M Durante

Summary

Country: Germany

Publications

  1. pmc The fate of a normal human cell traversed by a single charged particle
    C Fournier
    Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany
    Sci Rep 2:643. 2012
  2. pmc Human embryo stem cells and DNA repair
    Marco Durante
    GSII Helmholtzzentrum für Schwerionenforschung, Planckstraβe 1, Darmstadt 64291, Germany
    Aging (Albany NY) 3:564. 2011
  3. pmc Biophysical characterization of a relativistic proton beam for image-guided radiosurgery
    Zhan Yu
    Biophysics Department, GSI Helmholtz Center for Heavy Ions Research, Planckstraße 1, Darmstadt, Germany
    J Radiat Res 53:620-7. 2012
  4. pmc Influence of acute hypoxia and radiation quality on cell survival
    Walter Tinganelli
    Biophysics Department, GSI Helmholtzzentrum fur Schwerionenforschung, 64291 Darmstadt, Germany
    J Radiat Res 54:i23-30. 2013
  5. pmc Influence of chronic hypoxia and radiation quality on cell survival
    Ning Yi Ma
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, 200032 Shanghai, China
    J Radiat Res 54:i13-22. 2013
  6. doi request reprint From DNA damage to chromosome aberrations: joining the break
    M Durante
    GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany Darmstadt University of Technology, Darmstadt, Germany Electronic address
    Mutat Res 756:5-13. 2013
  7. doi request reprint Immunologically augmented cancer treatment using modern radiotherapy
    Marco Durante
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Darmstadt, Germany Technische Universität Darmstadt, Darmstadt, Germany Electronic address
    Trends Mol Med 19:565-82. 2013
  8. doi request reprint Eighth Warren K. Sinclair keynote address: Heavy ions in therapy and space: benefits and risks
    Marco Durante
    GSI Helmholtz Center for Heavy Ion Research and Darmstadt University of Technology, Planckstrasse 1, 64291 Darmstadt, Germany
    Health Phys 103:532-9. 2012
  9. pmc Scanned carbon beam irradiation of moving films: comparison of measured and calculated response
    Christoph Bert
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstr 1, 64291 Darmstadt, Germany
    Radiat Oncol 7:55. 2012
  10. pmc Dosimetric precision of an ion beam tracking system
    Christoph Bert
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Abteilung Biophysik, Planckstrasse 1, 64291 Darmstadt, Germany
    Radiat Oncol 5:61. 2010

Collaborators

Detail Information

Publications64

  1. pmc The fate of a normal human cell traversed by a single charged particle
    C Fournier
    Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany
    Sci Rep 2:643. 2012
    ..We conclude that cells surviving single-ion traversal, often carrying clonal chromosome aberrations, undergo accelerated senescence but maintain chromosomal stability...
  2. pmc Human embryo stem cells and DNA repair
    Marco Durante
    GSII Helmholtzzentrum für Schwerionenforschung, Planckstraβe 1, Darmstadt 64291, Germany
    Aging (Albany NY) 3:564. 2011
    ..Comment on:Bogomazova AN et al. Aging. 2011; this issue. Bogomazova et al. now convincingly prove that hESCs use the error-prone NHEJ DNA repair pathway in G2-phase...
  3. pmc Biophysical characterization of a relativistic proton beam for image-guided radiosurgery
    Zhan Yu
    Biophysics Department, GSI Helmholtz Center for Heavy Ions Research, Planckstraße 1, Darmstadt, Germany
    J Radiat Res 53:620-7. 2012
    ..The very low lateral scattering of relativistic protons and the possibility of using online proton radiography during the treatment make them attractive for image-guided plateau (non-Bragg peak) stereotactic radiosurgery...
  4. pmc Influence of acute hypoxia and radiation quality on cell survival
    Walter Tinganelli
    Biophysics Department, GSI Helmholtzzentrum fur Schwerionenforschung, 64291 Darmstadt, Germany
    J Radiat Res 54:i23-30. 2013
    ..Measurements suggest that ions heavier than carbon could be of additional advantage in the irradiation, especially of radioresistant hypoxic tumor regions. ..
  5. pmc Influence of chronic hypoxia and radiation quality on cell survival
    Ning Yi Ma
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, 200032 Shanghai, China
    J Radiat Res 54:i13-22. 2013
    ..We conclude that, in hamster cells, chronic anoxia is less effective than acute anoxia in inducing radioresistance for both X-rays and carbon ions, whereas in hypoxia, acute and chronic exposures have a similar impact on cell killing. ..
  6. doi request reprint From DNA damage to chromosome aberrations: joining the break
    M Durante
    GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany Darmstadt University of Technology, Darmstadt, Germany Electronic address
    Mutat Res 756:5-13. 2013
    ..These topics have been recently debated by molecular biologists and cytogeneticists, whose opinions are summarized in this paper. ..
  7. doi request reprint Immunologically augmented cancer treatment using modern radiotherapy
    Marco Durante
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Darmstadt, Germany Technische Universität Darmstadt, Darmstadt, Germany Electronic address
    Trends Mol Med 19:565-82. 2013
    ..Only a detailed understanding of the molecular mechanisms can guide the implementation of combined therapy modalities. ..
  8. doi request reprint Eighth Warren K. Sinclair keynote address: Heavy ions in therapy and space: benefits and risks
    Marco Durante
    GSI Helmholtz Center for Heavy Ion Research and Darmstadt University of Technology, Planckstrasse 1, 64291 Darmstadt, Germany
    Health Phys 103:532-9. 2012
    ..These special characteristics of heavy ions can be used to treat tumors efficiently, as it is currently done in Japan and Germany, but they represent a threat for human space exploration...
  9. pmc Scanned carbon beam irradiation of moving films: comparison of measured and calculated response
    Christoph Bert
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstr 1, 64291 Darmstadt, Germany
    Radiat Oncol 7:55. 2012
    ..These calculation codes should be verified against suitable measurements. We performed simulations and measurements to validate calculation of the film response in the presence of target motion...
  10. pmc Dosimetric precision of an ion beam tracking system
    Christoph Bert
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Abteilung Biophysik, Planckstrasse 1, 64291 Darmstadt, Germany
    Radiat Oncol 5:61. 2010
    ..Scanned ion beam therapy of intra-fractionally moving tumors requires motion mitigation. GSI proposed beam tracking and performed several experimental studies to analyse the dosimetric precision of the system for scanned carbon beams...
  11. doi request reprint Influence of nuclear geometry on the formation of genetic rearrangements in human cells
    M Durante
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, 64291 Darmstadt, Germany
    Radiat Res 174:20-6. 2010
    ..The results demonstrate that the architecture of the cell nucleus determines the formation of chromosomal rearrangements...
  12. doi request reprint Heavy ion carcinogenesis and human space exploration
    Marco Durante
    Biophysics group at GSI, Planckstrasse 1, 64291 Darmstadt, Germany
    Nat Rev Cancer 8:465-72. 2008
    ..Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets...
  13. ncbi request reprint Physical and biomedical countermeasures for space radiation risk
    Marco Durante
    GSI, Biophysics Department, 1 Planckstrasse, 64291 Darmstadt, Germany
    Z Med Phys 18:244-52. 2008
    ..It is foreseeable that research in passive and active radiation shielding, radioprotective chemicals, and individual susceptibility will boost in the next years to provide efficient countermeasures to the space radiation threat...
  14. ncbi request reprint Applications of particle microbeams in space radiation research
    Marco Durante
    GSI, Biophysics Department, and Technical University of Darmstadt, Planckstrasse 1, D 64291 Darmstadt, Germany
    J Radiat Res 50:A55-8. 2009
    ..3D tissue or animal systems represent a more promising target for space radiobiology using microbeams...
  15. doi request reprint Charged particles in radiation oncology
    Marco Durante
    Gesellschaft fur Schwerionenforschung GSI, Helmholtzzentrum für Schwerionenforschung, Biophysics Department, Plackstrasse 1, Darmstadt, Germany
    Nat Rev Clin Oncol 7:37-43. 2010
    ..This Review considers the present clinical results in the field, and identifies and discusses the research questions that have resulted with this technique...
  16. pmc New challenges in high-energy particle radiobiology
    M Durante
    GSI Helmholtz Center for Heavy Ion Research, Biophysics Department, Darmstadt, Germany
    Br J Radiol 87:20130626. 2014
    ..Particle radiobiology is therefore now entering into a new phase, where beyond RBE, the tissue response is considered. These results may open new applications for both cancer therapy and protection in deep space. ..
  17. doi request reprint A DNA double-strand break kinetic rejoining model based on the local effect model
    F Tommasino
    a GSI Helmholtzzentrum für Schwerionenforschung, Department of Biophysics, Darmstadt, Germany and
    Radiat Res 180:524-38. 2013
    ..Importantly the density of DSB within DNA giant loops of around 2 Mbp size, i.e., on a micrometer scale, is identified as a key parameter for the description of radiation effectiveness. ..
  18. pmc Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci
    J Splinter
    Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutagenesis 25:289-97. 2010
    ..Hence, our results indicate that the local dose delivered by UVA-LMI is extremely high and cannot be accurately translated into an equivalent ionizing radiation dose, despite the sophisticated techniques used in this study...
  19. ncbi request reprint Fate of D3 mouse embryonic stem cells exposed to X-rays or carbon ions
    S Luft
    Biophysics Department, GSI Helmholtz Centre for Heavy Ion Research, Planckstraße 1, 64291 Darmstadt, Germany
    Mutat Res Genet Toxicol Environ Mutagen 760:56-63. 2014
    ..We conclude that cells surviving the radiation exposure maintain pluripotency but may carry stable chromosomal rearrangements after densely ionizing radiation. ..
  20. doi request reprint Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning
    Thilo Elsasser
    Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
    Int J Radiat Oncol Biol Phys 78:1177-83. 2010
    ....
  21. ncbi request reprint Radiation dose detection by imaging response in biological targets
    B Jakob
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Planckstraße 1, 64291 Darmstadt, Germany
    Radiat Res 177:524-32. 2012
    ..Alternatively, prompt γ rays or scattered secondary particles are under study for in vivo dosimetry of ion beams in therapy...
  22. doi request reprint Sensitivity analysis of the relative biological effectiveness predicted by the local effect model
    T Friedrich
    GSI Helmholtzzentrum fur Schwerionenforschung, Darmstadt, Germany
    Phys Med Biol 58:6827-49. 2013
    ..These results may be used for the assessment of treatment plans and for general uncertainty estimations of the RBE. ..
  23. doi request reprint Cellular effects of energetic heavy ions: from DNA breaks to chromosomal rearrangements
    D Pignalosa
    Biophysics Department, GSI, Planckstrasse 1, Darmstadt, Germany
    Radiat Prot Dosimetry 143:391-3. 2011
    ..A clear difference is seen in the fraction of aberrant cells, owing to the different nuclear cross sections...
  24. ncbi request reprint Accuracy of RBE: experimental and theoretical considerations
    T Friedrich
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstrasse 1, 64291 Darmstadt, Germany
    Radiat Environ Biophys 49:345-9. 2010
    ..Uncertainties of RBE, visualized by error bars, are of importance for treatment planning and also for setting up a precision goal for predicting biophysical models such as the local effect model...
  25. ncbi request reprint Prediction methods for synchronization of scanned ion beam tracking
    N Saito
    GSI Helmholtz Centre for Heavy Ion Research GmbH, Planckstraße 1, 64291 Darmstadt, Germany
    Phys Med 29:639-43. 2013
    ..Prediction times of 25 ms for target spot prediction were required for ~6 mm water-equivalent longitudinal beam shifts. The experimental tests proved feasibility of the implemented prediction algorithm...
  26. doi request reprint Spatiotemporal analysis of DNA repair using charged particle radiation
    F Tobias
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutat Res 704:54-60. 2010
    ..With the help of the microbeam, geometrical patterns of traversing ions can be applied facilitating the analysis of spatial organisation of repair...
  27. doi request reprint Upgrade and benchmarking of a 4D treatment planning system for scanned ion beam therapy
    D Richter
    GSI Helmholtzzentrum für Schwerionenforschung GmbH, Abt Biophysik, Planckstraße 1, 64291 Darmstadt, Germany
    Med Phys 40:051722. 2013
    ..e., modeling of dose heterogeneities due to interplay effects and range changes caused by patient motion and dynamic beam delivery...
  28. doi request reprint Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribution in carbon ion therapy
    R Grun
    Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
    Phys Med Biol 57:7261-74. 2012
    ..Median RBE-weighted doses predicted by LEM IV in the target region are consistent with clinically observed dose-response behavior as demonstrated by comparison to the 5-year local control curve for skull base chordoma...
