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Genomes and Genes | Gerd DoringSummaryCountry: Germany Publications
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Publications
Treatment of lung infection in patients with cystic fibrosis: current and future strategiesGerd Doring
Institute of Medical Microbiology and Hygiene, University of Tubingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
J Cyst Fibros 11:461-79. 2012..Finally, cost-effectiveness analyses for antibiotic treatment in CF patients are discussed...- Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary diseaseGerd Doring
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
FEMS Microbiol Rev 35:124-46. 2011..In this review, we will discuss the pathophysiology of lung disease in CF and COPD, the complex genotypic and phenotypic adaptation processes of the opportunistic bacterial pathogens and novel treatment options... - Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung diseaseGerd Doring
Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, 72074 Tubingen, Germany
Cell Microbiol 11:208-16. 2009..Consequently, chronic airway colonization with opportunistic bacterial pathogens develops and leads to life-threatening lung disease... - Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patientsGerd Doring
Institute of Medical Microbiology and Hygiene, University of Tubingen, Germany
Int J Med Microbiol 300:573-7. 2010..Principles to achieve this goal include vaccination, immediate use of antibiotics in patients newly colonized with the pathogen, and hygienic measures. The purpose of this review is to discuss recent developments in this context... - Validation criteria for nucleic acid amplification techniques for bacterial infectionsGerd Doring
Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
Clin Chem Lab Med 46:909-18. 2008..Because of these limitations, NATs can only serve as adjunct tools for the diagnosis of infection in selected cases; they cannot replace conventional culturing techniques... 
Clinical trials in cystic fibrosisGerd Doring
J Cyst Fibros 6:85-99. 2007....
A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patientsGerd Doring
Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, D 72074 Tubingen, Germany
Proc Natl Acad Sci U S A 104:11020-5. 2007..Active immunization of patients with cystic fibrosis lowers the risk for infection with P. aeruginosa and therefore may contribute to a longer survival of these patients...- Vaccines and immunotherapy against Pseudomonas aeruginosaGerd Doring
Institute of Medical Microbiology and Hygiene, University of Tubingen, D 72074 Tubingen, Germany
Vaccine 26:1011-24. 2008..Finally, the inherent problem of testing P. aeruginosa candidate vaccines in patient populations is discussed... - Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosisMartina Ulrich
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tubingen, Germany
Thorax 65:978-84. 2010..Whether obligate anaerobes contribute to the pathophysiology of CF lung disease is unknown... - Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung diseaseNikolaus Rieber
Department of Pediatrics I, University of Tubingen, Tubingen, 72076 Germany
J Immunol 190:1276-84. 2013..These studies demonstrate that flagellin induces the generation of MDSCs and suggest that P. aeruginosa uses this mechanism to undermine T cell-mediated host defense in CF and other P. aeruginosa-associated chronic lung diseases... - Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosaGloria Herrmann
Institute of Medical Microbiology and Hygiene, Universitatsklinikum, University of Tubingen, Tubingen, Germany
J Infect Dis 202:1585-92. 2010..We tested the ability of colistin sulphate-tobramycin combinations and single antibiotics to kill P. aeruginosa biofilms... - Virulence of Burkholderia cepacia complex strains in gp91phox-/- miceSilvia A Sousa
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Wilhelmstrasse 31, 72074 Tubingen, Germany
Cell Microbiol 9:2817-25. 2007..We conclude that the Bcc infection model in CGD mice is well suited for the assessment of Bcc virulence... - Alveolar inflammation in cystic fibrosisMartina Ulrich
Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
J Cyst Fibros 9:217-27. 2010..We sought to investigate CF lung inflammation in the alveoli... - Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosisJoachim Riethmüller
Department of Paediatrics, University Hospital Tuebingen, Tuebingen, Germany
Cell Physiol Biochem 24:65-72. 2009..0+/-7%; p = 0.048). Amitriptyline was well tolerated in both studies and 96% of the patients completed the studies. Amitriptyline as a novel therapeutic option in patients with CF is safe and seems to be efficacious... - Early intervention and prevention of lung disease in cystic fibrosis: a European consensusGerd Doring
Institute of General and Environmental Hygiene, Eberhard, Karls University of Tübingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
J Cyst Fibros 3:67-91. 2004.... - The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditionsMartina Ulrich
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Germany
Mol Microbiol 65:1276-87. 2007..These results demonstrate that SrrAB is a major activator of ica expression and PIA production in anaerobic environments, where it contributes to the protection of S. aureus against non-oxidative defence mechanisms... - Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophilsAndreas Hector
Children s Hospital, University of Tubingen, Tubingen, Germany
Am J Respir Cell Mol Biol 48:71-7. 2013..Understanding the regulation of IFRD1 may pave the way for novel therapeutic approaches to target neutrophilic inflammation in CF... - Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse modelAlessandra Bragonzi
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Germany
J Infect Dis 192:410-9. 2005..aeruginosa. This trait may contribute to early persistence, leading to chronic P. aeruginosa infection once stable mucoid strains are generated... - Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the hostKerstin Gronbach
Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
Infect Immun 78:3036-46. 2010..coli strain Nissle 1917 may occur and have potentially severe adverse effects. Future work should define the possibly related molecular factors that promote probiotic functions, fitness, and facultative pathogenicity... - Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patientsDieter Worlitzsch
Institute of General and Environmental Hygiene, , , Germany
J Clin Invest 109:317-25. 2002..These studies indicate that novel therapies for CF include removal of hypoxic mucus plaques and antibiotics effective against P. aeruginosa adapted to anaerobic environments... - Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosisAlessandra Bragonzi
Institute of Medical Microbiology and Hygiene, , , Germany
Microbiology 152:3261-9. 2006..The exceptions point to intragenic mosaicism and interclonal recombination as major forces for intraclonal evolution at the mucABD locus... - Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidaseMartina Ulrich
Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tübingen 72074, Germany
J Biol Chem 283:28629-40. 2008..Tyrosine nitration of eosinophil granule toxins occurs during maturation of eosinophils, independent of inflammation. These results provide evidence that post-translational tyrosine nitration is unique to eosinophils... - Suicidal erythrocyte death in sepsisDaniela S Kempe
Department of Physiology, University of Tubingen, Tubingen, Germany
J Mol Med (Berl) 85:273-81. 2007..Exposure to plasma from septic patients triggers phosphatidylserine exposure leading to adherence to the vascular wall and clearance from circulating blood... - Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challengeMartina Ulrich
Institute of Medical Microbiology and Hygiene, , Wilhelmstrasse 31, , Germany
Antimicrob Agents Chemother 49:5119-22. 2005..Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective...