Ulrich Dobrindt

Summary

Country: Germany

Publications

  1. ncbi request reprint A subtractive hybridisation analysis of genomic differences between the uropathogenic E. coli strain 536 and the E. coli K-12 strain MG1655
    B Janke
    , , , D-97070, , Germany
    FEMS Microbiol Lett 199:61-6. 2001
  2. ncbi request reprint (Patho-)Genomics of Escherichia coli
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie, Universittät Wütrzburg, Rontgenring 11, D 97070 Wütrzburg, Germany
    Int J Med Microbiol 295:357-71. 2005
  3. doi request reprint Characterisation of Escherichia coli strains involved in transcytosis across gut epithelial cells exposed to metabolic and inflammatory stress
    Christian Macutkiewicz
    Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Hope Hospital, Salford M6 8HD, UK
    Microbes Infect 10:424-31. 2008
  4. pmc Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Wurzburg, Germany
    J Bacteriol 185:1831-40. 2003
  5. doi request reprint Genome dynamics and its impact on evolution of Escherichia coli
    Ulrich Dobrindt
    Institute for Molecular Biology of Infectious Diseases, University of Wurzburg, Josef Schneider Str 2 Bau D15, Wurzburg, Germany
    Med Microbiol Immunol 199:145-54. 2010
  6. doi request reprint [Virulence factors of uropathogens]
    U Dobrindt
    Institut für Molekulare Infektionsbiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Deutschland
    Urologe A 49:598-605. 2010
  7. doi request reprint Bacterial genome plasticity and its impact on adaptation during persistent infection
    Ulrich Dobrindt
    Julius Maximilians Universitat Wurzburg, Institut für Molekulare Infektionsbiologie, Josef Schneider Str 2 Bau D15, 97080 Wurzburg, Germany
    Int J Med Microbiol 300:363-6. 2010
  8. ncbi request reprint Whole genome plasticity in pathogenic bacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Microbiol 4:550-7. 2001
  9. pmc The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536
    György Schneider
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wurzburg, Germany
    Infect Immun 72:5993-6001. 2004
  10. pmc Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917
    Lubomir Grozdanov
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wuerzburg, Germany
    J Bacteriol 186:5432-41. 2004

Detail Information

Publications68

  1. ncbi request reprint A subtractive hybridisation analysis of genomic differences between the uropathogenic E. coli strain 536 and the E. coli K-12 strain MG1655
    B Janke
    , , , D-97070, , Germany
    FEMS Microbiol Lett 199:61-6. 2001
    ..Whereas two fragments were highly specific for uropathogenic E. coli (UPEC), the other fragments could also be detected among the other tested wild-type strains...
  2. ncbi request reprint (Patho-)Genomics of Escherichia coli
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie, Universittät Wütrzburg, Rontgenring 11, D 97070 Wütrzburg, Germany
    Int J Med Microbiol 295:357-71. 2005
    ....
  3. doi request reprint Characterisation of Escherichia coli strains involved in transcytosis across gut epithelial cells exposed to metabolic and inflammatory stress
    Christian Macutkiewicz
    Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Hope Hospital, Salford M6 8HD, UK
    Microbes Infect 10:424-31. 2008
    ..These data suggest translocating E. coli strains associated with infections are not opportunistic ExPEC strains but may comprise a separate group of E. coli strains...
  4. pmc Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Wurzburg, Germany
    J Bacteriol 185:1831-40. 2003
    ..coli strains and underline the fact that both the acquisition and deletion of DNA elements are important processes involved in the evolution of prokaryotes...
  5. doi request reprint Genome dynamics and its impact on evolution of Escherichia coli
    Ulrich Dobrindt
    Institute for Molecular Biology of Infectious Diseases, University of Wurzburg, Josef Schneider Str 2 Bau D15, Wurzburg, Germany
    Med Microbiol Immunol 199:145-54. 2010
    ..Using Escherichia coli model organisms, such as uropathogenic strain 536 or commensal strain Nissle 1917, we studied mechanisms of genome dynamics and discuss these processes in the light of the evolution of microbes...
  6. doi request reprint [Virulence factors of uropathogens]
    U Dobrindt
    Institut für Molekulare Infektionsbiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Deutschland
    Urologe A 49:598-605. 2010
    ..Furthermore, uropathogens may also directly inhibit the mucosal inflammatory response. Specific metabolic traits promote fitness, growth and survival in the urinary tract...
  7. doi request reprint Bacterial genome plasticity and its impact on adaptation during persistent infection
    Ulrich Dobrindt
    Julius Maximilians Universitat Wurzburg, Institut für Molekulare Infektionsbiologie, Josef Schneider Str 2 Bau D15, 97080 Wurzburg, Germany
    Int J Med Microbiol 300:363-6. 2010
    ....
  8. ncbi request reprint Whole genome plasticity in pathogenic bacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Microbiol 4:550-7. 2001
    ....
  9. pmc The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536
    György Schneider
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wurzburg, Germany
    Infect Immun 72:5993-6001. 2004
    ..Expression of the K15 capsule is important for virulence in a murine model of ascending urinary tract infection but not for serum resistance of E. coli strain 536...
  10. pmc Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917
    Lubomir Grozdanov
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wuerzburg, Germany
    J Bacteriol 186:5432-41. 2004
    ..coli strain Nissle 1917...
  11. doi request reprint Delineation of the recombination sites necessary for integration of pathogenicity islands II and III into the Escherichia coli 536 chromosome
    Caroline Wilde
    Universitat Wurzburg, Institut für Molekulare Infektionsbiologie, 97070 Wurzburg, Germany
    Mol Microbiol 68:139-51. 2008
    ..These data suggest that PAI intasomes differ from those of lambda and P4 integrase paradigms...
  12. pmc Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?
    Jaroslaw Zdziarski
    Institut für Molekulare Infektionsbiologie, Julius Maximilians Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Infect Immun 76:695-703. 2008
    ..We propose that virulence attenuation might constitute a general mechanism for mucosal pathogens to evolve toward commensalism...
  13. ncbi request reprint Pathogenomics of mobile genetic elements of toxigenic bacteria
    Jörg Hacker
    University of Wurzburg, Institute for Molecular Biology of Infectious Diseases, Wurzburg, Germany
    Int J Med Microbiol 293:453-61. 2004
    ..In this review, we focus on the role of mobile genetic elements that may also contain toxin-encoding genes for genome variability and evolution of bacteria...
  14. pmc Comparison of asymptomatic bacteriuria Escherichia coli isolates from healthy individuals versus those from hospital patients shows that long-term bladder colonization selects for attenuated virulence phenotypes
    Ellaine Salvador
    Institute for Molecular Biology of Infectious Diseases, University of Wurzburg, Wurzburg, Germany
    Infect Immun 80:668-78. 2012
    ....
  15. pmc Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae
    Johannes Putze
    Julius Maximilians Universitat Wurzburg, Institut für Molekulare Infektionsbiologie, Rontgenring 11, D 97070 Wurzburg, Germany
    Infect Immun 77:4696-703. 2009
    ..Our results shed light on the mechanisms of genetic exchange between members of the family Enterobacteriaceae...
  16. pmc Role of histone-like proteins H-NS and StpA in expression of virulence determinants of uropathogenic Escherichia coli
    Claudia M Müller
    Institut für Molekulare Infektionsbiologie, Rontgenring 11, D 97070 Wurzburg, Germany
    J Bacteriol 188:5428-38. 2006
    ..At a lower infectious dose, however, mutants lacking H-NS are attenuated through their impaired growth rate, which can only partially be compensated for by the higher expression of numerous virulence factors...
