Thomas Efferth

Summary

Country: Germany

Publications

  1. ncbi request reprint Diagnosis and therapy of oral squamous cell carcinoma
    V Badireenath Konkimalla
    German Cancer Research Centre, Pharmaceutical Biology of Natural Products C015, Heidelberg, Germany
    Expert Rev Anticancer Ther 7:317-29. 2007
  2. ncbi request reprint Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate
    Sebastian Sieber
    German Cancer Research Center, Pharmaceutical Biology C015, D 69120 Heidelberg, Germany
    Int J Oncol 35:149-58. 2009
  3. ncbi request reprint Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate
    Thomas Efferth
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    In Vivo 19:225-32. 2005
  4. ncbi request reprint Molecular modes of action of artesunate in tumor cell lines
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Mol Pharmacol 64:382-94. 2003
  5. ncbi request reprint Identification of gene expression profiles predicting tumor cell response to L-alanosine
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Biochem Pharmacol 66:613-21. 2003
  6. ncbi request reprint Role of antioxidant genes for the activity of artesunate against tumor cells
    Thomas Efferth
    Center for Molecular Biology at the University of Heidelberg ZMBH, 69120 Heidelberg, Germany
    Int J Oncol 23:1231-5. 2003
  7. ncbi request reprint Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774
    Thomas Efferth
    Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, Heidelberg 69120, Germany
    Biochem Pharmacol 67:1689-700. 2004
  8. ncbi request reprint Microarray-based prediction of cytotoxicity of tumor cells to cantharidin
    Thomas Efferth
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Oncol Rep 13:459-63. 2005
  9. ncbi request reprint Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines
    Thomas Efferth
    Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Biochem Pharmacol 68:3-10. 2004
  10. ncbi request reprint Pharmacogenetics for individualized cancer chemotherapy
    Thomas Efferth
    German Cancer Research Center, M070, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Pharmacol Ther 107:155-76. 2005

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Diagnosis and therapy of oral squamous cell carcinoma
    V Badireenath Konkimalla
    German Cancer Research Centre, Pharmaceutical Biology of Natural Products C015, Heidelberg, Germany
    Expert Rev Anticancer Ther 7:317-29. 2007
    ..We estimate these results will be a further step toward the ultimate goal of individualized, patient-adapted tumor treatment based on tumor molecular profiling...
  2. ncbi request reprint Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate
    Sebastian Sieber
    German Cancer Research Center, Pharmaceutical Biology C015, D 69120 Heidelberg, Germany
    Int J Oncol 35:149-58. 2009
    ..The effects of rituximab on antioxidant genes represent a novel mechanism of rituximab for chemosensitization...
  3. ncbi request reprint Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate
    Thomas Efferth
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    In Vivo 19:225-32. 2005
    ..GST expression in normal organs may, therefore, contribute to the good tolerability and minimal toxicity of ART in normal organs...
  4. ncbi request reprint Molecular modes of action of artesunate in tumor cell lines
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Mol Pharmacol 64:382-94. 2003
    ..ART acts via p53-dependent and- independent pathways in isogenic p53+/+ p21WAF1/CIP1+/+, p53-/- p21WAF1/CIP1+/+, and p53+/+ p21WAF1/CIP1-/- colon carcinoma cells...
  5. ncbi request reprint Identification of gene expression profiles predicting tumor cell response to L-alanosine
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Biochem Pharmacol 66:613-21. 2003
    ..We found that p53 mutated cell lines were more resistant to L-alanosine than p53 wild type cell lines...
  6. ncbi request reprint Role of antioxidant genes for the activity of artesunate against tumor cells
    Thomas Efferth
    Center for Molecular Biology at the University of Heidelberg ZMBH, 69120 Heidelberg, Germany
    Int J Oncol 23:1231-5. 2003
    ..Taken together these data support a role for oxidative stress in the mechanism of ART action in tumor cells and suggest that antioxidant defenses act in combination to affect the cellular response to ART...
  7. ncbi request reprint Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774
    Thomas Efferth
    Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, Heidelberg 69120, Germany
    Biochem Pharmacol 67:1689-700. 2004
    ..In conclusion, the combination treatment of ART and OSI-774 resulted in an increased growth inhibition of GBM cell lines as compared to each drug alone...
  8. ncbi request reprint Microarray-based prediction of cytotoxicity of tumor cells to cantharidin
    Thomas Efferth
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Oncol Rep 13:459-63. 2005
    ..The present investigation represents a starting point to dissect the genes and molecular pathways responsible for cellular response to cantharidin in more detail...
  9. ncbi request reprint Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines
    Thomas Efferth
    Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Biochem Pharmacol 68:3-10. 2004
    ..This indicates that different sets of genes involved in oxidative stress response and metabolism may contribute to the cytotoxic and differing toxic side effects of these drug classes...
  10. ncbi request reprint Pharmacogenetics for individualized cancer chemotherapy
    Thomas Efferth
    German Cancer Research Center, M070, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Pharmacol Ther 107:155-76. 2005
    ..The implementation of pharmacogenetics into clinical routine diagnostics including genotype-based recommendations for treatment decisions and risk assessment for practitioners represents a challenge for the future...
  11. ncbi request reprint Molecular modes of action of cantharidin in tumor cells
    Thomas Efferth
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Biochem Pharmacol 69:811-8. 2005
    ..Oxidative stress-resistant thymic lymphoma-derived WEHI7.2 variants are also more resistant to cantharidin. These data suggest that cantharidin treatment causes oxidative stress that provokes DNA damage and p53-dependent apoptosis...
  12. ncbi request reprint Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy
    Thomas Efferth
    German Cancer Research Center, M070, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Drug Resist Updat 8:85-97. 2005
    ..The multi-factorial nature of cellular response to artemisinin and its derivatives may be beneficial to treat otherwise drug-resistant tumors and may explain why resistance development has not been observed in either cancer or malaria...
  13. ncbi request reprint Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, D 55126 Mainz, Germany
    Int J Oncol 23:509-17. 2003
    ..Homo- or heterozygosity did not correlate to survival of patients in the Kaplan-Meier analysis. In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients...
  14. doi request reprint Prediction of broad spectrum resistance of tumors towards anticancer drugs
    Thomas Efferth
    German Cancer Research Center, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 14:2405-12. 2008
    ..The concept of individualized therapy aims to determine in vitro the drug response of tumors beforehand to choose effective treatment options for each individual patient...
  15. doi request reprint Pharmacogenomic identification of c-Myc/Max-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Molecules 15:2886-910. 2010
    ..We conclude that c-Myc and Max-mediated transcriptional control of gene expression might contribute to the therapeutic effects of ART in cancer cells, but may also confer unwanted side effects by affecting therapy-unrelated genes...
  16. ncbi request reprint Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, P O Box 4380, 55033, Mainz, Germany
    Blood Cells Mol Dis 29:1-13. 2002
    ..Furthermore, methotrexate-resistant cell lines clustered together. Our future efforts will be directed toward those imbalances which implicate still unknown candidate drug resistance genes...
  17. doi request reprint Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells
    Thomas Efferth
    German Cancer Research Centre, Pharmaceutical Biology C015, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 7:152-61. 2008
    ..By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone...
  18. ncbi request reprint Anti-cancer natural product library from traditional chinese medicine
    V Badirenaath Konkimalla
    German Cancer Research Center, Pharmaceutical Biology C015, Heidelberg, Germany
    Comb Chem High Throughput Screen 11:7-15. 2008
    ..By hierarchical cluster analyses, candidate genes were identified which significantly predicted sensitivity or resistance of cell lines to hellebrin...
  19. ncbi request reprint Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, P O Box 4380, 55033 Mainz, Germany
    Naunyn Schmiedebergs Arch Pharmacol 367:56-67. 2003
    ..The present investigation presents a starting point to dissect the genes and molecular pathways involved in the tumor cells' response to CET and HHT in greater detail...
  20. doi request reprint Factors determining sensitivity or resistance of tumor cell lines towards artesunate
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Chem Biol Interact 185:42-52. 2010
    ..It merits further investigation, whether ART is responsive in clinically refractory tumors and whether the genes identified in the present study also determine clinical responsiveness towards ART...
  21. doi request reprint Inhibition of inducible nitric oxide synthase by bis(helenalinyl)glutarate in RAW264.7 macrophages
    V Badireenath Konkimalla
    German Cancer Research Centre, Heidelberg, Germany
    Biochem Pharmacol 79:1573-80. 2010
    ..An interference of these two pathways and NO is known for inflammation and auto-immune diseases. The therapeutic potential of this compound has to be explored in the future...
  22. ncbi request reprint Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron
    Thomas Efferth
    Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany
    Free Radic Biol Med 37:998-1009. 2004
    ..This pointed to mitochondrial aconitase and ceruloplasmin (ferroxidase)...
  23. ncbi request reprint Microarray-based expression of DNA repair genes does not correlate with growth inhibition of cancer cells by natural products derived from traditional Chinese medicine
    V S Badireenath Konkimalla
    Pharmaceutical Biology C015, German Cancer Research Center, Heidelberg, Germany
    Cancer Genomics Proteomics 5:79-84. 2008
    ..In conclusion, our data indicate that TCM-derived natural products are worth being further investigated as novel compounds to eradicate tumors which reveal resistance to established anti-cancer drugs...
  24. ncbi request reprint Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
    Thomas Efferth
    German Cancer Research Center, M070, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Drug Targets 7:407-21. 2006
    ..g. the translationally controlled tumor protein (TCTP). Emphasis is given to pharmacogenomic approaches to analyze the pleiotropic nature of mechanisms of artemisinins in cancer cells...
  25. ncbi request reprint Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients
    Manfred Volm
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Clin Cancer Res 8:1843-8. 2002
    ..The purpose of this investigation was to evaluate expression profiles of proteins determining the survival of NSCLC patients for 5 years...
  26. ncbi request reprint Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, Mainz, Germany
    Blood Cells Mol Dis 28:47-56. 2002
    ..Pretherapeutical detection of 9p21 and MTAP deletion may be helpful in developing a predictive molecular chemosensitivity test for T-ALL...
  27. pmc Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells
    Thomas Efferth
    Pharmaceutical Biology of Natural Products, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 2:e693. 2007
    ..Another salient feature of these compounds is the lack of severe side effects in malaria patients...
  28. ncbi request reprint Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, Saac Fulda Allee 3, 55124 Mainz, Germany
    Anticancer Res 22:4221-4. 2002
    ..We found that ascaridol exerts antineoplastic activity. The findings of the present investigation are the first hint that ascaridol may be an interesting novel candidate drug for cancer treatment...
  29. doi request reprint Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells
    Lina Pinto-Garcia
    Department of Functional Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Planta Med 76:1155-61. 2010
    ..The activation of these signalling pathways might be explained by the fact that berberine intercalates DNA and induces DNA strand break through inhibition of topoisomerases and induction of DNA lesions...
  30. doi request reprint Inhibition of epidermal growth factor receptor over-expressing cancer cells by the aphorphine-type isoquinoline alkaloid, dicentrine
    V Badireenath Konkimalla
    German Cancer Research Center, Heidelberg, Germany
    Biochem Pharmacol 79:1092-9. 2010
    ..The cell cycle might be arrested by dicentrine-induced DNA lesions...
  31. ncbi request reprint Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases
    Manfred Volm
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Clin Exp Metastasis 19:385-90. 2002
    ..The data suggest that various metastasis profiles exist...
  32. doi request reprint Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma
    Dirk Theile
    Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Head Neck 33:959-68. 2011
    ..Multidrug resistance (MDR) hampers chemotherapy in head and neck squamous cell carcinoma (HNSCC). There is little information about MDR mediating drug transporters in HNSCC...
