David Elmenhorst

Summary

Country: Germany

Publications

  1. doi request reprint In vivo kinetic and steady-state quantification of 18F-CPFPX binding to rat cerebral A1 adenosine receptors: validation by displacement and autoradiographic experiments
    David Elmenhorst
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Julich, Julich, Germany
    J Nucl Med 54:1411-9. 2013
  2. pmc Sleep deprivation increases cerebral serotonin 2A receptor binding in humans
    David Elmenhorst
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Jüulich, Jüulich, Germany
    Sleep 35:1615-23. 2012
  3. doi request reprint Caffeine occupancy of human cerebral A1 adenosine receptors: in vivo quantification with 18F-CPFPX and PET
    David Elmenhorst
    Institute of Neuroscience and Medicine INM 2, Forschungszentrum Julich, Julich, Germany
    J Nucl Med 53:1723-9. 2012
  4. doi request reprint Adenosine A(1) receptors in human brain and transfected CHO cells: Inhibition of [(3)H]CPFPX binding by adenosine and caffeine
    David Elmenhorst
    Institute of Neuroscience and Medicine, INM 2, Research Center Juelich, Leo Brandt Str, 52425 Juelich, Germany
    Neurosci Lett 487:415-20. 2011
  5. pmc Sleep deprivation increases A(1) adenosine receptor density in the rat brain
    David Elmenhorst
    Institute of Neurosciences and Biophysics, INB 3, Research Center Juelich, 52425 Juelich, Germany
    Brain Res 1258:53-8. 2009
  6. doi request reprint Suitability of [18F]altanserin and PET to determine 5-HT2A receptor availability in the rat brain: in vivo and in vitro validation of invasive and non-invasive kinetic models
    Tina Kroll
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Julich GmbH, Julich, 52425, Germany
    Mol Imaging Biol 15:456-67. 2013
  7. ncbi request reprint Quantification of cerebral A1 adenosine receptors in humans using [18F]CPFPX and PET: an equilibrium approach
    Philipp T Meyer
    Institute of Medicine, Molecular NeuroImaging, Research Center Juelich, Leo Brandt Str, 52425 Juelich, Germany
    Neuroimage 24:1192-204. 2005
  8. ncbi request reprint Sleep deprivation increases A1 adenosine receptor binding in the human brain: a positron emission tomography study
    David Elmenhorst
    Institute of Medicine, Research Center Juelich, 52425 Juelich, Germany
    J Neurosci 27:2410-5. 2007
  9. ncbi request reprint A1 adenosine receptor PET using [18F]CPFPX: displacement studies in humans
    Philipp T Meyer
    Institute of Medicine, Research Center Juelich, 52425 Juelich, Germany
    Neuroimage 32:1100-5. 2006
  10. ncbi request reprint Cerebral A1 adenosine receptors (A1AR) in liver cirrhosis
    Christian Boy
    Brain Imaging Centre West, Institute of Medicine, Research Centre Julich, Julich, Germany
    Eur J Nucl Med Mol Imaging 35:589-97. 2008

