Erwin Eder

Summary

Country: Germany

Publications

  1. ncbi request reprint In vitro induction of micronuclei by monofunctional methanesulphonic acid esters: possible role of alkylation mechanisms
    Erwin Eder
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Chem Biol Interact 164:76-84. 2006
  2. ncbi request reprint Autoxidative activation of the nematocide 1,3-dichloropropene to highly genotoxic and mutagenic derivatives: consideration of genotoxic/carcinogenic mechanisms
    Erwin Eder
    Department of Toxicology, University of Wurzburg, Germany
    Chem Res Toxicol 19:952-9. 2006
  3. ncbi request reprint Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets
    E Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Chem Biol Interact 159:81-9. 2006
  4. ncbi request reprint Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil
    Erwin Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Mutat Res 654:101-7. 2008
  5. ncbi request reprint The influence of the solvents DMSO and ethanol on the genotoxicity of alpha,beta-unsaturated aldehydes in the SOS chromotest
    Erwin Eder
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078, Germany
    Mutat Res 516:81-9. 2002
  6. ncbi request reprint On the role of alkylating mechanisms, O-alkylation and DNA-repair in genotoxicity and mutagenicity of alkylating methanesulfonates of widely varying structures in bacterial systems
    E Eder
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Chem Biol Interact 137:89-99. 2001
  7. ncbi request reprint Cancer risk assessment for the environmental mutagen and carcinogen crotonaldehyde on the basis of TD(50) and comparison with 1,N(2)-propanodeoxyguanosine adduct levels
    E Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Cancer Epidemiol Biomarkers Prev 10:883-8. 2001
  8. ncbi request reprint Mutagenicity of 2-alkylpropenals in Salmonella typhimurium strain TA 100: structural influences
    E Eder
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Environ Mol Mutagen 37:324-8. 2001
  9. ncbi request reprint An approach to cancer risk assessment for the food constituent 2-hexenal on the basis of 1,N2-propanodeoxyguanosine adducts of 2-hexenal in vivo
    E Eder
    Department of Toxicology, University of Wurzburg, Germany
    Arch Toxicol 74:642-8. 2000
  10. ncbi request reprint Intraindividual variations of DNA adduct levels in humans
    E Eder
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, D 97078, Wurzburg, Germany
    Mutat Res 424:249-61. 1999

