L Eckardt

Summary

Country: Germany

Publications

  1. pmc Approach to wide complex tachycardias in patients without structural heart disease
    L Eckardt
    Medizinische Klinik und Poliklinik C, Universitatsklinikum Munster, Munster, Germany
    Heart 92:704-11. 2006
  2. ncbi request reprint Divergent effect of acute ventricular dilatation on the electrophysiologic characteristics of d,l-sotalol and flecainide in the isolated rabbit heart
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 9:366-83. 1998
  3. ncbi request reprint Brugada syndrome and supraventricular tachyarrhythmias: a novel association?
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 12:680-5. 2001
  4. ncbi request reprint Load-induced changes in repolarization: evidence from experimental and clinical data
    L Eckardt
    Westfälische Wilhelms Universität Innere Medizin C, Munster, Germany
    Basic Res Cardiol 96:369-80. 2001
  5. pmc Idiopathic left ventricular tachycardia localised at the distal end of the posterior fascicle by non-contact activation mapping
    L Eckardt
    Heart 87:374. 2002
  6. doi request reprint Catheter ablation of ventricular tachycardia. From indication to three-dimensional mapping technology
    Lars Eckardt
    Medizinischen Klinik und Poliklinik C, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Herz 34:187-96. 2009
  7. ncbi request reprint Is there a role for amiodarone in the era of the implantable cardioverter-defibrillator?
    Lars Eckardt
    Medizinische Klinik und Poliklinik C, Universitatsklinikum Munster, Germany
    Heart Rhythm 3:484-7. 2006
  8. ncbi request reprint Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome
    Lars Eckardt
    Westfälische Wilhelms University Hospital, Department of Cardiology and Angiology, Munster, Germany
    Circulation 111:257-63. 2005
  9. ncbi request reprint Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhythmias in Brugada syndrome
    Lars Eckardt
    Hospital of the Westfälischen Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 13:742-9. 2002
  10. ncbi request reprint In vivo recording of monophasic action potentials in awake dogs--new applications for experimental electrophysiology
    L Eckardt
    Westfalische Wilhelms Universitat, Innere Medizin C, Munster, Germany
    Basic Res Cardiol 96:169-74. 2001

Detail Information

Publications104 found, 100 shown here

  1. pmc Approach to wide complex tachycardias in patients without structural heart disease
    L Eckardt
    Medizinische Klinik und Poliklinik C, Universitatsklinikum Munster, Munster, Germany
    Heart 92:704-11. 2006
  2. ncbi request reprint Divergent effect of acute ventricular dilatation on the electrophysiologic characteristics of d,l-sotalol and flecainide in the isolated rabbit heart
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 9:366-83. 1998
    ..We therefore investigated the effects of AVD on the electrophysiologic properties of d,l-sotalol and flecainide...
  3. ncbi request reprint Brugada syndrome and supraventricular tachyarrhythmias: a novel association?
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 12:680-5. 2001
    ..As a high induction rate of ventricular tachyarrhythmias has been reported in Brugada syndrome, we hypothesized that this also may be true for supraventricular tachycardias in these patients...
  4. ncbi request reprint Load-induced changes in repolarization: evidence from experimental and clinical data
    L Eckardt
    Westfälische Wilhelms Universität Innere Medizin C, Munster, Germany
    Basic Res Cardiol 96:369-80. 2001
    ..Additional studies will further clarify the nature and clinical significance of load-related changes in repolarization and arrhythmogenesis...
  5. pmc Idiopathic left ventricular tachycardia localised at the distal end of the posterior fascicle by non-contact activation mapping
    L Eckardt
    Heart 87:374. 2002
  6. doi request reprint Catheter ablation of ventricular tachycardia. From indication to three-dimensional mapping technology
    Lars Eckardt
    Medizinischen Klinik und Poliklinik C, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Herz 34:187-96. 2009
    ..The aim of the present article is to review current three-dimensional mapping systems in comparison to conventional mapping and to describe a reasonable, tailored approach for the individual patient with VT...
  7. ncbi request reprint Is there a role for amiodarone in the era of the implantable cardioverter-defibrillator?
    Lars Eckardt
    Medizinische Klinik und Poliklinik C, Universitatsklinikum Munster, Germany
    Heart Rhythm 3:484-7. 2006
  8. ncbi request reprint Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome
    Lars Eckardt
    Westfälische Wilhelms University Hospital, Department of Cardiology and Angiology, Munster, Germany
    Circulation 111:257-63. 2005
    ..Controversy exists with regard to risk stratification and therapeutic management, particularly in asymptomatic individuals...
  9. ncbi request reprint Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhythmias in Brugada syndrome
    Lars Eckardt
    Hospital of the Westfälischen Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 13:742-9. 2002
    ..Therefore, the body surface area of ST elevation and the presence of late potentials were compared to the inducibility of VT in patients with the characteristic ECG of Brugada syndrome...
  10. ncbi request reprint In vivo recording of monophasic action potentials in awake dogs--new applications for experimental electrophysiology
    L Eckardt
    Westfalische Wilhelms Universitat, Innere Medizin C, Munster, Germany
    Basic Res Cardiol 96:169-74. 2001
    ..However, an approach for recording MAP in awake dogs without interference of anesthesia has not yet been developed...
  11. ncbi request reprint Transient local changes in right ventricular monophasic action potentials due to ajmaline in a patient with Brugada Syndrome
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 10:1010-5. 1999
    ..Ajmaline led to a cycle length-dependent increase in RV dispersion of repolarization. Thus, right endocardial MAPs may demonstrate regionally different action potential changes that may contribute to the ECG changes in Brugada syndrome...
  12. ncbi request reprint Modification of stretch-induced shortening of repolarization by streptomycin in the isolated rabbit heart
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Pharmacol 36:711-21. 2000
    ..This may have clinically important implications for the development of new antiarrhythmic drugs...
  13. ncbi request reprint A NavX guided cryoablation of an accessory pathway in a large coronary sinus diverticulum
    Lars Eckardt
    Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms University, Munster, Germany
    J Cardiovasc Electrophysiol 16:233-4. 2005
    ..J Cardiovasc Electrophysiol, Vol. 16, pp. 1-2, February 2005...
  14. ncbi request reprint Experimental models of torsade de pointes
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology, Munster, Germany
    Cardiovasc Res 39:178-93. 1998
    ..The development of subsequent beats is less clear. Reentry based on inhomogeneity of refractoriness has been suggested as the underlying mechanism...
  15. ncbi request reprint Arrhythmias in heart failure: current concepts of mechanisms and therapy
    L Eckardt
    Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Hospital of the Westfälische Wilhelms University, Munster, Germany
    J Cardiovasc Electrophysiol 11:106-17. 2000
    ..Catheter ablation or map-guided endocardial resection are additional options in selected patients but seldom represent the only therapeutic strategy...
  16. pmc Blockade of I(Ca) suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure
    P Milberg
    Division of Experimental and Clinical Electrophysiology, Department of Cardiology and Angiology, University Hospital of Munster, Munster, Germany
    Br J Pharmacol 166:557-68. 2012
    ..LINKED ARTICLE This article is commented on by Stams et al., pp. 554-556 of this issue. To view this commentary visit http://dx.doi.org/10.1111/j.1476-5381.2011.01818.x...
  17. ncbi request reprint Effects of thoracic epidural anesthesia with and without autonomic nervous system blockade on cardiac monophasic action potentials and effective refractoriness in awake dogs
    A Meissner
    Medizinische Klinik und Poliklinik, Westfalische Wilhelms Universitat, Munster, Germany
    Anesthesiology 95:132-8; discussion 6A. 2001
    ..The authors hypothesized that an antiarrhythmic role of TEA exists, which may be related to a direct effect of TEA on myocardial repolarization...
  18. ncbi request reprint Electrophysiologic investigation in Brugada syndrome; yield of programmed ventricular stimulation at two ventricular sites with up to three premature beats
    L Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    Eur Heart J 23:1394-401. 2002
    ..Therefore, we prospectively investigated the inducibility of VT in these patients using a uniform protocol...
  19. ncbi request reprint Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3
    P Milberg
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Str 33, 48149, Munster, Germany
    Basic Res Cardiol 100:365-71. 2005
    ..We investigated the electrophysiologic mechanism by which verapamil suppresses TdP, in a recently developed intact heart model of LQT3...
  20. ncbi request reprint Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs
    R Johna
    Westfalische Wilhelms Universitat, Innere Medizin C, Munster, Germany
    Basic Res Cardiol 93:127-35. 1998
    ..The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III drug-induced ventricular arrhythmias...
  21. ncbi request reprint Prolonged QRS duration increases QT dispersion but does not relate to arrhythmias in survivors of acute myocardial infarction
    P Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, and Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Pacing Clin Electrophysiol 24:789-95. 2001
    ..Presence of late potentials, in contrast, relates to arrhythmic events but does not affect QT dispersion. Therefore, QT dispersion may not be an adequate parameter to assess arrhythmic risk in survivors of myocardial infarction...
  22. ncbi request reprint Antiarrhythmic therapy in heart failure
    Lars Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Institute for Arteriosclerosis Research, Munster, Germany
    Heart Fail Monit 2:110-9. 2002
    ..Many of these patients require additional antiarrhythmic therapy (e.g. amiodarone) because of atrial fibrillation or non-sustained VT that may activate the device...
