H G Drexler

Summary

Affiliation: DSMZ-German Collection of Microorganisms and Cell Cultures
Country: Germany

Publications

  1. ncbi Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines
    H J Gruss
    Immunex Research and Development Corporation, Seattle, WA
    Leukemia 8:2083-94. 1994
  2. ncbi Leukemia-lymphoma cell lines as model systems for hematopoietic research
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Ann Med 35:404-12. 2003
  3. ncbi Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 18:227-32. 2004
  4. ncbi Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Transl Med 9:197. 2011
  5. ncbi DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)
    Hilmar Quentmeier
    Department of Human and Animal Cell Cultures, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    BMC Cancer 12:19. 2012
  6. ncbi Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Mol Cancer 9:151. 2010
  7. ncbi Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Mol Cancer 8:86. 2009
  8. ncbi BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance
    Hilmar Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 4:6. 2011
  9. ncbi CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 3:15. 2010
  10. ncbi SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
    Hilmar Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 2:3. 2009

Collaborators

Detail Information

Publications71

  1. ncbi Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines
    H J Gruss
    Immunex Research and Development Corporation, Seattle, WA
    Leukemia 8:2083-94. 1994
    ..Collectively, these data suggest that the CD30L-CD30 interaction has potent biological activity and might play a critical role in the immune response and pathogenesis of HD and some NHL, in particular Burkitt lymphomas...
  2. ncbi Leukemia-lymphoma cell lines as model systems for hematopoietic research
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Ann Med 35:404-12. 2003
    ..A list of the most useful, robust and freely available reference cell lines is proposed in this review. Clearly, studies of LL cell lines have provided seminal insights into the biology of hematopoietic neoplasia...
  3. ncbi Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 18:227-32. 2004
    ..The availability of these cell lines as model systems provides the opportunity to explore the altered expression or functions of MLL genes and their partners in oncogenesis...
  4. ncbi Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Transl Med 9:197. 2011
    ..MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis...
  5. ncbi DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)
    Hilmar Quentmeier
    Department of Human and Animal Cell Cultures, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    BMC Cancer 12:19. 2012
    ..This study was performed to examine whether VEGF-R2 (KDR) and VEGF-R3 (FLT4) are regulated by DNA methylation...
  6. ncbi Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr 7B, 38124 Braunschweig, Germany
    Mol Cancer 9:151. 2010
    ....
  7. ncbi Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Mol Cancer 8:86. 2009
    ..Here, we aimed to relate MLL mutational status and tumor suppressor gene (TSG) methylation/expression in acute leukemia cell lines...
  8. ncbi BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance
    Hilmar Quentmeier
    Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 4:6. 2011
    ..Furthermore, de novo or secondary TKI-resistance is a significant problem in CML. We screened a panel of BCR-ABL1 positive ALL and CML cell lines to find models for imatinib-resistance...
  9. ncbi CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation
    Sonja Röhrs
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 3:15. 2010
    ..Aim of this study was to find out whether C/EBPalpha is a negative regulator of CD7 and which other regulatory mechanisms might be involved...
  10. ncbi SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
    Hilmar Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    J Hematol Oncol 2:3. 2009
    ..We screened a panel of ALL and AML cell lines for SET-NUP214 expression to find model systems that might help to elucidate the cellular function of this fusion gene...
  11. ncbi NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells
    Stefan Nagel
    Dept of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstr, 7B, 38124 Braunschweig, Germany
    BMC Cancer 9:371. 2009
    ..Here we screened further NKLs in 24 T-ALL cell lines and identified the common expression of MSX2. The subsequent aim of this study was to analyze the role of MSX2 in T-cell differentiation which may be disturbed by oncogenic NKLs...
  12. ncbi Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma
    Sonja Eberth
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    BMC Cancer 10:517. 2010
    ..To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-derived cell lines as well as in patient samples...
  13. ncbi Persistent use of false myeloma cell lines
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Hum Cell 16:101-5. 2003
    ..The availability of well characterized and authenticated bona fide MM cell lines is of great importance for the study of the biology, etiology and treatment of the disease...
  14. ncbi Commentary: what is an 'NK-precursor cell line'?
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Mascheroder Weg 1b, 38124 Braunschweig, Germany
    Leuk Res 26:297-9. 2002
  15. ncbi Continuous hematopoietic cell lines as model systems for leukemia-lymphoma research
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leuk Res 24:881-911. 2000
    ..Over a period of nearly four decades, these initially rather exotic cell cultures, known only to a few specialists, have become ubiquitous powerful research tools that are available to every investigator...
  16. ncbi Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma
    H G Drexler
    DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 18:1569-71. 2004
  17. ncbi Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia
    H G Drexler
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Mascheroder Weg 1b, D 38124, Braunschweig, Germany
    Leuk Res 24:681-703. 2000
    ..The availability of these bona fide MM cell lines is of great importance for the study of the biology, etiology and treatment of the disease...
  18. ncbi FLT3: receptor and ligand
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Mascheroder Weg 1b, D 38124 Braunschweig, Germany
    Growth Factors 22:71-3. 2004
    ..AML patients with FLT3 mutations tend to have a poor prognosis, thus FLT3 is an attractive target of therapy, for instance using kinase inhibitors...
  19. ncbi Malignant hematopoietic cell lines: in vitro models for the study of Waldenström's macroglobulinemia
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Inhoffenstr 7B, D 38124 Braunschweig, Germany
    Leuk Res 32:1669-73. 2008
    ..In summary, although three WM cell lines are currently used as in vitro models, none convincingly pass muster...
  20. ncbi Mycoplasma contamination of cell cultures: Incidence, sources, effects, detection, elimination, prevention
    Hans G Drexler
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany Author for correspondence E mail
    Cytotechnology 39:75-90. 2002
    ..The availability of accurate, sensitive and reliable detection methods and the application of robust and successful elimination methods provide powerful means for overcoming the problem of mycoplasma contamination in cell cultures...
  21. ncbi Malignant hematopoietic cell lines: in vitro models for the study of myelodysplastic syndromes
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leuk Res 24:109-15. 2000
    ..Properly authenticated and verified MDS-derived cell lines which should be made freely available will represent important research tools for the study of MDS biology...
  22. ncbi Establishment and culture of leukemia-lymphoma cell lines
    Hans G Drexler
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany
    Methods Mol Biol 731:181-200. 2011
    ..g., choice of culture medium and culture conditions, specimen site of the primary cells, and status of the patient at the time of sample collection...
  23. ncbi History of leukemia-lymphoma cell lines
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Hum Cell 23:75-82. 2010
    ..Given their manifold applications in biomedicine, there is little doubt that LL-derived cell lines will continue to play a vital part well into the next half-century as well...
  24. ncbi Malignant hematopoietic cell lines: in vitro models for the study of mantle cell lymphoma
    Hans G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Mascheroder Weg 1 B, Braunschweig, Germany
    Leuk Res 26:781-7. 2002
    ....
  25. ncbi Many are called MDS cell lines: one is chosen
    Hans G Drexler
    DSMZ, German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
    Leuk Res 33:1011-6. 2009
    ..While MDS and AML/MDS cell lines both provide singular resources for modelling pathology, mining oncogenically modified macromolecules, and testing druggability, we contend these groups should be considered separately...
  26. ncbi Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines
    W Dirks
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig
    Leuk Res 23:643-51. 1999
    ..Although a general mechanism seems most unlikely, further studies are necessary to demonstrate the involvement of GAS6 in single cases of disordered growth or chemotaxis/adhesion of leukemia and lymphomas...
  27. ncbi Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma
    S Nagel
    Department of Human and Animal Cell Cultures, DSMZ, Braunschweig, Germany
    Leukemia 22:387-92. 2008
    ..Taken together, analysis of the 7q22 amplicon identified CDK6 as an important cell cycle regulator in T-cell lymphomas, representing a novel potential target for rational therapy...
  28. ncbi SOCS2: inhibitor of JAK2V617F-mediated signal transduction
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 22:2169-75. 2008
    ..Our results provide solid evidence that SOCS2 epigenetic downregulation might be an important second step in the genesis of cytokine-independent MPD clones...
  29. ncbi FLT3 mutations in acute myeloid leukemia cell lines
    H Quentmeier
    DSMZ - German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 17:120-4. 2003
    ....
  30. ncbi Widespread intraspecies cross-contamination of human tumor cell lines arising at source
    R A MacLeod
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Int J Cancer 83:555-63. 1999
    ..We believe these findings indicate a grave and chronic problem demanding radical measures, to include extra controls over cell line authentication, provenance and availability...
  31. ncbi Growth-inhibitory effects of transforming growth factor-beta 1 on myeloid leukemia cell lines
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig
    Leuk Res 22:927-38. 1998
    ....
  32. ncbi c-kit expression in human megakaryoblastic leukemia cell lines
    Z B Hu
    DSM German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig
    Blood 83:2133-44. 1994
    ....
  33. ncbi MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
    S Nagel
    Human and Animal Cell Cultures, DSMZ, Braunschweig, Germany
    Leukemia 22:600-7. 2008
    ..Taken together, our data identify distinct mechanisms underlying ectopic MEF2C expression in T-ALL, either as a downstream target of NKX2-5, or via chromosomal aberrations deleting proximal gene regions...
  34. ncbi Esterase isoenzyme profiles of 255 leukemia-lymphoma cell lines from all hematopoietic cell lineages
    S M Gignac
    DSM German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leuk Lymphoma 22:143-51,follow. 186, color plate XII. 1996
    ..The present study using continuous leukemia-lymphoma cell lines as model systems provides a biochemical characterization of different hematopoietic cell lineages and stages of differentiation...
  35. ncbi Tumor necrosis factor-alpha-induced proliferation requires synthesis of granulocyte-macrophage colony-stimulating factor
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Exp Hematol 28:1008-15. 2000
    ..Tumor necrosis factor- alpha (TNF-alpha) induces a variety of cellular responses, some of them being at least seemingly contradictory. Thus, we set out to find differences in the modes of proliferative and apoptotic responses to TNF- alpha...
  36. ncbi Establishment of the B cell precursor acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation
    C Meyer
    DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 15:1471-4. 2001
    ..MUTZ-5 represents a new unique leukemia B cell line; its scientific significance lies in the t(12;13)...
  37. ncbi Induction and secretion of the chemokines interleukin-8 and monocyte chemotactic protein-1 in human immature leukemia cell lines
    K G Steube
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Mol Cell Biol Res Commun 3:60-5. 2000
    ....
  38. ncbi A new calyculin derivative from the sponge Theonella swinhoei is a novel and potent inhibitor of tumor cell proliferation
    K G Steube
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Anticancer Res 18:129-37. 1998
    ..Our data introduce a new calyculin as a marine natural product with interesting features stimulating further studies as a chemotherapeutic or investigational drug...
  39. ncbi First searchable database for DNA profiles of human cell lines: sequential use of fingerprint techniques for authentication
    W Dirks
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
    Cell Mol Biol (Noisy-le-grand) 45:841-53. 1999
    ....
  40. ncbi Enhanced proliferative activity of PIXY-321, the granulocyte-macrophage colony-stimulating factor and interleukin-3 fusion protein
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures Braunschweig, Germany
    Leuk Lymphoma 29:119-28. 1998
    ..The use of PIXY-321 provides an opportunity for taking greater advantage in vitro and in vivo of the hematopoietic stimulatory activities of GM-CSF and IL-3...
  41. ncbi Detection of mycoplasma in leukemia-lymphoma cell lines using polymerase chain reaction
    C C Uphoff
    DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 16:289-93. 2002
    ..PCR mycoplasma analysis provides a readily available, quick and reliable test system with which to manage the important issue of mycoplasma contamination of cell lines...
