Wulf Dietrich

Summary

Country: Germany

Publications

  1. doi request reprint The influence of antithrombin substitution on heparin sensitivity and activation of hemostasis during coronary artery bypass graft surgery: a dose-finding study
    Wulf Dietrich
    Department of Anaesthesiology, Working Group of Perioperative Hemostasis, University of Munich, Winthirstrasse 4, Munich, Germany
    Anesth Analg 116:1223-30. 2013
  2. doi request reprint Aprotinin: 1 year on
    Wulf Dietrich
    Departments of Anesthesiology and Transfusion Medicine, Institute for Research in Cardiac Anesthesia and Working Group of Perioperative Hemostasis, University of Munich, Munich, Germany
    Curr Opin Anaesthesiol 22:121-7. 2009
  3. doi request reprint Tranexamic acid and aprotinin in primary cardiac operations: an analysis of 220 cardiac surgical patients treated with tranexamic acid or aprotinin
    Wulf Dietrich
    Institute for Research in Cardiac Anesthesia, 80639 Munich, Winthirstr 4, 80639 Munich, Germany
    Anesth Analg 107:1469-78. 2008
  4. doi request reprint Autologous blood predonation in cardiac surgery
    W Dietrich
    Institute for Research in Cardiac Anesthesia, Winthistrasse 4, Munich, Germany
    Transfus Clin Biol 14:526-9. 2007
  5. doi request reprint Effects of aprotinin dosage on renal function: an analysis of 8,548 cardiac surgical patients treated with different dosages of aprotinin
    Wulf Dietrich
    Institute for Research in Cardiac Anesthesia, Munich, Germany
    Anesthesiology 108:189-98. 2008
  6. ncbi request reprint Aprotinin and anaphylaxis: analysis of 12,403 exposures to aprotinin in cardiac surgery
    Wulf Dietrich
    Department of Anesthesiology, German Heart Center Munich, Germany
    Ann Thorac Surg 84:1144-50. 2007
  7. doi request reprint A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery
    Christian F Weber
    Clinic for Anesthesiology, University of Munich, Max Lebsche Platz 32, D 81377 Munich, Germany
    Anesth Analg 110:702-7. 2010
  8. doi request reprint Enhanced thrombin generation after cardiopulmonary bypass surgery
    Susanne Lison
    Working Group of Perioperative Hemostasis, Ludwig Maximilians Universitaet, Munich, Germany
    Anesth Analg 112:37-45. 2011
  9. ncbi request reprint High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery
    Hansjörg Mössinger
    Department of Anesthesiology, German Heart Center, Munich, Germany
    Ann Thorac Surg 75:430-7. 2003
  10. doi request reprint Hemophilia A in cardiac operations: a model of reduced thrombin generation
    Susanne Lison
    Department of Transfusion and Hemostaseology, Clinic of Anesthesiology, Ludwig Maximilians University of Munich, Munich, Germany
    Ann Thorac Surg 91:1606-8. 2011

Detail Information

Publications27

  1. doi request reprint The influence of antithrombin substitution on heparin sensitivity and activation of hemostasis during coronary artery bypass graft surgery: a dose-finding study
    Wulf Dietrich
    Department of Anaesthesiology, Working Group of Perioperative Hemostasis, University of Munich, Winthirstrasse 4, Munich, Germany
    Anesth Analg 116:1223-30. 2013
    ..However, the appropriate dosage of AT has not been defined. We sought to determine the dosage of AT concentrate necessary to achieve >100% AT activity at the end of cardiac surgery and the influence of AT on heparin sensitivity...
  2. doi request reprint Aprotinin: 1 year on
    Wulf Dietrich
    Departments of Anesthesiology and Transfusion Medicine, Institute for Research in Cardiac Anesthesia and Working Group of Perioperative Hemostasis, University of Munich, Munich, Germany
    Curr Opin Anaesthesiol 22:121-7. 2009
    ..Recent investigations have questioned its safety, and aprotinin has finally been withdrawn from marketing after a large prospective study demonstrated a trend toward higher mortality...
  3. doi request reprint Tranexamic acid and aprotinin in primary cardiac operations: an analysis of 220 cardiac surgical patients treated with tranexamic acid or aprotinin
    Wulf Dietrich
    Institute for Research in Cardiac Anesthesia, 80639 Munich, Winthirstr 4, 80639 Munich, Germany
    Anesth Analg 107:1469-78. 2008
    ..In the present study we evaluated the impact of tranexamic acid compared to aprotinin on the transfusion incidence in cardiac surgical patients with low risk of bleeding...
  4. doi request reprint Autologous blood predonation in cardiac surgery
    W Dietrich
    Institute for Research in Cardiac Anesthesia, Winthistrasse 4, Munich, Germany
    Transfus Clin Biol 14:526-9. 2007
    ..Autologous blood donation still remains a promising and cost-effective alternative to reduce allogeneic blood transfusion in elective cardiac surgery...
  5. doi request reprint Effects of aprotinin dosage on renal function: an analysis of 8,548 cardiac surgical patients treated with different dosages of aprotinin
    Wulf Dietrich
    Institute for Research in Cardiac Anesthesia, Munich, Germany
    Anesthesiology 108:189-98. 2008
    ..Recently, concerns about the safety of this drug were raised, especially regarding impaired renal outcome. This event rate was supposed to be dose dependent...
  6. ncbi request reprint Aprotinin and anaphylaxis: analysis of 12,403 exposures to aprotinin in cardiac surgery
    Wulf Dietrich
    Department of Anesthesiology, German Heart Center Munich, Germany
    Ann Thorac Surg 84:1144-50. 2007
    ..Hypersensitivity reactions to the nonspecific proteinase inhibitor aprotinin may occur. The present study evaluates the incidence of hypersensitivity reactions to aprotinin...
  7. doi request reprint A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery
    Christian F Weber
    Clinic for Anesthesiology, University of Munich, Max Lebsche Platz 32, D 81377 Munich, Germany
    Anesth Analg 110:702-7. 2010
    ..In this study, we examined the feasibility of whole blood multiple electrode aggregometry (MEA) for the detection of cardiopulmonary bypass-induced platelet dysfunction and investigated its ability to monitor DDAVP treatment...
  8. doi request reprint Enhanced thrombin generation after cardiopulmonary bypass surgery
    Susanne Lison
    Working Group of Perioperative Hemostasis, Ludwig Maximilians Universitaet, Munich, Germany
    Anesth Analg 112:37-45. 2011
    ..The thrombin dynamics test (TDT) assesses the initial kinetics of thrombin formation. We hypothesized that there would be an increase in thrombin generation as well as thrombin capacity after cardiac surgery...
  9. ncbi request reprint High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery
    Hansjörg Mössinger
    Department of Anesthesiology, German Heart Center, Munich, Germany
    Ann Thorac Surg 75:430-7. 2003
    ..Though multiple studies have affirmed the effectiveness of aprotinin in reducing blood loss in adult cardiac surgery, the possible benefit in pediatric cardiac surgery is controversial...
  10. doi request reprint Hemophilia A in cardiac operations: a model of reduced thrombin generation
    Susanne Lison
    Department of Transfusion and Hemostaseology, Clinic of Anesthesiology, Ludwig Maximilians University of Munich, Munich, Germany
    Ann Thorac Surg 91:1606-8. 2011
    ..This approach facilitated adequate anticoagulation and minimized the amount of factor VIII treatment necessary without compromising bleeding control...
  11. ncbi request reprint Factor V Leiden does not affect bleeding in aprotinin recipients after cardiopulmonary bypass
    Johannes Boehm
    Department of Cardiovascular Surgery, German Heart Center Munich, Technische Universitaet Muenchen, Munich, Germany
    Anesthesiology 106:681-6. 2007
    ..The primary endpoint of this study was the amount of blood loss after CPB in aprotinin recipients, and secondary endpoints were thromboembolic complications...
  12. doi request reprint Review article: unexpected bleeding in the operating room: the role of acquired von Willebrand disease
    Susanne Lison
    Department of Anaesthesiology, Working Group of Perioperative Hemostasis, University of Munich, Germany
    Anesth Analg 114:73-81. 2012
    ..In the present review, we focus on the current understanding of AvWD, outlining the associated disorders, underlying pathophysiological mechanisms, and possible treatment options...
  13. doi request reprint CU-2010--a novel small molecule protease inhibitor with antifibrinolytic and anticoagulant properties
    Wulf Dietrich
    Institute for Research in Cardiac Anesthesia, and Department of Hemostasiology, Ludwig Maximilian University, Munich, Germany
    Anesthesiology 110:123-30. 2009
    ..Moreover, aprotinin is a protein of animal origin and has antigenic properties. As a result, alternative antifibrinolytic compounds are desirable...
