Martin Eigenthaler

Summary

Country: Germany

Publications

  1. pmc Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin
    Heiko Slanina
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e39613. 2012
  2. ncbi Genome-based bacterial vaccines: current state and future outlook
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Straße 2, 97080, Wuerzburg, Germany
    BioDrugs 27:419-30. 2013
  3. ncbi Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells
    Alexandra Unkmeir
    Institute of Hygiene and Microbiology, University of Wurzburg, Germany
    Mol Microbiol 46:933-46. 2002
  4. pmc Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany
    Infect Immun 75:899-914. 2007
  5. doi Mammalian cell transcriptome in response to meningitis-causing pathogens
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Expert Rev Mol Diagn 9:833-42. 2009
  6. pmc Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS Pathog 6:e1000874. 2010
  7. doi Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathways
    Anna Kobsar
    Institute of Clinical Biochemistry and Pathobiochemistry Central Laboratory, University of Wuerzburg, Germany
    Thromb Haemost 106:1127-38. 2011
  8. ncbi ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Thromb Haemost 100:618-25. 2008
  9. ncbi Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 26:2813-8. 2006
  10. ncbi Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release
    Olga Sokolova
    Institute of Hygiene and Microbiology, University of Wuerzburg, Germany
    Cell Microbiol 6:1153-66. 2004

Collaborators

Detail Information

Publications42

  1. pmc Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin
    Heiko Slanina
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e39613. 2012
    ..A cooperative interplay between FAK, Src and cortactin then enables endocytosis of N. meningitidis into host cells...
  2. ncbi Genome-based bacterial vaccines: current state and future outlook
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Straße 2, 97080, Wuerzburg, Germany
    BioDrugs 27:419-30. 2013
    ....
  3. ncbi Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells
    Alexandra Unkmeir
    Institute of Hygiene and Microbiology, University of Wurzburg, Germany
    Mol Microbiol 46:933-46. 2002
    ....
  4. pmc Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany
    Infect Immun 75:899-914. 2007
    ..This global transcriptional analysis creates a new platform for further molecular and cellular analysis of the interaction between N. meningitidis and target cells...
  5. doi Mammalian cell transcriptome in response to meningitis-causing pathogens
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Expert Rev Mol Diagn 9:833-42. 2009
    ..This review will also outline the contributions of global gene analyses to our understanding of the pathophysiology of bacterial meningitis...
  6. pmc Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8
    Alexandra Schubert-Unkmeir
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS Pathog 6:e1000874. 2010
    ..Together, we established that MMP-8 activity plays a crucial role in disassembly of cell junction components and cell adhesion during meningococcal infection...
  7. doi Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathways
    Anna Kobsar
    Institute of Clinical Biochemistry and Pathobiochemistry Central Laboratory, University of Wuerzburg, Germany
    Thromb Haemost 106:1127-38. 2011
    ..In contrast to platelet inhibition, the NO effects on HBMEC were not mediated by cyclic nucleotides. Our study provides evidence that NO plays an essential role in the pathophysiology of septicaemic meningococcal infection...
  8. ncbi ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Thromb Haemost 100:618-25. 2008
    ..PRI detected significantly more patients with impaired response than conventional platelet aggregation...
  9. ncbi Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 26:2813-8. 2006
    ..Guanylyl cyclase activation enhances the reduced signaling via the NO/cGMP pathway. We investigated whether chronic guanylyl cyclase activation would beneficially modulate platelet activation in experimental diabetes mellitus...
  10. ncbi Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release
    Olga Sokolova
    Institute of Hygiene and Microbiology, University of Wuerzburg, Germany
    Cell Microbiol 6:1153-66. 2004
    ....
  11. pmc Infection of human coronary artery endothelial cells by group B streptococcus contributes to dysregulation of apoptosis, hemostasis, and innate immune responses
    Claudia Beyrich
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Mediators Inflamm 2011:971502. 2011
    ..These results indicate that GBS infection might influence signalling pathways leading to impaired function of the innate immune system and hemorrhagic and inflammatory complications during GBS sepsis...
  12. ncbi Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition
    Andreas Schafer
    Medizinische Universitatsklinik, Wurzburg, Germany
    Thromb Haemost 89:1024-30. 2003
    ..Increased nitric oxide bioavailability can only partially explain the reduced platelet activation by eplerenone and ACE inhibition...
  13. ncbi Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion
    Andreas Schafer
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Blood 103:407-12. 2004
    ....
  14. doi Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin/convulxin stimulated platelets/particles of different sizes
    Natalia Rukoyatkina
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Br J Haematol 144:591-602. 2009
    ....
  15. ncbi The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:55-62. 2007
    ..Expression of fractalkine and its receptor, CX3CR1, is elevated in coronary artery disease. We assessed the effects of fractalkine on vascular function in isolated rat aorta...
  16. ncbi Severe neutropenia under clopidogrel treatment three weeks after coronary stenting
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Thromb Haemost 97:317-8. 2007
  17. ncbi Group B streptococcus isolates from septic patients and healthy carriers differentially activate platelet signaling cascades
    Celine Siauw
    University Children s Hospital, University of Wuerzburg, Wuerzburg, Germany
    Thromb Haemost 95:836-49. 2006
    ..These mechanisms lead to platelet aggregation and secretion, thereby possibly modulating the pathophysiologic course of GBS infections...
  18. ncbi Late thrombosis of a drug-eluting stent during combined anti-platelet therapy in a clopidogrel nonresponsive diabetic patient: shall we routinely test platelet function?
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Thromb Haemost 97:862-5. 2007
  19. doi [Clopidogrel--clinical use and potential therapeutic problems]
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg
    Herz 33:280-6. 2008
    ..Further prospective studies are needed to determine the risk reduction by an individually adjusted antiplatelet therapy...
  20. doi Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer
    Andreas Schafer
    Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Heart Fail 11:336-41. 2009
    ..We investigated whether treatment with a novel endothelial NO synthase (eNOS)-transcription enhancer positively modulates systemic NO bioavailability and reduces platelet activation in rats with CHF...
  21. ncbi Platelet activation in heart failure
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Germany
    Clin Lab 50:559-66. 2004
    ....
  22. ncbi Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailability
    Andreas Schafer
    Medizinische Klinik and Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Arterioscler Thromb Vasc Biol 25:1071-7. 2005
    ..We investigated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition would beneficially modulate vascular NO bioavailability and platelet activation in experimental CHF...
  23. ncbi Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats
    Andreas Schafer
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Biochem Pharmacol 67:2273-9. 2004
    ..Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in platelets was used as a sensitive monitor of in vivo NO bioavailability...
  24. ncbi Variable extent of clopidogrel responsiveness in patients after coronary stenting
    Ralf Grossmann
    Central Laboratory and Blood Coagulation Unit, Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Thromb Haemost 92:1201-6. 2004
    ..We suggest that individual differences in clopidogrel metabolization could cause relevant variations in clopidogrel responsiveness despite the use of a 300 mg clopidogrel loading dose...
