M W Elmlinger

Summary

Country: Germany

Publications

  1. ncbi Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin
    M W Elmlinger
    Pediatric Endocrinology, Children s Hospital, University of Tubingen, Germany
    Regul Pept 84:37-42. 1999
  2. ncbi Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adul
    Martin W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 40:1151-60. 2002
  3. ncbi Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH)
    M W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 39:973-9. 2001
  4. ncbi Decreased expression of IGF-II and its binding protein, IGF-binding protein-2, in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males
    M W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:4741-6. 2001
  5. ncbi Transactivation of the IGFBP-2 promoter in human tumor cell lines
    M W Elminger
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse, 72076, Tuebingen, Germany
    Mol Cell Endocrinol 175:211-8. 2001
  6. ncbi Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)
    Martin W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    Clin Chem Lab Med 42:654-64. 2004
  7. ncbi Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines
    M W Elmlinger
    Paediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 52:178-85. 1999
  8. ncbi In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade
    M W Elmlinger
    Pediatric Endocrinology, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Endocrinology 142:1652-8. 2001
  9. ncbi Genital skin fibroblasts (GF) of patients with androgen insensitivity syndrome express higher insulin-like growth factor binding protein (IGFBP)-2, -3 and -5 than GF of normally virilized males
    D Diesing
    Pediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 60:73-8. 2003
  10. ncbi Significance of basal IGF-I, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 54:60-8. 2000

Collaborators

Detail Information

Publications17

  1. ncbi Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin
    M W Elmlinger
    Pediatric Endocrinology, Children s Hospital, University of Tubingen, Germany
    Regul Pept 84:37-42. 1999
    ..The tight coupling of their mRNA expression suggests a functional association of both receptors in the tumor cells...
  2. ncbi Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adul
    Martin W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 40:1151-60. 2002
    ..Our findings agree with earlier studies. The calculated reference intervals can be used to assess the development of children, particularly for measurements performed by the Immulite and Immulite 2000 chemiluminescence assay systems...
  3. ncbi Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH)
    M W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 39:973-9. 2001
    ..Our findings complement these of earlier studies. The developed reference intervals can be used to assess the thyroid status of patients, particularly if the measurements are done on the Immulite/Immulite 2000 system...
  4. ncbi Decreased expression of IGF-II and its binding protein, IGF-binding protein-2, in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males
    M W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:4741-6. 2001
    ....
  5. ncbi Transactivation of the IGFBP-2 promoter in human tumor cell lines
    M W Elminger
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse, 72076, Tuebingen, Germany
    Mol Cell Endocrinol 175:211-8. 2001
    ..Since increased biological activity had also been demonstrated for natural pro-IGF forms often produced by tumors, pro-IGFs may be involved in the mechanism leading to elevated IGFBP-2 expression of tumors in vivo...
  6. ncbi Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)
    Martin W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    Clin Chem Lab Med 42:654-64. 2004
    ..5th centile. In conclusion, the automated IMMULITE IGF-I and IGFBP-3 assays are reliable tools in the diagnosis of pathologies of the GH/IGF axis and in the follow-up of their therapies...
  7. ncbi Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines
    M W Elmlinger
    Paediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 52:178-85. 1999
    ..Due to these characteristics, the big-IGF-II forms probably have an altered biological effect on the tumour cells when compared to IGF-II...
  8. ncbi In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade
    M W Elmlinger
    Pediatric Endocrinology, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Endocrinology 142:1652-8. 2001
    ..The results suggest cell type-specific accumulation of IGFBP-1, -2, and -3 in human glial tumors of the brain. The increase in IGFBP-2 expression with this malignancy suggests a role of IGFBP-2 in the biology of human gliomas...
  9. ncbi Genital skin fibroblasts (GF) of patients with androgen insensitivity syndrome express higher insulin-like growth factor binding protein (IGFBP)-2, -3 and -5 than GF of normally virilized males
    D Diesing
    Pediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 60:73-8. 2003
    ....
  10. ncbi Significance of basal IGF-I, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 54:60-8. 2000
    ..We conclude that the determination of basal IGF parameters is, together with anthropometry and imaging techniques, an indispensable tool for differentiating between GHD and ISS; and that IGFBP-2 plays an additional role in this process...
  11. ncbi Relevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Horm Res 55:115-24. 2001
    ..We determined the extent to which the IGF parameters exceed the normal ranges and identified those parameters which are predictive of 1st-year growth...
  12. ncbi Integrin-mediated action of insulin-like growth factor binding protein-2 in tumor cells
    B S Schütt
    Pediatric Endocrinology Section, University Children s Hospital, 72076 Tuebingen, Germany
    J Mol Endocrinol 32:859-68. 2004
    ..01). Since one of the cell lines used does not express a functional IGF-I receptor, these data demonstrate that IGFBP-2 can act in an IGF-independent manner, at least in part by an interaction with alpha5beta1-integrin...
  13. ncbi Measuring IGF-I, IGFBP-2 and IGFBP-3 from dried blood spots on filter paper is not only practical but also reliable
    B S Schütt
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Growth Horm IGF Res 13:75-80. 2003
    ..The aim of this study is to adapt measurements of IGF-I, IGFBP-2 and IGFBP-3 to dried blood filter disk assays...
  14. ncbi Identification and characterization of insulin-like growth factor (IGF)-binding protein expression and secretion by adult human adrenocortical cells: differential regulation by IGFs and adrenocorticotropin
    C Fottner
    Medical Department II, University of Cologne, Germany
    J Endocrinol 168:465-74. 2001
    ..Together with earlier findings, these results suggest that IGFBPs play an important modulatory role in the regulation of the differentiated adrenocortical function...
  15. ncbi Mutation of the RGD sequence does not affect plasma membrane association and growth inhibitory effects of elevated IGFBP-2 in vivo
    A Hoeflich
    Institute of Molecular Animal Breeding, Gene Center, Ludwig Maximilian University, Feodor Lynen Str 25, 81377, Munich, Germany
    FEBS Lett 523:63-7. 2002
    ..Our data demonstrate that in vivo IGFBP-2 cell surface association is not dependent on the RGD motif and that mutation of this sequence does not alter growth inhibitory effects of IGFBP-2...
  16. ncbi Malnutrition, zinc supplementation and catch-up growth: changes in insulin-like growth factor I, its binding proteins, bone formation and collagen turnover
    C P Doherty
    Department of Child Life and Health, University of Edinburgh, UK
    Clin Endocrinol (Oxf) 57:391-9. 2002
    ....
  17. ncbi [Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma]
    K Plikat
    Klinik und Poliklinik für Innere Medizin I, Universitatsklinikum Regensburg
    Dtsch Med Wochenschr 128:257-60. 2003
    ..As diabetes mellitus, hyperinsulinism and reactive forms of hypoglycemia could be excluded, the presumptive diagnosis was non-islet-cell tumor hypoglycemia (NICTH)...