  23. ncbi request reprint A new algorithm to determine complete isthmus conduction block after radiofrequency catheter ablation for typical atrial flutter
    R Johna
    Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms Universität, and Institute of Arteriosclerosis Research, Munster, Germany
    Am J Cardiol 83:1666-8, A6-7. 1999
    ..We evaluated a simplified algorithm to determine complete isthmus block that, in our series, had a predictive accuracy of 100% when compared with the gold standard...
  24. ncbi request reprint [Right ventricular tachyarrhythmias--diagnostics and therapy]
    M Paul
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster
    Herzschrittmacherther Elektrophysiol 16:260-9. 2005
    ..This review is a summary of the available literature on pathogenesis, diagnosis, treatment, and prognosis of such diseases associated with right ventricular tachyarrhythmias...
  25. ncbi request reprint Clinical value of electrocardiographic parameters in genotyped individuals with familial long QT syndrome
    G Moennig
    Department of Cardiology and Angiology, Westfälische Wilhelms University Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Pacing Clin Electrophysiol 24:406-15. 2001
    ..QT dispersion and QT product might be helpful in finding LQTS mutation carriers and might serve as additional ECG tools to identify asymptomatic LQTS patients...
  26. doi request reprint [Class I antiarrhythmic drugs: mechanisms, contraindications, and current indications]
    C Pott
    Medizinische Klinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Str 33, 48149, Munster, Deutschland
    Herzschrittmacherther Elektrophysiol 21:228-38. 2010
    ..This review gives an overview on the classification, antiarrhythmic mechanisms, indications, side effects, and application modes of class I antiarrhythmic drugs...
  27. ncbi request reprint Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease
    Eric Schulze-Bahr
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Hum Mutat 21:651-2. 2003
    ..In sporadic cases, however, a genetic basis and the value of mutation screening has to be further determined. These results are in line with a possibly genetic and clinical heterogeneity of BS...
  28. ncbi request reprint [The autonomic nervous system and cardiac arrhythmias]
    K Wasmer
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48129 Munster
    Internist (Berl) 43:1076, 1079-84. 2002
  29. ncbi request reprint Simultaneous in utero assessment of AV nodal and ventricular electrophysiologic parameters in the fetal sheep heart
    P Kirchhof
    Medizinische Klinik und Poliklinik, Innere Medizin C, Kardiologie und Angiologie, Germany
    Basic Res Cardiol 96:251-7. 2001
    ..Since overdrive pacing may help to establish the mechanism of an arrhythmia and may be used to treat fetal tachycardias, different modes of transesophageal pacing in utero were also assessed...
  30. ncbi request reprint [Heart hypertrophy and heart failure--experimental findings for arrhythmogenesis]
    P Milberg
    Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum, Munster
    Dtsch Med Wochenschr 133:S285-9. 2008
    ....
  31. ncbi request reprint [The ICD as primary prevention. Rare indications]
    K Wasmer
    Medizinische Klinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Str 33, 48149, Munster, Deutschland
    Herzschrittmacherther Elektrophysiol 21:117-22. 2010
    ..Risk stratification is difficult in this patient population. Risk of sudden death has to be weighed individually against risks associated with an implantable cardioverter defibrillator (ICD) in these young patients...
  32. ncbi request reprint Absence of pathognomonic or inflammatory patterns in cardiac biopsies from patients with Brugada syndrome
    Sven Zumhagen
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Circ Arrhythm Electrophysiol 2:16-23. 2009
    ..Recent studies have discussed whether BrS is merely a primary electric disorder or whether inflammatory or other histopathologic abnormalities in the right ventricle (RV) underlie the ECG phenotype...
  33. doi request reprint [Catecholaminergic polymorphic ventricular tachycardia]
    G Frommeyer
    Abteilung für Rhythmologie Department für Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Campus 1, 48149, Munster, Germany
    Herzschrittmacherther Elektrophysiol 23:231-6. 2012
    ..Left thoracic sympathectomy represents a subsidiary interventional therapy for individual cases. In addition, modifications of the patient's lifestyle including avoidance of physical stress and heart rates> 120/min are recommended...
  34. ncbi request reprint Transvenous ICD implantation after artificial tricuspid valve replacement. A new approach placing a transvenous ICD lead in the mid cardiac vein of the coronary sinus
    R Gradaus
    Universitatsklinikum Munster, Medizinische Klinik und Poliklinik für Kardiologie und Angiologie, 48129 Munster, Germany
    Z Kardiol 94:588-91. 2005
    ..This approach may avoid implantation of additional subcutaneous defibrillation leads or even thoracotomy for ICD implantation...
