Sven Dänicke

Summary

Country: Germany

Publications

  1. doi request reprint Toxic effects, metabolism, and carry-over of ergot alkaloids in laying hens, with a special focus on changes of the alkaloid isomeric ratio in feed caused by hydrothermal treatment
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Mycotoxin Res 32:37-52. 2016
  2. doi request reprint Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over)
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany Electronic address
    Food Chem Toxicol 84:225-49. 2015
  3. pmc Ergot alkaloids in feed for Pekin ducks: toxic effects, metabolism and carry over into edible tissues
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Braunschweig, Germany
    Toxins (Basel) 7:2006-23. 2015
  4. doi request reprint Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 30:161-70. 2014
  5. doi request reprint Ascaridia galli infection affects pullets differently when feed is contaminated with the Fusarium toxin deoxynivalenol (DON)
    S Danicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany Electronic address
    Vet Parasitol 198:351-63. 2013
  6. doi request reprint Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany Electronic address
    Food Chem Toxicol 60:58-75. 2013
  7. doi request reprint The Fusarium toxin deoxynivalenol (DON) modulates the LPS induced acute phase reaction in pigs
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Toxicol Lett 220:172-80. 2013
  8. doi request reprint Humic substances failed to prevent the systemic absorption of deoxynivalenol (DON) and its adverse effects on piglets
    Sven Dänicke
    Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 28:253-60. 2012
  9. doi request reprint Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects
    Sven Dänicke
    Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 28:199-218. 2012
  10. doi request reprint Effects of deoxynivalenol (DON) and related compounds on bovine peripheral blood mononuclear cells (PBMC) in vitro and in vivo
    Sven Daenicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 27:49-55. 2011

Collaborators

Detail Information

Publications81

  1. doi request reprint Toxic effects, metabolism, and carry-over of ergot alkaloids in laying hens, with a special focus on changes of the alkaloid isomeric ratio in feed caused by hydrothermal treatment
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Mycotoxin Res 32:37-52. 2016
    ....
  2. doi request reprint Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over)
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany Electronic address
    Food Chem Toxicol 84:225-49. 2015
    ..25 μg ZEN/kg body weight and day is exploited to approximately 8%, when a daily basket of animal foodstuffs and associated carry over factors are assumed at reported ZEN contamination levels of complete feed...
  3. pmc Ergot alkaloids in feed for Pekin ducks: toxic effects, metabolism and carry over into edible tissues
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Braunschweig, Germany
    Toxins (Basel) 7:2006-23. 2015
    ..Overall, the LOAEL amounted to 0.6 mg TA/kg diet suggesting that ducks are not protected by current European Union legislation (1 g ergot/kg unground cereal grains). ..
  4. doi request reprint Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 30:161-70. 2014
    ..The conjugation degree for DON in blood and bile was not influenced by treatments. In conclusion, endotoxemic pigs are characterized by higher DON residue levels in blood, liver, and kidney, probably by a compromised elimination. ..
  5. doi request reprint Ascaridia galli infection affects pullets differently when feed is contaminated with the Fusarium toxin deoxynivalenol (DON)
    S Danicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany Electronic address
    Vet Parasitol 198:351-63. 2013
    ..galli might increase the susceptibility towards DON as indicated by an increased DON absorption rate and a compromised antibody formation. The effects of DON on fecundity and worm morphology require further examination...
  6. doi request reprint Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany Electronic address
    Food Chem Toxicol 60:58-75. 2013
    ..The situation is further complicated by the lack of established relationships between DON residues in physiological matrices and the adverse effects of DON on the health and performance of farm animals. ..
  7. doi request reprint The Fusarium toxin deoxynivalenol (DON) modulates the LPS induced acute phase reaction in pigs
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Toxicol Lett 220:172-80. 2013
    ..In conclusion, the LPS-induced effects were only marginally modified by DON...
