Gerd Doring

Summary

Country: Germany

Publications

  1. doi Treatment of lung infection in patients with cystic fibrosis: current and future strategies
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    J Cyst Fibros 11:461-79. 2012
  2. doi Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patients
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Germany
    Int J Med Microbiol 300:573-7. 2010
  3. doi Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    FEMS Microbiol Rev 35:124-46. 2011
  4. doi Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, 72074 Tubingen, Germany
    Cell Microbiol 11:208-16. 2009
  5. doi Validation criteria for nucleic acid amplification techniques for bacterial infections
    Gerd Doring
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Clin Chem Lab Med 46:909-18. 2008
  6. doi Vaccines and immunotherapy against Pseudomonas aeruginosa
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, University of Tubingen, D 72074 Tubingen, Germany
    Vaccine 26:1011-24. 2008
  7. pmc A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    Proc Natl Acad Sci U S A 104:11020-5. 2007
  8. ncbi Clinical trials in cystic fibrosis
    Gerd Doring
    J Cyst Fibros 6:85-99. 2007
  9. ncbi Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    Alessandra Bragonzi
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    Microbiology 152:3261-9. 2006
  10. doi Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    Thorax 65:978-84. 2010

Detail Information

Publications27

  1. doi Treatment of lung infection in patients with cystic fibrosis: current and future strategies
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    J Cyst Fibros 11:461-79. 2012
    ..Finally, cost-effectiveness analyses for antibiotic treatment in CF patients are discussed...
  2. doi Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patients
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Germany
    Int J Med Microbiol 300:573-7. 2010
    ..Principles to achieve this goal include vaccination, immediate use of antibiotics in patients newly colonized with the pathogen, and hygienic measures. The purpose of this review is to discuss recent developments in this context...
  3. doi Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    FEMS Microbiol Rev 35:124-46. 2011
    ..In this review, we will discuss the pathophysiology of lung disease in CF and COPD, the complex genotypic and phenotypic adaptation processes of the opportunistic bacterial pathogens and novel treatment options...
  4. doi Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, 72074 Tubingen, Germany
    Cell Microbiol 11:208-16. 2009
    ..Consequently, chronic airway colonization with opportunistic bacterial pathogens develops and leads to life-threatening lung disease...
  5. doi Validation criteria for nucleic acid amplification techniques for bacterial infections
    Gerd Doring
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Clin Chem Lab Med 46:909-18. 2008
    ..Because of these limitations, NATs can only serve as adjunct tools for the diagnosis of infection in selected cases; they cannot replace conventional culturing techniques...
  6. doi Vaccines and immunotherapy against Pseudomonas aeruginosa
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, University of Tubingen, D 72074 Tubingen, Germany
    Vaccine 26:1011-24. 2008
    ..Finally, the inherent problem of testing P. aeruginosa candidate vaccines in patient populations is discussed...
  7. pmc A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    Proc Natl Acad Sci U S A 104:11020-5. 2007
    ..Active immunization of patients with cystic fibrosis lowers the risk for infection with P. aeruginosa and therefore may contribute to a longer survival of these patients...
  8. ncbi Clinical trials in cystic fibrosis
    Gerd Doring
    J Cyst Fibros 6:85-99. 2007
    ....
  9. ncbi Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    Alessandra Bragonzi
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    Microbiology 152:3261-9. 2006
    ..The exceptions point to intragenic mosaicism and interclonal recombination as major forces for intraclonal evolution at the mucABD locus...
  10. doi Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    Thorax 65:978-84. 2010
    ..Whether obligate anaerobes contribute to the pathophysiology of CF lung disease is unknown...
  11. doi Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease
    Nikolaus Rieber
    Department of Pediatrics I, University of Tubingen, Tubingen, 72076 Germany
    J Immunol 190:1276-84. 2013
    ..These studies demonstrate that flagellin induces the generation of MDSCs and suggest that P. aeruginosa uses this mechanism to undermine T cell-mediated host defense in CF and other P. aeruginosa-associated chronic lung diseases...
  12. pmc DNase pretreatment of master mix reagents improves the validity of universal 16S rRNA gene PCR results
    Alexandra Heininger
    Klinik für Anästhesiologie und Transfusionsmedizin, Abteilung für Anästhesiologie, Eberhard Karls Universitat Tubingen, D 72074 Tubingen, Germany
    J Clin Microbiol 41:1763-5. 2003
    ..The DNase I requirement for the elimination of false-positive results varied between 0.1 and 70 IU per master mix depending on the applied Taq polymerase. PCR sensitivity was mostly maintained when 0.1 IU of DNase I was used...
  13. pmc Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    Dieter Worlitzsch
    Institute of General and Environmental Hygiene, University of Tubingen, Tubingen, Germany
    J Clin Invest 109:317-25. 2002
    ..These studies indicate that novel therapies for CF include removal of hypoxic mucus plaques and antibiotics effective against P. aeruginosa adapted to anaerobic environments...
  14. ncbi Virulence of Burkholderia cepacia complex strains in gp91phox-/- mice
    Silvia A Sousa
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Wilhelmstrasse 31, 72074 Tubingen, Germany
    Cell Microbiol 9:2817-25. 2007
    ..We conclude that the Bcc infection model in CGD mice is well suited for the assessment of Bcc virulence...
  15. doi Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa
    Gloria Herrmann
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum, University of Tubingen, Tubingen, Germany
    J Infect Dis 202:1585-92. 2010
    ..We tested the ability of colistin sulphate-tobramycin combinations and single antibiotics to kill P. aeruginosa biofilms...
  16. pmc Alveolar inflammation in cystic fibrosis
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
    J Cyst Fibros 9:217-27. 2010
    ..We sought to investigate CF lung inflammation in the alveoli...
  17. doi Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis
    Joachim Riethmüller
    Department of Paediatrics, University Hospital Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 24:65-72. 2009
    ..0+/-7%; p = 0.048). Amitriptyline was well tolerated in both studies and 96% of the patients completed the studies. Amitriptyline as a novel therapeutic option in patients with CF is safe and seems to be efficacious...
  18. ncbi Early intervention and prevention of lung disease in cystic fibrosis: a European consensus
    Gerd Doring
    Institute of General and Environmental Hygiene, Eberhard, Karls University of Tübingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    J Cyst Fibros 3:67-91. 2004
    ....
  19. ncbi The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Germany
    Mol Microbiol 65:1276-87. 2007
    ..These results demonstrate that SrrAB is a major activator of ica expression and PIA production in anaerobic environments, where it contributes to the protection of S. aureus against non-oxidative defence mechanisms...
  20. pmc Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    Antimicrob Agents Chemother 49:5119-22. 2005
    ..Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective...
  21. doi Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophils
    Andreas Hector
    Children s Hospital, University of Tubingen, Tubingen, Germany
    Am J Respir Cell Mol Biol 48:71-7. 2013
    ..Understanding the regulation of IFRD1 may pave the way for novel therapeutic approaches to target neutrophilic inflammation in CF...
  22. pmc Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host
    Kerstin Gronbach
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
    Infect Immun 78:3036-46. 2010
    ..coli strain Nissle 1917 may occur and have potentially severe adverse effects. Future work should define the possibly related molecular factors that promote probiotic functions, fitness, and facultative pathogenicity...
  23. pmc Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model
    Alessandra Bragonzi
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Germany
    J Infect Dis 192:410-9. 2005
    ..We investigated the kinetics, impact of environmental signals, and genetics of P. aeruginosa alginate expression in a mouse model and in patients with CF...
  24. ncbi BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
    J Cyst Fibros 13:156-63. 2014
    ..We aimed to establish the effect of BIIL284 in models of Pseudomonas aeruginosa lung infection, thereby contributing to a better understanding of what could have led to adverse pulmonary events in CF patients...
  25. ncbi Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis
    Nanna Siegmann
    Institute of Medical Microbiology and Hygiene University Hospital, Tubingen, Germany
    Cell Physiol Biochem 34:56-70. 2014
    ..iNKT cells suppress the auto-immune response induced by ceramide-mediated death of epithelial cells in CF lungs, but also induce a chronic pulmonary inflammation. © 2014 S. Karger AG, Basel. ..
  26. pmc Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tübingen 72074, Germany
    J Biol Chem 283:28629-40. 2008
    ..Tyrosine nitration of eosinophil granule toxins occurs during maturation of eosinophils, independent of inflammation. These results provide evidence that post-translational tyrosine nitration is unique to eosinophils...
  27. ncbi Suicidal erythrocyte death in sepsis
    Daniela S Kempe
    Department of Physiology, University of Tubingen, Tubingen, Germany
    J Mol Med (Berl) 85:273-81. 2007
    ..Exposure to plasma from septic patients triggers phosphatidylserine exposure leading to adherence to the vascular wall and clearance from circulating blood...