S Nagel

Summary

Affiliation: DSMZ-German Collection of Microorganisms and Cell Cultures
Country: Germany

Publications

  1. doi request reprint Chromothripsis in Hodgkin lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Genes Chromosomes Cancer 52:741-7. 2013
  2. pmc Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    PLoS ONE 8:e61447. 2013
  3. pmc Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL)
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    PLoS ONE 7:e40747. 2012
  4. doi request reprint Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Res 36:646-55. 2012
  5. ncbi request reprint MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
    S Nagel
    Human and Animal Cell Cultures, DSMZ, Braunschweig, Germany
    Leukemia 22:600-7. 2008
  6. pmc Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Mol Cancer 9:151. 2010
  7. doi request reprint Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ, German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Lymphoma 51:881-91. 2010
  8. pmc NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr, 7B, 38124 Braunschweig, Germany
    BMC Cancer 9:371. 2009
  9. doi request reprint Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia
    Stefan Nagel
    Department of Human and Animal Cell Cultures, DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 50:101-8. 2009
  10. ncbi request reprint Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma
    S Nagel
    Department of Human and Animal Cell Cultures, DSMZ, Braunschweig, Germany
    Leukemia 22:387-92. 2008

Detail Information

Publications29

  1. doi request reprint Chromothripsis in Hodgkin lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Genes Chromosomes Cancer 52:741-7. 2013
    ..Collectively, we identified and characterized chromothriptic rearrangements in HL cell lines to serve as models for analyzing this novel oncogenomic mechanism...
  2. pmc Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    PLoS ONE 8:e61447. 2013
    ..Thus, our data extend the paradigm of NKL homeobox gene deregulation in lymphoid malignancies...
  3. pmc Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL)
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    PLoS ONE 7:e40747. 2012
    ..These results may contribute to the understanding of leukemic transcriptional networks underlying disturbed T-cell differentiation in T-ALL...
  4. doi request reprint Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Res 36:646-55. 2012
    ..Moreover, chromosomal deregulations of genes involved in this regulative network highlight their role in development and malignancy of B-cells...
  5. ncbi request reprint MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
    S Nagel
    Human and Animal Cell Cultures, DSMZ, Braunschweig, Germany
    Leukemia 22:600-7. 2008
    ..Taken together, our data identify distinct mechanisms underlying ectopic MEF2C expression in T-ALL, either as a downstream target of NKX2-5, or via chromosomal aberrations deleting proximal gene regions...
  6. pmc Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Mol Cancer 9:151. 2010
    ....
  7. doi request reprint Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ, German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Lymphoma 51:881-91. 2010
    ..Nevertheless, identification of SIK2 as an amplification target highlights this kinase along with its regulatory network as potential therapeutic targets in DLBCL...
  8. pmc NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr, 7B, 38124 Braunschweig, Germany
    BMC Cancer 9:371. 2009
    ..Here we screened further NKLs in 24 T-ALL cell lines and identified the common expression of MSX2. The subsequent aim of this study was to analyze the role of MSX2 in T-cell differentiation which may be disturbed by oncogenic NKLs...
  9. doi request reprint Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia
    Stefan Nagel
    Department of Human and Animal Cell Cultures, DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 50:101-8. 2009
    ..These data support an activatory effect of NK-like homeodomain proteins on pri-miR-17-92 expression and concomitantly reduced E2F1 protein levels, thereby enhancing survival of leukemic T-cells...
  10. ncbi request reprint Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma
    S Nagel
    Department of Human and Animal Cell Cultures, DSMZ, Braunschweig, Germany
    Leukemia 22:387-92. 2008
    ..Taken together, analysis of the 7q22 amplicon identified CDK6 as an important cell cycle regulator in T-cell lymphomas, representing a novel potential target for rational therapy...
  11. ncbi request reprint Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1
    Stefan Nagel
    German Collection of Microorganisms and Cell Cultures, Department of Cell Cultures, Inhoffenstrasse 7b, 38124 Braunschweig, Germany
    Cancer Res 67:1461-71. 2007
    ..Our data document homeobox gene dysregulation by a novel regulatory region at 3'-BCL11B responsive to histone deacetylase inhibition and highlight a novel class of potential therapeutic target amid noncoding DNA...
  12. ncbi request reprint Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1
    Stefan Nagel
    Human and Animal Cell Cultures, Deutsche Sammlung von Mikroorganismen und Zellkulturen DSMZ, Braunschweig, Germany
    Blood 109:3015-23. 2007
    ..In summary, we identified up-regulation of HOXB9 in HL mediated by constitutively active ERK5 signaling which may represent novel therapeutic targets in HL...
  13. doi request reprint Transcriptional deregulation of oncogenic myocyte enhancer factor 2C in T-cell acute lymphoblastic leukemia
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 52:290-7. 2011