  25. doi Cyclic nucleotide-regulated proliferation and differentiation vary in human hematopoietic progenitor cells derived from healthy persons, tumor patients, and chronic myelocytic leukemia patients
    Anna Kobsar
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, 97080 Wuerzburg, Germany
    Stem Cells Dev 17:81-91. 2008
    ..Pharmacological strategies using cyclic nucleotide-elevating substances to influence HPC growth and differentiation in the bone marrow might support current strategies in HPC recovery from the peripheral blood...
  26. ncbi Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine
    Thomas Thum
    Bayerische Julius Maximilians Universität, Medizinische Klinik I, Wurzburg, Germany
    J Am Coll Cardiol 46:1693-701. 2005
    ..We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs)...
  27. ncbi Increased platelet activation in young Zucker rats with impaired glucose tolerance is improved by acarbose
    Andreas Schafer
    Department of Internal Medicine, Cardiology, University of Wurzburg, Wuerzburg, Germany
    Thromb Haemost 92:97-103. 2004
    ..The positive modulation of platelet activation by acarbose may contribute to the reduction of cardiovascular events in patients with IGT...
  28. ncbi Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation
    Paul Barragan
    Department of Cardiology, Beauregard Private Hospital Center, Marseille, France
    Catheter Cardiovasc Interv 59:295-302. 2003
    ..We found a significant difference between group 3 (63.28% +/- 9.56%) and group 4 (39.80% +/- 10.9%; P < 0.0001). VASP phosphorylation analysis may be useful for the detection of coronary SAT...
  29. ncbi Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy
    Martin Eigenthaler
    Institut für Klinische Biochemie und Pathobiochemie, Universitat Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 285:H2471-81. 2003
    ..The results demonstrate that Ena-VASP proteins may play an important role in intercalated disk function at the interface between cardiac myocytes...
  30. ncbi Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics?
    Bernhard Schick
    Department of Otolaryngology, Head and Neck Surgery, University of Homburg Saar, Kirrberger Strasse, D 66421 Homburg Saar Germany
    Cell Tissue Res 311:315-23. 2003
    ..Thus, pillar cells may be more dynamically involved in controlling longer-lasting mechanical properties of the cochlea as hitherto presumed...
  31. ncbi A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Blood 101:4423-9. 2003
    ..Thus, PKA plays a predominant role in the cGMP-induced phosphorylation of VASP and platelet inhibition in human platelets...
  32. ncbi A stimulatory role for cGMP-dependent protein kinase in platelet activation
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    Cell 112:77-86. 2003
    ..The cGMP-stimulated platelet responses are biphasic, consisting of an initial transient stimulatory response that promotes platelet aggregation and a subsequent inhibitory response that limits the size of thrombi...
  33. ncbi Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice
    Steffen Massberg
    Deutsches Herzzentrum und 1, Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Blood 103:136-42. 2004
    ..These data show for the first time in vivo that VASP is involved in down-regulation of platelet adhesion to the vascular wall under both physiologic and pathophysiologic conditions...
  34. ncbi Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation
    Shunhui Zhuang
    Department of Medicine and Cancer Center, University of California, San Diego, La Jolla 92093 0652, USA
    J Biol Chem 279:10397-407. 2004
    ..These studies show that VASP, an important component of the cellular microfilament system, plays a major role in regulating SRE-dependent transcription, and that G-kinase regulates VASP activity...
  35. ncbi Rapid regulation of platelet activation in vivo by nitric oxide
    Andreas Schafer
    Department of Cardiovascular Medicine, University of Oxford, UK
    Circulation 109:1819-22. 2004
    ..We investigated whether acute inhibition of NO production in humans modulates platelet activation in vivo and whether exogenous NO would counteract such an effect...
  36. ncbi Hearing development and spiral ganglion neurite growth in VASP deficient mice
    Stefan Dazert
    Department of Otorhinolaryngology Head and Neck Surgery, Ruhr Universitaet Bochum, St Elisabeth Hospital Bochum, Germany
    Brain Res 1178:73-82. 2007
    ..Temporary VASP deficits in the neonatal inner ear may be compensated by related proteins like MENA leading to a delayed but complete development of hearing function in VASP-/- animals...
  37. pmc Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells
    Lihua Chen
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 24:1403-8. 2004
    ..We have investigated the effects of VASP and VASP phosphorylation at serine157 and serine239 on smooth muscle cell (SMC) proliferation and nitric oxide (NO)-mediated growth inhibition...
  38. ncbi Delayed formation of actin filaments in the outer pillar head plate of VASP-/- mice
    Bernhard Schick
    Department of Otolaryngology, Head and Neck Surgery, University of Erlangen, Erlangen, Germany
    Cells Tissues Organs 184:88-95. 2006
    ..The delayed hearing development in VASP-/- mice is supposed to be caused by a delayed formation of actin filaments in the outer pillar head plate indicating the importance of appropriate pillar cell stiffness in cochlear mechanics...
  39. ncbi Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo
    Andreas Schafer
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Arterioscler Thromb Vasc Biol 24:1720-6. 2004
    ..We investigated whether acute inhibition of NO production modulates platelet activation in mice and whether specific rescue of endothelial function in diabetes modifies platelet activation...
  40. ncbi Increased noise sensitivity and altered inner ear MENA distribution in VASP-/- mice
    Bernhard Schick
    Department of Otolaryngology, University Erlangen Nurnberg, Waldstrasse 1, 91054, Erlangen, Germany
    Cell Tissue Res 318:493-502. 2004
    ..The finding of a cell-specific, and not organ-specific, redundancy of MENA protein expression noted for the first time in VASP-/- mice is proposed as the reason for the observed distinct cochlear phenotype...
  41. ncbi Enhanced platelet activation by prolactin in patients with ischemic stroke
    Henri Wallaschofski
    Department of Gastroenterology, Endocrinology and Nutrition, University of Greifswald, Friedrich Loeffler Strasse 23a, 17487 Greifswald, Germany
    Thromb Haemost 96:38-44. 2006
    ....
  42. ncbi Hyperprolactinemia in patients on antipsychotic drugs causes ADP-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot study
    Henri Wallaschofski
    Department of Internal Medicine, University of Erlangen, Erlangen, Germany
    J Clin Psychopharmacol 23:479-83. 2003
    ..Therefore, hyperprolactinemia might be the yet unknown acquired risk factor in patients on antipsychotic drugs explaining the increased risk for venous thromboembolism in these patients...