Werner Koch

Summary

Affiliation: Deutsches Herzzentrum
Country: Germany

Publications

  1. ncbi request reprint TaqMan assays for genotyping of single nucleotide polymorphisms present at a disease susceptibility locus on chromosome 6
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Munich, Germany
    Clin Chem Lab Med 43:167-72. 2005
  2. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
  3. doi request reprint Interleukin 18 gene variation and risk of acute myocardial infarction
    Werner Koch
    Deutsches Herzzentrum Munchen, Munich, Germany
    Cytokine 56:786-91. 2011
  4. ncbi request reprint Genotyping of the angiotensin I-converting enzyme gene insertion/deletion polymorphism by the TaqMan method
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Chem 51:1547-9. 2005
  5. doi request reprint Fibrinogen genes and myocardial infarction: a haplotype analysis
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Munich, Germany
    Arterioscler Thromb Vasc Biol 28:758-63. 2008
  6. ncbi request reprint Tumor necrosis factor-alpha, lymphotoxin-alpha, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting
    Werner Koch
    Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Lazarettstrasse 36, D 80636 Munich, Germany
    Cytokine 24:161-71. 2003
  7. ncbi request reprint Haptoglobin gene subtyping by restriction enzyme analysis
    Werner Koch
    Deutsches Herzzentrum Munchen, Technische Universitat Munchen, D 80636 München, Germany
    Clin Chem 49:1937-40. 2003
  8. doi request reprint Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence
    Werner Koch
    Deutsches Herzzentrum Munchen, 80636 Munich, Germany
    Hum Mol Genet 17:1120-6. 2008
  9. ncbi request reprint Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries
    Werner Koch
    Deutsches Herzzentrum Munchen, Experimentelle Kardiologie, Lazarettstrasse 36, D 80636 München, Germany
    Arterioscler Thromb Vasc Biol 23:2229-34. 2003
  10. ncbi request reprint Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans
    Werner Koch
    Deutsches Herzzentrum Munchen, 80636 Munich, Germany
    Hum Mol Genet 16:1821-7. 2007