  33. ncbi request reprint Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia
    Thomas Efferth
    German Cancer Research Center M070, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mol Cancer Ther 5:1986-94. 2006
    ..As a consequence, a significant sensitization of cells to cytostatic drugs was achieved. In conclusion, ABCA2 and ABCA3 are expressed in many T-ALL and contribute to drug resistance...
  34. ncbi request reprint Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 31:81-7. 2011
    ..The majority of anticancer drugs are of natural origin. However, it is unknown whether the medicinal plant Thymus vulgaris L. (thyme) is cytotoxic towards head and neck squamous cell carcinoma (HNSCC)...
  35. ncbi request reprint mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, P O Box 4380, 55033 Mainz, Germany
    Biochem Pharmacol 64:617-23. 2002
    ..The present analysis is a starting point for the generation of hypotheses on candidate genes and for a more detailed dissection of the functional role of individual genes for the activity of artemisinin derivatives in tumor cells...
  36. ncbi request reprint Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, Mainz, Germany
    Blood Cells Mol Dis 28:160-8. 2002
    ....
  37. pmc Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production
    Anne Hamacher-Brady
    Division of Theoretical Bioinformatics, Applied Systems Biology Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 286:6587-601. 2011
    ....
  38. ncbi request reprint Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine
    Anne Mahringer
    Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    Cancer Genomics Proteomics 7:191-205. 2010
    ..Taken together, these data show that scillarenin is a potential novel candidate for P-glycoprotein inhibition at BBB, and, thereby, may improve the efficacy of therapy regimens in treating brain diseases...
  39. doi request reprint Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells
    Cindy Horwedel
    Pharmaceutical Biology C015, German Cancer Research Center, Heidelberg, Germany
    J Med Chem 53:4842-8. 2010
    ..Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species...
  40. doi request reprint Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells
    Mahmoud Youns
    Department of Functional Genome Analysis, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem Pharmacol 78:273-83. 2009
    ..The present analysis is a starting point for the generation of hypotheses on candidate genes and for a more detailed dissection of the functional role of individual genes for the activity of Artesunate in tumor cells...
  41. doi request reprint The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells
    Rashda Abbasi
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Toxicol Appl Pharmacol 259:302-10. 2012
    ..This could provide a new therapeutic option to treat cancer cells with mutations in NER genes...
  42. doi request reprint Inhibition of epidermal growth factor receptor-overexpressing cancer cells by camptothecin, 20-(N,N-diethyl) glycinate
    V Badireenath Konkimalla
    German Cancer Research Center, Pharmaceutical Biology C015, Heidelberg, Germany
    Biochem Pharmacol 80:39-49. 2010
    ..Multiple mechanisms may account for cytotoxicity of these camptothecins...
  43. doi request reprint Chemical composition and biological activity of the essential oil obtained from Bupleurum marginatum (Apiaceae)
    Mohamed L Ashour
    Institute of Pharmacy and Molecular Biotechnology, University Heidelberg, Heidelberg, Germany
    J Pharm Pharmacol 61:1079-87. 2009
    ..marginatum to validate some of its ethnopharmacologial uses...
  44. ncbi request reprint Protein expression profiles of non-small cell lung carcinomas: correlation with histological subtype
    Manfred Volm
    German Cancer Research Center, Heidelberg
    Anticancer Res 22:2321-4. 2002
    ..These findings could explain the different biological behaviour and treatment response of these tumours...
  45. doi request reprint First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases
    Suhail Ahmed Kabeer Rasheed
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg and German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 127:1475-85. 2010
    ....
  46. doi request reprint Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    J Nutr Biochem 23:875-84. 2012
    ..From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy...
  47. pmc Factors determining sensitivity and resistance of tumor cells to arsenic trioxide
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e35584. 2012
    ..Multidrug-resistant cells overexpressing the MDR1, MRP1 or BCRP genes were not cross-resistant to arsenic trioxide. Our approach revealed that response of tumor cells towards arsenic trioxide is multi-factorial...
