9:10-2. 2004
    ..However, there are some limitations for all these follow-up studies, which have to be taken into account, when interpreting results. These are discussed in this commentary...
  4. ncbi request reprint Does the addition of luteinizing hormone in ovarian stimulation protocols improve the outcome?
    Michael Ludwig
    Centre of Reproductive Medicine and Gynecologic Endocrinology, Endokrinologikum Hamburg, Hamburg, Germany
    Treat Endocrinol 2:305-13. 2003
    ..However, more data are necessary before evidence-based recommendations regarding LH supplementation in ovarian stimulation protocols can be given...
  5. ncbi request reprint [Optimisation of possible success in an IVF program]
    M Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Hamburg
    Zentralbl Gynakol 126:368-72. 2004
    ..The use of the GnRH antagonist protocol with cetrorelix (Cetrotide) lead to more comfort to the patients but did not influence the results...
  6. pmc Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples
    M Ludwig
    Endokrinologikum Hamburg, Hamburg, Germany
    J Med Genet 42:289-91. 2005
    ..5; 95% CI 1.40 to 45.13). Our findings suggest that imprinting defects and subfertility may have a common cause, and that superovulation rather than ICSI may further increase the risk of conceiving a child with an imprinting defect...
  7. ncbi request reprint Risk during pregnancy and birth after assisted reproductive technologies: an integral view of the problem
    Michael Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Gynäkologische Endokrinologie und Reproduktionsmedizin, Hamburg, Germany
    Semin Reprod Med 23:363-70. 2005
    ..A long time to pregnancy with subsequent spontaneous pregnancy results in a similar risk profile as pregnancies following infertility treatment. This article discusses a possible pathogenetic model for these observations...
  8. ncbi request reprint Is women's health endangered by the German Embryo Protection Law?
    Michael Ludwig
    Centre for Reproductive Medicine and Gynaecologic Endocrinology, Endokrinologikum Hamburg, Lornsenstrasse 6, 22767 Hamburg, Germany
    Curr Womens Health Rep 3:349-50. 2003
  9. doi request reprint Assessment of vision and hearing in children conceived spontaneously and by ICSI: a prospective controlled, single-blinded follow-up study
    A K Ludwig
    Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Endokrinologikum Hamburg, Lornsenstr 4 6, 22767 Hamburg, Germany
    Reprod Biomed Online 20:391-7. 2010
    ..But only few parents knew about hearing problems of their child after undergoing routine screening examinations. Parental interviews would therefore not be sufficient in order to assess vision and hearing in follow-up studies...
  10. doi request reprint Can we sense ART? The blinded examiner is not blind-a problem with follow-up studies on children born after assisted reproduction
    Annika K Ludwig
    Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Endokrinologikum Hamburg, Germany
    Fertil Steril 92:950-2. 2009
    ....
  11. ncbi request reprint Spontaneous pregnancy after successful ICSI treatment: evaluation of risk factors in 899 families in Germany
    A K Ludwig
    Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Endokrinologikum Hamburg, Hamburg, Germany
    Reprod Biomed Online 17:403-9. 2008
    ..Therefore, it is important to counsel patients about the possibility of natural conception and necessity to use contraception despite their history of subfertility...
  12. ncbi request reprint Is there a need for recombinant human luteinizing hormone (lutropin alfa) supplementation in ovarian stimulation for assisted reproduction?
    Frank Nawroth
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Lornsenstrasse 4 6, 22767 Hamburg, Germany
    Womens Health (Lond Engl) 2:375-84. 2006
    ..The available data are reviewed herein...
  13. ncbi request reprint What is the 'ideal' duration of progesterone supplementation before the transfer of cryopreserved-thawed embryos in estrogen/progesterone replacement protocols?
    Frank Nawroth
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Germany
    Hum Reprod 20:1127-34. 2005
    ..If this is so, we must look for practicable methods to modify the protocols according to the individual patient, the embryonic developmental stage during transfer and other variables...
  14. ncbi request reprint Use of recombinant human chorionic gonadotropin in ovulation induction
    Michael Ludwig
    Reproductive Medicine and Gynecologic Endocrinology, Endokrinologikum Hamburg, Hamburg, Germany
    Fertil Steril 79:1051-9. 2003
    ....