  14. ncbi request reprint High-dose aprotinin in cardiac surgery: is high-dose high enough? An analysis of 8281 cardiac surgical patients treated with aprotinin
    Wulf Dietrich
    Department of Anesthesiology, German Heart Center Munich
    Anesth Analg 103:1074-81. 2006
    ..Our results support the hypothesis that a more individualized aprotinin regimen with potentially higher doses may optimize the effectiveness of aprotinin therapy in cardiac surgery...
  15. doi request reprint Multiple electrode whole blood aggregometry, PFA-100, and in vivo bleeding time for the point-of-care assessment of aspirin-induced platelet dysfunction in the preoperative setting
    Csilla Jambor
    Clinic for Anesthesiology, Working Group Perioperative Haemostasis, University of Munich, Max Lebsche Platz 32, D 81377 Munich, Germany
    Anesth Analg 113:31-9. 2011
    ..Thus, we examined the diagnostic accuracy of in vivo bleeding time (BT) and 2 platelet function assays for the preoperative assessment of a residual antiplatelet effect in patients treated with aspirin...
  16. ncbi request reprint Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions
    Wolfram Beierlein
    Department of Thoracic, Cardiac, and Vascular Surgery, Tubingen University Hospital, Tubingen, Germany
    Ann Thorac Surg 79:741-8. 2005
    ..This review looks at the profile of patients at risk so preventive measures may be taken. Past and future exposures have to be taken into account before any aprotinin administration...
  17. doi request reprint Whole blood multiple electrode aggregometry is a reliable point-of-care test of aspirin-induced platelet dysfunction
    Csilla Jambor
    Clinic for Anesthesiology, University of Munich, Max Lebsche Platz 32, D 81377 Munich, Germany
    Anesth Analg 109:25-31. 2009
    ..We also determined the applicability of this method in the point-of-care (POC) setting by comparing the results of the test after different time intervals after blood sampling...
  18. ncbi request reprint Autologous blood donation in cardiac surgery: reduction of allogeneic blood transfusion and cost-effectiveness
    Wulf Dietrich
    Department of Anesthesiology, German Heart Center Munich, Munich, Germany
    J Cardiothorac Vasc Anesth 19:589-96. 2005
    ..The purpose of this study was to assess transfusion requirements in patients undergoing cardiac surgery with and without autologous blood donation and to calculate the costs of predonation from the hospital perspective...
  19. ncbi request reprint The predictive value of modified computerized thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgery
    Ursula Cammerer
    Department of Anesthesiology, German Heart Center, Munich, Germany
    Anesth Analg 96:51-7, table of contents. 2003
    ..Bleeding in these patients is probably caused surgically. The high negative predictive value supports early identification and targeted treatment of surgical bleeding by distinguishing it from a significant coagulopathy...
  20. ncbi request reprint Influence of high- and low-dose aprotinin on activation of hemostasis in open heart operations
    W Dietrich
    Department of Anesthesiology, German Heart Center Munich
    Ann Thorac Surg 65:70-7; discussion 77-8. 1998
    ..The aim of the present study was to investigate the influence of two different aprotinin doses on hemostatic activation and to identify the most effective dose to reduce the postoperative bleeding tendency...
  21. ncbi request reprint Low preoperative antithrombin activity causes reduced response to heparin in adult but not in infant cardiac-surgical patients
    W Dietrich
    Department of Anesthesiology, German Heart Center, Munich, Germany
    Anesth Analg 92:66-71. 2001
    ..Measurement of preoperative AT activity identifies patients at risk of inadequate anticoagulation during CPB...
  22. ncbi request reprint Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies
    W Dietrich
    Department of Anesthesiology, German Heart Center Munich
    Anesthesiology 95:64-71; discussion 5A-6A. 2001
    ..This investigation examined the incidence of anaphylactic reactions in patients reexposed to aprotinin and the relation to preformed antiaprotinin immunoglobulin (Ig)G and IgE antibodies...
  23. doi request reprint Perioperative hemostatic management of patients treated with vitamin K antagonists
    Jerrold H Levy
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322 1061, USA
    Anesthesiology 109:918-26. 2008
    ..Although many patients who require rapid reversal of warfarin are currently treated with fresh frozen plasma, PCCs should be considered as an alternative therapy...
  24. ncbi request reprint Thrombophilia in cardiac surgery--patients with protein S deficiency
    Parwis Massoudy
    Department of Thoracic and Cardiovascular Surgery, West German Heart Center, Essen, Germany
    Ann Thorac Surg 82:2187-91. 2006
    ..Among these, protein S deficiency is a coagulation disorder associated with recurrent thromboembolic events. We analyzed our experience with 7 patients with protein S deficiency who underwent cardiac surgery...
  25. ncbi request reprint Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, Virginia 23298 0695, USA
    Transfusion 44:1143-8. 2004
    ..The current analysis investigates the hypothesis that PLT transfusion is associated with adverse outcomes associated with coronary artery bypass graft surgery (CABG)...
  26. ncbi request reprint Caveat against the use of activated recombinant factor VII for intractable bleeding in cardiac surgery
    Wulf Dietrich
    Anesth Analg 94:1369-70; author reply 1370-1. 2002
  27. ncbi request reprint Full-dose aprotinin use in coronary artery bypass graft surgery: an analysis of perioperative pharmacotherapy and patient outcomes
    David Royston
    Department of Anaesthesia and Critical Care, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK
    Anesth Analg 103:1082-8. 2006
    ..In this retrospective analysis, we evaluated the relationship of aprotinin therapy with organ dysfunction in humans undergoing coronary artery bypass graft surgery (CABG)...