  48. doi request reprint Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells
    Mahmoud Youns
    Functional Genome Analysis, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Pharmacol 650:170-7. 2011
    ..Moreover, we reported, for the first time, that the growth inhibitory effect of NS-398 is mediated by down-regulation of RRM2, CTGF, MCM2 and PCNA and up-regulation of NAG-1 in all cell lines...
  49. ncbi request reprint Role of transporter genes in cisplatin resistance
    V Badireenath Konkimalla
    German Cancer Research Center, Pharmaceutical Biology C015, Heidelberg
    In Vivo 22:279-83. 2008
    ..We conclude that our microarray-based approach is a feasible and effective tool in identifying prognostic markers for drug resistance in antitumor therapy...
  50. doi request reprint The antiviral activities of artemisinin and artesunate
    Thomas Efferth
    German Cancer Research Center, Pharmaceutical Biology, Im Neuenheimer Feld 280, Heidelberg, Germany
    Clin Infect Dis 47:804-11. 2008
    ....
  51. ncbi request reprint Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin--from bench to bedside
    Thomas Efferth
    German Cancer Research Center, Heidelberg, Germany
    Planta Med 73:299-309. 2007
    ..First encouraging experience in the clinical treatment of patients suffering from uveal melanoma calls for comprehensive clinical trials with artesunate for cancer treatment in the near future...
  52. ncbi request reprint Chemical Composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 31:185-91. 2011
    ..We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC)...
  53. pmc Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells
    V Badireenath Konkimalla
    German Cancer Research Center, Pharmaceutical Biology C015, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nitric Oxide 19:184-91. 2008
    ..In addition, other signaling pathways also contribute to the inhibitory effect of artesunate towards RAW 264.7 cells pointing to a multi-factorial mode of action of artesunate...
  54. doi request reprint Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine
    Serkan Sertel
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Biochem Pharmacol 81:723-35. 2011
    ..In addition to tubulin as primary target, microarray-based mRNA signatures of responsiveness of these compounds have been identified by COMPARE and signaling pathway profiling...
  55. ncbi request reprint Modulation of human BCRP (ABCG2) activity by anti-HIV drugs
    Johanna Weiss
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Antimicrob Chemother 59:238-45. 2007
    ..The aim of this study was therefore to investigate the influence of all important anti-HIV drugs on BCRP activity in vitro in one assay to allow unrestricted comparison of the results...
  56. ncbi request reprint Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine
    Thomas Efferth
    German Cancer Research Center, Pharmaceutical Biology C015, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Med Chem 14:2024-32. 2007
    ..In the long term, natural products from TCM can contribute to the development of molecular target-guided therapies and individualized treatment strategies...
  57. ncbi request reprint The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells
    V Badireenath Konkimalla
    German Cancer Research Center, Pharmaceutical Biology, Hei delberg, Germany
    Curr Cancer Drug Targets 9:72-80. 2009
    ....
  58. ncbi request reprint Review. Drug resistance of human immunodeficiency virus and overcoming it by natural products
    Julia Hupfeld
    University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Germany
    In Vivo 23:1-6. 2009
    ..Chemical compounds from natural sources provide a large variety of potential anti-HIV compounds. The most promising natural products are discussed in this review...
  59. ncbi request reprint Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy
    Thomas Efferth
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Cancer Genomics Proteomics 4:81-91. 2007
    ..Kampo-derived natural products represent a valuable reservoir for individual tumour treatment strategies in the future...
  60. ncbi request reprint From traditional Chinese medicine to rational cancer therapy
    Thomas Efferth
    German Cancer Research Center, Pharmaceutical Biology C015, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Trends Mol Med 13:353-61. 2007
    ....
  61. doi request reprint Fighting cancer with red wine? Molecular mechanisms of resveratrol
    Thomas E Kraft
    University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Germany thomas
    Crit Rev Food Sci Nutr 49:782-99. 2009
    ..The cytotoxic effects of resveratrol on healthy cells can be neglected, and, as several pathways leading to chemotherapeutic effects are activated by resveratrol, chemoresistance-inducing mutations in cancer cells can be overcome...
