Maczewsky J, Kaiser J, Gresch A, Gerst F, Dufer M, Krippeit Drews P, et al
. TGR5 Activation Promotes Stimulus-Secretion Coupling of Pancreatic Beta-Cells via a PKA-Dependent Pathway. Diabetes. 2018;: pubmed publisher
Bauer C, Kaiser J, Sikimic J, Krippeit Drews P, Dufer M, Drews G. ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic ?-cells. Endocrine. 2018;: pubmed publisher
Dufer M, Haspel D, Krippeit Drews P, Aguilar Bryan L, Bryan J, Drews G. Oscillations of membrane potential and cytosolic Ca(2+) concentration in SUR1(-/-) beta cells. Diabetologia. 2004;47:488-498 pubmed publisher
..We examined how this gene deletion interferes with stimulus-secretion coupling. We tested the influence of metabolic inhibition and galanin, whose mode of action is controversial...
Drews G. Physiological significance of SK4 channels in pancreatic ?-cell oscillations. Islets. 2009;1:148-50 pubmed publisher
..We further propose that the SK4 component of the Kslow current can trigger oscillations in mice without functioning KATP channels. ..
Undank S, Kaiser J, Sikimic J, Dufer M, Krippeit Drews P, Drews G. Atrial Natriuretic Peptide Affects Stimulus-Secretion Coupling of Pancreatic ?-Cells. Diabetes. 2017;66:2840-2848 pubmed publisher
..Moreover, ANP potentiated the effect of glucagon-like peptide 1 (GLP-1) on glucose-induced insulin secretion, which could be caused by a cGMP-mediated inhibition of PDE3B, which in turn reduces cAMP degradation. ..
Barroso Oquendo M, Layer N, Wagner R, Krippeit Drews P, Drews G. Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells. Pflugers Arch. 2018;470:537-547 pubmed publisher
..Overall, GLTx-induced energy depletion may be a primary step in the cascade of events leading to loss of beta cell function in type-2 diabetes mellitus. ..