Andreas Koster

Summary

Affiliation: Deutsches Herzzentrum Berlin
Country: Germany

Publications

  1. ncbi request reprint A quick assay for monitoring recombinant hirudin during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II : adaptation of the ecarin clotting time to the act II device
    A Koster
    Department of Anesthesiology, Deutsches Herzzentrum Berlin, Germany
    J Thorac Cardiovasc Surg 119:1278-83. 2000
  2. ncbi request reprint Anticoagulation with argatroban in patients with heparin-induced thrombocytopenia antibodies after cardiovascular surgery with cardiopulmonary bypass: first results from the ARG-E03 trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 132:699-700. 2006
  3. ncbi request reprint Bivalirudin provides rapid, effective, and reliable anticoagulation during off-pump coronary revascularization: results of the "EVOLUTION OFF" trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    Anesth Analg 103:540-4. 2006
  4. ncbi request reprint Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, and Institute of Physiology, Freie Universitat, Berlin, Germany
    Anesthesiology 97:837-41. 2002
  5. ncbi request reprint Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Anesth Analg 96:383-6, table of contents. 2003
  6. ncbi request reprint Effects of tirofiban on hemostatic activation and inflammatory response during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Am J Cardiol 91:346-7. 2003
  7. ncbi request reprint Management of heparin resistance during cardiopulmonary bypass: the effect of five different anticoagulation strategies on hemostatic activation
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    J Cardiothorac Vasc Anesth 17:171-5. 2003
  8. ncbi request reprint An assessment of different filter systems for extracorporeal elimination of bivalirudin: an in vitro study
    Andreas Koster
    Department for Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Anesth Analg 96:1316-9, table of contents. 2003
  9. ncbi request reprint High antithrombin III levels attenuate hemostatic activation and leukocyte activation during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Augustenburgerplatz 1, D 13353 Berlin, Germany
    J Thorac Cardiovasc Surg 126:906-7. 2003
  10. ncbi request reprint The more closed the bypass system the better: a pilot study on the effects of reduction of cardiotomy suction and passive venting on hemostatic activation during on-pump coronary artery bypass grafting
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Perfusion 20:285-8. 2005

Detail Information

Publications77

  1. ncbi request reprint A quick assay for monitoring recombinant hirudin during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II : adaptation of the ecarin clotting time to the act II device
    A Koster
    Department of Anesthesiology, Deutsches Herzzentrum Berlin, Germany
    J Thorac Cardiovasc Surg 119:1278-83. 2000
    ..This requires monitoring of the ecarin clotting time. No commercial ecarin clotting time assay is available for clinical use. We adapted the ecarin clotting time to the easy-to-handle ACT II device...
  2. ncbi request reprint Anticoagulation with argatroban in patients with heparin-induced thrombocytopenia antibodies after cardiovascular surgery with cardiopulmonary bypass: first results from the ARG-E03 trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 132:699-700. 2006
  3. ncbi request reprint Bivalirudin provides rapid, effective, and reliable anticoagulation during off-pump coronary revascularization: results of the "EVOLUTION OFF" trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    Anesth Analg 103:540-4. 2006
    ..These results suggest that bivalirudin, given according to the current protocol, provides reliable and effective anticoagulation during off-pump coronary artery bypass graft surgery...
  4. ncbi request reprint Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, and Institute of Physiology, Freie Universitat, Berlin, Germany
    Anesthesiology 97:837-41. 2002
    ....
  5. ncbi request reprint Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Anesth Analg 96:383-6, table of contents. 2003
  6. ncbi request reprint Effects of tirofiban on hemostatic activation and inflammatory response during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Am J Cardiol 91:346-7. 2003
  7. ncbi request reprint Management of heparin resistance during cardiopulmonary bypass: the effect of five different anticoagulation strategies on hemostatic activation
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    J Cardiothorac Vasc Anesth 17:171-5. 2003
    ..However, this poses a problem in patients insensitive to heparin. The present investigation was performed to assess different strategies of managing patients with heparin resistance during CPB...
