Dressel R, Grzeszik C, Kreiss M, Lindemann D, Herrmann T, Walter L, et al
. Differential effect of acute and permanent heat shock protein 70 overexpression in tumor cells on lysability by cytotoxic T lymphocytes. Cancer Res. 2003;63:8212-20 pubmed
..The implications of the differential effect of acute versus permanent Hsp70 overexpression for tumor therapy are discussed. ..
Dressel R, Raja S, Honing S, Seidler T, Froelich C, von Figura K, et al
. Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem. 2004;279:20200-10 pubmed
..In conclusion, these results strongly argue against an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing and provide new insight in the internalization of monomeric and complexed granzyme B. ..
Isernhagen A, Malzahn D, Viktorova E, Elsner L, Monecke S, von Bonin F, et al
. The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation. EMBO Mol Med. 2015;7:1480-502 pubmed publisher
..The reduced cell surface expression of NKG2D in response to engagement by MICA-129Met variants appeared to reduce the severity of aGVHD. ..
Isernhagen A, Schilling D, Monecke S, Shah P, Elsner L, Walter L, et al
. The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA. Immunogenetics. 2016;68:109-23 pubmed publisher
..If expressed at the cell surface, the MICA-129Met isoform was more susceptible to shedding. Both processes appear to limit the cell surface expression of MICA-129Met variants that have a high binding avidity to NKG2D. ..
Dressel R. Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells. Semin Immunopathol. 2011;33:573-91 pubmed publisher
..This has to be considered when the results of experimental transplantation models are interpreted and even more when translation into clinics is planned. ..
Dressel R, Schindehütte J, Kuhlmann T, Elsner L, Novota P, Baier P, et al
. The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response. PLoS ONE. 2008;3:e2622 pubmed publisher
..Interestingly, the differentiated cells must contain a tumorigenic cell population that is not present among ES cells and which might be resistant to NK cell-mediated killing. ..
Dressel R, Guan K, Nolte J, Elsner L, Monecke S, Nayernia K, et al
. Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules. Biol Direct. 2009;4:31 pubmed publisher
Dressel R, Elsner L, Novota P, Kanwar N, Fischer von Mollard G. The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation. J Immunol. 2010;185:1005-14 pubmed publisher
..However, a deficiency can apparently be compensated and affects only transiently the cytotoxic activity of CTL during their development to armed effector cells. ..
Gröschel C, Sasse A, Röhrborn C, Monecke S, Didié M, Elsner L, et al
. T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure. Sci Rep. 2017;7:15998 pubmed publisher
..Thus, T helper cells with specificity for an antigen in cardiomyocytes can directly promote the progression of heart failure in response to pressure overload independently of autoantibodies. ..