Ulrich Duhrsen

Summary

Country: Germany

Publications

  1. doi request reprint Positron emission tomography guided therapy of aggressive non-Hodgkin lymphomas--the PETAL trial
    Ulrich Duhrsen
    Department of Hematology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Leuk Lymphoma 50:1757-60. 2009
  2. pmc Long-term outcome of hemizygous and heterozygous carriers of a germline GATA1 (G208R) mutation
    Ulrich Duhrsen
    Klinik für Hämatologie, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
    Ann Hematol 90:301-6. 2011
  3. doi request reprint FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University of Duisburg Essen, Germany
    Eur J Haematol 83:541-9. 2009
  4. doi request reprint Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    Semra Aydin
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Eur J Haematol 87:10-9. 2011
  5. ncbi request reprint Granulocyte colony-stimulating factor-induced blood stem cell mobilisation in patients with chronic heart failure--Feasibility, safety and effects on exercise tolerance and cardiac function
    Andreas Hüttmann
    Klinik für Hämatologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Basic Res Cardiol 101:78-86. 2006
  6. pmc Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia
    Maher Hanoun
    Department of Hematology, University Hospital, Essen, Germany
    PLoS ONE 7:e34347. 2012
  7. doi request reprint Telomeres and prognosis in patients with chronic lymphocytic leukaemia
    Ludger Sellmann
    Department of Haematology, University of Duisburg Essen, Essen, Germany
    Int J Hematol 93:74-82. 2011
  8. doi request reprint Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia
    Lothar Vassen
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, 45122 Essen, Germany
    Int J Hematol 89:422-30. 2009
  9. doi request reprint Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study
    Lewin Eisele
    Department of Hematology, University Hospital Essen, Essen, Germany
    Ann Hematol 92:731-7. 2013
  10. doi request reprint p53 protein expression in chronic lymphocytic leukemia
    Ludger Sellmann
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Leuk Lymphoma 53:1282-8. 2012

Collaborators

Detail Information

Publications41

  1. doi request reprint Positron emission tomography guided therapy of aggressive non-Hodgkin lymphomas--the PETAL trial
    Ulrich Duhrsen
    Department of Hematology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Leuk Lymphoma 50:1757-60. 2009
    ..So far, 175 patients have been enrolled of whom 128 have reached interim-PET scanning. In patients with a positive scan, relapses were six times more frequent than in patients with a negative scan. Recruitment into the trial continues...
  2. pmc Long-term outcome of hemizygous and heterozygous carriers of a germline GATA1 (G208R) mutation
    Ulrich Duhrsen
    Klinik für Hämatologie, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
    Ann Hematol 90:301-6. 2011
    ....
  3. doi request reprint FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University of Duisburg Essen, Germany
    Eur J Haematol 83:541-9. 2009
    ..In multivariate analysis low FCRL2 expression was a significant independent prognostic factor (HR 2.4; P = 0.005). Here we demonstrate that the level of FCRL2 expression is correlated with prognosis in B-CLL...
  4. doi request reprint Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    Semra Aydin
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Eur J Haematol 87:10-9. 2011
    ..This model could be useful for evaluating the biological basis of CLL growth in the context of the hematopoietic microenvironment as well as preclinical testing of novel compounds...
  5. ncbi request reprint Granulocyte colony-stimulating factor-induced blood stem cell mobilisation in patients with chronic heart failure--Feasibility, safety and effects on exercise tolerance and cardiac function
    Andreas Hüttmann
    Klinik für Hämatologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Basic Res Cardiol 101:78-86. 2006
    ..Sequential administration of G-CSF is feasible and possibly effective in improving physical performance in patients with chronic heart failure. Patients with ICM may be at risk of increased angina and arrhythmias...
  6. pmc Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia
    Maher Hanoun
    Department of Hematology, University Hospital, Essen, Germany
    PLoS ONE 7:e34347. 2012
    ..We also compared the CRY1 expression in CLL with other lymphoid malignancies and observed epigenetic silencing of CRY1 in a patient with B cell acute lymphoblastic leukemia (B-ALL)...
  7. doi request reprint Telomeres and prognosis in patients with chronic lymphocytic leukaemia
    Ludger Sellmann
    Department of Haematology, University of Duisburg Essen, Essen, Germany
    Int J Hematol 93:74-82. 2011
    ..Short telomeres and high telomerase activity as occurs in some patients with CLL with a worse prognosis might be an ideal target for treatment with telomerase inhibitors...
  8. doi request reprint Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia
    Lothar Vassen
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, 45122 Essen, Germany
    Int J Hematol 89:422-30. 2009
    ....
  9. doi request reprint Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study
    Lewin Eisele
    Department of Hematology, University Hospital Essen, Essen, Germany
    Ann Hematol 92:731-7. 2013
    ..Participants with elevated FLC and high-sensitivity C-reactive protein (hsCRP) had an increased risk of anemia at 5-year FU. FLC-alone or in combination with hsCRP-may serve as biomarker indicating an increased risk of developing anemia...
  10. doi request reprint p53 protein expression in chronic lymphocytic leukemia
    Ludger Sellmann
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Leuk Lymphoma 53:1282-8. 2012
    ..Taken together, the differential expression of p53 isoforms could disrupt the p53 response and contribute to CLL pathogenesis...
  11. ncbi request reprint Rituximab plus ASHAP for the treatment of patients with relapsed or refractory aggressive non-Hodgkin's lymphoma: a single-centre study of 20 patients
    Semra Aydin
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Ann Hematol 86:271-6. 2007
    ....
  12. doi request reprint The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels
    Hagen S Bachmann
    Institute of Pharmacogenetics, Medical Faculty, University of Duisburg Essen, Duisburg, Germany
    Eur J Haematol 85:108-13. 2010
    ..Moreover, PSMA6 mRNA expression in human B-cell lines depended on genotypes. We investigated a potential role of this novel SNP in patients with MM...
  13. ncbi request reprint The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia
    Ulrich H Frey
    Institut für Pharmakogenetik, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Clin Cancer Res 12:5686-92. 2006
    ..The TT genotype of the GNAS1 T393C polymorphism is associated with increased Galphas transcript levels and a more favorable clinical course in different solid cancers...
  14. doi request reprint Prevalence and progression of monoclonal gammopathy of undetermined significance and light-chain MGUS in Germany
    Lewin Eisele
    Department of Hematology, University Hospital Essen, Hufelandstr 55, 45122, Essen, Germany
    Ann Hematol 91:243-8. 2012
    ..7%, 95% CI 0.5-1.0). None of the LCMGUS cases progressed. We demonstrate a MGUS prevalence of 3.5% and a LCMGUS prevalence of 0.7% in the general population aged 45-75 years in Germany using a sensitive screening approach...
  15. doi request reprint Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia
    Lewin Eisele
    Department of Hematology, University Hospital, Hufelandstrasse 55, Essen, Germany
    Eur J Haematol 83:320-7. 2009
    ..Because of their role in the expression of cell cycle-related and DNA-damage response genes, we suggest that the deregulated expression of circadian genes may be linked to the molecular pathogenesis of CLL...
  16. doi request reprint Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia
    Alexander Roth
    Department of Haematology, University Hospital, Essen, Germany
    Br J Haematol 143:383-6. 2008
    ..This indicated an extensive expansion and a role for T-cells in ZAP-70(+)/CD38(+) CLL patients...
  17. doi request reprint Outpatient management of acute myeloid leukemia after intensive consolidation chemotherapy is feasible and reduces hospital treatment costs
    Lewin Eisele
    Department of Hematology, University Hospital Essen, Germany
    Onkologie 33:658-64. 2010
    ..This study assessed the feasibility and safety of out of hospital management of acute myeloid leukemia (AML) patients during consolidation therapy...
  18. doi request reprint Expression levels of CD38 on leukemic B cells but not on non-leukemic T cells are comparably stable over time and predict the course of disease in patients with chronic lymphocytic leukemia
    Lewin Eisele
    Department of Haematology, University Hospital, Essen, Germany
    Leuk Res 33:775-8. 2009
    ..By contrast, CD38 expression on T cells was not significantly associated with an adverse clinical outcome...
  19. ncbi request reprint Acute myocardial infarction in thrombotic microangiopathies--clinical characteristics, risk factors and outcome
    Daniel Patschan
    Department of Nephrology, University Hospital, Essen, University of Duisburg Essen, Germany
    Nephrol Dial Transplant 21:1549-54. 2006
    ..However, data are very limited in regard to the clinical characteristics, risk factors and outcome of AMI during TMA. Furthermore, current AMI definitions based on troponins are more sensitive and specific to detect myocardial injury...
  20. doi request reprint Prognostic significance of serum cystatin C in multiple myeloma
    Holger Nuckel
    Department of Hematology, University Hospital Essen, Hufelandstr 55, 45122, Essen, Germany
    Int J Hematol 95:545-50. 2012
    ..The level of serum cystatin C is not only a sensitive marker of renal function, but also reflects tumor burden and delivers prognostic information in MM...
  21. ncbi request reprint Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL)
    Oliver G Ottmann
    Department of Hematology, University Hospital of Frankfurt, Germany
    Cancer 109:2068-76. 2007
    ..Imatinib in combination with intensive chemotherapy has yielded promising results as front-line therapy, but its value as monotherapy in newly diagnosed Ph+ALL is not known...
  22. ncbi request reprint No association of the NFKB1 insertion/deletion promoter polymorphism with survival in colorectal and renal cell carcinoma as well as disease progression in B-cell chronic lymphocytic leukemia
    Kathrin Riemann
    Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany
    Pharmacogenet Genomics 16:783-8. 2006
    ..The purpose of this study was, therefore, to investigate associations of the -94ins/delATTG polymorphism with susceptibility and survival of patients with different types of cancer...
  23. ncbi request reprint Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Germany
    Blood 109:290-7. 2007
    ..034) together with disease stage at diagnosis (HR 2.5; P = .004) and ZAP-70 status (HR 3.0; P = .001). The BCL2-938AA genotype is associated with increased Bcl-2 expression and a novel unfavorable genetic marker in patients with B-CLL...
  24. pmc Progranulin is a novel independent predictor of disease progression and overall survival in chronic lymphocytic leukemia
    Maria Göbel
    Department of Hematology, University Hospital, University of Duisburg Essen, Essen, Germany
    PLoS ONE 8:e72107. 2013
    ..09-3.89, p = 0.026) but not poor risk cytogenetics were independent prognostic markers. In summary our results suggest that Pgrn is a novel, robust and independent prognostic marker in CLL that can be easily measured by ELISA. ..
  25. doi request reprint Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia
    Christina A Ortmann
    Klinik für Hämatologie, Zentrum für Konservative Onkologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Ann Hematol 87:809-18. 2008
    ..Such a role is further supported by the observation that treatment of PRAME-negative cell lines U-937 and THP-1 with the demethylating agent 5'-Aza-2'dC resulted in a dose-related upregulation of PRAME expression...
  26. doi request reprint High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Haematology, University of Duisburg Essen, Germany
    Clin Immunol 131:472-80. 2009
    ..Collectively, our data confirm the prognostic significance supporting the idea to use CD49d as target molecules for therapeutic approaches in B-CLL...
  27. ncbi request reprint Rapid succession of peripheral blood progenitor cell mobilization cycles in patients with chronic heart failure: effects on the hematopoietic system
    Andreas Hüttmann
    Hematology Clinic and the Cardiology Clinic, Center for Internal Medicine, University Hospital, Essen, Germany
    Transfusion 46:1424-31. 2006
    ..The safety and cardiovascular efficacy data have been described elsewhere. In the hematopoietic system, the trial offered an opportunity to study several new aspects of granulocyte-colony-stimulating factor (G-CSF) action...
  28. doi request reprint Gene dosage effects in chronic lymphocytic leukemia
    Ludger Sellmann
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Hufelandstrase 55, 45122 Essen, Germany
    Cancer Genet Cytogenet 203:149-60. 2010
    ..We did not confirm a consistent correlation between MIRN15A and MIRN16-1 expression levels and BCL2 protein levels, indicating a complex regulation of BCL2 expression...
  29. ncbi request reprint Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia
    Ludger Sellmann
    Department of Haematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Br J Haematol 138:217-20. 2007
    ..Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells...
  30. ncbi request reprint Gemcitabine, vinorelbine and prednisone for refractory or relapsed aggressive lymphoma, results of a phase II single center study
    Hannes Müller-Beissenhirtz
    Klinik für Hämatologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Ann Hematol 84:796-801. 2005
    ..There was no treatment-related mortality. GVP shows substantial activity in poor prognosis relapsed or refractory aggressive lymphomas and is generally well tolerated, but haematological toxicity is dose limiting...
  31. ncbi request reprint Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University Hospital Essen, Essen, Germany
    Leuk Lymphoma 47:1053-61. 2006
    ..The LPL/ADAM29 expression ratio was not found to be an independent prognostic factor and did not offer any advantages over the use of LPL alone. Collectively, our data confirm a role for LPL as a novel prognostic indicator in B-CLL...
  32. ncbi request reprint Detection of malignant haematopoietic cells in the cerebrospinal fluid by conventional cytology and flow cytometry
    Holger Nuckel
    Department of Haematology, University of Duisburg Essen Medical Centre, Essen, Germany
    Clin Lab Haematol 28:22-9. 2006
    ..When combined with conventional cytology, flow cytometric analysis improves the detection rate of CSF involvement in patients with haematological malignancies. It is particularly useful in B cell neoplasms with low CSF cell numbers...
  33. doi request reprint Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena
    Alexander Roth
    Department of Hematology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Int J Hematol 93:704-14. 2011
    ..Iron should not be routinely supplemented in PNH patients treated with eculizumab without close monitoring of iron parameters, and iron depletion therapy should be considered in the case of overload...
  34. ncbi request reprint HLA-G in B-chronic lymphocytic leukaemia: clinical relevance and functional implications
    Vera Rebmann
    Institut fur Immunologie, Universitatsklinikum Essen, Virchowstr 171, D 45122 Essen, Germany
    Semin Cancer Biol 17:430-5. 2007
    ..The corresponding immunological parameters point to a broad immunosuppression in these patients. Thus, HLA-G seems to contribute to the impaired immune response in B-CLL supporting disease progression...
  35. ncbi request reprint A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease
    Jan Dürig
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Cancer Res 67:8653-61. 2007
    ..These results suggest that this model reflects the heterogeneity and important clinical characteristics of the disease, and thus may serve as a tool for preclinical drug testing and investigation of the pathophysiology of CLL...
  36. doi request reprint Treatment of paroxysmal nocturnal hemoglobinuria in the era of eculizumab
    Alexander Roth
    Department of Hematology, West German Cancer Center, University Hospital Essen, Germany
    Eur J Haematol 87:473-9. 2011
    ....
  37. ncbi request reprint Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia
    Jan Dürig
    Department of Hematology, Medical Faculty, University of Essen, Germany
    Blood 101:2748-55. 2003
    ..05). Our data show that gene expression profiling can help identify B-CLL subtypes with different clinical characteristics. Furthermore, our results suggest a role of translation-associated genes in the pathogenesis of B-CLL...
  38. ncbi request reprint 1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Essen, Essen, Germany
    Eur J Haematol 72:259-63. 2004
    ..In conclusion, our data do not support a role of the P2X7 genotype as a prognostic marker in B-cell CLL...
  39. ncbi request reprint Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity
    Holger Nuckel
    Department of Hematology, Medical School, University of Duisburg Essen, Germany
    Eur J Pharmacol 514:217-24. 2005
    ..Alemtuzumab significantly enhances apoptosis in chronic lymphocytic leukemia cells in vitro, especially in combination with a cross-linking anti-Fc-antibody, this effect being mediated by a caspase-dependent pathway...
  40. ncbi request reprint Anti-CD20 monoclonal antibody therapy in relapsed MALT lymphoma of the conjunctiva
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Essen, Germany
    Eur J Haematol 73:258-62. 2004
    ..Rituximab is a highly effective and well-tolerated treatment of conjunctival MALT lymphoma, which may not only be of value in relapse, but also in cases of contraindication to radiotherapy...
  41. ncbi request reprint The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia
    Holger Nuckel
    Department of Haematology, University of Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
    Leuk Lymphoma 44:1739-43. 2003
    ..0043). The GNB3 genotype (p = 0.024) and age (p = 0.042) were identified as independent prognostic factors for a second therapy. Thus, the long-term success of the treatment appears to be correlated with the GNB3 genotype...