R Dringen

Summary

Country: Germany

Publications

  1. ncbi request reprint Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    Eur J Biochem 267:4912-6. 2000
  2. ncbi request reprint Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons
    R Dringen
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Street, 4, D 72076 Tubingen, Germany
    J Neurosci Res 66:1003-8. 2001
  3. ncbi request reprint Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    Glia 23:139-45. 1998
  4. ncbi request reprint Metabolism and functions of glutathione in brain
    R Dringen
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
    Prog Neurobiol 62:649-71. 2000
  5. ncbi request reprint The gamma-glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen
    Neurochem Res 22:727-33. 1997
  6. ncbi request reprint N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    Neurosci Lett 259:79-82. 1999
  7. ncbi request reprint The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress
    J Hirrlinger
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    J Neurochem 76:627-36. 2001

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    Eur J Biochem 267:4912-6. 2000
    ..In coculture astrocytes protect neurons against the toxicity of reactive oxygen species. One mechanism of this interaction is the supply by astrocytes of glutathione precursors to neurons...
  2. ncbi request reprint Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons
    R Dringen
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Street, 4, D 72076 Tubingen, Germany
    J Neurosci Res 66:1003-8. 2001
    ..The data presented demonstrates that cultured rat neurons express ApN and that this ectopeptidase participates in the utilization of CysGly as precursor for neuronal glutathione...
  3. ncbi request reprint Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    Glia 23:139-45. 1998
    ..In the presence of 3 mM mercaptosuccinate oxidation of glutathione was almost completely inhibited. These results demonstrate that an exogenous hydroperoxide is detoxified rapidly by astroglial cells via the glutathione system...
  4. ncbi request reprint Metabolism and functions of glutathione in brain
    R Dringen
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
    Prog Neurobiol 62:649-71. 2000
    ..These results also suggest an involvement of a compromised astroglial glutathione system in the oxidative stress reported for neurological disorders...
  5. ncbi request reprint The gamma-glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen
    Neurochem Res 22:727-33. 1997
    ..These results suggest that glutathione released from astroglial cells can serve as substrate for the ectoenzyme gamma-glutamyl transpeptidase of these cells...
  6. ncbi request reprint N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    Neurosci Lett 259:79-82. 1999
    ..In contrast, generation of cysteine from 2-oxothiazolidine-4-carboxylate by the reaction of 5-oxoprolinase or from methionine by the transsulfuration pathway appears not to take place in these cultured neurons...
  7. ncbi request reprint The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress
    J Hirrlinger
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    J Neurochem 76:627-36. 2001
    ..Our data identify rat astrocytes as a MRP1-expressin, brain cell type and demonstrate that this transporter participates in the release of glutathione disulfide from astrocytes during oxidative stress...