Simon C Drew

Summary

Country: Germany

Publications

  1. doi request reprint The heterogeneous nature of Cu2+ interactions with Alzheimer's amyloid-β peptide
    Simon C Drew
    Max Planck Institute for Bioinorganic Chemistry, 45470 Mulheim an der Ruhr, Germany
    Acc Chem Res 44:1146-55. 2011
  2. pmc Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination
    Simon C Drew
    Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 5:e15875. 2010
  3. doi request reprint Theoretical calculation of the magnetic resonance parameters of trigonal-prismatic tris(o-aminobenzenethiol)technetium and -rhenium complexes
    Simon C Drew
    Max Planck Institut fur Bioanorganische Chemie, 45470 Mulheim an der Ruhr, Germany
    Inorg Chem 49:6799-801. 2010
  4. doi request reprint Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity
    Giuseppe D Ciccotosto
    Department of Pathology, The University of Melbourne, VIC 3010, Australia
    Neurobiol Aging 32:235-48. 2011
  5. doi request reprint Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
    Cathryn L Haigh
    Department of Pathology, The University of Melbourne, 3010, Australia
    J Cell Sci 122:1518-28. 2009
  6. doi request reprint Mixed ligand Cu2+ complexes of a model therapeutic with Alzheimer's amyloid-β peptide and monoamine neurotransmitters
    Vijaya B Kenche
    Mental Health Research Institute, The University of Melbourne, Victoria 3010, Australia
    Inorg Chem 52:4303-18. 2013
  7. pmc Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease
    Victoria A Lawson
    Department of Pathology, University of Melbourne, Victoria 3010, Australia Mental Health Research Institute, Parkville, Victoria 352, Australia
    ACS Chem Neurosci 1:720-7. 2010
  8. doi request reprint Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms
    Simon C Drew
    Department of Pathology and Neuroproteomics Platform, National Neuroscience Facility, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 131:8760-1. 2009
  9. doi request reprint Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide
    Simon C Drew
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 131:1195-207. 2009
  10. doi request reprint Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy
    Simon C Drew
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 130:7766-73. 2008

Collaborators

Detail Information

Publications15

  1. doi request reprint The heterogeneous nature of Cu2+ interactions with Alzheimer's amyloid-β peptide
    Simon C Drew
    Max Planck Institute for Bioinorganic Chemistry, 45470 Mulheim an der Ruhr, Germany
    Acc Chem Res 44:1146-55. 2011
    ..This focused picture of the role of Cu(2+) in AD-related plaques offers welcome potential for the development of new methods to combat this devastating disease...
  2. pmc Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination
    Simon C Drew
    Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 5:e15875. 2010
    ..In particular, Aβ in plaques contain a significant amount of truncated pyroglutamate species, which appear to correlate with disease progression...
  3. doi request reprint Theoretical calculation of the magnetic resonance parameters of trigonal-prismatic tris(o-aminobenzenethiol)technetium and -rhenium complexes
    Simon C Drew
    Max Planck Institut fur Bioanorganische Chemie, 45470 Mulheim an der Ruhr, Germany
    Inorg Chem 49:6799-801. 2010
    ..The absence of this resonance at low solute concentrations provides evidence of intermolecular interactions in these systems...
  4. doi request reprint Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity
    Giuseppe D Ciccotosto
    Department of Pathology, The University of Melbourne, VIC 3010, Australia
    Neurobiol Aging 32:235-48. 2011
    ..This suggests that Aβ mediated toxicity in Alzheimer disease is dependent upon Aβ binding to phosphatidylserine on neuronal cells...
  5. doi request reprint Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
    Cathryn L Haigh
    Department of Pathology, The University of Melbourne, 3010, Australia
    J Cell Sci 122:1518-28. 2009
    ..Our findings show that N2 is a biologically active fragment that is able to modulate stress-induced intracellular ROS through interaction of its structurally defined N-terminal polybasic region with cell-surface proteoglycans...
  6. doi request reprint Mixed ligand Cu2+ complexes of a model therapeutic with Alzheimer's amyloid-β peptide and monoamine neurotransmitters
    Vijaya B Kenche
    Mental Health Research Institute, The University of Melbourne, Victoria 3010, Australia
    Inorg Chem 52:4303-18. 2013
    ..Our findings suggest a molecular basis for the strong metal chaperone activity of PBT2, its ability to attenuate Cu(2+)/Aβ interactions, and its potential to promote neuroprotective and neuroregenerative effects...
  7. pmc Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease
    Victoria A Lawson
    Department of Pathology, University of Melbourne, Victoria 3010, Australia Mental Health Research Institute, Parkville, Victoria 352, Australia
    ACS Chem Neurosci 1:720-7. 2010
    ..The contrast agent and related analogues will enable the longitudinal study of disease progression and therapy in animal models of many neurodegenerative conditions...
  8. doi request reprint Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms
    Simon C Drew
    Department of Pathology and Neuroproteomics Platform, National Neuroscience Facility, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 131:8760-1. 2009
    ....
  9. doi request reprint Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide
    Simon C Drew
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 131:1195-207. 2009
    ....
  10. doi request reprint Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy
    Simon C Drew
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 130:7766-73. 2008
    ..In total, four Cu(2+) binding modes were identified within pH 5.0-7.4, providing a more comprehensive picture of the Cu(2+) binding properties of recombinant alphaS...
  11. doi request reprint Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli
    Simon C Drew
    Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Inorg Chem 13:899-907. 2008
    ..The markedly different spectra of the H1F and nA forms compared with the wild-type and H92F proteins further highlight the integral role of the N-terminal histidine residue in the high-affinity Cu(II) site of PcoC...
  12. doi request reprint Optical imaging detects apoptosis in the brain and peripheral organs of prion-infected mice
    Simon C Drew
    Department of Pathology, Neuroproteomics Platform National Neuroscience Facility, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia
    J Neuropathol Exp Neurol 70:143-50. 2011
    ....
  13. pmc Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands
    Aphrodite Caragounis
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Biochem J 407:435-50. 2007
    ..Given that a structurally diverse array of ligands was assessed, the results are consistent with the effects being due to metal transport rather than the chelating ligand interacting directly with a receptor...
  14. ncbi request reprint Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge
    David P Smith
    Department of Pathology, Centre for Neuroscience, and School of Chemistry, University of Melbourne, Victoria 3010, Australia
    J Biol Chem 281:15145-54. 2006
    ..These findings indicate that the generation of the Abeta toxic species is modulated by the Cu2+ concentration and the ability to form an intermolecular His bridge...
  15. doi request reprint Biophysical investigations of the prion protein using electron paramagnetic resonance
    Simon C Drew
    Department of Pathology and Mental Health Research Institute of Victoria, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia
    Methods Mol Biol 459:173-96. 2008
    ..An overview of the EPR technique as applied to the prion protein is given, key results are summarized, and some future experimental avenues are outlined...