  8. doi request reprint Humic substances failed to prevent the systemic absorption of deoxynivalenol (DON) and its adverse effects on piglets
    Sven Dänicke
    Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 28:253-60. 2012
    ..1 and 20.2% for groups FUS and FUS-HS, respectively. In conclusion, the tested HS preparation cannot be recommended as a DON inactivating feed supplement for pigs...
  9. doi request reprint Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects
    Sven Dänicke
    Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 28:199-218. 2012
    ....
  10. doi request reprint Effects of deoxynivalenol (DON) and related compounds on bovine peripheral blood mononuclear cells (PBMC) in vitro and in vivo
    Sven Daenicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 27:49-55. 2011
    ..Thus, the factors responsible for these apparent discrepancies need to be clarified...
  11. doi request reprint Effects of increasing concentrations of sodium metabisulphite (Na2S 2O 5, SBS) on deoxynivalenol (DON) concentration and microbial spoilage of triticale kernels preserved without and with propionic acid at various moisture contents
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 25:215-23. 2009
    ....
  12. doi request reprint Effects of ergot alkaloids in feed on performance and liver function of piglets as evaluated by the ¹³C-methacetin breath test
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:15-36. 2013
    ..The mechanisms by which TA affects porcine liver function need to be studied further...
  13. pmc Effects of ergot alkaloids on liver function of piglets as evaluated by the (13)C-methacetin and (13)C-α-ketoisocaproic acid breath test
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig D 38116, Germany
    Toxins (Basel) 5:139-61. 2013
    ..065). Therefore, both microsomal and mitochondrial liver function was slightly affected by ergot alkaloids...
  14. ncbi request reprint Effects of ergot alkaloids on liver function of piglets can be detected by the [(13)C]methacetin breath test irrespective of oral or intramuscular route of tracer administration
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Isotopes Environ Health Stud 48:558-72. 2012
    ..044). As a discrimination of the diet effects through both tracer administration routes is possible, the i.m. application should be preferred in piglets as this causes less stress than the oral forced administration...
  15. doi request reprint The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Food Chem Toxicol 50:4405-11. 2012
    ..Whether the higher plasma DON concentrations in endotoxemic pigs are due to a hemodynamically associated longer persistence of the DON glucuronide or because of an altered glucuronidation activity needs to be examined further...
  16. doi request reprint Effects of conjugated linoleic acids fed to dairy cows during early gestation on hematological, immunological, and metabolic characteristics of cows and their calves
    S Danicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, D 38116 Braunschweig, Germany
    J Dairy Sci 95:3938-53. 2012
    ..However, CLA dose effects were inconsistent and require further investigation...
  17. doi request reprint Systemic and local effects of the Fusarium toxin deoxynivalenol (DON) are not alleviated by dietary supplementation of humic substances (HS)
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Food Chem Toxicol 50:979-88. 2012
    ..These changes had no consequences for nutrient digestibility or LPS levels in systemic blood (0.02-0.08 EU/mL). As portal LPS levels were not measured, FUS effects on intestinal LPS translocation cannot be excluded...
  18. pmc Influence of in vitro supplementation with lipids from conventional and Alpine milk on fatty acid distribution and cell growth of HT-29 cells
    Christian Degen
    Institute of Nutrition, Dept of Nutritional Physiology, Friedrich Schiller University, Dornburger Strasse 24, Jena, Germany
    Lipids Health Dis 10:131. 2011
    ....
  19. doi request reprint Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the 13C-methacetin breath test
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler lnstitute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 62:263-86. 2008
    ....
  20. ncbi request reprint Effects of feeding a Fusarium toxin-contaminated diet to infectious bursal disease virus-infected broilers on the protein turnover of the bursa of Fabricius and spleen
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 65:1-20. 2011
    ..It can be concluded that feeding a FUS diet to IBDV-infected broilers might modulate the virulence-dependent pathogenesis of an IBDV infection...
  21. doi request reprint Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels
    S Danicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, D 38116 Braunschweig, Germany
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1558-65. 2010
    ..Moreover, ZON and α-zearalenol could only be detected in bile and urine where their levels were not influenced by the SBS treatment...
  22. doi request reprint Ascaridia galli infection of pullets and intestinal viscosity: consequences for nutrient retention and gut morphology
    S Danicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Br Poult Sci 50:512-20. 2009
    ..7. Histopathology of jejunal and ileal sections revealed no pathological alterations. 8. The apparent retention of organic matter was increased after enzyme addition while parasite infection exerted no effect...
  23. doi request reprint A probiotic feed additive containing spores of Bacillus subtilis and B. licheniformis does not prevent absorption and toxic effects of the Fusarium toxin deoxynivalenol in piglets
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany
    Food Chem Toxicol 48:152-8. 2010
    ..Thus, it can be concluded that the fed probiotic bacteria neither bound nor degraded DON prior to absorption. Taken together, the tested probiotic additive is not suited to prevent the performance depressing effects of DON in piglets...
  24. doi request reprint Studies on the toxicity of deoxynivalenol (DON), sodium metabisulfite, DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2, and on effects of DON and DONS
    S Danicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany
    Food Chem Toxicol 48:2154-62. 2010
    ..Further studies should clarify the possible impact of SBS on the porcine immune system...
  25. doi request reprint Investigations on the kinetics of the concentration of deoxynivalenol (DON) and on spoilage by moulds and yeasts of wheat grain preserved with sodium metabisulfite (Na2S2O5, SBS) and propionic acid at various moisture contents
    Sven Dänicke
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 64:190-203. 2010
    ..In conclusion, for the conditions examined, the wet preservation of DON-contaminated wheat with SBS seems to be promising as an on-farm detoxification measure...
  26. ncbi request reprint Influence of a Fusarium culmorum inoculation of wheat on the progression of mycotoxin accumulation, ingredient concentrations and ruminal in sacco dry matter degradation of wheat residues
    Ute Brinkmeyer
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL Braunschweig, Germany
    Arch Anim Nutr 60:141-57. 2006
    ..culmorum of wheat involves an increased risk of mycotoxin contamination in straw. Also, a Fusarium infection may have an impact on chemical composition and may result in Fusarium growth-related modifications of host cell wall components...
  27. doi request reprint Ruminal fermentation patterns and parameters of the acid base metabolism in the urine as influenced by the proportion of concentrate in the ration of dairy cows with and without Fusarium toxin-contaminated triticale
    Christina Keese
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 62:287-302. 2008
    ..This indicates a switch in the microbial community due to direct mycotoxin effects and/or indirect effects of the Fusarium infection related alterations in the physico-chemical properties of the infected cereal on ruminal microbes...
  28. ncbi request reprint On the effects of graded levels of Fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone
    Sven Dänicke
    Institute of Animal Nutrition, Federal Agricultural Research Centre Braunschweig, Bundesallee 50, D 38116 Braunschweig, Germany
    Mol Nutr Food Res 49:932-43. 2005
    ..The maximum ratio between DON concentration in liver and diet was 0.0013, and suggests that a possible contamination of pig liver with DON is negligible and does not contribute significantly to human DON exposure...
  29. pmc Does Dietary Deoxynivalenol Modulate the Acute Phase Reaction in Endotoxaemic Pigs?--Lessons from Clinical Signs, White Blood Cell Counts, and TNF-Alpha
    Tanja Tesch
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute of Animal Health, Bundesallee 50, 38116 Braunschweig, Germany
    Toxins (Basel) 8:. 2015
    ..DON_LPS(jug.)-CON(por.) resulted in a lower temperature rise (p = 0.08) compared to CON_LPS(jug.)-CON(por.). In conclusion, APR resulting from a post-hepatic immune stimulus was altered by chronic DON-feeding...
  30. doi request reprint Effects of a Fusarium toxin-contaminated maize treated with sodium metabisulphite, methylamine and calcium hydroxide in diets for female piglets
    Inga Rempe
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:314-29. 2013
    ..No undesired side effects of the treated-feed stuff or the chemicals themselves on the health of piglets were detected. ..
  31. doi request reprint Effects of the thermal environment on metabolism of deoxynivalenol and thermoregulatory response of sheep fed on corn silage grown at enriched atmospheric carbon dioxide and drought
    Malte Lohölter
    Federal Research Institute for Animal Health, Bundesallee 50, 38116, Brunswick, Germany
    Mycotoxin Res 28:219-27. 2012
    ..Though the thermoregulatory activity of sheep was influenced by the thermal environment, the investigated cultivation factors did not indicate considerable impacts on the analysed parameters...
  32. doi request reprint Transfer of conjugated linoleic acids into different tissues of dairy cows
    Dirk von Soosten
    Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:119-33. 2013
    ..1% and <0.2%, respectively. Overall, the transfer of supplemented CLA isomers into the dairy cow's body was only marginal during the first 105 DIM...
  33. ncbi request reprint Carry-over of Fusarium toxins (deoxynivalenol and zearalenone) from naturally contaminated wheat to pigs
    Tanja Goyarts
    Institute of Animal Nutrition, Federal Agricultural Research Centre, Braunschweig, Germany
    Food Addit Contam 24:369-80. 2007
    ..However, the exposure risk to humans by consumption of edible tissues of animals exposed to Fusarium toxins is negligible compared to the direct consumption of grain-based food...
  34. doi request reprint On the effects of the concentrate proportion of dairy cow rations in the presence and absence of a fusarium toxin-contaminated triticale on cow performance
    Christina Keese
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 62:241-62. 2008
    ..A concentrate proportion of 60% had a depressing effect on milk fat concentration but was significantly more pronounced in the presence of Fusarium toxin-contaminated and Fusarium damaged-triticale...
  35. doi request reprint Effects of long-term supplementation of dairy cow diets with rumen-protected conjugated linoleic acids (CLA) on performance, metabolic parameters and fatty acid profile in milk fat
    Julia Pappritz
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 65:89-107. 2011
    ..Overall, under the conditions of the present study no improvement in the calculated energy balance by CLA supplementation could be shown for the entire evaluation period...
  36. ncbi request reprint The influence of ergot-contaminated feed on growth and slaughtering performance, nutrient digestibility and carry over of ergot alkaloids in growing-finishing pigs
    Simone Mainka
    Institute of Animal Nutrition, Federal Agricultural Research Centre, Braunschweig, Germany
    Arch Anim Nutr 59:377-95. 2005
    ..No genuine ergot alkaloids were found in physiological samples. The balance trials demonstrated a significantly decreased protein digestibility for the most highly supplemented diet...
  37. ncbi request reprint Effects of different levels of ergot in concentrates on the growing and slaughtering performance of bulls and on carry-over into edible tissue
    Barbara Schumann
    Institute of Animal Nutrition, Federal Agriculture Research Centre FAL, Braunschweig, Germany
    Arch Anim Nutr 61:357-70. 2007
    ..41 kg/d with a mean dry matter intake of 7.35 kg/d. No carry over into tissues could be proved out of the experiment. To derive a no-effect level for beef cattle further research including higher ergot doses will be necessary...
  38. ncbi request reprint Effect of niacin supplementation on rumen fermentation characteristics and nutrient flow at the duodenum in lactating dairy cows fed a diet with a negative rumen nitrogen balance
    Martina Aschemann
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 66:303-18. 2012
    ..The results indicated a more efficient use of rumen degradable N due to changes in the microbial population in the rumen when niacin was supplemented to diets deficient in RNB for lactating dairy cows...
  39. doi request reprint No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions
    Christina Keese
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Mol Nutr Food Res 52:1514-29. 2008
    ..0001 and 0.0011) but significantly higher in Group Myco-30 than in Group Myco-60. This effect may result from an altered bioavailability of DON from maize silage which made up a higher proportion of the daily ration...