Collaborators

Detail Information

Publications18

  1. ncbi request reprint In vitro induction of micronuclei by monofunctional methanesulphonic acid esters: possible role of alkylation mechanisms
    Erwin Eder
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Chem Biol Interact 164:76-84. 2006
    ..This effect can be explained by a higher disturbance during mitosis after alkylation of the spindle apparatus with the structurally more bulky methanesulphonates...
  2. ncbi request reprint Autoxidative activation of the nematocide 1,3-dichloropropene to highly genotoxic and mutagenic derivatives: consideration of genotoxic/carcinogenic mechanisms
    Erwin Eder
    Department of Toxicology, University of Wurzburg, Germany
    Chem Res Toxicol 19:952-9. 2006
    ..As a consequence, it is questionable whether any stabilizers can prevent oxidation during application...
  3. ncbi request reprint Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets
    E Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Chem Biol Interact 159:81-9. 2006
    ..Our results indicate that a high linoleic acid diet may contribute to oxidative stress in the liver of female rats leading to a marginal increase in oxidative DNA-damage...
  4. ncbi request reprint Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil
    Erwin Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Mutat Res 654:101-7. 2008
    ..Saturated fatty acids are not considered to directly influence lipid peroxidation to a major extent...
  5. ncbi request reprint The influence of the solvents DMSO and ethanol on the genotoxicity of alpha,beta-unsaturated aldehydes in the SOS chromotest
    Erwin Eder
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078, Germany
    Mutat Res 516:81-9. 2002
    ..The decreasing genotoxicities can be explained (a) by increasing bacterial toxicity due to increasing lipophilicities of the higher substituted aldehydes and (b) by decreasing reactivity due to steric hindrance by the alkyl substituents...
  6. ncbi request reprint On the role of alkylating mechanisms, O-alkylation and DNA-repair in genotoxicity and mutagenicity of alkylating methanesulfonates of widely varying structures in bacterial systems
    E Eder
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Chem Biol Interact 137:89-99. 2001
    ....
  7. ncbi request reprint Cancer risk assessment for the environmental mutagen and carcinogen crotonaldehyde on the basis of TD(50) and comparison with 1,N(2)-propanodeoxyguanosine adduct levels
    E Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Cancer Epidemiol Biomarkers Prev 10:883-8. 2001
    ..in the case that cancer from crotonaldehyde depends exclusively on the 1,N(2)-propanodeoxyguanosine adducts considered here. No propanodeoxyguanosine adducts of crotonaldehyde were found in the DNA of untreated animals in our studies...
  8. ncbi request reprint Mutagenicity of 2-alkylpropenals in Salmonella typhimurium strain TA 100: structural influences
    E Eder
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Environ Mol Mutagen 37:324-8. 2001
    ..The effect of S9-mix can be explained by partial detoxication of the substances by nucleophilic components of the S9-mix such as glutathione...
  9. ncbi request reprint An approach to cancer risk assessment for the food constituent 2-hexenal on the basis of 1,N2-propanodeoxyguanosine adducts of 2-hexenal in vivo
    E Eder
    Department of Toxicology, University of Wurzburg, Germany
    Arch Toxicol 74:642-8. 2000
    ....
  10. ncbi request reprint Intraindividual variations of DNA adduct levels in humans
    E Eder
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, D 97078, Wurzburg, Germany
    Mutat Res 424:249-61. 1999
    ....
  11. ncbi request reprint The role of alcohols as solvents in the genotoxicity testing of alpha,beta-unsaturated ketones in the SOS chromotest
    E Eder
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078, Wurzburg, Germany
    Mutat Res 470:29-37. 2000
    ....
  12. ncbi request reprint Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats
    Angela Mally
    Department of Toxicology, University of Wurzburg, Germany
    Chem Res Toxicol 18:1242-52. 2005
    ..Taken together, the uncommon changes induced by OTA suggest that a unique mechanism may be involved in OTA nephrotoxicity and carcinogenicity...
  13. ncbi request reprint Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats
    M Wacker
    Department of Toxicology, , Versbacher Str. 9, D-97078, , Germany
    Chem Biol Interact 137:269-83. 2001
    ....
  14. ncbi request reprint Effect of enzyme-resistant starch on formation of 1,N(2)-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal and cell proliferation in the colonic mucosa of healthy volunteers
    Matthias Wacker
    Department of Toxicology, University of Wuerzburg, D 97078 Wuerzburg, Germany
    Cancer Epidemiol Biomarkers Prev 11:915-20. 2002
    ..If it is accepted that the formation of DNA adducts reflects oxidative stress, which in turn accelerates the process of carcinogenesis, then certain forms of RS may have a tumor-enhancing effect rather than a tumor-protective effect...
  15. ncbi request reprint Ochratoxin A: lack of formation of covalent DNA adducts
    Angela Mally
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 17:234-42. 2004
    ..In summary, the results presented here demonstrate that DNA binding of OTA is not detectable with sensitive analytical methods and is unlikely to represent a mechanism for OTA-induced tumor formation...
  16. ncbi request reprint Unaltered brain levels of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in Alzheimer's disease
    M E Götz
    Department of Toxicology, University of Wurzburg, Germany
    Neurosci Lett 324:49-52. 2002
    ..Although distinctively present in the human brain, the level of HNE-dGp adducts appears not to be useful as a biomarker for AD...
  17. ncbi request reprint Mutagenic and carcinogenic risk of oxygen containing chlorinated C-3 hydrocarbons: putative secondary products of C-3 chlorohydrocarbons and chlorination of water
    E Eder
    Institute of Toxicology, University of Wurzburg, Germany
    Chemosphere 29:2455-66. 1994
    ..2-Chloroacroleins are extremely strong mutagens and genotoxins and form 1,N2-cyclic deoxyguanosine adducts. The role of such adducts in mutagenicity and carcinogenicity is discussed...
  18. ncbi request reprint DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants
    Donald W Boerth
    Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts 02747, USA
    J Agric Food Chem 56:6751-60. 2008
    ..The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant...