Research Topics
| Gerd DoringSummaryCountry: Germany Publications
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Detail Information
Publications
Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosisG Doring
Department of General and Environmental Hygiene, Hygiene Institut, University of Tubingen, Germany
Pediatr Pulmonol 28:363-75. 1999..Studies in both patient groups using plasma-derived or transgenic alpha(1)-AT, recombinant secretory leukoprotease inhibitor or synthetic elastase inhibitors show promising results concerning drug safety and efficacy...- Inflammation in cystic fibrosis and its managementG Doring
Department of General and Environmental Hygiene, Hygiene Institute, University of Tubingen, Tubingen, Germany
Paediatr Respir Rev 1:101-6. 2000.... - Early intervention and prevention of lung disease in cystic fibrosis: a European consensusGerd Doring
Institute of General and Environmental Hygiene, Eberhard, Karls University of Tübingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
J Cyst Fibros 3:67-91. 2004.... 
Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosaGloria Herrmann
Institute of Medical Microbiology and Hygiene, Universitatsklinikum, University of Tubingen, Tubingen, Germany
J Infect Dis 202:1585-92. 2010..We tested the ability of colistin sulphate-tobramycin combinations and single antibiotics to kill P. aeruginosa biofilms...- Clinical trials in cystic fibrosisGerd Doring
J Cyst Fibros 6:85-99. 2007.... - Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung diseaseGerd Doring
Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, 72074 Tubingen, Germany
Cell Microbiol 11:208-16. 2009..Consequently, chronic airway colonization with opportunistic bacterial pathogens develops and leads to life-threatening lung disease... - Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosisJoachim Riethmüller
Department of Paediatrics, University Hospital Tuebingen, Tuebingen, Germany
Cell Physiol Biochem 24:65-72. 2009..0+/-7%; p = 0.048). Amitriptyline was well tolerated in both studies and 96% of the patients completed the studies. Amitriptyline as a novel therapeutic option in patients with CF is safe and seems to be efficacious... - Validation criteria for nucleic acid amplification techniques for bacterial infectionsGerd Doring
Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
Clin Chem Lab Med 46:909-18. 2008..Because of these limitations, NATs can only serve as adjunct tools for the diagnosis of infection in selected cases; they cannot replace conventional culturing techniques... - Vaccines and immunotherapy against Pseudomonas aeruginosaGerd Doring
Institute of Medical Microbiology and Hygiene, University of Tubingen, D 72074 Tubingen, Germany
Vaccine 26:1011-24. 2008..Finally, the inherent problem of testing P. aeruginosa candidate vaccines in patient populations is discussed... 
A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patientsGerd Doring
Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, D 72074 Tubingen, Germany
Proc Natl Acad Sci U S A 104:11020-5. 2007..Active immunization of patients with cystic fibrosis lowers the risk for infection with P. aeruginosa and therefore may contribute to a longer survival of these patients...- Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosisMartina Ulrich
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
Thorax 65:978-84. 2010..Whether obligate anaerobes contribute to the pathophysiology of CF lung disease is unknown... - Alveolar inflammation in cystic fibrosisMartina Ulrich
Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
J Cyst Fibros 9:217-27. 2010..We sought to investigate CF lung inflammation in the alveoli... - Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the hostKerstin Gronbach
Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
Infect Immun 78:3036-46. 2010..coli strain Nissle 1917 may occur and have potentially severe adverse effects. Future work should define the possibly related molecular factors that promote probiotic functions, fitness, and facultative pathogenicity... - Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary diseaseGerd Doring
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
FEMS Microbiol Rev 35:124-46. 2011..In this review, we will discuss the pathophysiology of lung disease in CF and COPD, the complex genotypic and phenotypic adaptation processes of the opportunistic bacterial pathogens and novel treatment options... - Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patientsGerd Doring
Institute of Medical Microbiology and Hygiene, University of Tubingen, Germany
Int J Med Microbiol 300:573-7. 2010..Principles to achieve this goal include vaccination, immediate use of antibiotics in patients newly colonized with the pathogen, and hygienic measures. The purpose of this review is to discuss recent developments in this context... - Suicidal erythrocyte death in sepsisDaniela S Kempe
Department of Physiology, University of Tubingen, Tubingen, Germany
J Mol Med (Berl) 85:273-81. 2007..Exposure to plasma from septic patients triggers phosphatidylserine exposure leading to adherence to the vascular wall and clearance from circulating blood...