  62. doi request reprint Natural products as promising drug candidates for the treatment of hepatitis B and C
    Carolin Wohlfarth
    University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Germany
    Acta Pharmacol Sin 30:25-30. 2009
    ..Natural products need to be investigated in more detail to explore their potential as novel adjuncts to established HBV or HCV therapy...
  63. doi request reprint Effect of artesunate on immune cells in ret-transgenic mouse melanoma model
    Marcel Ramacher
    German Cancer Research Center, Skin Cancer Unit G300, Im Neuenheimer Feld, Heidelberg, Germany
    Anticancer Drugs 20:910-7. 2009
    ..These results indicate that the cytostatic and apoptotic effects of artesunate are not diminished by concomitant immunosuppression...
  64. doi request reprint Evidence-based Chinese medicine for cancer therapy
    V Badireenath Konkimalla
    German Cancer Research Centre, Pharmaceutical Biology C015, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Ethnopharmacol 116:207-10. 2008
    ..In conclusion, the most important question for recognition and implementation of TCM into WM concerns the clinical evidence for the efficacy of TCM and international quality standards for TCM products...
  65. ncbi request reprint Drug resistance in Plasmodium: natural products in the fight against malaria
    Simon Turschner
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mini Rev Med Chem 9:206-2124. 2009
    ..Furthermore, the most promising and recently discovered natural products with anti-malarial potential will be introduced...
  66. ncbi request reprint Expression profile of proteins involved in the xenotransplantability of non-small cell lung cancers into athymic nude mice
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, 55033 Mainz, Germany
    Int J Oncol 20:391-5. 2002
    ..Thus, the up-regulation of the proteins JUN, N-RAS, FOS, cyclin D and cdk4 predicts the growth of NSCLC in nude mice...
  67. ncbi request reprint Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses
    Thomas Efferth
    Virtual Campus Rhineland Palatinate, P O Box 4380, 55033 Mainz, Germany
    J Mol Med (Berl) 80:233-42. 2002
    ..Thus, artesunate possesses attractive antiviral characteristics which are suggestively based on the interference with essential steps in the host cell kinase cascades...
  68. ncbi request reprint Molecular mechanisms underlying St. John's wort drug interactions
    Maike Kober
    Institute of Pharmacy and Molecular Biotechnology, Ruprecht Karls University, Heidelberg, Germany
    Curr Drug Metab 9:1027-37. 2008
    ..Upon excitation by light, hypericin generates cytotoxic products rendering its use attractive as photosensitizing agent. In this review both PPD and PDT are explained in detail, with a particular focus on molecular mechanisms...
  69. ncbi request reprint Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms
    Sonja M Schwarzl
    Computational Molecular Biophysics, Interdisciplinary Center for Scientific Computing IWR, University of Heidelberg, Im Neuenheimer Feld 368, 69120 Heidelberg, Germany
    Int J Mol Med 16:553-7. 2005
    ..A further L84F mutant might affect Zn2+ binding. W65C was found to possibly be unstable...
  70. ncbi request reprint Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines
    Marc Eric Halatsch
    Klinik und Poliklinik fur Neurochirurgie, Georg August Universitat, Gottingen, Germany
    J Neurosurg 100:523-33. 2004
    ..The aim of the current study was to evaluate molecular and cellular effects of OSI-774, a novel EGFR tyrosine kinase inhibitor, on nine glioblastoma multiforme (GBM) cell lines...
  71. ncbi request reprint Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas
    Erich Gebhart
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlander, Germany
    Arch Med Res 35:385-94. 2004
    ....
  72. ncbi request reprint Genomic imbalances in T-cell acute lymphoblastic leukemia cell lines
    Erich Gebhart
    Institute for Human Genetics, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Int J Oncol 21:887-94. 2002
    ..The average number of CNAs per cell line was higher in the sensitive than in the resistant group (total 13.1:8.5; significant CNAs 9.1:5.8)...