  40. ncbi request reprint Effect of graded levels of rare earth elements in diets of fattening bulls on growing and slaughtering performance, and on nutrient digestibility of wethers
    Annett Schwabe
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 65:55-73. 2011
    ..These results suggest that, under the conditions of the present study, the supplementation of fattening bull diets with REE cannot be recommended...
  41. ncbi request reprint Effect of conjugated linoleic acid on proliferation and cytokine expression of bovine peripheral blood mononuclear cells and splenocytes ex vivo
    Lydia Renner
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 66:73-85. 2012
    ..There was no effect of CLA feeding or slaughter time on histopathology of the spleen. In conclusion, the present results demonstrate an inhibiting effect of CLA on the mitogen-induced activation of splenocytes...
  42. doi request reprint Effects of conjugated linoleic acids and dietary concentrate proportion on performance, milk composition, milk yield and metabolic parameters of periparturient dairy cows
    Maria Petzold
    Institute of Animal Nutrition, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:185-201. 2013
    ..But feeding CLA in a high-concentrate diet a.p. seems to increase DMI and thereby improve the energy balance of cows immediately after calving...
  43. doi request reprint Effects of niacin supplementation and dietary concentrate proportion on body temperature, ruminal pH and milk performance of primiparous dairy cows
    Malte Lohölter
    Institute of Animal Nutrition, Federal Research Institute for Animal Health, Brunswick, Germany
    Arch Anim Nutr 67:202-18. 2013
    ..In conclusion, niacin did not affect body temperature but stimulated milk performance. High concentrate partially influenced body temperatures and had beneficial effects on milk production...
  44. doi request reprint Bioavailability of the Fusarium toxin deoxynivalenol (DON) from wheat straw and chaff in pigs
    Dirk Rohweder
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:37-47. 2013
    ..9, 87.3 and 109.8% for straw, grain and chaff, respectively, without significant differences. Thus, the uptake of DON from straw may contribute comparably to the overall exposure of animals...
  45. ncbi request reprint Practically relevant concentrations of deoxynivalenol in diets for growing-finishing pigs offered as mash or pellets
    Susanne Doll
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Braunschweig, Dummerstorf, Germany
    Arch Anim Nutr 61:247-65. 2007
    ..A contribution of the feed processing to the variation of the deoxynivalenol (DON) effect may not be deduced from the present results...
  46. ncbi request reprint Effect of niacin supplementation on digestibility, nitrogen utilisation and milk and blood variables in lactating dairy cows fed a diet with a negative rumen nitrogen balance
    Martina Aschemann
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 66:200-14. 2012
    ..Supplementing the diet with a negative RNB with niacin led to a more efficient use of dietary N thereby avoiding the negative effects of the negative RNB on the digestibility of DM, OM and NDF...
  47. doi request reprint Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations
    Susanne Doll
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany
    Mol Nutr Food Res 52:727-34. 2008
    ..9 mg DON/kg, and those fed diets containing 137% of this concentration. The different feed forms did not affect residue concentrations in any of the investigated specimens...
  48. doi request reprint Haematological and immunological adaptations of non-pregnant, non-lactating dairy cows to a high-energetic diet containing mycotoxins
    Sven Dänicke
    a Institute of Animal Nutrition Braunschweig, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Germany
    Arch Anim Nutr 70:1-16. 2016
    ..In conclusion, both diet change and prolonged positive energy balance influenced the bovine immune system. ..
  49. doi request reprint Hydrothermal treatment of naturally contaminated maize in the presence of sodium metabisulfite, methylamine and calcium hydroxide; effects on the concentration of zearalenone and deoxynivalenol
    Inga Rempe
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Mycotoxin Res 29:169-75. 2013
    ....
  50. doi request reprint The effect of free air carbon dioxide enrichment and nitrogen fertilisation on the chemical composition and nutritional value of wheat and barley grain
    Stefanie Wroblewitz
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:263-78. 2013
    ..Based on these results, future scenarios of climate change would have an impact on the nutritional value of cereal grains. ..
  51. pmc Fatty acid profile and proliferation of bovine blood mononuclear cells after conjugated linoleic acid supplementation
    Lydia Renner
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Lipids Health Dis 11:63. 2012
    ..Therefore, in the present study we investigated the effects of a long term supplementation of dairy cows with CLA on the fatty acid profile of peripheral blood mononuclear cells (PBMC) and their proliferation ex vivo...
  52. ncbi request reprint Comparative studies on the effect of ergot contaminated feed on performance and health of piglets and chickens
    Simone Mainka
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Braunschweig, Germany
    Arch Anim Nutr 59:81-98. 2005
    ..8 mg and 11.1 mg total ergot alkaloids/kg although live performance remained unaffected. Further studies are necessary to define the critical level of ergot alkaloids in dependence on alkaloid pattern...
  53. doi request reprint Effect of rare earth elements on beef cattle growth performance, blood clinical chemical parameters and mitogen stimulated proliferation of bovine peripheral blood mononuclear cells in vitro and ex vivo
    Lydia Renner
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Toxicol Lett 201:277-84. 2011
    ..However, the great differences in effective doses in vitro and ex vivo (serum REE concentrations) might explain the different results from the experiments...
  54. ncbi request reprint Effects of the Fusarium toxin deoxynivalenol from naturally contaminated wheat given subchronically or as one single dose on the in vivo protein synthesis of peripheral blood lymphocytes and plasma proteins in the pig
    Tanja Goyarts
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Bundesallee 50, 38116 Braunschweig, Germany
    Food Chem Toxicol 44:1953-65. 2006
    ..In conclusion, the flooding dose technique appeared to be suitable for distinguishing DON-related effects on the protein synthesis, while determination of plasma protein concentrations seemed not to be an appropriate parameter...
  55. doi request reprint Effects of concentrate proportion in the diet with or without Fusarium toxin-contaminated triticale on ruminal fermentation and the structural diversity of rumen microbial communities in vitro
    Jeannette Boguhn
    Institut für Tierernährung, Universitat Hohenheim, Germany
    Arch Anim Nutr 64:467-83. 2010
    ..These findings are independent of the concentrate level in the diets. A change in the microbial community composition of the genus Clostridia may be the reason for a reduction in the cellulolytic activity...
  56. ncbi request reprint On the specific and unspecific effects of a polymeric glucomannan mycotoxin adsorbent on piglets when fed with uncontaminated or with Fusarium toxins contaminated diets
    Sven Dänicke
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Braunschweig, Germany
    Arch Anim Nutr 61:266-75. 2007
    ....
  57. doi request reprint Influence of dietary amino acid level on chemical body composition and performance of growing-finishing boars of two sire lines
    Caroline Otten
    a Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:477-91. 2013
    ..Boars sired with Piétrain line 1 demonstrated increased lean meat content and protein body content (p < 0.05) as compared to Piétrain line 2-sired boars...
  58. ncbi request reprint Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig
    Tanja Goyarts
    Institute of Animal Nutrition, Federal Agricultural Research Centre, FAL, Bundesallee 50, 38116 Braunschweig, Germany
    Toxicol Lett 163:171-82. 2006
    ..Twenty-four hours following oral dosing, DON could not be detected in the serum, except in one chronically fed pig at the level of the detection limit...
  59. doi request reprint The effects of iodine level and source on iodine carry-over in eggs and body tissues of laying hens
    Anna S Röttger
    Institute for Animal Nutrition, Friedrich Loeffler Institute, Braunschweig, Germany
    Arch Anim Nutr 66:385-401. 2012
    ..Due to the high carry-over of iodine into eggs, eggs may considerably contribute to the iodine supply of the consumers...
  60. ncbi request reprint Effects of free air carbon dioxide enrichment and drought stress on the feed value of maize silage fed to sheep at different thermal regimes
    Malte Lohölter
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 66:335-46. 2012
    ..Enriched CO2 may decrease DON contaminations during drought. The thermal environment during the balance experiment did not interact with feeding maize silage grown under elevated CO2, but may affect cell wall and OM digestibility...
  61. doi request reprint Effects of the level of feed intake and ergot contaminated concentrate on ergot alkaloid metabolism and carry over into milk
    Barbara Schumann
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany
    Mol Nutr Food Res 53:931-8. 2009
    ..Approximately 67% of the alkaloids fed were recovered in the duodenal ingesta, and approximately 24% were excreted with the faeces. No alkaloid residues could be detected in the blood or milk samples...
  62. pmc Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity
    Reka Tienken
    Institute of Animal Nutrition, Friedrich Loeffler Insitute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany
    Animals (Basel) 5:910-33. 2015
    ..The overfeeding of energy to cows which were similar in body condition score had only minor effects on periparturient immune system function and the metabolism of those cows. ..
  63. pmc Effects of Inhibiting Dipeptidyl Peptidase-4 (DPP4) in Cows with Subclinical Ketosis
    Kirsten Schulz
    Institute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich Loeffler Institute, Braunschweig, Germany
    PLoS ONE 10:e0136078. 2015
    ..In sum, the DPP4 inhibition in cows did not affect glycaemic control like it is shown in humans, but was able to impact hyperlipemia, as NEFA and TG decreased. ..
  64. doi request reprint Description of a bovine model for studying digestive and metabolic effects of a positive energy balance not biased by lactation or gravidity
    Sven Dänicke
    a Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 68:460-77. 2014
    ....
  65. ncbi request reprint Dose-response feeding study of short chain chlorinated paraffins (SCCPs) in laying hens: effects on laying performance and tissue distribution, accumulation and elimination kinetics
    Karl Heinz Ueberschär
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Braunschweig, Germany
    Mol Nutr Food Res 51:248-54. 2007
    ....
  66. doi request reprint Determination of very low stable isotope enrichments of [(2)H(5)]-phenylalanine in chicken liver using liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    Katrin Wilkerling
    Institute of Animal Nutrition, Friedrich Loeffler Institut FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Braunschweig, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 911:147-53. 2012
    ..Compared to GC-MS, the main advantages of the LC-MS/MS method are its higher selectivity as well as the elimination of the need to convert and derivatize the samples prior to measuring...
  67. ncbi request reprint Influence of various amounts of fumaric acid on performance and parameters of the acid-base balance of growing bulls fed with grass or maize silage
    Nicole Remling
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 65:386-401. 2011
    ..However, it seems to be necessary to conduct more long-term studies with different silage types and addition of organic acids combined with direct measurements of methane...
  68. doi request reprint Systemic E. coli lipopolysaccharide but not deoxynivalenol results in transient leukopenia and diminished metabolic activity of peripheral blood mononuclear cells ex vivo
    Jeannette Kluess
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 31:41-50. 2015
    ..001), but already regained 80% of its activity at 24 h, thus showing no difference between treatments. DON alone did not affect leukocytes in vivo or PBMC activity ex vivo and neither aggravated the effect of LPS...
  69. doi request reprint Effects of oregano on performance and immunmodulating factors in weaned piglets
    Katrin Stelter
    a Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 67:461-76. 2013
    ..In conclusion, whole plant supplementation of oregano to piglet feed altered immune-related parameters, but did not modulate the acute inflammatory response induced by LPS stimulation...
  70. doi request reprint UV-induced cis-trans isomerization of zearalenone in contaminated maize
    Ulrike Brezina
    Institute of Animal Nutrition, Friedrich Loeffler Institut FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 29:221-7. 2013
    ..The consequence of this finding for practical liquid feeding systems for pigs requires further investigation. Additionally, an improvement of the analytical method for cis-ZEN determination is needed. ..
  71. pmc Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells
    Lydia Renner
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Braunschweig, Germany
    Nutrients 5:2667-83. 2013
    ..In conclusion, all FA inhibit the proliferation of PBMC dose dependently without significantly altering the induced cytokine spectrum of activated bovine PBMC. ..
  72. doi request reprint Effect of different storage conditions on the mycotoxin contamination of Fusarium culmorum-infected and non-infected wheat straw
    Dirk Rohweder
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 27:145-53. 2011
    ....
  73. doi request reprint Digestibility, ruminal fermentation, ingesta kinetics and nitrogen utilisation in dairy cows fed diets based on silage of a brown midrib or a standard maize hybrid
    Tobias Gorniak
    a Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Braunschweig, Germany
    Arch Anim Nutr 68:143-58. 2014
    ..However, further research is necessary to draw more precise conclusions on the potential of Bm maize hybrids in general...
  74. ncbi request reprint Investigations on the effects of rape oil quality, choline and methionine concentration in diets for laying hens on the trimethylamine content of the eggs, on trimethylamine metabolism and on laying performance
    Sven Dänicke
    Institute of Animal Nutrition of the Federal Agricultural Research Centre FAL, Braunschweig, Germany
    Arch Anim Nutr 60:57-79. 2006
    ..An inadequate methionine supply cannot be compensated by an increased addition of choline. Neither degummed nor refined rape oil influenced the TMA content of eggs...
  75. ncbi request reprint Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes
    Tanja Goyarts
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Bundesallee 50, 38116 Braunschweig, Germany
    Toxicol In Vitro 20:858-67. 2006
    ..Serum IgA of pigs showed no significant differences between the groups, whereas IgM and IgG were significant increased in the DON acute group...
  76. doi request reprint The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding
    Susanne Doll
    Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Bundesallee 50, D 38116 Braunschweig, Germany
    Prev Vet Med 102:132-45. 2011
    ..The effects of DON and ZON on susceptible animals as well as management strategies to cope with the contamination of grain with those toxins are reviewed...
  77. doi request reprint On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation
    Tanja Goyarts
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute for Animal Health, Bundesallee 50, 38116, Braunschweig, Germany
    Mycotoxin Res 26:119-31. 2010
    ....
  78. ncbi request reprint Study on the transmission of deoxynivalenol and de-epoxy-deoxynivalenol into eggs of laying hens using a high-performance liquid chromatography-ultraviolet method with clean-up by immunoaffinity columns
    Hana Valenta
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL, Braunschweig, Germany
    Mol Nutr Food Res 49:779-85. 2005
    ..Neither DON nor de-epoxy-DON or glucuronide conjugates of both substances could be detected in any of the samples. These results indicate that eggs do not contribute significantly to the dietary DON intake of humans...
  79. doi request reprint Interactions of deoxynivalenol and lipopolysaccharides on cytokine excretion and mRNA expression in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures
    Susanne Doll
    Division of Veterinary Pharmacology, Pharmacy and Toxicology, Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Toxicol Lett 190:96-105. 2009
    ....
  80. doi request reprint Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures
    Susanne Doll
    Division of Veterinary Pharmacology, Pharmacy and Toxicology, Department of Equine Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Toxicol Lett 189:121-9. 2009
    ..Glucuronidation rate, as well as total DON recovery, decreased with increasing concentrations of DON, giving rise to assumptions on the formation of undetected metabolites...
  81. doi request reprint Deoxynivalenol-induced cytotoxicity, cytokines and related genes in unstimulated or lipopolysaccharide stimulated primary porcine macrophages
    Susanne Doll
    Department of Equine Science, Utrecht University, The Netherlands
    Toxicol Lett 184:97-106. 2009
    ..The results of the present investigation suggest a contribution of cytokines, especially TNF-alpha and IL-1beta, induced by DON in porcine macrophages to the effects observed in vivo...