  8. ncbi request reprint An assessment of different filter systems for extracorporeal elimination of bivalirudin: an in vitro study
    Andreas Koster
    Department for Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Anesth Analg 96:1316-9, table of contents. 2003
    ..Our data show that bivalirudin can be effectively eliminated via hemofiltration and plasmapheresis, although there were significant differences in the elimination rates among the filter systems investigated...
  9. ncbi request reprint High antithrombin III levels attenuate hemostatic activation and leukocyte activation during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Augustenburgerplatz 1, D 13353 Berlin, Germany
    J Thorac Cardiovasc Surg 126:906-7. 2003
  10. ncbi request reprint The more closed the bypass system the better: a pilot study on the effects of reduction of cardiotomy suction and passive venting on hemostatic activation during on-pump coronary artery bypass grafting
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Perfusion 20:285-8. 2005
    ..However, further attenuation of hemostatic activation can be achieved by further closing the system and minimizing the blood/air interface by passive venting of the heart...
  11. ncbi request reprint Heparin-level-based anticoagulation management during cardiopulmonary bypass: a pilot investigation on the effects of a half-dose aprotinin protocol on postoperative blood loss and hemostatic activation and inflammatory response
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    Anesth Analg 98:285-90, table of contents. 2004
    ..This effect can most likely be attributed to the antifibrinolytic effects of aprotinin, as we did not observe effects on other variables of activation of the hemostatic/inflammatory system...
  12. ncbi request reprint Effectiveness of bivalirudin as a replacement for heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting
    Andreas Koster
    Department of Anesthesia, Deutsches Herrzentrum, Berlin, Germany
    Am J Cardiol 93:356-9. 2004
    ..Our data provide the first evidence of clinical feasibility of anticoagulation with bivalirudin during cardiopulmonary bypass...
  13. ncbi request reprint Transfusion-free complex cardiac surgery with cardiopulmonary bypass in a 3.55-kg Jehovah's Witness neonate
    Michael Huebler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 80:1504-6. 2005
    ..55 kg Jehovah's Witness neonate boy...
  14. ncbi request reprint Assessment of hemostatic activation during cardiopulmonary bypass for coronary artery bypass grafting with bivalirudin: results of a pilot study
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 129:1391-4. 2005
    ..This study was conducted to assess the effects of the currently suggested protocol for bivalirudin on hemostatic activation during cardiopulmonary bypass with and without cardiotomy suction...
  15. ncbi request reprint Extracorporeal elimination of large concentrations of tirofiban by zero-balanced ultrafiltration during cardiopulmonary bypass: an in vitro investigation
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Anesth Analg 99:989-92, table of contents. 2004
    ..The subsidence coefficient b revealed no significant differences in elimination between the filter systems. These data suggest that ultrafiltration is an effective means for extracorporeal elimination of therapeutic levels of tirofiban...
  16. ncbi request reprint The plasma supplemented modified activated clotting time for monitoring of heparinization during cardiopulmonary bypass: a pilot investigation
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Charite, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Anesth Analg 95:26-30, table of contents. 2002
    ..The improved correlation most likely results from a correction of the effects of the impairment of the coagulation system caused by hemodilution and consumption of procoagulants on extracorporeal surfaces...
  17. ncbi request reprint Impact of heparin-induced thrombocytopenia on outcome in patients with ventricular assist device support: single-institution experience in 358 consecutive patients
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 83:72-6. 2007
    ..We assessed the occurrence of this disease and its influence on clinical outcome in patients after implantation of a ventricular assist device (VAD)...
  18. ncbi request reprint In vitro cross-reactivity of danaparoid sodium in patients with heparin-induced thrombocytopenia type II undergoing cardiovascular surgery
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    J Clin Anesth 12:324-7. 2000
    ..To assess the cross-reactivity of danaparoid sodium in patients undergoing cardiovascular surgery...