  42. ncbi Immunocytochemical analysis of cell lines derived from solid tumors
    H Quentmeier
    DSMZ, German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    J Histochem Cytochem 49:1369-78. 2001
    ..Our data question the identity of some cell lines submitted to the bank in the past. The immunoprofiles of 167 solid tumor-derived and 131 hematopoetic cell lines can be found at www.dsmz.de...
  43. ncbi ABL-BCR expression in BCR-ABL-positive human leukemia cell lines
    C C Uphoff
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig
    Leuk Res 23:1055-60. 1999
    ..Further work is required to determine the exact role of the reciprocal fusion gene transcripts on the pathophysiological mechanisms of leukemogenesis...
  44. ncbi Secretion of functional hematopoietic growth factors by human carcinoma cell lines
    K G Steube
    Department of Human and Animal Cell Cultures, Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany
    Int J Cancer 78:120-4. 1998
    ..The cytokines secreted have been proven to be functionally active and can support growth and viability of cytokine-dependent hematopoietic cell lines...
  45. ncbi Constitutive protein expression of monocyte chemotactic protein-1 (MCP-1) by myelomonocytic cell lines and regulation of the secretion by anti- and proinflammatory stimuli
    K G Steube
    Department of Human and Animal Cell Cultures, DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany
    Leuk Res 23:843-9. 1999
    ....
  46. ncbi The human bladder carcinoma cell line 5637 constitutively secretes functional cytokines
    H Quentmeier
    German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leuk Res 21:343-50. 1997
    ....
  47. ncbi JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders
    H Quentmeier
    DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 20:471-6. 2006
    ..In summary, JAK2 V617F cell lines, derived from patients with history of MPD/MDS, represent novel research tools for elucidating the pathobiology of this JAK2 mutation...
  48. ncbi HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3
    S Nagel
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 19:841-6. 2005
    ..Taken together, our data show that the PI3K signalling pathway in HL cells is constitutively activated and promotes HLXB9 expression, probably via E2F3, thereby enhancing malignant expression of IL6...
  49. ncbi Proposals for the characterization and description of new human leukemia-lymphoma cell lines
    H G Drexler
    DSMZ German Collection of Microorganisms and Cell Cultures Dept of Human and Animal Cell Cultures, Braunschweig, Germany
    Hum Cell 11:51-60. 1998
    ..In summary, leukemia-lymphoma cell lines have the potential to greatly facilitate diverse studies of normal and malignant hematopoiesis; to that end, these cell lines must be extensively characterized and adequately described...
  50. ncbi False leukemia-lymphoma cell lines: an update on over 500 cell lines
    H G Drexler
    DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 17:416-26. 2003
    ..These findings provide a rationale for mandating the procurement of reputably sourced LL cell lines and their regular authentication thereafter...
  51. ncbi Detection of mycoplasma contaminations in cell cultures by PCR analysis
    C C Uphoff
    DSMZ German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Hum Cell 12:229-36. 1999
    ....
  52. ncbi Retrovirus tests of human leukemia/lymphoma cell lines at DSM
    B G Häne
    German Collection of Microorganisms and Cell Cultures DSM, Braunschweig, Germany
    Leuk Lymphoma 11:293-8. 1993
    ..Reverse transcriptase assay, polymerase chain reaction, and dot-blot hybridization of in-vitro amplified DNA with virus-specific probes are used...
  53. ncbi Chromosomal breakage correlates with delayed lethality in normal and ataxia telangiectasia cell lines treated with bleomycin
    R A MacLeod
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms, Braunschweig, Germany
    Mutat Res 372:33-42. 1996
    ..66 x (0.50 x). Significant correlations were observed between lethality and both, the yields of most types of chromosomal aberrations (excepting unambiguous exchanges) and also, the percentages of cells bearing CA...
  54. ncbi Elimination of mycoplasma from leukemia-lymphoma cell lines using antibiotics
    C C Uphoff
    DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 16:284-8. 2002
    ..In conclusion, antibiotic treatment represents the most practical and efficient option to cleanse mycoplasma-positive cell lines...