Collaborators

Detail Information

Publications63

  1. ncbi request reprint TaqMan assays for genotyping of single nucleotide polymorphisms present at a disease susceptibility locus on chromosome 6
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Munich, Germany
    Clin Chem Lab Med 43:167-72. 2005
    ..The new TaqMan systems provide relatively simple and fast assays to test the clinical relevance of these polymorphisms...
  2. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
    ..We investigated the association of 9p21.3 variants with severity of CAD (defined by the number of vessel diseased [VD]) in the presence and absence of T2D...
  3. doi request reprint Interleukin 18 gene variation and risk of acute myocardial infarction
    Werner Koch
    Deutsches Herzzentrum Munchen, Munich, Germany
    Cytokine 56:786-91. 2011
    ..22). These observations suggest that the interleukin 18 gene is a susceptibility locus for acute myocardial infarction, a finding of potential interest in the clinical practice...
  4. ncbi request reprint Genotyping of the angiotensin I-converting enzyme gene insertion/deletion polymorphism by the TaqMan method
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Chem 51:1547-9. 2005
  5. doi request reprint Fibrinogen genes and myocardial infarction: a haplotype analysis
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Munich, Germany
    Arterioscler Thromb Vasc Biol 28:758-63. 2008
    ..We examined the association of haplotypes in the 50-kb fibrinogen gene region with myocardial infarction in 2 large case-control samples...
  6. ncbi request reprint Tumor necrosis factor-alpha, lymphotoxin-alpha, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting
    Werner Koch
    Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Lazarettstrasse 36, D 80636 Munich, Germany
    Cytokine 24:161-71. 2003
    ..In conclusion, functionally relevant polymorphisms of the genes for TNF-alpha, LT-alpha, and IL-10 do not represent genetic markers indicating the risk of restenosis, death, or MI after coronary stenting...
  7. ncbi request reprint Haptoglobin gene subtyping by restriction enzyme analysis
    Werner Koch
    Deutsches Herzzentrum Munchen, Technische Universitat Munchen, D 80636 München, Germany
    Clin Chem 49:1937-40. 2003
  8. doi request reprint Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence
    Werner Koch
    Deutsches Herzzentrum Munchen, 80636 Munich, Germany
    Hum Mol Genet 17:1120-6. 2008
    ..Thus, despite associations in certain individual studies, the synthesis of available evidence did not suggest that the TSP polymorphisms included in this study were associated with MI...
  9. ncbi request reprint Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries
    Werner Koch
    Deutsches Herzzentrum Munchen, Experimentelle Kardiologie, Lazarettstrasse 36, D 80636 München, Germany
    Arterioscler Thromb Vasc Biol 23:2229-34. 2003
    ....
  10. ncbi request reprint Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans
    Werner Koch
    Deutsches Herzzentrum Munchen, 80636 Munich, Germany
    Hum Mol Genet 16:1821-7. 2007
    ..98, 95% CI 0.83-1.16; P = 0.84). Our finding that protective effects are linked with minor homozygous genotypes and haplotype 1 of the BAT1-NFKBIL1-LTA region in Europeans is opposite to the observation of associated risks in Japanese...
  11. ncbi request reprint Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population
    Werner Koch
    Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 München, Germany
    Eur Heart J 27:2524-9. 2006
    ....
  12. ncbi request reprint No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Genet Med 9:123-9. 2007
    ..We sought to replicate these association findings in a large case-control sample from Germany...
  13. ncbi request reprint Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Lipid Res 45:2221-6. 2004
    ....
  14. ncbi request reprint Association of transforming growth factor-beta1 gene polymorphisms with myocardial infarction in patients with angiographically proven coronary heart disease
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Arterioscler Thromb Vasc Biol 26:1114-9. 2006
    ..We investigated whether the -509C/T (rs1800469), 868T/C (rs1982073), 913G/C (rs1800471), and 11929C/T (rs1800472) polymorphisms of TGFB1 are associated with myocardial infarction...
  15. ncbi request reprint No replication of association between estrogen receptor alpha gene polymorphisms and susceptibility to myocardial infarction in a large sample of patients of European descent
    Werner Koch
    Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 Munich, Germany
    Circulation 112:2138-42. 2005
    ..To test these findings, we examined the relationship of the polymorphisms to myocardial infarction in a large sample of white patients and control individuals of predominantly European descent...
  16. ncbi request reprint Angiotensin I-converting enzyme (ACE) inhibitors and restenosis after coronary artery stenting in patients with the DD genotype of the ACE gene
    Werner Koch
    Deutsches Herzzentrum Munchen, Experimentelle Kardiologie, Technische Universitat Munchen, Lazarettstrasse 36, D 80636 Munich, Germany
    J Am Coll Cardiol 41:1957-61. 2003
    ....
  17. doi request reprint Variations of specific non-candidate genes and risk of myocardial infarction: a replication study
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Cardiol 147:38-41. 2011
    ..The genes encode the cytoskeletal protein palladin (PALLD), a receptor tyrosine kinase (ROS1), a taste receptor (TAS2R50), an olfactory receptor (OR13G1), and a zinc finger protein (ZNF627)...
  18. doi request reprint Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: case-control study and a meta-analysis
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, Munich, Germany
    Atherosclerosis 208:171-6. 2010
    ....
  19. doi request reprint Extended evidence for association between the melanoma inhibitory activity 3 gene and myocardial infarction
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Thromb Haemost 105:670-5. 2011
    ..In addition to correspond with such isolated evidence of association with MI, the present study identified specific haplotypes capturing the risk-related variation in the entire MIA3 region...
  20. doi request reprint The chromosome 9p21 region and myocardial infarction in a European population
    Werner Koch
    Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 Munich, Germany
    Atherosclerosis 217:220-6. 2011
    ....
  21. ncbi request reprint Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction
    W Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Atherosclerosis 159:137-44. 2001
    ....
  22. ncbi request reprint Association of a CD18 gene polymorphism with a reduced risk of restenosis after coronary stenting
    W Koch
    Deutsches Herzzentrum Munchen, Munich, Germany
    Am J Cardiol 88:1120-4. 2001
    ..This finding suggests that Mac-1 is involved in the development of restenosis after coronary stent placement...
  23. ncbi request reprint CD14 gene -159C/T polymorphism is not associated with coronary artery disease and myocardial infarction
