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Genomes and Genes | M EigenthalerSummaryCountry: Germany Publications
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Publications
Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the ratT Deuse
Clinic of Heart and Thoracic Surgery, Julius Maximilian University, Wurzburg, Germany
Eur Surg Res 35:6-13. 2003..This emphasizes the influence of mononuclear infiltration cells on microfilamental structures of the cytoskeleton in adjacent cells...
Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cellsLihua Chen
Department of Surgery, University of Washington, Seattle, WA 98195, USA
Arterioscler Thromb Vasc Biol 24:1403-8. 2004..We have investigated the effects of VASP and VASP phosphorylation at serine157 and serine239 on smooth muscle cell (SMC) proliferation and nitric oxide (NO)-mediated growth inhibition...- High-altitude pulmonary edema: potential protection by red wineA Schafer
Department of Medicine, Julius Maximilians University, Wurzburg, Germany
Nutr Metab Cardiovasc Dis 12:306-10. 2002..CONCLUSION: This article briefly summarises the pathophysiological cellular events leading to HAPE and describes the potential mechanisms by which the ingredients of red wine may have a beneficial effect... - Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic ratsAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Arterioscler Thromb Vasc Biol 26:2813-8. 2006..Guanylyl cyclase activation enhances the reduced signaling via the NO/cGMP pathway. We investigated whether chronic guanylyl cyclase activation would beneficially modulate platelet activation in experimental diabetes mellitus... - Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosisAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Wurzburg, Germany
Curr Vasc Pharmacol 6:52-60. 2008..Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of atherosclerosis triggering myocardial infarction and stroke... - Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive ratsAndreas Schafer
Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
Biochem Pharmacol 67:2273-9. 2004..Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in platelets was used as a sensitive monitor of in vivo NO bioavailability... - Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitusA Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Wurzburg, Bavaria, Germany
Br J Pharmacol 153:886-93. 2008..Diabetes-associated vascular dysfunction contributes to increased cardiovascular risk. We investigated whether the phosphodiesterase-5 inhibitor sildenafil would improve vascular function in diabetic rats... - The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anionsAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Arterioscler Thromb Vasc Biol 27:55-62. 2007..Expression of fractalkine and its receptor, CX3CR1, is elevated in coronary artery disease. We assessed the effects of fractalkine on vascular function in isolated rat aorta... - Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitusAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Pharmacol Res 56:217-23. 2007..Telmisartan normalizes vascular dysfunction and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by angiotensin II receptor blockers in diabetic patients... - Platelet activation in heart failureAndreas Schafer
Medizinische Klinik der Julius Maximilians Universität Würzburg, Germany
Clin Lab 50:559-66. 2004.... - Late thrombosis of a drug-eluting stent during combined anti-platelet therapy in a clopidogrel nonresponsive diabetic patient: shall we routinely test platelet function?Andreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Thromb Haemost 97:862-5. 2007 - Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes mellitusAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Universitat Wurzburg, Germany
Biochem Pharmacol 73:1367-75. 2007..Therefore, rosuvastatin treatment normalizes endothelial function and reduces platelet activation in diabetic rats. These effects may contribute to the reduction of cardiovascular events by statins in diabetic patients... - Severe neutropenia under clopidogrel treatment three weeks after coronary stentingAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Thromb Haemost 97:317-8. 2007 - Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailabilityAndreas Schafer
Medizinische Klinik and Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
Arterioscler Thromb Vasc Biol 25:1071-7. 2005..We investigated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition would beneficially modulate vascular NO bioavailability and platelet activation in experimental CHF... - The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker ratsA Schafer
Department of Internal Medicine I Cardiology, University Hospital Wurzburg, Julius Maximilians University, Wurzburg, Germany
Br J Pharmacol 154:1047-54. 2008..We investigated the effect of rimonabant on inflammation and enhanced platelet reactivity in type 2 diabetic Zucker rats, an experimental model of impaired glucose tolerance and the metabolic syndrome... 
The H(2)-receptor antagonist ranitidine interferes with clopidogrel-mediated P2Y(12) inhibition in plateletsAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Oberdürrbacher Str 6, 97080 Wurzburg, Germany
Pharmacol Res 62:352-6. 2010..We investigated whether ranitidine interacts with P2Y(12) inhibition on the platelet level...- [Clopidogrel--clinical use and potential therapeutic problems]Andreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg
Herz 33:280-6. 2008..Further prospective studies are needed to determine the risk reduction by an individually adjusted antiplatelet therapy... - ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assayAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
Thromb Haemost 100:618-25. 2008..PRI detected significantly more patients with impaired response than conventional platelet aggregation... - Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failureAndreas Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
Pharmacol Res 62:432-8. 2010..We investigated whether chronic activation of the NO target enzyme soluble guanylyl cyclase (sGC) would beneficially modulate vascular function and platelet activation in experimental CHF... - Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancerAndreas Schafer
Medizinische Klinik und Poliklinik I, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Eur J Heart Fail 11:336-41. 2009..We investigated whether treatment with a novel endothelial NO synthase (eNOS)-transcription enhancer positively modulates systemic NO bioavailability and reduces platelet activation in rats with CHF... - Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activationAndreas Schafer
Department of Internal Medicine I, University Hospital Wurzburg, Julius Maximilians University Würzburg, Wurzburg, Germany
Diabetes 59:2001-9. 2010..We investigated the mechanisms underlying vascular endothelial and contractile dysfunction in diabetes as well as the effect of HMR1766, a novel nitric oxide (NO)-independent activator of soluble guanylyl cyclase (sGC)... - Eplerenone improves vascular function and reduces platelet activation in diabetic ratsA Schafer
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
J Physiol Pharmacol 61:45-52. 2010..Platelet activation was significantly reduced by eplerenone. Selective MR blockade may constitute a useful therapeutic approach for treatment of vascular dysfunction in diabetes... - Differences in platelet activation by prolactin and leptinH Wallaschofski
Department of Internal Medicine I, University of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
Horm Metab Res 36:453-7. 2004..Moreover, our data suggest that the stronger effect of prolactin on ADP-stimulated platelet aggregation, compared to leptin, depends on higher stimulation of CD62p expression by prolactin... - Co-activation of platelets by prolactin or leptin--pathophysiological findings and clinical implicationsH Wallaschofski
Department of Internal Medicine I, University of Erlangen, Germany
Horm Metab Res 36:1-6. 2004.... - Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibitionAndreas Schafer
Medizinische Universitatsklinik, Wurzburg, Germany
Thromb Haemost 89:1024-30. 2003..Increased nitric oxide bioavailability can only partially explain the reduced platelet activation by eplerenone and ACE inhibition... - Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesionAndreas Schafer
Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Blood 103:407-12. 2004.... - Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout miceW Hauser
Institut für Klinische Biochemie und Pathobiochemie und, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Proc Natl Acad Sci U S A 96:8120-5. 1999..VASP-deficient mice may provide an interesting model system for diseases in which enhanced platelet activation plays a major role... - Variable extent of clopidogrel responsiveness in patients after coronary stentingRalf Grossmann
Central Laboratory and Blood Coagulation Unit, Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Thromb Haemost 92:1201-6. 2004..We suggest that individual differences in clopidogrel metabolization could cause relevant variations in clopidogrel responsiveness despite the use of a 300 mg clopidogrel loading dose... - Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cellsAlexandra Unkmeir
Institute of Hygiene and Microbiology, University of Wurzburg, Germany
Mol Microbiol 46:933-46. 2002.... - Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginineThomas Thum
Bayerische Julius Maximilians Universität, Medizinische Klinik I, Wurzburg, Germany
J Am Coll Cardiol 46:1693-701. 2005..We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs)... - Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidisAlexandra Schubert-Unkmeir
Institute of Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany
Infect Immun 75:899-914. 2007..This global transcriptional analysis creates a new platform for further molecular and cellular analysis of the interaction between N. meningitidis and target cells... - Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortalityS Frantz
Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Wurzburg, Wurzburg, Germany
Eur J Heart Fail 10:388-95. 2008..Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF)... - Prolactin receptor signaling during platelet activationH Wallaschofski
Department of Internal Medicine I, University of Erlangen, Germany
Horm Metab Res 35:228-35. 2003..Revealing the molecular mechanisms of prolactin signaling will allow the design of new antithrombotic therapies... - Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytesM Halbrügge
Labor für klinische Biochemie and Kinderklinik der Universität, Wurzburg, Germany
Cell Signal 4:189-99. 1992..These data support the hypothesis that VASP phosphorylation may be an important component of cAMP-mediated regulation of lymphocyte function... - Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin/convulxin stimulated platelets/particles of different sizesNatalia Rukoyatkina
Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
Br J Haematol 144:591-602. 2009.... - Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathyMartin Eigenthaler
Institut für Klinische Biochemie und Pathobiochemie, Universitat Wurzburg, Germany
Am J Physiol Heart Circ Physiol 285:H2471-81. 2003..The results demonstrate that Ena-VASP proteins may play an important role in intercalated disk function at the interface between cardiac myocytes... - Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathwaysAnna Kobsar
