Hilmar Quentmeier

Summary

Affiliation: DSMZ-German Collection of Microorganisms and Cell Cultures
Country: Germany

Publications

  1. doi request reprint U-2932: two clones in one cell line, a tool for the study of clonal evolution
    H Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 27:1155-64. 2013
  2. ncbi request reprint Tumor necrosis factor-alpha-induced proliferation requires synthesis of granulocyte-macrophage colony-stimulating factor
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Exp Hematol 28:1008-15. 2000
  3. ncbi request reprint Immunocytochemical analysis of cell lines derived from solid tumors
    H Quentmeier
    DSMZ, German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    J Histochem Cytochem 49:1369-78. 2001
  4. ncbi request reprint Granulocyte-macrophage colony-stimulating factor: inhibitor of tumor necrosis factor-induced apoptosis
    Hilmar Quentmeier
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Mascheroder Weg 1b, D 38124, Braunschweig, Germany
    Leuk Res 27:539-45. 2003
  5. ncbi request reprint Expression of HOX genes in acute leukemia cell lines with and without MLL translocations
    Hilmar Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 45:567-74. 2004
  6. ncbi request reprint JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 20:471-6. 2006
  7. doi request reprint SOCS2: inhibitor of JAK2V617F-mediated signal transduction
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 22:2169-75. 2008
  8. pmc BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance
    Hilmar Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 4:6. 2011
  9. pmc SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
    Hilmar Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 2:3. 2009
  10. doi request reprint Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ, German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Lymphoma 51:881-91. 2010