  15. ncbi request reprint Is there an association between septate uterus and endometriosis?
    Frank Nawroth
    Endokrinologikum Hamburg, Centre for Hormone and Metabolic Diseases, Reproductive Medicine and Gynaecological Endocrinology, University of Cologne, Germany
    Hum Reprod 21:542-4. 2006
    ..The aim of this study was to evaluate the incidence of endometriosis in patients with a septate uterus as a non-obstructive form of Müllerian anomalies...
  16. ncbi request reprint What can we expect if we measure hormones in eumenorrhoeic infertile patients?
    Frank Nawroth
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Lornsenstrasse 4 6, 22767 Hamburg, Germany
    Reprod Biomed Online 16:621-6. 2008
    ..The paper discusses the questions on the basis of the currently available literature...
  17. ncbi request reprint Congenital partial atresia of the Fallopian tube
    Frank Nawroth
    Endokrinologikum Hamburg, Centre for Hormone and Metabolic Diseases, Reproductive Medicine and Gynaecological Endocrinology, Hamburg, Germany
    Reprod Biomed Online 12:205-8. 2006
    ..A MEDLINE search was performed and 18 patients found with partial atresia of different tubal portions. This report describes a further patient and reviews the available literature...
  18. doi request reprint Physical health at 5.5 years of age of term-born singletons after intracytoplasmic sperm injection: results of a prospective, controlled, single-blinded study
    Annika K Ludwig
    Department of Prenatal Medicine, Endokrinologikum Hamburg, Lornsenstr 4 6, 22767 Hamburg, Germany
    Fertil Steril 91:115-24. 2009
    ..To study the health of children born after ICSI and of spontaneously conceived control children at the age of 4-6 years...
  19. doi request reprint Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany
    Annika Ludwig
    Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Endokrinologikum Hamburg, Hamburg, Germany
    Fertil Steril 91:125-32. 2009
    ..To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI)...
  20. ncbi request reprint Recombinant gonadotrophins in reproductive medicine: gold standard for ovarian stimulation therapy in the 21st century
    M Ludwig
    Endokrinologikum Hamburg, Zentrum für Hormon und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie
    Reprod Biomed Online 11:535-6. 2005
    ..It is difficult to understand why even today women are exposed to urinary products although the benefits of recombinant gonadotropohins in terms of safety are obvious...
  21. ncbi request reprint Medical management of endometriosis: a systematic review
    Annika K Schroder
    University Schleswig Holstein, Department of Gynecology and Obstetrics, University Clinic Hospital, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    IDrugs 7:451-63. 2004
    ..Future options may include the use of GnRH agonists, selective estrogen receptor modulators (SERMs) and anti-estrogens, as well as immunomodulators...
  22. ncbi request reprint Unilateral follicular aspiration and in-vitro maturation before contralateral oocyte retrieval: a method to prevent ovarian hyperstimulation syndrome
    Annika K Schroder
    Division of Reproductive Medicine, Department of Gynaecology and Obstetrics, Medical University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Eur J Obstet Gynecol Reprod Biol 110:186-9. 2003
    ..Five women undergoing intracytoplasmatic sperm injection (ICSI) considered to be at high risk of developing an ovarian hyperstimulation syndrome (OHSS) from March to July 2002 underwent unilateral follicular aspiration...
  23. ncbi request reprint Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme
    Matthias Simon
    Department of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosurgery 59:1078-85; discussion 1085. 2006
    ..Patients with LFS experience a variety of cancers, including malignant astrocytomas. We investigated a potential role for a CHEK2 gene polymorphism in glioblastomas...
  24. pmc Distribution of persistent organochlorine contaminants in infertile patients from Tanzania and Germany
    Jürgen M Weiss
    Department of Obstetrics and Gynecology, University Clinic Luebeck, Ratzeburger Allee 160, D 23538, Luebeck, Germany
    J Assist Reprod Genet 23:393-9. 2006
    ..To test whether environmental pollutants could affect fertility in humans...
  25. ncbi request reprint Outcome of assisted reproduction
    Alastair G Sutcliffe
    Department of Paediatrics, University College London, London, UK
    Lancet 370:351-9. 2007
    ..No increase in discord or other difficulties within families has been recorded. Long-term follow-up of children born after ART to reproductive age and beyond is necessary...
  26. ncbi request reprint Sperm to zona pellucida binding depends on the use of a gonadotropin-releasing hormone agonist or a gonadotropin-releasing hormone antagonist
    Annika K Schroder
    Department of Gynecology and Obstetrics, University Clinic Hospital, Lubeck, Germany
    Fertil Steril 79:648-50. 2003
  27. ncbi request reprint Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilizatio
    Nicole G M Beckers
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:4186-92. 2003
    ..Hence, support of corpus luteum function remains mandatory after ovarian stimulation for IVF with GnRH antagonist cotreatment...
  28. ncbi request reprint Follow-up of children born after assisted reproductive technologies
    Michael Ludwig
    Department of Gynecology and Obstetrics, University Clinic, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Reprod Biomed Online 5:317-22. 2002
    ..Therefore, there are more infertility related problems than those related to technique. Finally, however, a risk related to the technique itself cannot be excluded completely by currently available data...
  29. ncbi request reprint The use of cryopreserved mature and immature testicular spermatozoa for intracytoplasmic sperm injection: risks and limitations
    Wolfgang Küpker
    Department of Obstetrics and Gynecology, Medical University Lubeck, Lubeck, Germany
    Semin Reprod Med 20:25-35. 2002
    ..Furthermore, limitations of these procedures and concerns with regard to genetic and epigenetic risks of using immature gametes are stressed...
  30. ncbi request reprint Comparison of cryopreservation outcome with gonadotropin-releasing hormone agonists or antagonists in the collecting cycle
    Anna Sophie Seelig
    Department of Gynecology and Obstetrics, University Clinic Hospital, Lubeck, Germany
    Fertil Steril 77:472-5. 2002
    ....
  31. ncbi request reprint Factors influencing response to ovarian stimulation
    Christoph Keck
    Serono International, Geneva, Switzerland
    Reprod Biomed Online 11:562-9. 2005
    ..This is an important step towards further minimizing drug-related variability of ovarian response to FSH treatment...
  32. ncbi request reprint Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study
    Alexander Katalinic
    Institute of Cancer Epidemiology and Institute for Social Medicine, University of Lubeck, Lubeck, Germany
    Fertil Steril 81:1604-16. 2004
    ..To determine pregnancy course and major malformation rate after intracytoplasmic sperm injection (ICSI)...
  33. ncbi request reprint Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias
    Boris Utsch
    Children s Hospital Medical Center, University of Bonn, Germany
    Scand J Urol Nephrol 37:498-501. 2003
    ....
  34. ncbi request reprint Use of clomiphene citrate in in vitro fertilization (IVF) and IVF/intracytoplasmic sperm injection cycles
    Klaus Fiedler
    Fertil Steril 80:1521-3. 2003
  35. ncbi request reprint The process of decision making in reproductive medicine
    Annika K Ludwig
    Department of Gynecology and Obstetrics, University Clinic Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Semin Reprod Med 23:348-53. 2005
    ..Couples who have undergone at least six IVF cycles should be counseled to discontinue therapy. The treatment program should be as individualized as possible, with individual counseling that is adapted after each single treatment cycle...
  36. ncbi request reprint Are major defects in children conceived in vitro due to innate problems in patients or to induced genetic damage?
    Robert G Edwards
    Reproductive BioMedicine Online, Duck End Farm, Dry Drayton, Cambridge CB3 8DB, UK
    Reprod Biomed Online 7:131-8. 2003
    ..Various genetic and developmental factors in infertile couples influencing the origin of such birth outcomes are assessed, and the significance of imprinting and its embryological roles are discussed...
  37. ncbi request reprint GnRH antagonists in the treatment of infertility
    Jürgen M Weiss
    Department of Gynecology and Obstetrics, Medical University Luebeck, Luebeck, Germany
    Ann Med 35:512-22. 2003
    ..e., the GnRH agonist long protocol. However, especially the effectiveness of these compounds will have to be clarified in the near future by carefully designed prospective, randomized studies...
  38. ncbi request reprint Pregnancy course and health of children born after ICSI depending on parameters of male factor infertility
    Michael Ludwig
    Division of Reproductive Medicine, Department of Gynecology and Obstetrics, University Hospital, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Hum Reprod 18:351-7. 2003
    ..There is an ongoing debate as to whether the outcome of ICSI is affected by the origin of sperm used or by the severity of male factor infertility...