  73. ncbi request reprint Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes
    Jean Pierre Gillet
    Research Unit of Cellular Biology, University of Namur, Namur, Belgium
    Cancer Res 64:8987-93. 2004
    ..As the microarray allows the determination of the expression profile of many ABC transporters in a single hybridization experiment, it may be useful as a diagnostic tool to detect drug resistance in clinical samples...
  74. ncbi request reprint Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate
    Raffaella Dell'eva
    Molecular Oncology, National Cancer Research Institute IST, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Biochem Pharmacol 68:2359-66. 2004
    ..As a low-cost drug, it might be of particular interest for areas of Kaposi's sarcoma endemics. ART could be useful for the prevention of tumor angiogenesis...
  75. ncbi request reprint Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines
    Sascha Raschke
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Genes Chromosomes Cancer 42:58-67. 2005
    ..Aberrant RAG-mediated recombination may be responsible in T-ALL, and exuberant DNA repair by nonhomologous end-joining is the likely prevailing mechanism in SCCHN, but a distinct mechanism in TCC and glioma remains to be elucidated...
  76. ncbi request reprint Synergism between rViscumin and cisplatin is not dependent on ERCC-1 expression
    Oliver Galm
    Medizinische Klinik IV, Universitatsklinikum Aachen, Pauwelstrasse 30, 52074 Aachen, Germany
    Cancer Lett 187:143-51. 2002
    ..Our study provides evidence that rViscumin is capable of enhancing cytotoxicity of anticancer agents in vitro. This synergism appears to be independent of transcriptional activity of DNA repair relevant genes...
  77. ncbi request reprint Specific patterns of DNA copy number gains and losses in eight new glioblastoma multiforme cell lines
    Tzutzuy Ramirez
    Institute of Human Genetics, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Int J Oncol 23:453-60. 2003
    ..Eventually, each of the cell lines could be characterized by its specific pattern of genomic imbalance...
  78. ncbi request reprint EGFR but not PDGFR-beta expression correlates to the antiproliferative effect of growth factor withdrawal in glioblastoma multiforme cell lines
    Marc E Halatsch
    Department of Neurosurgery, Georg August University, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Anticancer Res 23:2315-20. 2003
    ....
  79. ncbi request reprint Artesunate in the treatment of metastatic uveal melanoma--first experiences
    Thomas G Berger
    Department of Dermatology, University Hospital of Erlangen, Erlangen, Germany
    Oncol Rep 14:1599-603. 2005
    ..Its good tolerability and lack of serious side effects will facilitate prospective randomized trials in the near future...
  80. ncbi request reprint The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo
    Suzanne J F Kaptein
    Department of Medical Microbiology, University Hospital Maastricht, Maastricht, The Netherlands
    Antiviral Res 69:60-9. 2006
    ..e. ganciclovir, cidofovir or foscarnet, was detected in HCMV-infected fibroblasts. These findings might open new perspectives regarding the use of ART in clinical trials...
  81. doi request reprint Artesunate derived from traditional Chinese medicine induces DNA damage and repair
    Paul C H Li
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Cancer Res 68:4347-51. 2008
    ..The data indicate that DSBs induced by artesunate are repaired by the HR and NHEJ pathways. They suggest that DNA damage induced by artesunate contributes to its therapeutic effect against cancer cells...
  82. pmc A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo
    Ananda Mookerjee
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute CNCI, 37 S, P, Mukherjee Road, Calcutta 700026, India
    BMC Cancer 6:267. 2006
    ..The objective of the present work was to decipher the effect of CuNG on reactive oxygen species (ROS) generation and antioxidant enzymes in normal and doxorubicin-resistant Ehrlich ascites carcinoma (EAC/Dox)-bearing Swiss albino mice...
  83. ncbi request reprint Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
    Ananda Mookerjee
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, India
    Clin Cancer Res 12:4339-49. 2006
    ..Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer using drug-resistant murine and human cancer cell lines...