Collaborators

Detail Information

Publications19

  1. doi request reprint In vivo kinetic and steady-state quantification of 18F-CPFPX binding to rat cerebral A1 adenosine receptors: validation by displacement and autoradiographic experiments
    David Elmenhorst
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Julich, Julich, Germany
    J Nucl Med 54:1411-9. 2013
    ..The aim of the present study was therefore to develop and evaluate suitable pharmacokinetic models for the quantification of the cerebral A1AR in high-resolution PET...
  2. pmc Sleep deprivation increases cerebral serotonin 2A receptor binding in humans
    David Elmenhorst
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Jüulich, Jüulich, Germany
    Sleep 35:1615-23. 2012
    ....
  3. doi request reprint Caffeine occupancy of human cerebral A1 adenosine receptors: in vivo quantification with 18F-CPFPX and PET
    David Elmenhorst
    Institute of Neuroscience and Medicine INM 2, Forschungszentrum Julich, Julich, Germany
    J Nucl Med 53:1723-9. 2012
    ..The objective of the present study was to visualize and quantify the in vivo occupancy of the human cerebral A(1)AR by caffeine using (18)F-CPFPX and PET...
  4. doi request reprint Adenosine A(1) receptors in human brain and transfected CHO cells: Inhibition of [(3)H]CPFPX binding by adenosine and caffeine
    David Elmenhorst
    Institute of Neuroscience and Medicine, INM 2, Research Center Juelich, Leo Brandt Str, 52425 Juelich, Germany
    Neurosci Lett 487:415-20. 2011
    ..Caffeine intake previous to the investigation should be considered as a confounding factor regarding the determination of receptor densities with [(18)F]CPFPX and PET...
  5. pmc Sleep deprivation increases A(1) adenosine receptor density in the rat brain
    David Elmenhorst
    Institute of Neurosciences and Biophysics, INB 3, Research Center Juelich, 52425 Juelich, Germany
    Brain Res 1258:53-8. 2009
    ....
  6. doi request reprint Suitability of [18F]altanserin and PET to determine 5-HT2A receptor availability in the rat brain: in vivo and in vitro validation of invasive and non-invasive kinetic models
    Tina Kroll
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Julich GmbH, Julich, 52425, Germany
    Mol Imaging Biol 15:456-67. 2013
    ....
  7. ncbi request reprint Quantification of cerebral A1 adenosine receptors in humans using [18F]CPFPX and PET: an equilibrium approach
    Philipp T Meyer
    Institute of Medicine, Molecular NeuroImaging, Research Center Juelich, Leo Brandt Str, 52425 Juelich, Germany
    Neuroimage 24:1192-204. 2005
    ..Carefully standardized venous equilibrium analyses may substitute arterial analyses and thus considerably enhance applicability of A(1)AR PET in clinical routine...
  8. ncbi request reprint Sleep deprivation increases A1 adenosine receptor binding in the human brain: a positron emission tomography study
    David Elmenhorst
    Institute of Medicine, Research Center Juelich, 52425 Juelich, Germany
    J Neurosci 27:2410-5. 2007
    ....
  9. ncbi request reprint A1 adenosine receptor PET using [18F]CPFPX: displacement studies in humans
    Philipp T Meyer
    Institute of Medicine, Research Center Juelich, 52425 Juelich, Germany
    Neuroimage 32:1100-5. 2006
    ..We conducted in vivo displacement studies in humans to elucidate this important question using the A(1)AR ligand [(18)F]CPFPX...
  10. ncbi request reprint Cerebral A1 adenosine receptors (A1AR) in liver cirrhosis
    Christian Boy
    Brain Imaging Centre West, Institute of Medicine, Research Centre Julich, Julich, Germany
    Eur J Nucl Med Mol Imaging 35:589-97. 2008
    ..The present study investigates changes of cerebral A(1)AR binding in cirrhotic patients by means of positron emission tomography (PET) and [(18)F]CPFPX, a novel selective A(1)AR antagonist...
  11. ncbi request reprint Effect of aging on cerebral A1 adenosine receptors: A [18F]CPFPX PET study in humans
    Philipp T Meyer
    Institute of Medicine Brain Imaging Center West, Research Center Juelich, 52425 Juelich, Germany
    Neurobiol Aging 28:1914-24. 2007
    ..Because of the discrepant results of the invasive (DV't) and the non-invasive (BP'2) analyses the present study needs further validation...
  12. ncbi request reprint [¹⁸F]Altanserin and small animal PET: impact of multidrug efflux transporters on ligand brain uptake and subsequent quantification of 5-HT₂A receptor densities in the rat brain
    Tina Kroll
    Institute of Neuroscience and Medicine, INM 2, Forschungszentrum Julich GmbH, Julich, Germany Electronic address
    Nucl Med Biol 41:1-9. 2014
    ....
  13. ncbi request reprint Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
    Maria Stamelou
    Institute of Neuroscience and Biophysics Medicine INB 3, Research Center Julich, Julich, Germany
    Mov Disord 24:1170-5. 2009
    ..Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings...
  14. ncbi request reprint 18F-CPFPX PET: on the generation of parametric images and the effect of scan duration
    Philipp T Meyer
    Institute of Medicine, Research Center Juelich, Juelich, Germany
    J Nucl Med 47:200-7. 2006
    ..Additionally, the effect of scan duration on the accuracy of analyses based on volumes of interest (VOIs) and individual voxels was explored...
  15. ncbi request reprint 5-HT2A receptor density is decreased in the at-risk mental state
    Rene Hurlemann
    Brain Imaging Center West, Research Center Juelich, 52425, Juelich, Germany
    Psychopharmacology (Berl) 195:579-90. 2008
    ..Current perspectives on the pathophysiology of schizophrenia direct attention to serotonergic (serotonin, 5-HT) dysregulation in the prodrome or at-risk mental state (ARMS)...
  16. pmc In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688
    David Elmenhorst
    Institute of Neurosciences and Medicine, INM 2, Research Center Juelich, Juelich, Germany
    J Cereb Blood Flow Metab 30:1538-49. 2010
    ..Blood-based and reference region-based PET quantification shows a significant linear relationship to autoradiographic determinations...
  17. doi request reprint Biodistribution and radiation dosimetry of the A1 adenosine receptor ligand 18F-CPFPX determined from human whole-body PET
    Hans Herzog
    Institute of Neuroscience and Biophysics Medicine, Forschungszentrum Juelich GmbH, D 52425, Juelich, Germany
    Eur J Nucl Med Mol Imaging 35:1499-506. 2008
    ..The purpose of this study was to determine the biodistribution and the radiation dose of (18)F-CPFPX by whole-body scans in humans...
  18. ncbi request reprint Simplified quantification of cerebral A1 adenosine receptors using [18F]CPFPX and PET: analyses based on venous blood sampling
    Philipp T Meyer
    Institute of Medicine, Research Centre Juelich, 52425 Juelich, Germany
    Synapse 55:212-23. 2005
    ..The applicability of [(18)F]CPFPX PET in basic and clinical neurosciences will be considerably enhanced by the avoidance of arterial blood sampling...
  19. ncbi request reprint Cross sectional PET study of cerebral adenosine A1 receptors in premanifest and manifest Huntington's disease
    Andreas Matusch
    Institute of Neuroscience and Medicine INM 2, Forschungszentrum Julich, 52425, Julich, Germany
    Eur J Nucl Med Mol Imaging 41:1210-20. 2014
    ..To study cerebral adenosine receptors (AR) in premanifest and manifest stages of Huntington's disease (HD)...