    ..Taken together, our results indicate that the expression of MEF2C in T-ALL cells is principally deregulated via activating leukemic transcription factors GFI1B or NKX2-5 and by escaping inhibitory developmental STAT5 signaling...
  14. doi request reprint Activation of Paired-homeobox gene PITX1 by del(5)(q31) in T-cell acute lymphoblastic leukemia
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 52:1348-59. 2011
    ..Taken together, our data show leukemic activation of PITX1, a novice PRD-class homeobox gene in a subset of early-staged T-ALL, which may promote leukemogenesis by inhibiting T-cell development...
  15. doi request reprint Expression analysis of homeobox genes in leukemia/lymphoma cell lines
    Stefan Nagel
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany
    Methods Mol Biol 731:371-80. 2011
    ..Here, we describe molecular methods for analysis and quantification of dysregulated homeobox gene expression in leukemia/lymphoma cell lines...
  16. doi request reprint t(4;8)(q27;q24) in Hodgkin lymphoma cells targets phosphodiesterase PDE5A and homeobox gene ZHX2
    Stefan Nagel
    Department of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Genes Chromosomes Cancer 50:996-1009. 2011
    ..Taken together, we have identified a novel aberration with recurrent breakpoints in HL, t(4;8)(q27;q24), which activate PDE5A and repress ZHX2, deregulating apoptosis, differentiation, and STAT1-signaling in HL cells...
  17. doi request reprint Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Leuk Res 34:521-8. 2010
    ....
  18. doi request reprint SOCS2: inhibitor of JAK2V617F-mediated signal transduction
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 22:2169-75. 2008
    ..Our results provide solid evidence that SOCS2 epigenetic downregulation might be an important second step in the genesis of cytokine-independent MPD clones...
  19. ncbi request reprint HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3
    S Nagel
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 19:841-6. 2005
    ..Taken together, our data show that the PI3K signalling pathway in HL cells is constitutively activated and promotes HLXB9 expression, probably via E2F3, thereby enhancing malignant expression of IL6...
  20. ncbi request reprint Activation of HLXB9 by juxtaposition with MYB via formation of t(6;7)(q23;q36) in an AML-M4 cell line (GDM-1)
    Stefan Nagel
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Genes Chromosomes Cancer 42:170-8. 2005
    ..Our data identified a cell line model for a novel leukemic translocation involving MYB with HLXB9, further implicating HLXB9 in leukemogenesis...
  21. doi request reprint U-2932: two clones in one cell line, a tool for the study of clonal evolution
    H Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 27:1155-64. 2013
    ..In summary, stable retention of genetically distinct subclones in U-2932 models tumor heterogeneity in vitro permitting functional analysis of oncogenes against a syngenic background...
  22. ncbi request reprint The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2)
    Stefan Nagel
    DSMZ, Department of Human and Animal Cell Cultures, 38124 Braunschweig, Germany
    Cancer Res 63:5329-34. 2003
    ..This study also identifies in vitro models for both t(5;14) variants and raises questions about diagnostic fluorescence in situ hybridization/reverse transcription-PCR screening in ALL...
  23. ncbi request reprint Human leukemia and lymphoma cell lines as models and resources
    Roderick A F MacLeod
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Curr Med Chem 15:339-59. 2008
    ..We also review the problem of mycoplasma contamination and means for its eradication...
  24. ncbi request reprint Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2)
    Roderick A F MacLeod
    DSMZ, German Collection of Microorganisms and Cell Cultures, Department of Cell Cultures, Braunschweig, Germany
    Genes Chromosomes Cancer 37:84-91. 2003
    ..As well as providing molecular cytogenetic documentation of t(5;14) ALL, this report validates HPB-ALL cells for investigating this important new disease entity in vitro...
  25. ncbi request reprint Multicolor-FISH analysis of a natural killer cell line (NK-92)
    Roderick A F MacLeod
    DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leuk Res 26:1027-33. 2002
    ..Our data strengthen the claim of NK-92 to model NK neoplasms and highlight this cell line as a potential resource for mining relevant oncogenic changes therein...
  26. ncbi request reprint BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia
    Roderick A F MacLeod
    Cancer Genet Cytogenet 153:88-9. 2004
  27. ncbi request reprint AML1/ETO inhibits AML1/CCAAT-enhancer binding protein-alpha mediated activation of the CD11c promoter and represses CD11c expression in HL60 cells
    Bettina Drescher
    Haematologica 88:956-8. 2003
  28. doi request reprint Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents
    Anne Neubert
    Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Friedrich Ludwig Jahn Strasse 17, 17487 Greifswald, Germany
    J Control Release 130:2-8. 2008
    ..These findings emphasize the necessity to adapt dissolution testing for DES to the unique conditions influencing delivery to the vessel wall to learn more about local distribution and to anticipate the in vivo performance of DES...
  29. ncbi request reprint Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy
    Stefan Nagel
    Department of Haematology and Oncology, Hannover Medical School, D 30625 Hannover, Germany
    J Hematother Stem Cell Res 11:401-8. 2002
    ..Finally, AML1/ETO could not be co-localized with PML and SUMO-1, indicating that AML1/ETO is not part of the nuclear bodies and probably not SUMOylated...