Research Topics
| Sebastian DolffSummaryCountry: Germany Publications
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Detail Information
Publications
Urinary T cells in active lupus nephritis show an effector memory phenotypeSebastian Dolff
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Hanzeplein, The Netherlands
Ann Rheum Dis 69:2034-41. 2010..The hypothesis that these T(EM) cells migrate to the kidney during active disease was tested...
Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosusSebastian Dolff
Department of Nephrology, University Hospital Essen, University Duisburg Essen, Hufelandstrase 55, Essen, Germany
Arthritis Res Ther 12:R150. 2010..The aim of this study was to investigate the distribution and phenotypical characteristics of IL-17 producing T-cells in SLE, in particular in patients with lupus nephritis, with emphasis on the expression of CD80 and CD134...
Increase in IL-21 producing T-cells in patients with systemic lupus erythematosusSebastian Dolff
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Arthritis Res Ther 13:R157. 2011..The novel cytokine interleukin-21 (IL-21) is suggested to be crucial for triggering T-cell responses towards IL-17 producing cells. Thus, we aimed to investigate the ability of T-cells to produce IL-21 and IL-17 in SLE patients...
Treatment of lupus nephritisSebastian Dolff
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
Expert Rev Clin Immunol 6:901-11. 2010..We review recently reported data on current treatment regimens in LN, in particular in the context of the International Society of Nephrology/Renal Pathology Society 2003 classification...
Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosusSebastian Dolff
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands
Clin Immunol 141:197-204. 2011..Even in quiescent SLE-patients T-cell homeostasis is aberrant in terms of skewing towards IL-17 producing T-cells...
Aberrant expression of the negative costimulator PD-1 on T cells in granulomatosis with polyangiitisBenjamin Wilde
Department of Nephrology, University Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Rheumatology (Oxford) 51:1188-97. 2012..The negative costimulator programmed death receptor-1 (PD-1) and its relevance to T-cell immunity have not been studied so far in GPA. Thus it is the aim of the study to characterize the role of PD-1 in GPA...
CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosisBenjamin Wilde
Department of Nephrology, University Duisburg Essen, Essen, Germany
Nephrol Dial Transplant 24:161-71. 2009..An increased CD4(+) CD25(+) T-cell population is observed in Wegener's granulomatosis (WG). This T-cell population is not well characterized yet and their contribution to the disease pathogenesis remains obscure...
T-lymphocytes and disease mechanisms in Wegener's granulomatosisFan Hua
Department of Nephrology, University Duisburg Essen, Essen, Germany
Kidney Blood Press Res 32:389-98. 2009..Moreover, the influence of Staphylococcus aureus on T-cells and self-tolerance in WG is further elucidated. Finally, therapeutic options and implications with regard to T-cell-mediated pathogenesis are highlighted...