  17. ncbi request reprint Prokaryotic chromosomes and disease
    Jörg Hacker
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Science 301:790-3. 2003
    ..Here, we will show that various processes of genomic instability have an influence on the many manifestations of infectious disease...
  18. pmc Host imprints on bacterial genomes--rapid, divergent evolution in individual patients
    Jaroslaw Zdziarski
    Institute for Molecular Biology of Infectious Diseases, Julius Maximilians University Würzburg, Wurzburg, Germany
    PLoS Pathog 6:e1001078. 2010
    ..Ongoing loss of gene function supports the hypothesis that evolution towards commensalism rather than virulence is favored during asymptomatic bladder colonization...
  19. ncbi request reprint Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536
    Bianca Hochhut
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, 97070 Wurzburg, Germany
    Mol Microbiol 61:584-95. 2006
    ..This work also demonstrates for the first time the existence of a cross-talk between integrases of different PAIs and shows that this cross-talk is unidirectional...
  20. pmc The transcriptional antiterminator RfaH represses biofilm formation in Escherichia coli
    Christophe Beloin
    Institut für Molekulare Infektionsbiologie, Bayerische Julius Maximilians Universität Würzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    J Bacteriol 188:1316-31. 2006
    ....
  21. ncbi request reprint Pathogenicity islands and their role in bacterial virulence and survival
    Bianca Hochhut
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, DE 97070 Würzburg, Germany
    Contrib Microbiol 12:234-54. 2005
  22. pmc Instability of pathogenicity islands in uropathogenic Escherichia coli 536
    Barbara Middendorf
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, 97070 Wurzburg, Germany
    J Bacteriol 186:3086-96. 2004
    ..Such extrachromosomal derivatives of PAI II536 and PAI III536 were detected by a specific PCR assay. Our data indicate that the genome content of uropathogenic E. coli can be modulated by deletion of PAIs...
  23. doi request reprint Pathogenomic comparison of human extraintestinal and avian pathogenic Escherichia coli--search for factors involved in host specificity or zoonotic potential
    Philippe Bauchart
    Institut für Molekulare Infektionsbiologie, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Microb Pathog 49:105-15. 2010
    ..Beside strain-specific effects, the common behavior of both strains at human or avian body temperature supports the idea of a potential zoonotic risk of certain human ExPEC and APEC variants...
  24. pmc Genetic structure and distribution of four pathogenicity islands (PAI I(536) to PAI IV(536)) of uropathogenic Escherichia coli strain 536
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, D 97070 Wurzburg, Germany
    Infect Immun 70:6365-72. 2002
    ..coli isolates. These results support our view that the acquisition of large DNA regions, such as PAIs, by horizontal gene transfer is an important factor for the evolution of bacterial pathogens...
  25. ncbi request reprint Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli
    Stefan Homburg
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wurzburg, Germany
    FEMS Microbiol Lett 275:255-62. 2007
    ..RT-PCR revealed an overall increased transcription in shaking cultures as well as of the genes clbA to clbH in general. Luciferase reporter gene fusions indicated an influence of the carbon source on clb gene expression...
  26. doi request reprint O-acetyltransferase gene neuO is segregated according to phylogenetic background and contributes to environmental desiccation resistance in Escherichia coli K1
    Ines L Mordhorst
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Environ Microbiol 11:3154-65. 2009
    ..In contrast, NeuO expression led to a reduced biofilm formation in biofilm positive E. coli K1 isolates. These findings suggest a delicate ecological balance of neuO'on'/'off' switching...
  27. pmc High-throughput microarray technology in diagnostics of enterobacteria based on genome-wide probe selection and regression analysis
    Torben Friedrich
    University of Wurzburg, Institute for Molecular Infection Biology, Wurzburg, Germany
    BMC Genomics 11:591. 2010
    ..The development of highly discriminative broad-range microbial diagnostic microarrays remains a challenge, because of marked genome plasticity of many bacterial pathogens...
  28. pmc Mobilisation and remobilisation of a large archetypal pathogenicity island of uropathogenic Escherichia coli in vitro support the role of conjugation for horizontal transfer of genomic islands
    György Schneider
    Institute for Molecular Infection Biology, University of Wurzburg, Josef Schneider Str, 2 Building D15, Wurzburg, 97070, Germany
    BMC Microbiol 11:210. 2011
    ..Transfer events of archetypal large genomic islands of enterobacteria which often lack genes required for mobilisation or transfer have been rarely investigated so far...
  29. doi request reprint Targeting virulence traits: potential strategies to combat extraintestinal pathogenic E. coli infections
    Ulrich Dobrindt
    University of Wurzburg, Institute for Molecular Infection Biology, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Microbiol 11:409-13. 2008
    ....
  30. doi request reprint Impact of O-glycosylation on the molecular and cellular adhesion properties of the Escherichia coli autotransporter protein Ag43
    Sebastian Reidl
    Julius Maximilians Universitat Wurzburg, Institut für Molekulare Infektionsbiologie, Rontgenring 11, 97070 Wurzburg, Germany
    Int J Med Microbiol 299:389-401. 2009
    ..e., biofilm formation, autoaggregation, adhesion to eukaryotic cells and extracellular matrix proteins, rely on distinct mechanisms...
  31. ncbi request reprint Influence of the leuX-encoded tRNA5(Leu) on the regulation of gene expression in pathogenic Escherichia coli
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Germany
    J Mol Microbiol Biotechnol 4:205-9. 2002
    ..coli strain 536 was studied by proteome analysis. The obtained results argue for a general importance of the tRNA5(Leu) for gene expression of E. coli and the involvement of this tRNA in global regulatory networks...
  32. ncbi request reprint Analysis of pathogenicity islands of STEC
    Tobias A Oelschlaeger
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wurzburg, Germany
    Methods Mol Med 73:99-112. 2003
  33. ncbi request reprint Genomic islands in pathogenic and environmental microorganisms
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wuerzburg, Germany
    Nat Rev Microbiol 2:414-24. 2004
  34. doi request reprint Pathogenomics: an updated European Research Agenda
    Andreas Demuth
    Institut für Molekulare Infektionsbiologie, Rontgenring 11, 97070 Wurzburg, Germany
    Infect Genet Evol 8:386-93. 2008
    ..Based on a proposed European Research Agenda in the field of pathogenomics by the ERA-NET PathoGenoMics the meeting's participants updated the established list of topics as the research agenda for the future...
  35. ncbi request reprint Commensal bacteria make a difference
    Ute Hentschel
    Institut für Molekulare Infektionsbiologie, Rontgenring 11, D 97070, Wurzburg, Germany
    Trends Microbiol 11:148-50. 2003
    ..However, recent work has provided new insights into these interactions...
  36. pmc Expression of hemin receptor molecule ChuA is influenced by RfaH in uropathogenic Escherichia coli strain 536
    G Nagy
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 69:1924-8. 2001
    ..Furthermore, the presence of two different subclasses of the chuA determinant and their distribution in E. coli pathogroups are described...
  37. ncbi request reprint The molecular basis of infectious diseases: pathogenicity islands and other mobile genetic elements. A review
    J Hacker
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Deutschland
    Acta Microbiol Immunol Hung 50:321-30. 2003
    ..This review summarises the current knowledge on bacterial genomic islands and their general features, and discusses their putative role in the evolution of microbes in the light of genomics of pathogenic bacteria...
  38. pmc Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli
    H Schmidt
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Wurzburg, Germany
    Infect Immun 69:6863-73. 2001
    ..We conclude that the newly described island occurs exclusively in a subgroup of STEC strains that are eae negative and contain the variant stx(2d )gene...
  39. ncbi request reprint Efficient expression of the alpha-haemolysin determinant in the uropathogenic Escherichia coli strain 536 requires the leuX-encoded tRNA(5)(Leu)
    U Dobrindt
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Mol Genet Genomics 267:370-9. 2002
    ..coli strain 536...
  40. ncbi request reprint Pathogenicity islands of uropathogenic E. coli and the evolution of virulence
    T A Oelschlaeger
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Roentgenring 11, 97070 Wurzburg, Germany
    Int J Antimicrob Agents 19:517-21. 2002
    ..In addition, assumptions can be made on the evolution of these important pathogens...
  41. ncbi request reprint Virulence factors of uropathogens
    Tobias A Oelschlaeger
    Institute for Molecular Biology of Infections, University of Wurzburg, Germany
    Curr Opin Urol 12:33-8. 2002
    ..The role of new virulence factors and the new functions of already known virulence factors will be discussed as well as the concept of the composite genome of uropathogenic Escherichia coli...
  42. pmc A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917
    Lubomir Grozdanov
    Institut für Molekulare Infektionsbiologie, Bayerische Julius Maximilians Universität Würzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    J Bacteriol 184:5912-25. 2002
    ..coli strain Nissle 1917 increased its ability to withstand antibacterial defense mechanisms of blood serum. These results underline the importance of LPS for serum resistance or sensitivity of E. coli...
  43. ncbi request reprint Regulation of tRNA5Leu-encoding gene leuX that is associated with a pathogenicity island in the uropathogenic Escherichia coli strain 536
    U Dobrindt
    , , Germany
    Mol Genet Genomics 265:895-904. 2001
    ..Our finding expands our knowledge of the regulation of tRNA gene transcription and represents an additional mode of regulation of gene expression that can also affect bacterial virulence...
  44. ncbi request reprint Genome plasticity in pathogenic and nonpathogenic enterobacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Top Microbiol Immunol 264:157-75. 2002
  45. pmc S-Fimbria-encoding determinant sfa(I) is located on pathogenicity island III(536) of uropathogenic Escherichia coli strain 536
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Wurzburg, Klinikum der Universität Jena, 07740 Jena, Germany
    Infect Immun 69:4248-56. 2001
    ..coli strain 536, replaces a 40-kb DNA region which represents an E. coli K-12-specific genomic island...
  46. ncbi request reprint Regulation of type 1 fimbriae synthesis and biofilm formation by the transcriptional regulator LrhA of Escherichia coli
    Caroline Blumer
    Institut für Mikrobiologie und Weinforschung, Johannes Gutenberg Universitat Mainz, Becherweg 15, 55099 Mainz, Germany
    Microbiology 151:3287-98. 2005
    ..Together, the data show a role for LrhA as a repressor of type 1 fimbrial expression, and thus as a regulator of the initial stages of biofilm development and, presumably, bacterial adherence to epithelial host cells also...
  47. pmc Presence and characterization of a mosaic genomic island which distinguishes sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H- from E. coli O157:H7
    Andreas Janka
    Institut fur Hygiene, Universitatsklinikum Munster, Robert Koch Strasse 41, D 48149 Munster, Germany
    Appl Environ Microbiol 71:4875-8. 2005
    ..This mosaic island is absent from strain EDL933. PCR targeting the SRL-related sequence is a useful tool to distinguish SF EHEC O157:H(-) from EHEC O157:H7...
  48. ncbi request reprint Identification and distribution of the enterohemorrhagic Escherichia coli factor for adherence (efa1) gene in sorbitol-fermenting Escherichia coli O157: H-
    Andreas Janka
    Institut fur Hygiene, Universitatsklinikum Munster, Germany
    Int J Med Microbiol 292:207-14. 2002
    ..coli O55:H7 ancestor than STEC O157:H7. Our data demonstrate the presence of a potential virulence gene in SF STEC O157:H- that is only rudimentarily present in STEC O157:H7...
  49. pmc Loss of regulatory protein RfaH attenuates virulence of uropathogenic Escherichia coli
    Gabor Nagy
    Institute of Medical Microbiology and Immunology, University of Pecs, Hungary
    Infect Immun 70:4406-13. 2002
    ..trans complementation of the mutant strain with the rfaH gene restores wild-type levels of the affected virulence factors and consequently restitutes virulence in the mouse model of ascending urinary tract infection...
  50. ncbi request reprint Both alpha-haemolysin determinants contribute to full virulence of uropathogenic Escherichia coli strain 536
    Gabor Nagy
    Department of Medical Microbiology and Immunology, University of Pecs, Szigeti ut 12, 7624 Pecs, Hungary
    Microbes Infect 8:2006-12. 2006
    ..Interestingly, the unrelated uropathogenic E. coli strain J96 shares the same two hly alleles, suggesting that acquisition of the two paralogues accorded a selective evolutionary advantage...
  51. ncbi request reprint Genotyping DNA chip for the simultaneous assessment of antibiotic resistance and pathogenic potential of extraintestinal pathogenic Escherichia coli
    Timo Barl
    Division of Pathway Medicine, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Int J Antimicrob Agents 32:272-7. 2008
    ..A complete genotyping assay could be performed in <4h after DNA extraction. Together with the excellent genotyping results, this constitutes a competitive alternative as a standard tool for routine clinical diagnostics...
  52. doi request reprint Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention
    Niyaz Ahmed
    Pathogen Evolution Laboratory, Center for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500076, India
    Nat Rev Microbiol 6:387-94. 2008
    ....
  53. pmc Active cytotoxic necrotizing factor 1 associated with outer membrane vesicles from uropathogenic Escherichia coli
    J Clavin Kouokam
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    Infect Immun 74:2022-30. 2006
    ..In addition, our results indicate that the histone-like nucleoid structuring protein H-NS has a role in the downregulation of CNF1 production and that it affects the outer membrane vesicle release in UPEC strain J96...
  54. pmc How to become a uropathogen: comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains
    Elzbieta Brzuszkiewicz
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August Universitat Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 103:12879-84. 2006
    ..Accordingly, instead of a common virulence mechanism, different ways exist among ExPEC to cause disease...
  55. ncbi request reprint Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83 : K24 : H31)
    Jana Hejnova
    Unité de Génomique des Microorganismes Pathogènes and CNRS URA 2171, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Microbiology 151:385-98. 2005
    ..These results highlight the thin line between bacterial 'virulence' and 'fitness' or 'colonization' factors, and question the definition of enterobacterial virulence factors...
  56. ncbi request reprint Escherichia coli alpha-haemolysin induces focal leaks in colonic epithelium: a novel mechanism of bacterial translocation
    Hanno Troeger
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite, Berlin, Germany
    Cell Microbiol 9:2530-40. 2007
    ..E. coli alpha-haemolysin is able to induce focal leaks in colonic cell cultures as well as in native colon. This process represents a novel route of bacterial translocation facilitated by pro-inflammatory cytokines...
  57. ncbi request reprint Aspects of genome plasticity in pathogenic Escherichia coli
    Martina Bielaszewska
    Institut fur Hygiene, Universitatsklinikum Munster, Robert Koch Str 41, D 48149 Munster, Germany
    Int J Med Microbiol 297:625-39. 2007
    ..coli pathotypes have been addressed and the results have been directly applied for the improvement of diagnostic methods...
  58. ncbi request reprint tDNA locus polymorphism and ecto-chromosomal DNA insertion hot-spots are related to the phylogenetic group of Escherichia coli strains
    Pierre Germon
    INRA Centre de Tours, UR 1282 IASP, Pathogénie Bactérienne, 37380 Nouzilly, France
    Microbiology 153:826-37. 2007
    ..Most interestingly, strains of different ECOR groups showed different patterns of tDNA loci polymorphism. More subtle differences were also observed between strains of different pathotypes...
  59. ncbi request reprint Transcriptional regulation through RfaH contributes to intestinal colonization by Escherichia coli
    Gabor Nagy
    Department of Medical Microbiology and Immunology, University of Pecs, 7624 Pécs Szigeti út 12, Hungary
    FEMS Microbiol Lett 244:173-80. 2005
    ..Increased susceptibility of rfaH mutants to bile salts, on the other hand, suggested that impaired in vivo survival could be responsible for the reduced colonization capacity...
  60. ncbi request reprint Demonstration of regulatory cross-talk between P fimbriae and type 1 fimbriae in uropathogenic Escherichia coli
    Nicola J Holden
    Zoonotic and Animal Pathogens Research Laboratory, Centre for Infectious Diseases, Chancellor s Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Microbiology 152:1143-53. 2006
    ..Using a number of novel genetic approaches, this work extends the initial finding that PapB inhibits FimB recombination to the impact of this regulation in clinical isolates...
  61. pmc Glycosylation of the self-recognizing Escherichia coli Ag43 autotransporter protein
    Orla Sherlock
    Centre for Biomedical Microbiology, BioCentrum DTU, Bldg 301, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 188:1798-807. 2006
    ..However, the glycosylated form of Ag43 enhances bacterial binding to human cell lines, whereas the nonglycosylated version of Ag43 does not to confer this property...
  62. pmc Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice
    Gabor Nagy
    Institute of Medical Microbiology and Immunology, University of Pecs, Szigeti ut 12, 7624 Pecs, Hungary
    Infect Immun 72:4297-301. 2004
    ..Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains...
  63. ncbi request reprint Escherichia coli induces DNA double-strand breaks in eukaryotic cells
    Jean Philippe Nougayrede
    INRA, UMR1225, Ecole Nationale Veterinaire de Toulouse, Toulouse F 31076, France
    Science 313:848-51. 2006
    ..Discovery of hybrid peptide-polyketide genotoxins in E. coli will change our view on pathogenesis and commensalism and open new biotechnological applications...
  64. pmc Cytolethal distending toxin gene cluster in enterohemorrhagic Escherichia coli O157:H- and O157:H7: characterization and evolutionary considerations
    Andreas Janka
    Institut fur Hygiene, Universitatsklinikum Munster, Germany
    Infect Immun 71:3634-8. 2003
    ..Our data demonstrate that cdt, encoding a potential virulence factor, is present in the EHEC O157 complex and suggest that cdt may have been acquired by phage transduction...
  65. ncbi request reprint Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice
    Marc Waidmann
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 125:162-77. 2003
    ..Specific pathogen-free (SPF), but not germ-free, interleukin (IL)-2-deficient (IL-2-/-) mice develop colitis. The colitogenicity of commensal bacteria was determined...
  66. ncbi request reprint Excision of the high-pathogenicity island of Yersinia pseudotuberculosis requires the combined actions of its cognate integrase and Hef, a new recombination directionality factor
    Biliana Lesic
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 52:1337-48. 2004
    ..The fact that the HPI, and probably several other pathogenicity islands, carry a machinery of integration/excision highly similar to those of bacteriophages argues for a phage-mediated acquisition and transfer of these elements...
  67. pmc Down-regulation of key virulence factors makes the Salmonella enterica serovar Typhimurium rfaH mutant a promising live-attenuated vaccine candidate
    Gabor Nagy
    Department of Medical Microbiology and Immunology, University of Pecs, Szigeti ut 12, 7624 Pecs, Hungary
    Infect Immun 74:5914-25. 2006
    ....
  68. pmc Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance
    Daniel Engel
    Institute for Molecular Medicine and Experimental Immunology, University Clinic of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Infect Immun 74:6100-7. 2006
    ..These findings demonstrate that some of the abundant DC recruited in UTI contributed innate immune effector functions, which were, however, dispensable in the microenvironment of the bladder...