  39. ncbi request reprint Gonadotropin-releasing hormone antagonists: pharmacology and clinical use in women
    Juergen M Weiss
    Department of Gynecology and Obstetrics, Medical University of Luebeck, Luebeck, Germany
    Treat Endocrinol 1:281-91. 2002
    ..This broadens the spectrum of indications for GnRH antagonists to sex hormone-dependent disorders like endometriosis, uterine fibroids, and gynecological cancers such as breast and ovarian cancer...
  40. ncbi request reprint Malformation rate in fetuses and children conceived after ICSI: results of a prospective cohort study
    Michael Ludwig
    Division of Reproductive Medicine and Gynecologic Endocrinology, Department of Gynecology and Obstetrics, University Hospital, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Reprod Biomed Online 5:171-8. 2002
    ....
  41. ncbi request reprint Assisted reproduction: the epigenetic perspective
    Bernhard Horsthemke
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Hum Reprod Update 11:473-82. 2005
    ..In addition, loss of epigenetic control may expose hidden genetic variation...
  42. ncbi request reprint Genome-wide analysis for micro-aberrations in familial exstrophy of the bladder using array-based comparative genomic hybridization
    Heiko Reutter
    Department of Human Genetics, Rheinische Friedrich Wilhelms University, Bonn, Germany
    BJU Int 100:646-50. 2007
    ..We aimed to investigate a possible genetic basis of BEEC in a consanguineous kindred of Moroccan origin with three members showing the same phenotypic expression of BEEC...
  43. ncbi request reprint Intraamniotic ethacridine lactate instillation versus vaginal PGE1 in second trimester termination of pregnancy
    Christoph Berg
    Department of Obstetrics and Prenatal Medicine, Center for Obstetrics and Gynecology, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Obstet Gynecol Reprod Biol 126:193-6. 2006
    ..To report on our experience with intraamniotic injection of ethacridine lactate (EL) for second trimester termination of pregnancy (TOP) and to compare its effectiveness with vaginal PGE1 in this setting...
  44. ncbi request reprint Successful assisted reproduction in adult males with bladder extrophy-epispadias complex
    Lisa Gambhir
    Eur J Obstet Gynecol Reprod Biol 139:259-60. 2008
  45. ncbi request reprint Germany votes to import embryo stem cells
    Michael Ludwig
    Department of Gynecology and Obstetrics, University Clinic, Lubeck, Germany
    Reprod Biomed Online 4:311. 2002
  46. ncbi request reprint Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain
    Stephan Steckelbroeck
    Department of Pharmacology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    J Steroid Biochem Mol Biol 86:79-92. 2003
    ....
  47. ncbi request reprint Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system
    Matthias Simon
    Neurochirurgische Klinik and Institut für Klinische Biochemie, Universitatskliniken Bonn, Germany
    J Neurosurg 104:945-9. 2006
    ..The authors studied whether sequence variations in ACVRL1 or ENG are associated with the development of clinically sporadic arteriovenous dysplasias and aneurysms of the CNS...
  48. ncbi request reprint Identification of a novel mutation in the human mineralocorticoid receptor gene in a german family with autosomal-dominant pseudohypoaldosteronism type 1: further evidence for marked interindividual clinical heterogeneity
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts University Kiel, Germany
    J Clin Endocrinol Metab 88:1683-6. 2003
    ..It remains to be elucidated whether other defects or polymorphisms in genes coding for regulatory proteins participating in sodium homeostasis are a cause of the heterogeneity of the clinical manifestations in autosomal dominant PHA1...
  49. ncbi request reprint Reproduction abnormalities and twin pregnancies in parents of sporadic patients with oculo-auriculo-vertebral spectrum/Goldenhar syndrome
    Dagmar Wieczorek
    Institut fur Humangenetik, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    Hum Genet 121:369-76. 2007
    ..0025). An excess of ART conceptions and monozygotic twinning in OAVS is compatible with the concept of overripeness ovopathy as proposed by Jongbloet (Maandschr Kindergeneeskd 36:352-367, 1968)...