Institute of Clinical Biochemistry and Pathobiochemistry Central Laboratory, University of Wuerzburg, Germany
Thromb Haemost 106:1127-38. 2011..In contrast to platelet inhibition, the NO effects on HBMEC were not mediated by cyclic nucleotides. Our study provides evidence that NO plays an essential role in the pathophysiology of septicaemic meningococcal infection... - Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylationPaul Barragan
Department of Cardiology, Beauregard Private Hospital Center, Marseille, France
Catheter Cardiovasc Interv 59:295-302. 2003..We found a significant difference between group 3 (63.28% +/- 9.56%) and group 4 (39.80% +/- 10.9%; P < 0.0001). VASP phosphorylation analysis may be useful for the detection of coronary SAT... - Enhanced platelet activation by prolactin in patients with ischemic strokeHenri Wallaschofski
Department of Gastroenterology, Endocrinology and Nutrition, University of Greifswald, Friedrich Loeffler Strasse 23a, 17487 Greifswald, Germany
Thromb Haemost 96:38-44. 2006.... - Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics?Bernhard Schick
Department of Otolaryngology, Head and Neck Surgery, University of Homburg Saar, Kirrberger Strasse, D 66421 Homburg Saar Germany
Cell Tissue Res 311:315-23. 2003..Thus, pillar cells may be more dynamically involved in controlling longer-lasting mechanical properties of the cochlea as hitherto presumed... - A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humansZhenyu Li
Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Blood 101:4423-9. 2003..Thus, PKA plays a predominant role in the cGMP-induced phosphorylation of VASP and platelet inhibition in human platelets... - A stimulatory role for cGMP-dependent protein kinase in platelet activationZhenyu Li
Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
Cell 112:77-86. 2003..The cGMP-stimulated platelet responses are biphasic, consisting of an initial transient stimulatory response that promotes platelet aggregation and a subsequent inhibitory response that limits the size of thrombi... - Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient miceSteffen Massberg
Deutsches Herzzentrum und 1, Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
Blood 103:136-42. 2004..These data show for the first time in vivo that VASP is involved in down-regulation of platelet adhesion to the vascular wall under both physiologic and pathophysiologic conditions... - Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylationShunhui Zhuang
Department of Medicine and Cancer Center, University of California, San Diego, La Jolla 92093 0652, USA
J Biol Chem 279:10397-407. 2004..These studies show that VASP, an important component of the cellular microfilament system, plays a major role in regulating SRE-dependent transcription, and that G-kinase regulates VASP activity... - Hearing development and spiral ganglion neurite growth in VASP deficient miceStefan Dazert
Department of Otorhinolaryngology Head and Neck Surgery, Ruhr Universitaet Bochum, St Elisabeth Hospital Bochum, Germany
Brain Res 1178:73-82. 2007..Temporary VASP deficits in the neonatal inner ear may be compensated by related proteins like MENA leading to a delayed but complete development of hearing function in VASP-/- animals... - Increased platelet activation in young Zucker rats with impaired glucose tolerance is improved by acarboseAndreas Schafer
Department of Internal Medicine, Cardiology, University of Wurzburg, Wuerzburg, Germany
Thromb Haemost 92:97-103. 2004..The positive modulation of platelet activation by acarbose may contribute to the reduction of cardiovascular events in patients with IGT... - Group B streptococcus isolates from septic patients and healthy carriers differentially activate platelet signaling cascadesCeline Siauw
University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany
Thromb Haemost 95:836-49. 2006..These mechanisms lead to platelet aggregation and secretion, thereby possibly modulating the pathophysiologic course of GBS infections... - Increased noise sensitivity and altered inner ear MENA distribution in VASP-/- miceBernhard Schick
Department of Otolaryngology, University Erlangen Nurnberg, Waldstrasse 1, 91054, Erlangen, Germany
Cell Tissue Res 318:493-502. 2004..The finding of a cell-specific, and not organ-specific, redundancy of MENA protein expression noted for the first time in VASP-/- mice is proposed as the reason for the observed distinct cochlear phenotype... - Delayed formation of actin filaments in the outer pillar head plate of VASP-/- miceBernhard Schick
Department of Otolaryngology, Head and Neck Surgery, University of Erlangen, Erlangen, Germany
Cells Tissues Organs 184:88-95. 2006..The delayed hearing development in VASP-/- mice is supposed to be caused by a delayed formation of actin filaments in the outer pillar head plate indicating the importance of appropriate pillar cell stiffness in cochlear mechanics... - Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: role of MAP- and tyrosine kinases in invasion and inflammatory cytokine releaseOlga Sokolova
Institute of Hygiene and Microbiology, University of Wuerzburg, Germany
Cell Microbiol 6:1153-66. 2004.... - Reduced vascular NO bioavailability in diabetes increases platelet activation in vivoAndreas Schafer
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Arterioscler Thromb Vasc Biol 24:1720-6. 2004..We investigated whether acute inhibition of NO production modulates platelet activation in mice and whether specific rescue of endothelial function in diabetes modifies platelet activation... - Rapid regulation of platelet activation in vivo by nitric oxideAndreas Schafer
Department of Cardiovascular Medicine, University of Oxford, UK
Circulation 109:1819-22. 2004..We investigated whether acute inhibition of NO production in humans modulates platelet activation in vivo and whether exogenous NO would counteract such an effect... - Hyperprolactinemia in patients on antipsychotic drugs causes ADP-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot studyHenri Wallaschofski
Department of Internal Medicine, University of Erlangen, Erlangen, Germany
J Clin Psychopharmacol 23:479-83. 2003..Therefore, hyperprolactinemia might be the yet unknown acquired risk factor in patients on antipsychotic drugs explaining the increased risk for venous thromboembolism in these patients...