  84. ncbi request reprint ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia
    Daniel Steinbach
    Children s Hospital, University of Jena, Jena, Germany
    Clin Cancer Res 12:4357-63. 2006
    ..Multidrug resistance can be caused by ATP-binding cassette (ABC) transporters that function as drug efflux pumps. The majority of these proteins have not yet been examined in malignant diseases...
  85. ncbi request reprint Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV)
    Marta R Romero
    Laboratory of Experimental Hepatology and Drug Targeting HEVEFARM, University of Salamanca, Salamanca, Spain
    Planta Med 72:1169-74. 2006
    ..These results suggest a potential usefulness of artemisinin in combination with current pharmacological therapy for the treatment of human and veterinary infections by flaviviruses...
  86. ncbi request reprint Antimicrobial activity of clove and rosemary essential oils alone and in combination
    Yujie Fu
    Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, P R China
    Phytother Res 21:989-94. 2007
    ..The time-kill curves of clove and rosemary essential oils towards three strains showed clearly bactericidal and fungicidal processes of (1)/(2) x MIC, MIC, MBC and 2 x MIC...
  87. ncbi request reprint Chemotherapy-induced resistance by ATP-binding cassette transporter genes
    Jean Pierre Gillet
    Department of Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochim Biophys Acta 1775:237-62. 2007
    ..This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters...
  88. ncbi request reprint Interleukin-6 affects melphalan-induced DNA damage and repair in human multiple myeloma cells
    Thomas Efferth
    Medizinische Klinik IV, RWTH Aachen, Germany
    Anticancer Res 22:231-4. 2002
    ..Similarly, the apoptotic cell fractions, as measured by flow cytometry, were lower if IL-6 was added to the medium. These results indicate that IL-6 may contribute to drug resistance in multiple myeloma...
  89. ncbi request reprint Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel
    Shougang Jiang
    Key Laboratory of Foresty Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, P R China
    Int J Oncol 33:103-11. 2008
    ..Moreover, 7-xylosyl-10-deacetylpaclitaxel had no effect on the expression of CD95 and NF-kappaB proteins, indicating that apoptosis was induced through the mitochondrial-dependent pathway in PC-3 cells...
  90. ncbi request reprint New glycosides from Tetracentron sinense and their cytotoxic activity
    Yi Fen Wang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P R China
    Chem Biodivers 3:1023-30. 2006
    ..1 to 29.7 microM...
  91. ncbi request reprint Activity of novel plant extracts against medullary thyroid carcinoma cells
    Beate Rinner
    Department of Pathophysiology, Medical University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Anticancer Res 24:495-500. 2004
    ..Medullary thyroid carcinoma (MTC) is a rare calcitonin-producing tumor, derived from the parafollicular C-cells of the thyroid. MTC is known to be relatively insensitive to conventional chemotherapy...
  92. ncbi request reprint Cytotoxic and new tetralone derivatives from Berchemia floribunda (Wall.) Brongn
    Yi Fen Wang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, PR China
    Chem Biodivers 3:646-53. 2006
    ..0, 5.3, 10.2, and 12.3 microM, respectively...
  93. ncbi request reprint Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi
    Michael Adams
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria
    Planta Med 72:862-4. 2006
    ..6 microM. In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and isoscopoletin...
  94. ncbi request reprint Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities
    Junsong Wang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongton, Kunming, Yunnan 650204, PR China
    Phytochemistry 66:697-701. 2005
    ..The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM...
  95. ncbi request reprint Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system
    Marta R Romero
    Department of Biochemistry and Molecular Biology, University of Salamanca, Spain
    Antiviral Res 68:75-83. 2005
    ..Moreover, artesunate in conjunction with lamivudine had synergic anti-HBV effects, which warrants further evaluation of artemisinin/artesunate as antiviral agents against HBV infection...
  96. ncbi request reprint Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa
    Michael Adams
    Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria
    Planta Med 73:1554-7. 2007
    ..In the calcein assay, these two quinolones were shown to be moderate modulators of p-gp activity. Evocarpine, on the other side, is not transported by p-gp, and showed only slight toxicity at the highest test concentration of 30 microM...