  35. ncbi request reprint Torsade de pointes induced by ajmaline
    W Haverkamp
    Medizinische Klinik und Poliklinik, Innere Medizin C Kardiologie, Angiologie Westfälische Wilhelms Universität Münster 48129 Münster, Germany
    Z Kardiol 90:586-90. 2001
    ....
  36. ncbi request reprint [Syncope of unknown origin in heart failure: which diagnostic possibilities should be considered today?]
    D Bocker
    Medizinische Klinik und Poliklinik Innere Medizin C, Universitäts klinikum Münster
    Herz 26:229-32. 2001
    ..Electrophysiological studies should be considered early in the work-up of syncope. Implantation of a defibrillator might become necessary in many patients with syncope and heart failure...
  37. ncbi request reprint [Clinical aspects and molecular genetics of the Jervell- and Lange-Nielsen Syndrome]
    G Mönnig
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie Universitätsklinikum Münster, Institut für Arterioskleroseforschung Westfälische Wilhelms Universität Münster Albert Schweitzer Strasse 33 48129 Münster, Germany
    Z Kardiol 91:380-8. 2002
    ..In the present paper, we review the clinical and genetic similarities and differences of the J-LN and the R-W syndrome as well as the diagnostic and therapeutic management of these patients and their family members...
  38. ncbi request reprint [Right ventricular arrhythmias]
    T Wichter
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster
    Internist (Berl) 45:1125-35. 2004
    ..This review summarizes the current knowledge on pathogenesis, diagnosis, treatment and prognosis of those conditions that are associated with arrhythmias originating from the right ventricle...
  39. ncbi request reprint [New knowledge in arrhythmogenesis--role of ion channels and genetic aspects]
    W Haverkamp
    Med Klinik und Poliklinik Innere Medizin C und Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Albert Schweitzer Str 33, D 48149 Munster
    Z Kardiol 89:2-9; discussion 9-10. 2000
    ..The results of these studies are not only of special interest from the scientific point of view. It is likely to assume that, in the future, they will increasingly influence the diagnosis and treatment of arrhythmias...
  40. ncbi request reprint A patient with "atrial torsades de pointes"
    P Kirchhof
    Department of Cardiology and Angiology and the Institute for Arteriosclerosis Research, University of Munster, Germany
    J Cardiovasc Electrophysiol 11:806-11. 2000
    ..When the arrhythmia was initiated, a new action potential reproducibly emerged from these afterdepolarizations. To the knowledge of the authors, this is the first reported case of "atrial torsades de pointes" in a patient...
  41. ncbi request reprint Arrhythmogenic right ventricular cardiomyopathy. Antiarrhythmic drugs, catheter ablation, or ICD?
    Thomas Wichter
    Department of Cardiology and Angiology, University Hospital of Munster, Munster, Germany
    Herz 30:91-101. 2005
    ....
  42. ncbi request reprint Implantable cardioverter-defibrillator therapy in patients with congenital long-QT syndrome: a long-term follow-up
    Gerold Mönnig
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Heart Rhythm 2:497-504. 2005
    ..The purpose of this study was to evaluate retrospectively a single-center experience with the use of ICDs in patients with long QT syndrome (LQTS) concerning outcome, complications, and optimal programming...
  43. ncbi request reprint Electrocardiography and Doppler echocardiography for risk stratification in patients with chronic heart failure: incremental prognostic value of QRS duration and a restrictive mitral filling pattern
    Christian Bruch
    Department of Cardiology and Angiology, University Hospital of Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    J Am Coll Cardiol 45:1072-5. 2005
    ..This prospective study tested whether Doppler echocardiographic variables add incremental value to QRS duration in determining the prognosis of patients with chronic heart failure (CHF) and systolic dysfunction...
  44. doi request reprint Diastolic isthmus length and 'vertical' isthmus angulation identify patients with difficult catheter ablation of typical atrial flutter: a pre-procedural MRI study
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Europace 11:42-7. 2009
    ..The intervention targets a defined anatomical structure, the so-called cavotricuspid isthmus (CTI). We sought to characterize CTI anatomy in vivo in patients with difficult and simple catheter ablation of atrial flutter...
  45. ncbi request reprint A trial of self-adhesive patch electrodes and hand-held paddle electrodes for external cardioversion of atrial fibrillation (MOBIPAPA)
    Paulus Kirchhof
    Department of Cardiology and Angiology, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Eur Heart J 26:1292-7. 2005
    ..Whether the type of shock electrode affects cardioversion success is not known. We tested whether hand-held steel electrodes improve cardioversion outcome with monophasic or biphasic shocks when compared with adhesive patch electrodes...