  55. ncbi Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin
    H Quentmeier
    DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Leukemia 19:1760-7. 2005
    ..For all these reasons, the OCI/AML3 cell line represents a remarkable tool for biomolecular studies of NPMc+ AML...
  56. ncbi Prevention of mycoplasma contamination in leukemia-lymphoma cell lines
    C C Uphoff
    Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Hum Cell 14:244-7. 2001
    ....
  57. ncbi Conservation of unreposited cell lines
    R A F MacLeod
    DSMZ, German Collection of Microorganisms and Cell Cultures Braunschweig, Braunschweig, Germany
    Cytogenet Genome Res 116:152. 2007
  58. ncbi Multiple regulation of constitutive and induced interleukin 8 secretion in human myelomonocytic cell lines
    K G Steube
    Department of Human and Animal Cell Cultures, DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Cytokine 12:1236-9. 2000
    ....
  59. ncbi Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation
    H Quentmeier
    DSMZ, German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 15:1286-92. 2001
    ..In summary, we describe the cloning of human TSLP and its proliferative effects on a myeloid cell line. TSLP-induced proliferation is preceded by phosphorylation of STAT-5, but not of JAK 3...
  60. ncbi Characterization and expression of tartrate-resistant acid phosphatase (TRAP) in hematopoietic cells
    H G Drexler
    Department of Human and Animal Cell Cultures, Braunschweig, Germany
    Leukemia 8:359-68. 1994
    ..The serum level of TRAP was found to be increased during physiological bone growth, in Gaucher's disease, and in malignancies metastasized to bone (resulting from increased osteoclastic activity).(ABSTRACT TRUNCATED AT 400 WORDS)..
  61. ncbi Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519
    C Rudolph
    Institute of Cell and Molecular Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    Cancer Genet Cytogenet 153:144-50. 2004
    ....
  62. ncbi Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells
    J H Tong
    Institut National de la Sante et de la Recherche Medicale, INSERM U496, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Leukemia 12:1733-40. 1998
    ..This work identifies JEM-1 as a novel ubiquitous gene whose expression is low in APL cells, but can be restored by RA treatment, concomitant with cell maturation...
  63. ncbi Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32)
    J W Janssen
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Blood 95:2691-8. 2000
    ..The clinical relevance of this dual activation remains to be elucidated. (Blood. 2000;95:2691-2698)..
  64. ncbi MLL partial tandem duplications in acute leukemia cell lines
    H Quentmeier
    Leukemia 17:980-1. 2003
  65. ncbi Expression of BEX1 in acute myeloid leukemia with MLL rearrangements
    H Quentmeier
    Leukemia 19:1488-9. 2005
  66. ncbi New acute myeloid leukemia-derived cell line: MUTZ-8 with 5q-
    Z-B Hu
    Department of Medicine, University of Illinois at Chicago, USA
    Leukemia 16:1556-61. 2002
    ..The scientific utility of MUTZ-8 lies (1) in its cluster of pathognomonic cytogenetic alterations including a 5q31 breakpoint and (2) in its absolute cytokine dependency and proliferative response to various cytokines...
  67. ncbi T(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29
    B Schneider
    Leukemia 22:1262-6. 2008
  68. ncbi Epigenetic regulation of brain expressed X-linked-2, a marker for acute myeloid leukemia with mixed lineage leukemia rearrangements
    C Fischer
    Leukemia 21:374-7. 2007
  69. ncbi e6-a2 BCR-ABL1 fusion in T-cell acute lymphoblastic leukemia
    H Quentmeier
    Leukemia 19:295-6. 2005
  70. ncbi Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
    C Graux
    Department of Human Genetics, University of Leuven, Leuven, Belgium
    Nat Genet 36:1084-9. 2004
    ..NUP214-ABL1 expression defines a new subgroup of individuals with T-ALL who could benefit from treatment with imatinib...
  71. ncbi DNA profiling and cytogenetic analysis of cell line WSU-CLL reveal cross-contamination with cell line REH (pre B-ALL)
    H G Drexler
    Leukemia 16:1868-70. 2002