Klaus Dietz

Summary

Country: Germany

Publications

  1. doi request reprint The neural correlates of impaired collision avoidance in hemianopic patients
    Eleni Papageorgiou
    Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tubingen, Tubingen, Germany
    Acta Ophthalmol 90:e198-205. 2012
  2. pmc Inter- and intraobserver reliability of the MTM-classification for proximal humeral fractures: a prospective study
    Christian Bahrs
    BG Trauma Center, Eberhard Karls University, Schnarrenbergstr, 95, D 72076 Tuebingen, Germany
    BMC Musculoskelet Disord 9:21. 2008
  3. pmc Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients
    Rainer Ritz
    Department of Neurosurgery, University Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 7:38. 2007
  4. pmc A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck
    W Budach
    Department of Radiation Oncology, University Hospital Dusseldorf, Germany
    BMC Cancer 6:28. 2006
  5. ncbi request reprint Darwinian fitness, evolutionary entropy and directionality theory
    Klaus Dietz
    Department of Medical Biometry, University of Tübingen Westbahnhofstrasse 55, D 72070 Tubingen, Germany
    Bioessays 27:1097-101. 2005
  6. ncbi request reprint Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals
    Klaus Dietz
    Department of Medical Biometry, University of Tubingen, Tubingen, Germany
    Am J Trop Med Hyg 75:46-55. 2006
  7. pmc Blood transfusion and spread of variant Creutzfeldt-Jakob disease
    Klaus Dietz
    University of Tubingen, Tubingen, Germany
    Emerg Infect Dis 13:89-96. 2007
  8. ncbi request reprint Daniel Bernoulli's epidemiological model revisited
    Klaus Dietz
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Math Biosci 180:1-21. 2002
  9. doi request reprint Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation
    Andreas Straub
    Dept of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Germany
    Thromb Haemost 99:609-15. 2008
  10. ncbi request reprint Using reagent-supported thromboelastometry (ROTEM) to monitor haemostatic changes in congenital heart surgery employing deep hypothermic circulatory arrest
    Andreas Straub
    Department of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Germany
    Eur J Cardiothorac Surg 34:641-7. 2008

Detail Information

Publications95

  1. doi request reprint The neural correlates of impaired collision avoidance in hemianopic patients
    Eleni Papageorgiou
    Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tubingen, Tubingen, Germany
    Acta Ophthalmol 90:e198-205. 2012
    ....
  2. pmc Inter- and intraobserver reliability of the MTM-classification for proximal humeral fractures: a prospective study
    Christian Bahrs
    BG Trauma Center, Eberhard Karls University, Schnarrenbergstr, 95, D 72076 Tuebingen, Germany
    BMC Musculoskelet Disord 9:21. 2008
    ..The classification was developed to evaluate whether a very detailed classification exceeding the analysis of fractured parts may be a valuable tool...
  3. pmc Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients
    Rainer Ritz
    Department of Neurosurgery, University Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 7:38. 2007
    ..The study was performed to analyze if AIS can diminish the rate of shunt infection. The pathogenic nature of shunt infection in patients with AIS systems and those without antibiotic impregnated shunts (non-AIS) was compared...
  4. pmc A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck
    W Budach
    Department of Radiation Oncology, University Hospital Dusseldorf, Germany
    BMC Cancer 6:28. 2006
    ....
  5. ncbi request reprint Darwinian fitness, evolutionary entropy and directionality theory
    Klaus Dietz
    Department of Medical Biometry, University of Tübingen Westbahnhofstrasse 55, D 72070 Tubingen, Germany
    Bioessays 27:1097-101. 2005
    ....
  6. ncbi request reprint Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals
    Klaus Dietz
    Department of Medical Biometry, University of Tubingen, Tubingen, Germany
    Am J Trop Med Hyg 75:46-55. 2006
    ..This has implications for the early testing of the protective efficacy of a vaccine in humans...
  7. pmc Blood transfusion and spread of variant Creutzfeldt-Jakob disease
    Klaus Dietz
    University of Tubingen, Tubingen, Germany
    Emerg Infect Dis 13:89-96. 2007
    ....
  8. ncbi request reprint Daniel Bernoulli's epidemiological model revisited
    Klaus Dietz
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Math Biosci 180:1-21. 2002
    ..One can use this estimate to assess the gain in life expectancy if only a fraction of the population is immunized...
  9. doi request reprint Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation
    Andreas Straub
    Dept of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Germany
    Thromb Haemost 99:609-15. 2008
    ..TGX-221 represents a promising alternative to GP IIb/IIIa blockade and should be further investigated for use during ECC in vivo...
  10. ncbi request reprint Using reagent-supported thromboelastometry (ROTEM) to monitor haemostatic changes in congenital heart surgery employing deep hypothermic circulatory arrest
    Andreas Straub
    Department of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Germany
    Eur J Cardiothorac Surg 34:641-7. 2008
    ..This study aimed to monitor coagulation defects in congenital heart surgery using rotational thromboelastometry (ROTEM), standard coagulation tests and platelet flow cytometry...
  11. pmc Long-term results after non-plate head-preserving fixation of proximal humeral fractures
    Christian Bahrs
    Klinik fur Unfall und Wiederherstellungschirurgie, BG Unfallklinik Tübingen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Int Orthop 34:883-9. 2010
    ..For these cases alternative methods such as prosthetic replacement should be chosen...
  12. doi request reprint Coinfections with Schistosoma haematobium, Necator americanus, and Entamoeba histolytica/Entamoeba dispar in children: chemokine and cytokine responses and changes after antiparasite treatment
    David M Hamm
    Institute for Tropical Medicine, University Clinics of Tübingen, Tubingen, Germany
    J Infect Dis 199:1583-91. 2009
    ..dispar, and N. americanus generated prominent proinflammatory cytokine and chemokine responses, and, after antihelminth treatment, the inflammatory chemokine response lessened as the Th2 responsiveness in coinfected children increased...
  13. pmc A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon
    Matthias Frank
    Institute of Tropical Medicine, University of Tubingen, Wilhelmstr 27, 72074 Tubingen, Germany
    Malar J 10:304. 2011
    ....
  14. ncbi request reprint Novel algorithm for more accurate calculation of renal function in adults with cancer
    Karin Holweger
    Department of Hospital Pharmacy, University of Tuebingen, Tuebingen, Germany
    Ann Pharmacother 42:1749-57. 2008
    ..Accurate assessment of an individual's glomerular filtration rate (GFR) helps to predict the pharmacokinetic behavior of those drugs more precisely. GFR calculations, however, have their limitations...
  15. ncbi request reprint Interobserver and intraobserver agreement of Lenke and King classifications for idiopathic scoliosis and the influence of level of professional training
    Thomas Niemeyer
    Spine Service, Department of Orthopaedic Surgery, University Hospital Tubingen, Tubingen, Germany
    Spine (Phila Pa 1976) 31:2103-7; discussion 2108. 2006
    ..This is a blinded study of radiographs by observers with different levels of professional training...
  16. ncbi request reprint Treating Class II patients with removable plates and functional orthopedic appliances-the importance of anterior tooth inclination and direction of growth on treatment outcome
    Mirjam Hönn
    Department of Orthodontics, Eberhard Karl University, Tubingen, Germany
    J Orofac Orthop 67:272-88. 2006
    ..To determine the influence of physiological growth pattern and anterior tooth inclination on the outcome in Class II patients treated with removable orthodontic plates and functional orthodontic appliances...
  17. ncbi request reprint Chloride and bicarbonate have similar affinities to the intestinal anion exchanger DRA (down regulated in adenoma)
    Georg Lamprecht
    1st Medical Department, University of Tubingen, 72076, Tubingen, Germany
    Pflugers Arch 452:307-15. 2006
    ..Under these conditions, competition of Cl and HCO3 is difficult to reconcile with a role of DRA in Cl reabsorption in exchange for HCO3. Our data, thus, provide indirect evidence against a role of DRA in pancreatic HCO3 secretion...
  18. ncbi request reprint Digital surface photogrammetry for anthropometric analysis of the cleft infant face
    Michael Krimmel
    Department of Oral and Maxillofacial Surgery, University Hospital Tubingen, Germany
    Cleft Palate Craniofac J 43:350-5. 2006
    ..To analyze the three-dimensional morphology of the cleft infant face with digital surface photogrammetry...
  19. doi request reprint Effects of MRI contrast agents on human embryonic lung fibroblasts
    Benjamin Wiesinger
    Department of Diagnostic Radiology, University of Tuebingen, Tuebingen, Germany
    Invest Radiol 45:513-9. 2010
    ..The objective of this investigation was to evaluate 6 magnetic resonance contrast media (CM) with regard to their different effects on human embryonic lung fibroblasts (HEL-299)...
  20. ncbi request reprint Alveolar recruitment during prone position: time matters
    Jörg Reutershan
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Clin Sci (Lond) 110:655-63. 2006
    ..Its measurement might be useful to apply prone positioning more individually and might also help to identify responders...
  21. ncbi request reprint Multipolar radiofrequency ablation with internally cooled electrodes: experimental study in ex vivo bovine liver with mathematic modeling
    Stephan Clasen
    Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    Radiology 238:881-90. 2006
    ..To evaluate the size and geometry of thermally induced coagulation by using multipolar radiofrequency (RF) ablation and to determine a mathematic model to predict coagulation volume...
  22. ncbi request reprint Comparison of Gadolinium-BOPTA and Ferucarbotran-enhanced three-dimensional T1-weighted dynamic liver magnetic resonance imaging in the same patient
    Annika Wersebe
    Department of Diagnostic Radiology, University Hospital Tubingen, Germany
    Invest Radiol 41:264-71. 2006
    ..We sought to compare signal changes using Ferucarbotran and gadobenate dimeglumine (Gd-BOPTA) in dynamic 3D T1-weighted (T1w) GRE imaging of the liver...
  23. pmc Evaluation of complications of three different types of proximal extra-articular femur fractures: differences in complications, age, sex and surviving rates
    Andreas A Suckel
    Department of Orthopedic Surgery, University Hospital, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Int Orthop 31:689-95. 2007
    ..3%/ 67.9%. Females show higher complication rates compared to males (19% versus 10%). The three types of fractures show different patterns of complications, survival rates, age, and sex distribution...
  24. doi request reprint Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors
    Jörg Fuchs
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Surg Oncol 17:323-30. 2008
    ..Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings...
  25. doi request reprint Growth modelling of non-functioning pituitary adenomas in patients referred for surgery
    Juergen Honegger
    Department of Neurosurgery, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Eur J Endocrinol 158:287-94. 2008
    ..However, it is still unknown how individual pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. The objective of this study was to define a growth model for non-functioning pituitary adenomas...
  26. doi request reprint Effects of different CMV-heat-inactivation-methods on growth factors in human breast milk
    Rangmar Goelz
    Department of Neonatology, University Hospital, Tuebingen, Germany
    Pediatr Res 65:458-61. 2009
    ..Only short heating methods (5 s, 62-72 degrees C) can preserve, almost completely, the concentrations of IGFs in human milk, whereas Holder-Pasteurization does not...
  27. ncbi request reprint Eccentric fixation in Stargardt's disease assessed by Tübingen perimetry
    Andre Messias
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 48:5815-22. 2007
    ..To measure eccentric fixation characteristics in visual fields of patients with Stargardt's disease...
  28. doi request reprint Enlargement of the common bile duct in patients with acute graft-versus-host disease: what does it mean?
    Dominik Ketelsen
    Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    AJR Am J Roentgenol 193:W181-5. 2009
    ....
  29. doi request reprint Comparison of surgical and conservative treatment for degenerative lumbar scoliosis
    Torsten Kluba
    Department of Orthopaedic Surgery, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Arch Orthop Trauma Surg 129:1-5. 2009
    ..Therefore, we compared the clinical and radiographic results of conservative and surgical treatment...
  30. ncbi request reprint Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines
    Rainer Ritz
    Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Int J Oncol 30:659-67. 2007
    ..These results obtained in cell culture are encouraging and justify further evaluation HY-PDT for the treatment of malignant glioma in animal experiments...
  31. ncbi request reprint Albumin in immunohistochemistry: Foe and friend
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Medical School, D 72076 Tuebingen, Germany
    Appl Immunohistochem Mol Morphol 14:441-4. 2006
    ..Furthermore, these results imply that in case of a good specific staining pattern, the use of albumin in immunohistochemical solutions merely exerts significant negative background staining effects...
  32. ncbi request reprint Quantifying fixation in patients with Stargardt disease
    Jens Reinhard
    University Eye Hospital, Schleichstr 12, 72076 Tubingen, Germany
    Vision Res 47:2076-85. 2007
    ..PRL eccentricity correlated positively with logMAR visual acuity (r=.72; p<.0001) and negatively with fixation stability (r=-.58; p<.0001). Multiple PRL were found only in three eyes...
  33. ncbi request reprint Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro
    Rainer Ritz
    Department of Neurosurgery, Eberhard Karls University, University Hospital Tuebingen, 72076 Tuebingen, Germany
    Int J Oncol 27:1543-9. 2005
    ..0001). Therefore, hypericin seems to be a promising substance for the photodynamic therapy of malignant brain tumors...
  34. ncbi request reprint Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials
    Stefan Plontke
    Department of Otorhinolaryngology Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Tubingen, Germany
    Acta Otolaryngol 125:830-9. 2005
    ..Comparison of different application protocols and drug delivery systems will allow assessment of the value of continuous versus intermittent intratympanic glucocorticoid drug delivery...
  35. ncbi request reprint Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze-thawing
    Klaus Hamprecht
    Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tubingen, Elfriede Aulhorn Strasse 6, 72076 Tubingen, Germany
    Pediatr Res 56:529-35. 2004
    ..Further studies are necessary to evaluate short-term heat treatment below 72 degrees Celsius as an effective tool for prevention of CMV transmission...
  36. ncbi request reprint Detection of high-risk human papillomavirus E6 and E7 oncogene transcripts in cervical scrapes by nested RT-polymerase chain reaction
    Karl Sotlar
    Institute of Pathology, University of Tuebingen, Germany
    J Med Virol 74:107-16. 2004
    ..Future applications of the assay described may include the monitoring of women in studies investigating antiviral treatment or vaccination...
  37. ncbi request reprint Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?
    Peter Bader
    Department of Pediatric Hematology and Oncology, University Children s Hospital, and Department of Medical Biometry, University of Tubingen, Tuebingen, Germany
    J Clin Oncol 22:1696-705. 2004
    ....
  38. ncbi request reprint Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria
    Markus S Mueller
    German Institute for Medical Mission, P O Box 1307, 72003 Tübingen, Germany
    Trans R Soc Trop Med Hyg 98:318-21. 2004
    ..However, recrudescence rates were high in the Artemisia groups. Therefore, monotherapy with Artemisia annua L. cannot be recommended as alternative to modern antimalarials, but may deserve further investigation...
  39. ncbi request reprint Increased frequency of genomic alterations in Staphylococcus aureus during chronic infection is in part due to phage mobilization
    Christiane Goerke
    Instituts für Allgemeine Hygiene und Umwelthygiene, Universitat Tubingen, Wilhelmstrasse 31, 72074 Tubingen, Germany
    J Infect Dis 189:724-34. 2004
    ..Genome plasticity may facilitate the adaptation to various host conditions...
  40. ncbi request reprint Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR
    Gunter Kerst
    Department of Pediatric Haematology and Oncology, University Children s Hospital, D 72076 Tubingen, Germany
    Br J Haematol 128:774-82. 2005
    ..We conclude that both MRD assays yield generally concordant results. Their combined use should enable MRD monitoring in virtually all patients and prevent false-negative results due to clonal evolution or phenotypic shifts...
  41. ncbi request reprint Rapid detection and quantification of cell free cytomegalovirus by a high-speed centrifugation-based microculture assay: comparison to longitudinally analyzed viral DNA load and pp67 late transcript during lactation
    Klaus Hamprecht
    Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    J Clin Virol 28:303-16. 2003
    ..Conventional tissue culture (TC) and low-speed centrifugation-enhanced microtiter culture methods are not able to detect HCMV from milk during all stages of lactation...
  42. ncbi request reprint Non-invasive measurement of pulmonary blood flow during prone positioning in patients with early acute respiratory distress syndrome
    Jörg Reutershan
    Department of Anaesthesiology and Intensive Care Medicine, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Clin Sci (Lond) 106:3-10. 2004
    ..It is able to reliably reflect changes in PBF induced by prone positioning. Moreover, measuring PBF might be a promising tool to identify responders to prone therapy...
  43. ncbi request reprint Radiopacity of current endovascular stents: evaluation in a multiple reader phantom study
    Jakub Wiskirchen
    Department of Diagnostic Radiology, University of Tubingen, Germany
    J Vasc Interv Radiol 15:843-52. 2004
    ..To evaluate the radiopacity of endovascular stents based on the fluoroscopy mode in a phantom of the human pelvis...
  44. ncbi request reprint Polymerase chain reaction detection of aspergillus DNA in experimental models of invasive aspergillosis
    Juergen Loeffler
    Medizinische Klinik Abteilung II, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    J Infect Dis 185:1203-6. 2002
    ..Quantitative PCR analysis of blood samples showed a fungus load of 10(1)-10(2) cfu/mL of blood. The data confirm the superior sensitivity of PCR for the diagnosis of experimental Aspergillus infections...
  45. ncbi request reprint Anabolic ergogenic substance users in fitness-sports: a distinct group supported by the health care system
    Heiko Striegel
    Department Sports Medicine, University of Tuebingen, Silchertrasse 5, 72076 Tuebingen, Germany
    Drug Alcohol Depend 81:11-9. 2006
    ..Nevertheless, it is subject to debate whether ergogenic substance users exhibit similar features as multiple substance users or whether they constitute a discrete group...
  46. ncbi request reprint Comparison of autofluorescence and iodine staining for detection of Isospora belli in feces
    Ralf Bialek
    Institute for Tropical Medicine, Department of Medical Biometry, University Hospital Tubingen, Germany
    Am J Trop Med Hyg 67:304-5. 2002
    ..2-99.5) was significantly more sensitive than iodine staining (48.4%; 95% CI, 37.7-59.1). Examination for autofluorescence is a simple, highly sensitive, inexpensive, and easily applicable method to detect Isospora spp. oocysts in feces...
  47. ncbi request reprint Comparison of fluorescence, antigen and PCR assays to detect Cryptosporidium parvum in fecal specimens
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Tubingen, Germany
    Diagn Microbiol Infect Dis 43:283-8. 2002
    ..None was obtained from 60 samples negative in the three other assays. PCR assays did not increase the detection rate. Antigen EIA or DFA appear sufficient for routine Cryptosporidium screening of fecal samples...
  48. ncbi request reprint Experimental thermoradiotherapy in malignant hepatocellular carcinoma
    Thomas Hehr
    Department of Radiation Oncology, Eberhard Karls University, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 55:1374-80. 2003
    ..We therefore developed an experimental model for combined radiotherapy and hyperthermia of the liver in transplantable rat Morris hepatoma 3924A...
  49. ncbi request reprint Normalization of previously shortened telomere length under treatment with imatinib argues against a preexisting telomere length deficit in normal hematopoietic stem cells from patients with chronic myeloid leukemia
    Tim H Brummendorf
    Abteilung Hämatologie Onkologie, Medizinische Universitatsklinik, Tubingen, Germany
    Ann N Y Acad Sci 996:26-38. 2003
    ..05), interphase FISH (n = 204, p = 0.002), or quantitative RT-PCR (n = 371, p < 0.05). In conclusion, the increase in telomere length under treatment with imatinib reflects a shift from Ph+ to Ph- cells in the PB of patients with CML...
  50. pmc Antibodies to Plasmodium falciparum rifin proteins are associated with rapid parasite clearance and asymptomatic infections
    Mohamed S Abdel-Latif
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
    Infect Immun 71:6229-33. 2003
    ....
  51. doi request reprint Attractiveness of facial profiles as rated by individuals with different levels of education
    Mirjam Hönn
    Department of Orthodontics, School of Dental Medicine, Eberhard Karl University, Osianderstrasse 2 8, Tubingen, Germany
    J Orofac Orthop 69:20-30. 2008
    ..We also were interested in identifying per group the degree of deviation (from a "normal" skeletal profile) from which the appraisers would judge that profile to be unattractive...
  52. pmc A conversion formula for comparing pulse oximeter desaturation rates obtained with different averaging times
    Jan Vagedes
    Children s Hospital, Department of Neonatology, University of Tubingen, Tubingen, Germany ARCIM Institute, Research Department, Filderklinik, Filderstadt, Germany
    PLoS ONE 9:e87280. 2014
    ..To make SpO2 data comparable, it is thus desirable to have a formula that allows conversion between desaturation rates obtained using different averaging times for various desaturation levels and minimal durations...
  53. ncbi request reprint Determinants of the eradicability of filarial infections: a conceptual approach
    Hans Peter Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Trends Parasitol 21:88-96. 2005
    ....
  54. doi request reprint Collision avoidance in persons with homonymous visual field defects under virtual reality conditions
    Eleni Papageorgiou
    Center for Ophthalmology, Institute for Ophthalmic Research, University of Tubingen, Germany
    Vision Res 52:20-30. 2012
    ..Individualized approaches which also consider compensatory strategies by means of eye and head movements should be introduced...
  55. pmc Indications for computed tomography (CT-) diagnostics in proximal humeral fractures: a comparative study of plain radiography and computed tomography
    Christian Bahrs
    Klinik fur Unfall und Wiederherstellungschirurgie, BG Unfallklinik Tübingen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    BMC Musculoskelet Disord 10:33. 2009
    ..The purpose of this study was a comparison of conventional radiographic views with different CT reconstructions with 2 D and 3 D imaging to establish indications for additional CT diagnostics depending on the fractured parts...
  56. doi request reprint Three-dimensional assessment of facial development in children with Pierre Robin sequence
    Michael Krimmel
    Department of Oral and Maxillofacial Surgery, University of Tubingen, Germany
    J Craniofac Surg 20:2055-60. 2009
    ..This indicates that children with PRS have a very early, severe, and persistent underdevelopment of this part of the face. We conclude that this disturbance must be addressed in early childhood with orthodontic and speech therapy...
  57. doi request reprint Schistosoma co-infection protects against brain pathology but does not prevent severe disease and death in a murine model of cerebral malaria
    Kirsten Bucher
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    Int J Parasitol 41:21-31. 2011
    ..mansoni. This might explain why, in co-infected mice, death could be induced in the absence of brain pathology...
  58. doi request reprint Influence of oxygen and carbogen breathing on renal oxygenation measured by T2*-weighted imaging at 3.0 T
    Andreas Boss
    Section of Experimental Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, Tubingen, Germany
    NMR Biomed 22:638-45. 2009
    ..The effects are in the expected range for the BOLD effect of 3-4% at 3.0 T. The proposed technique might be interesting for the assessment of renal tissue oxygenation and its regulation in patients with kidney diseases...
  59. doi request reprint Immune surveillance of the normal human CNS takes place in dependence of the locoregional blood-brain barrier configuration and is mainly performed by CD3(+)/CD8(+) lymphocytes
    Christian Loeffler
    Institute of Brain Research, University of Tuebingen, Medical School, Tubingen, Germany
    Neuropathology 31:230-8. 2011
    ..Our results provide evidence that immunosurveillance is associated with locoregional BBB configuration and is mainly performed by CD3(+)/CD8(+)/granzyme B(-)/perforin(-) lymphocytes...
  60. doi request reprint Platelet anaesthesia during extracorporeal circulation: differential effects of GP IIb/IIIa blockers on platelet activation marker P-selectin expression at hypothermia
    Andreas Straub
    Department of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Germany
    Thromb Res 122:383-9. 2008
    ..This in-vitro study investigated potentially platelet-activating effects of short-acting GP IIb/IIIa blockers during normothermic and hypothermic ECC...
  61. ncbi request reprint Bipolar radiofrequency ablation using internally cooled electrodes in ex vivo bovine liver: prediction of coagulation volume from applied energy
    Stephan Clasen
    Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    Invest Radiol 42:29-36. 2007
    ..We sought to evaluate the relationship between parameters of bipolar radiofrequency (RF) ablation using internally cooled electrodes...
  62. ncbi request reprint Proliferation and progesterone receptor status in benign meningiomas are not age dependent
    Florian Roser
    Department of Neurosurgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Cancer 104:598-601. 2005
    ..In the current study, proliferation activity with the Ki-67/MIB-1 antibody was evaluated by immunohistochemistry in meningioma tissue specimens from young and elderly patients...
  63. doi request reprint Parafoveal letter recognition at reduced contrast in normal aging and in patients with risk factors for AMD
    Gesa Astrid Hahn
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:43-51. 2009
    ....
  64. doi request reprint Three-dimensional constructive interference in steady-state magnetic resonance imaging in syringomyelia: advantages over conventional imaging
    Florian Roser
    Department of Neurosurgery, University of Tubingen, Germany
    J Neurosurg Spine 8:429-35. 2008
    ..As this region is critical in preoperative evaluation, the authors hypothesized that CISS imaging would provide superior assessment of syrinx pathology and surgical planning...
  65. ncbi request reprint Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis
    Christopher Weidenmaier
    Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, University of Tubingen, 72076 Tubingen, Germany
    J Infect Dis 191:1771-7. 2005
    ..001). We conclude that WTA is an important factor in the induction and progression of endovascular S. aureus infection, likely through a specific interaction with endothelial cells...
  66. pmc Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes
    Angelica B W Boldt
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    BMC Genet 11:38. 2010
    ..We recently used haplotype-specific sequencing to identify 23 MBL2 haplotypes, associated with enhanced susceptibility to several diseases...
  67. doi request reprint Averaging time, desaturation level, duration and extent
    Jan Vagedes
    Department of Neonatology, Children s Hospital, University of Tubingen, Calwerstr 7, 72076 Tubingen, Germany
    Arch Dis Child Fetal Neonatal Ed 98:F265-6. 2013
    ..Pulse oximeter saturation values are usually obtained by averaging over preceding measurements. This study investigates the dynamics between the averaging time and desaturation level, duration and extent...
  68. doi request reprint Changes in esthetic standards since 1940
    Mirjam Berneburg
    Department of Orthodontics, University of Tubingen, Osianderstrasse 2 8, Tubingen, Germany
    Am J Orthod Dentofacial Orthop 137:450.e1-9; discussion 450-1. 2010
    ..The goals of this study were to investigate differences between the most popular female and male faces, past and present, and to determine whether they had changed over time and, if so, to what extent...
  69. ncbi request reprint Peripheral arteries: treatment with antibodies of platelet receptors and reteplase for thrombolysis--APART trial
    Gunnar Tepe
    Department of Diagnostic Radiology, University of Tubingen, Tubingen, Germany
    Radiology 239:892-900. 2006
    ....
  70. ncbi request reprint Transmission potential of smallpox: estimates based on detailed data from an outbreak
    Martin Eichner
    Department of Medical Biometry, University of Tubingen, Tubingen, Germany
    Am J Epidemiol 158:110-7. 2003
    ..1) sufficiently close contacts during the whole course of infectivity. These results support the widely held belief that smallpox spreads slowly, mainly among close contacts, and that infectivity before the onset of rash was negligible...
  71. ncbi request reprint Accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH
    Fabian Beier
    Division of Hematology, Oncology and Immunology, Department of Medical Biometry, University of Tubingen, Germany
    Blood 106:531-3. 2005
    ..23 TFU; P < .001). Our findings are in support of a selective growth advantage model of PNH assuming that damage to the GPI+ hematopoietic stem-cell (HSC) compartment leads to compensatory hyperproliferation of residual GPI- HSCs...
  72. doi request reprint Echinococcus multilocularis: inflammatory and regulatory chemokine responses in patients with progressive, stable and cured alveolar echinococcosis
    Lars Kocherscheidt
    Institute for Tropical Medicine, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
    Exp Parasitol 119:467-74. 2008
    ....
  73. doi request reprint Novel multi-peptide vaccination in Hla-A2+ hormone sensitive patients with biochemical relapse of prostate cancer
    Susan Feyerabend
    Department of Urology, University of Tubingen, Germany
    Prostate 69:917-27. 2009
    ..A phase I/II trial was conducted to assess feasibility and tolerability of tumor associated antigen peptide vaccination in hormone sensitive prostate carcinoma (PC) patients with biochemical recurrence after primary surgical treatment...
  74. ncbi request reprint Insulin resistant young subjects at risk of accelerated atherosclerosis exhibit a marked reduction in peripheral endothelial function early in life but not differences in intima-media thickness
    Bernd M Balletshofer
    Department of Endocrinology, Diabetes and Vascular Medicine, University of Tubingen, Otfried Muller Strasse 10, 72076, Tubingen, Germany
    Atherosclerosis 171:303-9. 2003
    ....
  75. ncbi request reprint The minimum effort required to eradicate infections in models with backward bifurcation
    Muntaser Safan
    Department of Medical Biometry, Eberhard Karls University Tubingen, Westbahnhofstr 55, 72070, Tubingen, Germany
    J Math Biol 53:703-18. 2006
    ..The method we present is relevant to the whole class of compartmental models with backward bifurcation...
  76. ncbi request reprint Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children
    Matthias Eyrich
    Children s Hospital, Pediatric Stem Cell Transplant Program, University of Tubingen, Germany
    Biol Blood Marrow Transplant 11:194-205. 2005
    ..Onset and plateau of thymic activity are independently regulated by different transplant-related factors...
  77. ncbi request reprint Perceived relative attractiveness of facial profiles with varying degrees of skeletal anomalies
    Mirjam Hönn
    Department of Orthodontics, University of Tubingen, Germany
    J Orofac Orthop 66:187-96. 2005
    ..as more attractive than profiles of Class II or Class III patients in Germany today? How pronounced must a skeletal malocclusion be to be perceived as less attractive? Are there differences in perception between dentists and laypersons?..
  78. ncbi request reprint Retinal safety of a new fluoroquinolone, pradofloxacin, in cats: assessment with electroretinography
    Andre Messias
    Center for Ophthalmology, University of Tubingen, Schleichstrasse 12 16, 72076, Tubingen, Germany
    Doc Ophthalmol 116:177-91. 2008
    ..To investigate the safety of a new fluoroquinolone, pradofloxacin, on the cat retina using electroretinogram...
  79. ncbi request reprint Comparison of staining methods and a nested PCR assay to detect Histoplasma capsulatum in tissue sections
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Germany
    Am J Clin Pathol 117:597-603. 2002
    ..The Grocott and fluorochrome stains did not differ significantly in detecting fungal elements. The PCR assay unambiguously identified H. capsulatum in tissue sections...
  80. ncbi request reprint Glycoprotein IIb/IIIa inhibition reduces prothrombotic events under conditions of deep hypothermic circulatory arrest
    Andreas Straub
    Dept of Thoracic, Cardiac and Vascular Surgery, Tubingen University Hospital, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Thromb Haemost 94:115-22. 2005
    ..Application of a short-acting and non-activating GP IIb/IIIa inhibitor should be considered during DHCA in vivo to prevent occlusion of the microvasculature and subsequent organ damage...
  81. ncbi request reprint Impact of vCJD on blood supply
    Rainer Seitz
    Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, D 63225 Langen, Germany
    Biologicals 35:79-97. 2007
    ..Therefore, an exclusion of transfusion recipients was not recommended in Germany...
  82. ncbi request reprint Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival
    Arne Warth
    Institute of Pathology, University of Tuebingen, Tuebingen, Germany
    J Neurosci Res 85:1336-46. 2007
    ..In addition, our results provide unexpectedly high AQP4 levels in pilocytic astrocytomas and present AQP4 as tumor progression marker in WHO grade II-IV astrocytomas...
  83. ncbi request reprint In vitro activity of ferroquine (SAR97193) is independent of chloroquine resistance in Plasmodium falciparum
    Andrea Kreidenweiss
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Am J Trop Med Hyg 75:1178-81. 2006
    ..We conclude that ferroquine is highly active in chloroquine-resistant parasites, and we anticipate no enhanced selection for resistance against ferroquine in chloroquine-resistant parasites...
  84. ncbi request reprint Longitudinal studies of telomere length in feline blood cells: implications for hematopoietic stem cell turnover in vivo
    Tim H Brummendorf
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Exp Hematol 30:1147-52. 2002
    ..To address questions about stem cell turnover in relation to telomere length dynamics, we analyzed telomere length in serial blood samples from cats...
  85. ncbi request reprint Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia
    Tim H Brummendorf
    Blood 101:375-6. 2003
  86. ncbi request reprint Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX
    Frank Duffner
    Department of Neurosurgery, Eberhard Karls University of Tuebingen, Germany
    J Neurooncol 71:107-11. 2005
    ..The glioma cell lines showed significant variation in this possibly limiting clinical use of fluorescence as a guide for resection...
  87. ncbi request reprint A model for natural immunity to asexual blood stages of Plasmodium falciparum malaria in endemic areas
    Nicolas Maire
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 75:19-31. 2006
    ..falciparum...
  88. doi request reprint Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction
    Ioakim Spyridopoulos
    Department of Cardiology, Wolfgang Goethe University of Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 28:968-74. 2008
    ....
  89. ncbi request reprint Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria
    Thomas Smith
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 75:11-8. 2006
    ..This forms one component of a new stochastic model for the entire transmission cycle of P. falciparum that we have derived to estimate the potential epidemiologic impact of malaria vaccines and other malaria control interventions...
  90. ncbi request reprint Doping in fitness sports: estimated number of unreported cases and individual probability of doping
    Perikles Simon
    University of Tuebingen, Department of Sports Medicine, General Internal Medicine V, Tuebingen, Germany
    Addiction 101:1640-4. 2006
    ..In this study we applied an alternative interview technique to assess more accurately unreported cases of doping in fitness centres...
  91. ncbi request reprint Mathematical modeling of the impact of malaria vaccines on the clinical epidemiology and natural history of Plasmodium falciparum malaria: Overview
    Thomas Smith
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 75:1-10. 2006
    ..This paper outlines for a non-mathematical audience the approach we have taken and its underlying rationale...
  92. ncbi request reprint Critical temperature ranges of hypothermia-induced platelet activation: possible implications for cooling patients in cardiac surgery
    Andreas Straub
    Baker Heart Research Institute, Centre for Thrombosis and Myocardial Infarction, Melbourne, Victoria, Australia
    Thromb Haemost 97:608-16. 2007
    ..These findings suggest that pharmacological protection of platelets against hypothermia-induced damage may be beneficial during cardiac surgery...
  93. ncbi request reprint Intensity of HLA class I expression and KIR-mismatch determine NK-cell mediated lysis of leukaemic blasts from children with acute lymphatic leukaemia
    Matthias Pfeiffer
    Department of Paediatric Haematology Oncology, University Children s Hospital, Eberhard Karl s University, Tuebingen, Germany
    Br J Haematol 138:97-100. 2007
    ..87), whereas KIR-ligand-mismatch alone was not significant. Assessment of these factors might identify patients who could benefit from NK-mediated graft-versus-leukaemia effects after mismatched stem cell transplantation...
  94. ncbi request reprint The earliest notes on the reproduction number in relation to herd immunity: Theophil Lotz and smallpox vaccination
    Hiroshi Nishiura
    J Theor Biol 241:964-7. 2006
  95. pmc Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors
    Markus Liebrich
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Arch Immunol Ther Exp (Warsz) 55:41-7. 2007
    ..Macrophages/microglial cells are considered as immune cells in the central nervous system. Interleukin (IL)-16 is a proinflammatory cytokine produced by activated monocytic cells...