  46. ncbi request reprint Further evidence of a close anatomical relation between the oesophagus and pulmonary veins
    Gerold Mönnig
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
    Europace 7:540-5. 2005
    ..Therefore, the position of the oesophagus in relation to the left atrium (LA) is of major importance for AF ablation...
  47. ncbi request reprint Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data
    Matthias Paul
    Department of Cardiology and Angiology, University Hospital of Muenster, Albert Schweitzer Str 33, D 48149 Muenster, Germany
    Eur Heart J 28:2126-33. 2007
    ..The role of programmed ventricular stimulation (PVS) in risk stratification has been controversially discussed. Therefore, we performed a meta-analysis on the prognostic role of PVS in BS...
  48. ncbi request reprint MRI of right atrial function after catheter ablation of atrial flutter
    Murat Ozgun
    Department of Radiology, St Franziskus Hospital, Muenster, Germany
    Acad Radiol 17:856-61. 2010
    ..The objective of this study was to evaluate the changes in CTI length and right atrial (RA) function after radiofrequency ablation of isthmus-dependent atrial flutter (isthmus ablation)...
  49. ncbi request reprint Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology, Munster, Germany
    J Cardiovasc Electrophysiol 18:647-54. 2007
    ..We therefore investigated the group of quinolone antibiotics that reduce repolarization reserve via I(Kr) blockade in an intact heart model of proarrhythmia...
  50. ncbi request reprint Cardiovascular characterization of Pkd2(+/LacZ) mice, an animal model for the autosomal dominant polycystic kidney disease type 2 (ADPKD2)
    Jörg Stypmann
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Int J Cardiol 120:158-66. 2007
    ..Even existing Pkd1 or Pkd2 mouse models were not thoroughly analyzed in this respect. Therefore, the aim of this project was the noninvasive functional cardiovascular characterization of a mouse model for ADPKD2...
  51. ncbi request reprint Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome
    Peter Milberg
    Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms University, Munster, Germany
    J Cardiovasc Electrophysiol 18:658-64. 2007
    ..As therapeutic options in SQTS are still controversial, we examined antiarrhythmic mechanisms in an experimental model of SQTS...
  52. pmc Primary prevention of sudden cardiac death
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Heart 92:1873-8. 2006
  53. ncbi request reprint Electrocardiographic risk stratification in families with congenital long QT syndrome
    Gerold Mönnig
    Department of Cardiology and Angiology, Medizinische Klinik und Poliklinik C, University Hospital Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Eur Heart J 27:2074-80. 2006
    ..The QT interval in the surface ECG is one of the most often used risk stratifiers in families with congenital long QT syndrome (LQTS). The best ECG lead for clinical management of LQTS families remains unclear...
  54. ncbi request reprint Reduced repolarization reserve due to anthracycline therapy facilitates torsade de pointes induced by IKr blockers
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Dept of Cardiology and Angiology, Munster, Germany
    Basic Res Cardiol 102:42-51. 2007
    ..We hypothesized that anthracyclines facilitate life-threatening proarrhythmic side effects of cardiovascular and non-cardiovascular repolarization prolonging drugs...
  55. ncbi request reprint Doppler echocardiography and tissue Doppler imaging in the healthy rabbit: differences of cardiac function during awake and anaesthetised examination
    Jörg Stypmann
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    Int J Cardiol 115:164-70. 2007
    ..Exploration of animal models may require anaesthesia but there is only very little information on the effect of anaesthesia on echocardiographic parameters in rabbits...
  56. doi request reprint Echocardiographic assessment of global left ventricular function in mice
    Jörg Stypmann
    Department of Cardiology and Angiology, Hospital of the University of Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Lab Anim 43:127-37. 2009
    ....
  57. ncbi request reprint Age and gender related reference values for transthoracic Doppler-echocardiography in the anesthetized CD1 mouse
    Jörg Stypmann
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Int J Cardiovasc Imaging 22:353-62. 2006
    ..Although mouse echocardiography is widely used, there is only little information on reference data for wild-type animals available, particularly in older mice...
  58. ncbi request reprint LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling
    Jörg Stypmann
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Basic Res Cardiol 101:281-91. 2006
    ..Extent and basis of the contractile dysfunction is not completely understood...
  59. ncbi request reprint Electrophysiological effects of flecainide and sotalol in the human atrium during persistent atrial fibrillation
    Paulus Kirchhof
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Munster, Germany
    Basic Res Cardiol 100:112-21. 2005
    ..We studied whether two antiarrhythmic drugs (sotalol, flecainide) prolong APD or induce PRR in the fibrillating human atrium...
  60. ncbi request reprint Cardiac autonomic dysfunction in Brugada syndrome
    Thomas Wichter
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology, Munster, Germany
    Circulation 105:702-6. 2002
    ....