  19. ncbi request reprint Cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia II and impaired renal function using heparin and the platelet GP IIb/IIIa inhibitor tirofiban as anticoagulant
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin
    Ann Thorac Surg 70:2160-1. 2000
    ....
  20. ncbi request reprint Heparin antibodies and thromboembolism in heparin-coated and noncoated ventricular assist devices
    A Koster
    Department of Anesthesiology, Deutsches Herzzentrum Berlin, Augustenberger Platz 1, D 13353 Berlin, Germany
    J Thorac Cardiovasc Surg 121:331-5. 2001
    ..We analyzed the occurrence of HPF4/A and thromboembolism in patients with heparin-coated and noncoated VADs...
  21. ncbi request reprint Anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II and renal impairment using heparin and the platelet glycoprotein IIb-IIIa antagonist tirofiban
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin Germany
    Anesthesiology 94:245-51. 2001
    ..The authors investigated a new concept using unfractionated heparins after platelet inhibition with the short-acting platelet glycoprotein IIb-IIIa antagonist tirofiban...
  22. doi request reprint Effect of modified ultrafiltration on bivalirudin elimination and postoperative blood loss after on-pump coronary artery bypass grafting: assessment of different filtration strategies
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    J Card Surg 23:655-8. 2008
    ..We assessed the effect of four different strategies of modified ultrafiltration after cardiopulmonary bypass on the bivalirudin elimination and postoperative blood loss...
  23. doi request reprint High-dose aprotinin effectively reduces blood loss during on-pump coronary artery bypass grafting with bivalirudin anticoagulation
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    J Thorac Cardiovasc Surg 135:685-7. 2008
  24. ncbi request reprint Evaluation of post-cardiopulmonary bypass coagulation disorders by differential diagnosis with a multichannel modified thromboelastogram: a pilot investigation
    A Koster
    Department for Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    J Extra Corpor Technol 33:153-8. 2001
    ..However, elaboration is desirable, and larger clinical trials are necessary for a final evaluation of the protocol...
  25. ncbi request reprint Assessment of the resonance thromboelastograph CS-3 for differentiation of coagulation disorders: a pilot in vitro investigation of simulated post-cardiopulmonary bypass coagulopathies
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    J Extra Corpor Technol 33:159-66. 2001
    ..Further improvement may be achieved using a modified RTG by adding plasma coagulation factors in one channel for an improved evaluation of platelet function, even under the condition of a loss of procoagulants...
  26. ncbi request reprint Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 83:572-7. 2007
    ....
  27. doi request reprint Monitoring of bivalirudin anticoagulation during and after cardiopulmonary bypass using an ecarin-activated TEG system
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    J Card Surg 23:321-3. 2008
  28. ncbi request reprint Successful use of bivalirudin as anticoagulant for ECMO in a patient with acute HIT
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 83:1865-7. 2007
    ..Surgery was successfully performed with moderate intraoperative and postoperative blood loss and transfusion requirements...
  29. ncbi request reprint Argatroban anticoagulation for renal replacement therapy in patients with heparin-induced thrombocytopenia after cardiovascular surgery
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    J Thorac Cardiovasc Surg 133:1376-7. 2007
  30. ncbi request reprint Some new perspectives in heparin-induced thrombocytopenia type II
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    J Extra Corpor Technol 33:193-6. 2001
    ..Otherwise, the combination of UFH with a potent antiplatelet agent, especially with short-acting GP IIb/IIIa antagonists, is an attractive alternative...
  31. doi request reprint Regional differences in tissue oxygenation during cardiopulmonary bypass for correction of congenital heart disease in neonates and small infants: relevance of near-infrared spectroscopy
    Mathias Redlin
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 136:962-7. 2008
    ..Moreover, we evaluated potential benefits of near-infrared spectroscopic monitoring of regional tissue oxygenation...
  32. ncbi request reprint Cardiopulmonary bypass for complex cardiac surgery using bivalirudin anticoagulation in a patient with heparin antibodies
    Michael Huebler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herssentrum Berlin, Germany
    J Card Surg 21:286-8. 2006
    ..Experience in complicated cases requiring extended cardiopulmonary bypass is limited, however. We report the successful use of bivalirudin in a patient who underwent complex cardiac surgery...
  33. ncbi request reprint Repair of ALCAPA in a 4-kg patient followed by successful weaning and "off-pump" explantation of an apical venting pulsatile LVAD
    Michael Huebler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
    J Card Surg 20:261-3. 2005
    ..The present case demonstrates successful weaning and complete removal of an apical venting pulsatile LVAD in a 4-kg infant without the employment of CPB...
  34. ncbi request reprint Consumption of blood products during mechanical circulatory support in children: comparison between ECMO and a pulsatile ventricular assist device
    Brigitte Stiller
    Department of Pediatric Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Intensive Care Med 30:1814-20. 2004
    ..We compared the coagulation disorders and the need for blood products in children treated either with extracorporeal membrane oxygenation (ECMO) or with the Berlin Heart pulsatile pneumatic ventricular assist device...
  35. ncbi request reprint Transfusion-free cardiopulmonary bypass in Jehovah's Witness patients weighing less than 5 kg
    Wolfgang Boettcher
    Department of Clinical Perfusion, Academy for Perfusion, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Extra Corpor Technol 37:282-5. 2005
    ..5 g/dL. The hemoglobin concentrations measured during CPB ranged from 5.9 to 6.5 g/dL, 6.4 to 6.8 g/dL, and 5.5 to 5.9 g/dL, respectively. The patients did not receive any blood or blood products during their entire hospital stay...
  36. pmc Transfusion-free cardiac reoperation in an 11-kg Jehovah's Witness child by use of a minimized cardiopulmonary bypass circuit
    Michael Huebler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum, D 13353 Berlin, Germany
    Tex Heart Inst J 34:108-11. 2007
    ..The goal of safe, transfusion-free surgery was achieved chiefly by minimizing the priming volume of the cardiopulmonary bypass circuit to 200 mL while providing adequate flow and standard safety features...
  37. ncbi request reprint Prognosis after the implantation of an intra-aortic balloon pump in cardiac surgery calculated with a new score
    Harald Hausmann
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Circulation 106:I203-6. 2002
    ..Nevertheless, indications for and timing of the implantation of a VAD in patients who have received an intra-aortic balloon pump (IABP) remain unclear...
  38. doi request reprint Experience with over 1000 implanted ventricular assist devices
    Evgenij V Potapov
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
    J Card Surg 23:185-94. 2008
    ..The use of ventricular assist devices (VADs) in patients with chronic end-stage or acute heart failure has led to improved survival. We present our experience since 1987...
  39. ncbi request reprint Transfusion-free cardiac surgery with cardiopulmonary bypass in a 2.2-kg neonate
    Michael Hubler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Card Surg 20:180-2. 2005
    ....
  40. doi request reprint Transfusion-free arterial switch operation in a 1.7-kg premature neonate using a new miniature cardiopulmonary bypass system
    Michael Huebler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
    J Card Surg 23:358-60. 2008
    ..Stringent improvement of these strategies, particularly the downsizing of the cardiopulmonary bypass system, have now enabled a transfusion-free arterial switch operation in a 1700-gram prematurely born neonate...
  41. ncbi request reprint Hybrid approach facilitates use of a minimized CPB circuit and transfusion free surgery in an extended Norwood stage II procedure
    Michael Huebler
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Card Surg 22:508-10. 2007
    ....
  42. ncbi request reprint The MicroMed DeBakey VAD--part II: Impact on the hemostatic systems
    Thomas Fischer
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    J Extra Corpor Technol 35:284-6. 2003
  43. ncbi request reprint The MicroMed DeBakey VAD--part I: The pump and the blood flow
    Evgenij V Potapov
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum, Berlin, Germany
    J Extra Corpor Technol 35:274-83. 2003
    ....
  44. ncbi request reprint Detection of lower torso ischemia by near-infrared spectroscopy during cardiopulmonary bypass in a 6.8-kg infant with complex aortic anatomy
    Mathias Redlin
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 82:323-5. 2006
    ..This shows that parallel near-infrared spectroscopy of the brain and the lower extremities may represent a novel non-invasive monitoring technique to ensure adequate cerebral and extracerebral perfusion during cardiopulmonary bypass...
  45. ncbi request reprint Perfusion technique for nonhaemic cardiopulmonary bypass prime in neonates and infants under 6 kg body weight
    Frank Merkle
    Academy for Perfusion, Deutsches Herzzentrum Berlin, Berlin, Germany
    Perfusion 19:229-37. 2004
    ..The degree of haemodilution and, thus, the requirements for blood transfusion may be reduced when the CPB circuit is miniaturized without compromising patient safety...
  46. ncbi request reprint Safe minimization of cardiopulmonary bypass circuit volume for complex cardiac surgery in a 3.7 kg neonate
    Wolfgang Boettcher
    Department of Perfusion, Deutsches Herzzentrum Berlin, Germany
    Perfusion 18:377-9. 2003
    ..We report on our efforts to minimize the CPB system and adjust the perfusion strategy to the goal of transfusion-free CPB in a 3.7 kg neonate scheduled for repair of transposition of the great arteries...
  47. ncbi request reprint Bloodless surgery of acute type A aortic dissection in a Jehovah's Witness patient
    Miralem Pasic
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 80:1507-10. 2005
    ..We combined the normothermic cross-clamping technique with a blood conservation strategy...
  48. doi request reprint Management of protamine allergy with bivalirudin during coronary artery revascularization
    Andreas Koster
    Department of Anesthesia, Herzzentrum Lahr Baden, Lahr, Germany
    Ann Thorac Surg 90:276-7. 2010
    ..Instead, complete coronary artery revascularization was successfully performed off-pump using bivalirudin as the anticoagulant...
  49. ncbi request reprint Effects of unfractionated heparin, low molecular weight heparin and r-hirudin on leukocyte adhesion in ischemia/reperfusion
    Helmut Habazettl
    Department of Physiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Blood Coagul Fibrinolysis 15:375-81. 2004
    ..This effect may contribute to the benefits of direct thrombin inhibitors seen in clinical studies after treatment for acute coronary syndromes...
  50. doi request reprint Inhaled milrinone attenuates experimental acute lung injury
    Moritz Bueltmann
    Department of Anesthesiology, German Heart Institute, Berlin, Germany
    Intensive Care Med 35:171-8. 2009
    ..To test whether inhalation of the phosphodiesterase 3 inhibitor milrinone may attenuate experimental acute lung injury (ALI)...
  51. ncbi request reprint Reduction of microemboli count in the priming fluid of cardiopulmonary bypass circuits
    Frank Merkle
    Academy for Perfusion, Department of Surgery, Deutsches Herzzentrum, Berlin, Germany
    J Extra Corpor Technol 35:133-8. 2003
    ..5 microm and 3 microm may be explained by a possible filtering capacity of membrane oxygenators. The 0.2 microm PBF is an effective tool to reduce the particle load in the CPB priming fluid...
  52. ncbi request reprint Factors influencing results and outcome after transmyocardial laser revascularization
    Thomas Krabatsch
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 73:1888-92. 2002
    ..Because this operation is associated with significant morbidity and mortality, it is important to select patients for TMR who are likely to benefit from the procedure...
  53. ncbi request reprint Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure
    Thomas Hentschel
    Department of Anesthesiology, German Heart Institute Berlin, Institute of Physiology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
    Anesthesiology 106:124-31. 2007
    ....
  54. doi request reprint Bivalirudin anticoagulation during cardiac surgery: a single-center experience in 141 patients
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Perfusion 24:7-11. 2009
    ..Recent problems associated with the production of heparin have emphasized the urgent need for an alternative for use beyond the limited indication of heparin-induced thrombocytopenia...