  29. doi request reprint Development and performance evaluation of a dynamic phantom for biological dosimetry of moving targets
    A Gemmel
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstr 1, 64291 Darmstadt, Germany
    Phys Med Biol 55:2997-3009. 2010
    ..75) and values reported in the literature. Mean differences between measured and calculated cell survival for these two irradiation modes were within +/-5% of the target dose of 6 Gy (RBE)...
  30. doi request reprint Algorithms for the optimization of RBE-weighted dose in particle therapy
    M Horcicka
    Biophysics Department, GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Planckstr 1, D 64291 Darmstadt, Germany
    Phys Med Biol 58:275-86. 2013
    ..At the end we discuss future goals concerning dose optimization issues in particle therapy which might benefit from fast optimization solvers...
  31. doi request reprint Out-of-field dose measurements in a water phantom using different radiotherapy modalities
    R Kaderka
    Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany
    Phys Med Biol 57:5059-74. 2012
    ..The out-of-field dose for x-rays increases with increasing beam energy because of the production of biologically harmful neutrons...
  32. doi request reprint A breathing thorax phantom with independently programmable 6D tumour motion for dosimetric measurements in radiation therapy
    P Steidl
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt, Germany
    Phys Med Biol 57:2235-50. 2012
    ..In addition, initial dosimetric tests for treatment with a scanned carbon beam are reported...
  33. ncbi request reprint Gating delays for two respiratory motion sensors in scanned particle radiation therapy
    P Steidl
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt, Germany
    Phys Med Biol 58:N295-302. 2013
    ..5%, D5-D95 = 13%). We conclude, that the delay of the motion monitoring system should be part of the commissioning process for gated treatments. The dosimetric impact should be studied in detail prior treatments with a scanned ion beam. ..
  34. doi request reprint Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification
    E Scifoni
    Biophysics Department, GSI Helmoltzzentrum für Schwerionenforschung, D 64291 Darmstadt, Germany
    Phys Med Biol 58:3871-95. 2013
    ..The comparison of the predictions resulting by using different model tables are also reported...
  35. ncbi request reprint Fast optimization and dose calculation in scanned ion beam therapy
    S Hild
    Department of Biophysics, GSI Helmholtzzentrum fur Schwerionenforschung GmbH, 64291 Darmstadt, Germany Department of Radiation Oncology, University Clinic Erlangen and Friedrich Alexander Universität Erlangen Nürnberg FAU, 91054 Erlangen, Germany and Institute for Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany
    Med Phys 41:071703. 2014
    ..For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98...
  36. ncbi request reprint Microdosimetry measurements characterizing the radiation fields of 300 MeV/u 12C and 185 MeV/u 7Li pencil beams stopping in water
    G Martino
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, 64291 Darmstadt, Germany
    Phys Med Biol 55:3441-9. 2010
    ..The measured (12)C dose profiles were found to be in good agreement with a similar experimental study at HIMAC (Japan)...
  37. ncbi request reprint Complex exchanges are responsible for the increased effectiveness of C-ions compared to X-rays at the first post-irradiation mitosis
    Ryonfa Lee
    Biophysics Department, GSI Helmholtzzentrum fur Schwerionenforschung, Planckstrasse 1, 64291 Darmstadt, Germany
    Mutat Res 701:52-9. 2010
    ....
  38. ncbi request reprint Speed and accuracy of a beam tracking system for treatment of moving targets with scanned ion beams
    Nami Saito
    GSI Helmholtz Centre for Heavy Ion Research GmbH, Planckstrasse 1, 64291 Darmstadt, Germany
    Phys Med Biol 54:4849-62. 2009
    ..For example, 5 mm water equivalence (WE) longitudinal beam tracking results in accuracy of 1.08 and 0.48 mm WE in root mean square for time windows of 10 and 50 ms, respectively...
  39. ncbi request reprint Ion beam tracking using ultrasound motion detection
    M Prall
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany
    Med Phys 41:041708. 2014
    ..The aim of this phantom-based study was to evaluate the option of diagnostic ultrasound (US) imaging (sonography) as real-time motion detection method for scanned heavy ion beam irradiation of moving targets...
  40. ncbi request reprint Characterization of the secondary neutron field produced during treatment of an anthropomorphic phantom with x-rays, protons and carbon ions
    C La Tessa
    Helmholtzzentrum für Schwerionenforschung GmbH, Planckstrasse 1, D 64291 Darmstadt, Germany
    Phys Med Biol 59:2111-25. 2014
    ....