  61. ncbi request reprint The long QT syndrome: considerations in the athletic population
    Eric Schulze-Bahr
    Department Molekular Kardiologie, Institut für Arterioskleroseforschung an der Westfälischen, Wilhelms Universitat Munster, Domagkstrasse 3, D 48149 Munster, Germany
    Curr Sports Med Rep 2:72-8. 2003
    ..Further achievements in the areas of clinical and molecular research, improvement of medical education, and expansion of genotyping facilities will facilitate the correct and immediate identification of affected patients...
  62. ncbi request reprint The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol
    Sascha Rolf
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology, Institute for Arteriosclerosis Research, Munster, Germany
    Eur Heart J 24:1104-12. 2003
    ..A detailed protocol for the ajmaline challenge in Brugada syndrome has not yet been described. Therefore, we prospectively studied the risks of a standardized ajmaline test...
  63. ncbi request reprint In vivo recording of monophasic action potentials in awake dogs
    Lars Eckardt
    Medizinische Klinik und Poliklinik C, Westfalische Wilhelms Universitat Munster, D 48129 Munster, Germany
    Methods 30:109-14. 2003
    ..In various canine in vivo models including in vivo models of long QT syndrome, heart failures or sudden cardiac death, the present technique permits electrophysiologic measurements without the interference of anesthesia...
  64. ncbi request reprint Effect of sotalol and acute ventricular dilatation on action potential duration and dispersion of repolarization after defibrillation shocks
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Germany
    J Cardiovasc Pharmacol 41:640-8. 2003
    ..Synchronization of repolarization, caused by both prolongation of short PS-APD and shortening of long PS-APD, is associated with successful defibrillation in the normal, acutely dilated, and sotalol-treated heart...
  65. ncbi request reprint Amiodarone-induced postrepolarization refractoriness suppresses induction of ventricular fibrillation
    Paulus Kirchhof
    Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, University Hospital Munster, Munster, Germany
    J Pharmacol Exp Ther 305:257-63. 2003
    ..PRR without conduction slowing is a desirable feature of drugs designed to prevent ventricular arrhythmias...
  66. ncbi request reprint Molecular mechanisms of inherited ventricular arrhythmias
    Thomas Wichter
    Department of Cardiology and Angiology, Institute for Arteriosclerosis Research, University of Munster, Germany
    Herz 27:712-39. 2002
    ..However, recent advances in research and science have identified a genetic background for many of these diseases...
  67. ncbi request reprint Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia
    Larissa Fabritz
    Medizinische Klinik und Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Germany
    Basic Res Cardiol 98:25-32. 2003
    ..We sought to develop a mouse heart model for such arrhythmias in order to identify the proarrhythmic potential in transgenic animals...
  68. ncbi request reprint Anterior-posterior versus anterior-lateral electrode positions for external cardioversion of atrial fibrillation: a randomised trial
    Paulus Kirchhof
    Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, University of Munster, Munster, Germany
    Lancet 360:1275-9. 2002
    ..We undertook a randomised trial comparing the two positions with the endpoint of successful cardioversion...
  69. ncbi request reprint Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Pharmacol Exp Ther 303:218-25. 2002
    ..This effect may be related to a rectangular pattern of action potential prolongation, whereas erythromycin and clarithromycin cause triangular action potential prolongation and induce TdP...
  70. ncbi request reprint [Atrial fibrillation: molecular biology bases]
    Wilhelm Haverkamp
    Medizinische Klinik, Poliklinik C Kardiologie und Angiologie, Universitatsklinikum Munster, Institut für Arterioskleroseforschung, Westfälischen Wilhelms Universität Münster
    Herz 27:301-5. 2002
    ..Recently, the chromosomal locus for familial atrial fibrillation has been mapped to chromosome 10q22-q23, however, so far the causative gene has not been identified...
  71. ncbi request reprint A novel nonfluoroscopic catheter visualization system (LocaLisa) to reduce radiation exposure during catheter ablation of supraventricular tachycardias
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, and Institute for Arteriosclerosis Research, University of Munster, Germany
    Am J Cardiol 90:340-3. 2002
  72. ncbi request reprint Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation
    Lars Eckardt
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Pharmacol Exp Ther 300:64-71. 2002
    ..It is likely that a different mode of interaction between sertindole and the channel and/or additional pharmacological effects of sertindole, e.g., its ability to inhibit I(Na) and/or its ability to block alpha(1)-receptors, play a role...
  73. ncbi request reprint Body surface potential mapping in patients with Brugada syndrome: right precordial ST segment variations and reverse changes in left precordial leads
    Hans Jürgen Bruns
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    Cardiovasc Res 54:58-66. 2002
    ..The diagnostic value of the QRS integral and of the gradient of the ST segment have not been elucidated in Brugada syndrome...