  55. ncbi request reprint Predictors of survival 1 hour after implantation of an intra-aortic balloon pump in cardiac surgery
    H Hausmann
    Deutsches Herzzentrum Berlin, Department of Cardiothoracic and Vascular Surgery, Germany
    J Card Surg 16:72-77; discussion 78. 2001
    ..In patients with low-output syndrome despite IABP support, implantation of a ventricular assist system should be considered...
  56. ncbi request reprint Pulsatile flow in patients with a novel nonpulsatile implantable ventricular assist device
    E V Potapov
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Circulation 102:III183-7. 2000
    ..To detect the flow in peripheral vessels, we measured transcranial Doppler signals in patients after implantation...
  57. ncbi request reprint Postoperative course of S-100B protein and neuron-specific enolase in patients after implantation of continuous and pulsatile flow LVADs
    E V Potapov
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Heart Lung Transplant 20:1310-6. 2001
    ....
  58. ncbi request reprint Correction of congenital heart defects in Jehovah's Witness children
    V Alexi-Meskishvili
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    Thorac Cardiovasc Surg 52:141-6. 2004
    ..6) and at discharge it was 7.1 - 14.5 g/dl (mean 15.5). No blood or blood products were used in any patient. CONCLUSION: Bloodless cardiac surgery with and without CPB can be safely performed in Jehovah's Witness infants and children...
  59. ncbi request reprint [Coronary artery bypass grafting in patients with highly impaired ventricular function. Long-term outcome]
    H Hausmann
    Abteilung für Herz, Thorax und Gefasschirurgie, Deutsches Herzzentrum Berlin, Germany
    Dtsch Med Wochenschr 127:2503-7. 2002
    ..In our study we investigated, how preoperative ventricular dysfunction influences long term survival after coronary bypass surgery...
  60. ncbi request reprint Floating nonocclusive thrombus in the ascending aorta
    Ralf Sodian
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 74:588-90. 2002
    ..In our judgment, a floating mass in the ascending aorta represents an emergency and should be removed before major thromboembolic complications occur...
  61. ncbi request reprint Transcranial detection of microembolic signals in patients with a novel nonpulsatile implantable LVAD
    E V Potapov
    Department of Cardiothoracic and Vascular Surgery, German Heart Institute, Berlin
    ASAIO J 47:249-53. 2001
    ..In one patient with preoperatively noted MES the prevalence of MES postoperatively was 50%. The high speed rotating impeller of the DeBakey VAD did not produce any detectable microthrombi or bubbles from cavitation effects...
  62. pmc The direct thrombin inhibitor argatroban: a review of its use in patients with and without HIT
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Biologics 1:105-12. 2007
    ..Additionally, data from clinical trials with argatroban use outside HIT, in more special indications such as in percutaneous coronary intervention, stroke, renal replacement therapy, and intensive care medicine, are reviewed...
  63. ncbi request reprint Autologous plasma and platelet sequestration at the beginning of cardiopulmonary bypass: a pilot investigation in five patients undergoing extended vascular surgery in deep hypothermia
    A Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    ASAIO J 48:106-9. 2002
    ..The data presented provide evidence that autologous plasma and platelet sequestration during CPB initiation is effective. The harvested material reveals a high platelet count and fibrinogen level and preserves functional integrity...
  64. ncbi request reprint Inflammatory response after implantation of a left ventricular assist device: comparison between the axial flow MicroMed DeBakey VAD and the pulsatile Novacor device
    M Loebe
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
    ASAIO J 47:272-4. 2001
    ..Further investigations are necessary for evaluation of the pathophysiologic mechanism and clinical implications of these findings...
  65. doi request reprint Specific p38 inhibition in stimulated endothelial cells: a possible new anti-inflammatory strategy after hypothermia and rewarming
    Antje Diestel
    Department of Pediatric Cardiology, Charite Universitaetsmedizin, Berlin, Germany
    Vascul Pharmacol 51:246-52. 2009
    ..Therefore inhibition of p38 or components of the p38 pathway could be a promising and selective antiinflammatory therapeutic target after hypothermic CPB...