Collaborators

Detail Information

Publications22

  1. doi request reprint U-2932: two clones in one cell line, a tool for the study of clonal evolution
    H Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 27:1155-64. 2013
    ..In summary, stable retention of genetically distinct subclones in U-2932 models tumor heterogeneity in vitro permitting functional analysis of oncogenes against a syngenic background...
  2. ncbi request reprint Tumor necrosis factor-alpha-induced proliferation requires synthesis of granulocyte-macrophage colony-stimulating factor
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Exp Hematol 28:1008-15. 2000
    ..Tumor necrosis factor- alpha (TNF-alpha) induces a variety of cellular responses, some of them being at least seemingly contradictory. Thus, we set out to find differences in the modes of proliferative and apoptotic responses to TNF- alpha...
  3. ncbi request reprint Immunocytochemical analysis of cell lines derived from solid tumors
    H Quentmeier
    DSMZ, German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    J Histochem Cytochem 49:1369-78. 2001
    ..Our data question the identity of some cell lines submitted to the bank in the past. The immunoprofiles of 167 solid tumor-derived and 131 hematopoetic cell lines can be found at www.dsmz.de...
  4. ncbi request reprint Granulocyte-macrophage colony-stimulating factor: inhibitor of tumor necrosis factor-induced apoptosis
    Hilmar Quentmeier
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Mascheroder Weg 1b, D 38124, Braunschweig, Germany
    Leuk Res 27:539-45. 2003
    ..This protection requires de novo protein synthesis and is not-or at least not exclusively-the consequence of a direct crosstalk between the GM-CSF and TNF signaling pathways...
  5. ncbi request reprint Expression of HOX genes in acute leukemia cell lines with and without MLL translocations
    Hilmar Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 45:567-74. 2004
    ..These results suggest that MLL aberrations may regulate MEIS1 and HOXA9 gene expression in ALL-derived cell lines, while AML-derived cell lines express these genes independently of the MLL status...
  6. ncbi request reprint JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 20:471-6. 2006
    ..In summary, JAK2 V617F cell lines, derived from patients with history of MPD/MDS, represent novel research tools for elucidating the pathobiology of this JAK2 mutation...
  7. doi request reprint SOCS2: inhibitor of JAK2V617F-mediated signal transduction
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 22:2169-75. 2008
    ..Our results provide solid evidence that SOCS2 epigenetic downregulation might be an important second step in the genesis of cytokine-independent MPD clones...
  8. pmc BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance
    Hilmar Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 4:6. 2011
    ..Furthermore, de novo or secondary TKI-resistance is a significant problem in CML. We screened a panel of BCR-ABL1 positive ALL and CML cell lines to find models for imatinib-resistance...
  9. pmc SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
    Hilmar Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 2:3. 2009
    ..We screened a panel of ALL and AML cell lines for SET-NUP214 expression to find model systems that might help to elucidate the cellular function of this fusion gene...
  10. doi request reprint Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ, German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Lymphoma 51:881-91. 2010
    ..Nevertheless, identification of SIK2 as an amplification target highlights this kinase along with its regulatory network as potential therapeutic targets in DLBCL...
  11. ncbi request reprint Human leukemia and lymphoma cell lines as models and resources
    Roderick A F MacLeod
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Curr Med Chem 15:339-59. 2008
    ..We also review the problem of mycoplasma contamination and means for its eradication...
  12. pmc Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma
    Sonja Eberth
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    BMC Cancer 10:517. 2010
    ..To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-derived cell lines as well as in patient samples...
  13. pmc CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 3:15. 2010
    ..Aim of this study was to find out whether C/EBPalpha is a negative regulator of CD7 and which other regulatory mechanisms might be involved...
  14. ncbi request reprint Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1
    Stefan Nagel
    Human and Animal Cell Cultures, Deutsche Sammlung von Mikroorganismen und Zellkulturen DSMZ, Braunschweig, Germany
    Blood 109:3015-23. 2007
    ..In summary, we identified up-regulation of HOXB9 in HL mediated by constitutively active ERK5 signaling which may represent novel therapeutic targets in HL...
  15. pmc Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Mol Cancer 8:86. 2009
    ..Here, we aimed to relate MLL mutational status and tumor suppressor gene (TSG) methylation/expression in acute leukemia cell lines...
  16. pmc DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)
    Hilmar Quentmeier
    Department of Human and Animal Cell Cultures, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    BMC Cancer 12:19. 2012
    ..This study was performed to examine whether VEGF-R2 (KDR) and VEGF-R3 (FLT4) are regulated by DNA methylation...
  17. ncbi request reprint Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines
    Diana S Fleckenstein
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Mascheroder Weg 1 B, D 38124 Braunschweig, Germany
    Leuk Res 26:207-14. 2002
    ..These results suggest that loss of Wild type (wt) p53 is not the decisive event causing tumor cells to proliferate in vitro without externally added growth factors...
  18. pmc t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5
    Stefan Ehrentraut
    Leibniz Institute, DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    PLoS ONE 8:e53767. 2013
    ..Our data support further investigation of SOCS2/3 as signalling effectors, prognostic indicators and potential therapeutic targets in cancers with JAK2 rearrangements...
  19. pmc Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    PLoS ONE 8:e61447. 2013
    ..Thus, our data extend the paradigm of NKL homeobox gene deregulation in lymphoid malignancies...
  20. doi request reprint Chromothripsis in Hodgkin lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Genes Chromosomes Cancer 52:741-7. 2013
    ..Collectively, we identified and characterized chromothriptic rearrangements in HL cell lines to serve as models for analyzing this novel oncogenomic mechanism...
  21. ncbi request reprint Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase
    Diana S Fleckenstein
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Mascheroder Weg 1b, 38124 Braunschweig, Germany
    Leuk Res 27:687-94. 2003
    ..In conclusion: (i) TNF-receptor activation leads to activation of the p70S6K; (ii) TRAF4 is a mediator in this TNF-induced signaling pathway; and (iii) TRAF4 inhibits Fas-induced apoptosis...
  22. ncbi request reprint FLT3: receptor and ligand
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Mascheroder Weg 1b, D 38124 Braunschweig, Germany
    Growth Factors 22:71-3. 2004
    ..AML patients with FLT3 mutations tend to have a poor prognosis, thus FLT3 is an attractive target of therapy, for instance using kinase inhibitors...