  74. ncbi request reprint Endocardial mapping of right ventricular outflow tract tachycardia using noncontact activation mapping
    Michael Ribbing
    Department of Cardiology and Angiology, University Hospital Munster, Institute for Arteriosclerosis Research at the University of Münster, Munster, Germany
    J Cardiovasc Electrophysiol 14:602-8. 2003
    ..These methods are limited in patients with nonsustained tachycardia or isolated ventricular ectopic beats. We investigated the feasibility of using noncontact mapping to guide the ablation of RVOT arrhythmias...
  75. ncbi request reprint Electrical alternans in long QT syndrome resembling a Brugada syndrome pattern
    Eric Schulze-Bahr
    Institute for Arteriosclerosis Research at the University of Münster, Molecular Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Pacing Clin Electrophysiol 26:2033-5. 2003
    ..A genetic basis for the long QT syndrome has been ruled out by sequencing of all coding areas of the LQT genes. Potential mechanisms for the electrical alternans are discussed...
  76. ncbi request reprint Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, and Institute for Arteriosclerosis Research at the University of Münster, Munster, Germany
    J Cardiovasc Electrophysiol 14:1027-33. 2003
    ..Atrial APD and Polymorphic AT in LQTS...
  77. ncbi request reprint Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology, Munster, Germany
    Cardiovasc Res 65:397-404. 2005
    ....
  78. ncbi request reprint Phytanic acid accumulation is associated with conduction delay and sudden cardiac death in sterol carrier protein-2/sterol carrier protein-x deficient mice
    Gerold Mönnig
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    J Cardiovasc Electrophysiol 15:1310-6. 2004
    ....
  79. ncbi request reprint Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome
    Peter Kies
    Department of Nuclear Medicine, University Hospital Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Circulation 110:3017-22. 2004
    ..The aim of this study was to investigate presynaptic and postsynaptic myocardial sympathetic function in patients with Brugada syndrome...
  80. ncbi request reprint Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Pharmacol 44:278-86. 2004
    ....
  81. ncbi request reprint Recurrent syncope triggered by inappropriate sinus tachycardia
    Gerold Mönnig
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Pacing Clin Electrophysiol 27:1324-6. 2004
    ....
  82. ncbi request reprint Catheter ablation of atrial tachycardia due to recipient-to-donor transatrial conduction after orthotopic heart transplantation
    Michael Ribbing
    Department of Cardiology and Angiology, Hospital of the University of Münster and Institute for Arteriosclerosis Research at the University of Münster, Germany
    Europace 6:215-9. 2004
    ..Electroanatomical mapping identified the site of transatrial conduction and guided successful catheter ablation...
  83. ncbi request reprint T wave alternans does not assess arrhythmic risk in patients with Brugada syndrome
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Institute of Arteriosclerosis Research at the University of Münster, Germany
    Ann Noninvasive Electrocardiol 9:162-5. 2004
    ..We therefore tested whether TWA is an indicator for arrhythmias in Brugada syndrome with a focus on right precordial ECG leads...
  84. pmc Atrioventricular nodal re-entrant tachycardia in a patient with Ebstein anomaly
    G Mönnig
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Heart 90:e58. 2004
    ..Thus, slow pathway modulation seems to be a safe procedure even in selected patients with Ebstein anomaly...
  85. ncbi request reprint Amiodarone and acetazolamide for the treatment of genetically confirmed severe Andersen syndrome
    J Junker
    Department of Neurology, Universitatsklinikum Munster, D 48129 Munster, Germany
    Neurology 59:466. 2002
  86. doi request reprint Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3
    Peter Milberg
    Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms University, Munster, Germany
    Heart Rhythm 5:1444-52. 2008
    ..The cardiac Na(+)/Ca(2+) exchanger (NCX) has been suggested to work as a trigger for EADs...
  87. ncbi request reprint [Catheter ablation of electrical storm : Ready for prime time?]
    D G Dechering
    Abteilung für Rhythmologie, Department für Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Campus 1, 48149, Munster, Deutschland
    Herzschrittmacherther Elektrophysiol 25:88-92. 2014
    ..Apart from pharmacological treatment options, catheter ablation remains a relatively novel, promising addition to the armamentarium of the cardiologist. Here, we will review the study data on ablation of patients with electrical storm. ..
  88. doi request reprint [ECG changes in primary neurological disorders, systemic diseases and primary cardioymopathies]
    E Kaya
    Abteilung für Rhythmologie, Department für Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Campus 1, Gebäude A1, 48149, Munster, Deutschland
    Herzschrittmacherther Elektrophysiol 24:109-14. 2013
    ..The takotsubo cardiomyopathy commonly reveals transient ST-segment elevation and therefore depicts an important differential diagnosis of acute coronary syndromes. ..
  89. ncbi request reprint [Current status and problems of the entirely subcutaneous ICD (S-ICD®)]
    F Reinke
    Abteilung für Rhythmologie, Department für Kardiologie und Angiologie, Universitatsklinikum Munster, Munster, Germany
    Herzschrittmacherther Elektrophysiol 24:165-70. 2013
    ..S-ICD® is no alternative to the transvenous system due to limited programming options and the lack of stimulation, but it is an interesting supplement of ICD therapy...
  90. doi request reprint [Atrial fibrillation : new anticoagulants and antiarrhythmic drugs]
    E Kaya
    Abteilung für Rhythmologie, Department für Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Campus 1, Gebäude A1, Munster, Germany
    Herz 37:159-65. 2012
    ..Vernakalant and dronedarone are new antiarrhythmic drugs for rhythm control of atrial fibrillation. However, therapeutic efficacy of the new agents still has to be proven...
  91. ncbi request reprint Cervical intramedullar schistosomiasis as a rare cause of acute tetraparesis
    J Junker
    Department of Neurology, University of Munster, Albert Schweitzer Street 33, 48129, Munster, Germany
    Clin Neurol Neurosurg 103:39-42. 2001
    ..Granulomas cause the typical manifestations of urogenital, intestinal and hepatolienal schistosomiasis. Involvement of other organs especially the central nervous system (CNS) is uncommon...
  92. ncbi request reprint A case of paroxysmal supraventricular tachycardia
    Kristina Wasmer
    From the Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    Pacing Clin Electrophysiol 27:1545-6. 2004
  93. ncbi request reprint Interatrial conduction delay and atrioventricular block due to primary cardiac lymphoma
    Markus A Engelen
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    J Cardiovasc Electrophysiol 16:926. 2005
  94. ncbi request reprint Gender differences in cardiac arrhythmias
    Eric Schulze-Bahr
    Department of Cardiology and Angiology, University Hospital Muenster, Muenster, Germany
    Herz 30:390-400. 2005
    ..The interaction of theses influences with regional cellular factors will help us in the future to analyze gender-specific factors of arrhythmogenesis and develop treatment and prevention strategies...
  95. doi request reprint Damage to the esophagus after atrial fibrillation ablation: Just the tip of the iceberg? High prevalence of mediastinal changes diagnosed by endosonography
    Stephan Zellerhoff
    Department of Cardiology and Angiology, University Hospital of Muenster, D 48149 Muenster, Germany
    Circ Arrhythm Electrophysiol 3:155-9. 2010
    ....
  96. ncbi request reprint True right bundle branch block masking the typical ECG in Brugada syndrome
    Sascha Rolf
    Charite Campus Virchow Klinikum, Department of Cardiology, Berlin, Germany
    Pacing Clin Electrophysiol 28:258-9. 2005
    ..In consideration of the inalienable diagnostic criterion of dynamic ECG abnormalities in the right precordial leads in Brugada syndrome, setting the diagnosis in patients with true RBBB may be unattainable...
  97. ncbi request reprint Real-time, three-dimensional, nonfluoroscopic localization of the Lasso catheter
    Fred Wittkampf
    Department of Cardiology, Heart Lung Center, Utrecht, The Netherlands
    J Cardiovasc Electrophysiol 13:630. 2002
  98. ncbi request reprint Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome
    Rainer Schimpf
    First Department of Medicine, Division of Cardiology, University Hospital Mannheim, Germany
    Ann Noninvasive Electrocardiol 13:266-9. 2008
    ..Initial reports in small numbers of patients suggest an association between supraventricular tachycardias and Brugada syndrome with a prevalence varying between 13% and 40%...
  99. ncbi request reprint [Long QT syndrome and Brugada syndrome. Drugs, ablation or ICD?]
    Wilhelm Haverkamp
    Medizinische Klinik mit Schwerpunkt Kardiologie, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    Herz 30:111-8. 2005
    ..In asymptomatic patients with a Brugada ECG pattern, risk stratification has become of utmost importance in order to discover which patients really need definitive treatment...
  100. ncbi request reprint A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification
    Christian Veltmann
    First Department of Medicine, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Heart J 27:2544-52. 2006
    ..The purpose of this study was to prospectively evaluate the spontaneous ECG changes between diagnostic and non-diagnostic ECG patterns in patients diagnosed with Brugada syndrome...
  101. ncbi request reprint Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome
    Arie O Verkerk
    Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 68:441-53. 2005
    ..Other causally related genes still await identification. We evaluated the role of HERG (KCNH2), which encodes the alpha-subunit of the rapid delayed rectifier K(+) channel (I(Kr)), in BrS...