  41. doi request reprint Simulations of dose enhancement for heavy atom nanoparticles irradiated by protons
    C Wälzlein
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Planckstraße 1, D 64291 Darmstadt, Germany Frankfurt Institute for Advanced Studies FIAS, Ruth Moufang Str 1, D 60438 Frankfurt am Main, Germany Technische Universität Darmstadt, Darmstadt, Germany
    Phys Med Biol 59:1441-58. 2014
    ..We find a noticeable impact of Auger electrons emitted from the nanoparticles. Special focus has been given to the assessment of complete sets of low-energy electron cross sections for the nanoparticle materials...
  42. doi request reprint Motion in radiotherapy: particle therapy
    C Bert
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstr 1, 64291 Darmstadt, Germany
    Phys Med Biol 56:R113-44. 2011
    ..In the field of scanned beam delivery, the report focuses on the results of research on countermeasures of the interference effect. Clinical application of these techniques can be expected in the near future...
  43. doi request reprint Inversions in chromosome 10 of human thyroid cells induced by accelerated heavy ions
    D Pignalosa
    GSI Helmholtzzentrum fur Schwerionenforschung, Department of Biophysics, 64291 Darmstadt, Germany
    Radiat Res 174:14-9. 2010
    ..Within the constraints imposed by the experimental model we used, we conclude that heavy ions would not necessarily be more effective than X rays in the induction of thyroid cancer...
  44. doi request reprint Chromosomal aberrations in peripheral blood lymphocytes of prostate cancer patients treated with IMRT and carbon ions
    Carola Hartel
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, 64291 Darmstadt, Germany
    Radiother Oncol 95:73-8. 2010
    ..To investigate the cytogenetic damage in blood lymphocytes of patients treated for prostate cancer with different radiation qualities and target volumes...
  45. ncbi request reprint Heavy-ion induced chromosomal aberrations: a review
    Sylvia Ritter
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Planckstrasse 1, 64291 Darmstadt, Germany
    Mutat Res 701:38-46. 2010
    ..In this review we will concentrate on recent data obtained with multicolor FISH methods in mammalian chromosomes exposed to heavy-ions, and the open questions that remain to be addressed...
  46. ncbi request reprint Multigating, a 4D Optimized Beam Tracking in Scanned Ion Beam Therapy
    C Graeff
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt, Germany
    Technol Cancer Res Treat 13:497-504. 2014
    ..In conclusion, we showed the technical feasibility of multigating, a 4D-optimization and delivery method using scanned beams that allows for conformal and homogeneous dose delivery to moving targets also in case of complex motion. ..
  47. doi request reprint Advancing the modeling in particle therapy: from track structure to treatment planning
    C Wälzlein
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Planckstraße 1, D 64291 Darmstadt, Germany Frankfurt Institute for Advanced Studies FIAS, Ruth Moufang Str 1, D 60438 Frankfurt am Main, Germany Electronic address
    Appl Radiat Isot 83:171-6. 2014
    ..We also implemented LiF as a possible target for efficiency calculations of thermoluminescent detectors (TLDs). ..
  48. ncbi request reprint Radiation-induced premature senescence is associated with specific cytogenetic changes
    Sebastian Zahnreich
    GSI, Biophysics, Darmstadt, Germany
    Mutat Res 701:60-6. 2010
    ..However, the time of the onset of senescence depends on previous exposure to radiation. We conclude that the occurrence of tetraploidy is associated with senescence independently of exposure to radiation...
  49. doi request reprint Response of human hematopoietic stem and progenitor cells to energetic carbon ions
    Daniela Becker
    GSI, Biophysics, Darmstadt, Germany
    Int J Radiat Biol 85:1051-9. 2009
    ..To characterise the radiation response of human hematopoietic stem and progenitor cells (HSPC) with respect to X and carbon ion irradiation...
  50. pmc Live cell microscopy analysis of radiation-induced DNA double-strand break motion
    B Jakob
    Department of Biophysics, GSI Helmholtzzentrum fur Schwerionenforschung, Planckstrasse 1, D 64291 Darmstadt, Germany
    Proc Natl Acad Sci U S A 106:3172-7. 2009
    ..These observations support the hypothesis that spatial proximity of DNA breaks is required for the formation of radiation-induced chromosomal exchanges...
  51. ncbi request reprint First biological images with high-energy proton microscopy
    D Varentsov
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstrasse 1, Darmstadt, Germany
    Phys Med 29:208-13. 2013
    ..The potential of obtaining high-resolution online imaging of the target using a therapeutic proton beam in the GeV energy region suggests that high-energy proton microscopy may be used for image-guided proton radiosurgery...
  52. ncbi request reprint Ion-optical studies for a range adaptation method in ion beam therapy using a static wedge degrader combined with magnetic beam deflection
    Naved Chaudhri
    GSI Helmholtz Centre for Heavy Ion Research GmbH, Planckstrasse 1, 64291 Darmstadt, Germany
    Phys Med Biol 55:3499-513. 2010
    ..The results demonstrate the feasibility/proof of the proposed range adaptation method for beam tracking from the beam quality point of view...
  53. ncbi request reprint Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings
    Francis A Cucinotta
    National Aeronautics and Space Administration, Lyndon B Johnson Space Centre, Houston, TX 77058, USA
    Lancet Oncol 7:431-5. 2006
    ..In recent years, worldwide efforts have focussed on an increased understanding of the oncogenic potential of galactic cosmic rays. A review of the new results in this specialty will be presented here...
  54. ncbi request reprint Influence of the shielding on the induction of chromosomal aberrations in human lymphocytes exposed to high-energy iron ions
    Marco Durante
    Dipartimento di Scienze Fisiche, Universita Federico II, Monte S Angelo, Via Cintia, 80126 Napoli, Italy
    J Radiat Res 43:S107-11. 2002
    ..These preliminary results prove that shielding can increase the effectiveness of heavy ions, and the damage is dependent upon shield thickness and material...
  55. ncbi request reprint Heavy ion radiobiology for hadrontherapy and space radiation protection
    Marco Durante
    Department of Physics and INFN, University Federico II, Naples, Italy
    Radiother Oncol 73:S158-60. 2004
    ....
  56. ncbi request reprint Radiation protection in deep space
    Marco Durante
    Z Med Phys 15:1-2. 2005
  57. ncbi request reprint Biomarkers of space radiation risk
    Marco Durante
    Department of Physics and INFN, University Federico II, Naples, Italy
    Radiat Res 164:467-73. 2005
    ..Biomarkers may be superior to dose in predicting space radiation risk, pending technical improvements in sensitivity, and validation by epidemiological studies...
  58. ncbi request reprint Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes
    Kerry George
    Wyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058, USA
    Radiat Res 160:425-35. 2003
    ....
  59. ncbi request reprint Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions
    Tetsuya Kawata
    Department of Radiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Radiat Res 43:S169-73. 2002
    ..The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks...
  60. ncbi request reprint Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions
    Honglu Wu
    National Space Biomedical Research Institute, Baylor College of Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 160:418-24. 2003
    ..After 0.7 Gy of iron ions, most complex aberrations were found to involve three or four chromosomes, which is a likely indication of the maximum number of chromosome domains traversed by a single iron-ion track...
  61. ncbi request reprint Estimates of radiological risk from a terrorist attack using plutonium
    Marco Durante
    Dipartimento di Scienze Fisiche, Universita Federico II, Monte S Angelo, Via Cintia, 80126, Napoli, Italy
    Radiat Environ Biophys 41:125-30. 2002
    ....
  62. ncbi request reprint Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients
    Valentina d'Alesio
    Department of Physics, University Federico II, Naples, Italy
    Int J Radiat Oncol Biol Phys 57:732-8. 2003
    ..To measure chromosomal aberrations in blood lymphocytes from breast cancer patients treated with radiotherapy after quadrantectomy or tumorectomy...
  63. ncbi request reprint Chromosomal aberrations in lymphocytes of lung cancer patients treated with carbon ions
    Ryonfa Lee
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 45:195-9. 2004
    ....
  64. ncbi request reprint Measurements of metaphase and interphase chromosome aberrations transmitted through early cell replication rounds in human lymphocytes exposed to low-LET protons and high-LET 12C ions
    Lorenzo Manti
    Radiation Biophysics Laboratory, Department of Physical Sciences, University of Naples Federico II, Complesso Universitario di Monte S Angelo, Via Cinthia, 80126 Naples, Italy
    Mutat Res 596:151-65. 2006
    ..Our data support a differential ability by aberrant cells to progress through post-irradiation mitoses that is influenced by the aberration burden and radiation quality...