  66. ncbi request reprint Bivalirudin: a review
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Expert Opin Pharmacother 6:1349-71. 2005
    ..Anecdotal 'off-label' experience for the treatment of heparin-induced thrombocytopenia shows promise...
  67. ncbi request reprint Impact of heparin management on release of tissue factor pathway inhibitor during cardiopulmonary bypass
    Thomas Fischer
    Anesthesiology 100:1040. 2004
  68. doi request reprint Bivalirudin
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster Unniversity, Hamilton, Ontario, L8L 2X2 Canada
    Thromb Haemost 99:830-9. 2008
    ....
  69. ncbi request reprint Preemptive use of bivalirudin for urgent on-pump coronary artery bypass grafting in patients with potential heparin-induced thrombocytopenia
    Cornelius M Dyke
    Department of Surgery and Anesthesiology, Gaston Memorial Hospital, Gastonia, North Carolina, USA
    Ann Thorac Surg 80:299-303. 2005
    ..The novel short-acting, direct-thrombin inhibitor bivalirudin is the only alternative to heparin/protamine being used in elective non-HIT patients during CPB...
  70. doi request reprint Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 237 Barton Street E, Hamilton, Ontario, Canada
    Chest 133:340S-380S. 2008
    ..For patients receiving VKAs at the time of diagnosis of HIT, we recommend use of vitamin K (10 mg po or 5 to 10 mg IV) [Grade 1C]...
  71. ncbi request reprint Case 1-2006: off-pump coronary artery bypass graft surgery anticoagulation with bivalirudin: a patient with heparin-induced thrombocytopenia syndrome type II and renal failure
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Health System, Richmond, VA 23298 0695, USA
    J Cardiothorac Vasc Anesth 20:106-11. 2006
  72. ncbi request reprint A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study
    Cornelius M Dyke
    Carolina Cardiovascular and Thoracic Surgery Associates, Gaston Memorial Hospital, Gastonia, NC 28056, USA
    J Thorac Cardiovasc Surg 131:533-9. 2006
    ..This trial was performed to evaluate the safety and efficacy of bivalirudin as an alternative to heparin with protamine reversal in on-pump cardiac surgery...
  73. ncbi request reprint Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study
    Nicholas G Smedira
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:686-92. 2006
    ..This trial was performed to evaluate the safety and efficacy of bivalirudin in off-pump coronary artery bypass grafting...
  74. doi request reprint Routine use of the direct thrombin inhibitor bivalirudin for off-pump coronary artery bypass grafting is safe and effective
    George J Palmer
    Florida Hospital Cardiovascular Institute, Orlando, Florida, USA
    Heart Surg Forum 11:E24-9. 2008
    ..This is evidenced by low hospital mortality and morbidity rates. Further follow-up is warranted to discern the influence of bivalirudin on long-term clinical outcomes...
  75. ncbi request reprint Sensitivity of a modified ACT test to levels of bivalirudin used during cardiac surgery
    Marcia L Zucker
    Clinical Affairs, ITC, Edison, New Jersey 07039, USA
    J Extra Corpor Technol 37:364-8. 2005
    ..The ACTT assay is sensitive to levels of bivalirudin and may offer a simple method for monitoring bivalirudin during cardiac surgery...
  76. ncbi request reprint Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies
    Cornelius M Dyke
    Department of Cardiovascular and Thoracic Surgery, Gaston Memorial Hospital, Gastonia, North Carolina 28054, USA
    Ann Thorac Surg 84:836-9. 2007
    ....
  77. ncbi request reprint Assessing errors in the determination of base excess
    Alexander Mentel
    Department of Anesthesiology and Intensive Care Medicine, Kraukenaustalten Gilead, Von Bodelschwinghsche Anstalten Bethel, Bielefeld, Germany
    Anesth Analg 94:1141-8, table of contents. 2002
    ..Comparison of the results from samples with different oxygen saturation showed that the relative alkalinity of deoxygenated hemoglobin (Haldane effect) can also influence the determinations of BE(ecf)...