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Germany
    Am Heart J 143:971-6. 2002
    ..We assessed the possibility that a C --> T nucleotide substitution polymorphism in the promoter (position -159) of the gene encoding CD14 constitutes a risk factor for CAD and MI...
  24. ncbi request reprint Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR
    Werner Koch
    Deutsches Herzzentrum Munchen, Experimentelle Kardiologie, Lazarettstrasse 36, D 80636 Munich, Germany
    Clin Chem 48:1377-82. 2002
    ..To enable the use of DNA samples for the study of this polymorphism, we established a haptoglobin genotyping method based on PCR...
  25. ncbi request reprint TaqMan systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Munchen, Germany
    Clin Chem Lab Med 40:1123-31. 2002
    ..6%, epsilon3epsilon3 = 61.3%, epsilon3epsilon4 = 23.1%, and epsilon4epsilon4 = 1.9% (p = 0.014). The TaqMan assays allow for fast and sensitive genotyping and are especially suitable for studies including large numbers of participants...
  26. doi request reprint 4G/5G polymorphism and haplotypes of SERPINE1 in atherosclerotic diseases of coronary arteries
    Werner Koch
    Deutsches Herzzentrum Munchen, 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Thromb Haemost 103:1170-80. 2010
    ....
  27. doi request reprint Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    Dirk Sibbing
    Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 München, Germany
    Circulation 121:512-8. 2010
    ..The aim of this study was to assess the impact of CYP2C19*17 on ADP-induced platelet aggregation, the risk of bleeding, and stent thrombosis in clopidogrel-treated patients undergoing percutaneous coronary intervention...
  28. doi request reprint No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents
    Petra Hoppmann
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    JACC Cardiovasc Interv 2:1149-55. 2009
    ..3 is a genetic factor for coronary heart disease, we investigated whether this locus influenced the clinical and angiographic outcomes after implantation of drug-eluting stents in coronary arteries...
  29. doi request reprint No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting
    Juliane Jaitner
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circ Cardiovasc Interv 5:82-8, S1-2. 2012
    ....
  30. ncbi request reprint Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease
    Klaus Kölling
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar der Technischen, Universität Munich, Lazarettstrasse 36, 80636 Munich, Germany
    Am J Cardiol 93:1201-6. 2004
    ..Although there is an apparent association between elevated levels of homocysteine and CAD, this association is not independent of conventional cardiovascular risk factors...
  31. doi request reprint No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting
    Dirk Sibbing
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, Munich, Germany
    Eur Heart J 32:1605-13. 2011
    ..The aim of this study was to assess the impact of the PON1 Q192R genotype in parallel to that of CYP2C19*2 on the antiplatelet effect of clopidogrel and the risk of ST in clopidogrel-treated patients...
  32. ncbi request reprint Circulating homocysteine levels in patients with type 2 diabetes mellitus
    Gjin Ndrepepa
    Klinik für Herz und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 Munich, Germany
    Nutr Metab Cardiovasc Dis 18:66-73. 2008
    ..Previous studies have shown conflicting results regarding circulating homocysteine levels in patients with type 2 diabetes...
  33. doi request reprint Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events
    Klaus A Tiroch
    Deutsches Herzzentrum Munchen, Rechts der Isar, Technische Universitat, Germany
    Am Heart J 160:506-12. 2010
    ..Reduced-function alleles have been associated with an increase in cardiovascular events...
  34. ncbi request reprint 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and risk of restenosis after coronary artery stenting
    Corinna Böttiger
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Am Heart J 146:855-61. 2003
    ..Transcription, level, and activity of PAI-1 are influenced by the 4G/5G polymorphism in the promoter region of PAI-1 gene. The polymorphism may therefore affect wound-healing processes in injured blood vessels and influence restenosis...
  35. ncbi request reprint G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease
    Nicolas von Beckerath
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Lazarettstr 36, Germany
    Atherosclerosis 167:135-9. 2003
    ..The strongest association was observed between T allele carriage and three-vessel disease (unadjusted OR 1.47 [95% CI, 1.10-1.96]). Thus, carrying this allele is associated with the presence as well as the severity of CAD...
  36. doi request reprint Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
    Dirk Sibbing
    Department of Cardiology, Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur Heart J 30:916-22. 2009
    ..The aim of this study was to assess the impact of the CYP2C19 681G>A loss-of-function polymorphism on ST following PCI performed after pre-treatment with clopidogrel...
  37. ncbi request reprint A prospective cohort study of predictive value of homocysteine in patients with type 2 diabetes and coronary artery disease
    Gjin Ndrepepa
    Klinik für Herz und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 Munich, Germany
    Clin Chim Acta 373:70-6. 2006
    ..The aim of this study was to investigate whether elevated plasma homocysteine levels are independently associated with all-cause or cardiovascular mortality in patients with type 2 diabetes and coronary artery disease...
  38. ncbi request reprint Plasminogen activator inhibitor-1 4G/5G polymorphism and efficacy of reperfusion therapy in acute myocardial infarction
    Dirk Sibbing
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Blood Coagul Fibrinolysis 16:511-5. 2005
    ..The PAI-1 4G/5G polymorphism has no impact on the amount of myocardial salvage achieved by reperfusion with stenting or thrombolysis in patients with AMI...
  39. ncbi request reprint Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement
    Olga Gorchakova
    Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Lazarettstrasse 36, 80636 München, Germany
    Eur Heart J 24:820-7. 2003
    ..We investigated the possibility that the 894 TT genotype has an unfavorable impact on the angiographic and clinical outcome after the placement of stents in coronary arteries...
  40. ncbi request reprint PlA polymorphism of the glycoprotein IIIa and efficacy of reperfusion therapy in patients with acute myocardial infarction
    Olga Gorchakova
    Deutsches Herzzentrum, I Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Thromb Haemost 91:141-5. 2004
    ..Thus, these findings show that the functional Pl(A) polymorphism of platelet glycoprotein IIIa has no influence on the degree of myocardial salvage achieved by reperfusion therapies in patients with acute myocardial infarction...
  41. ncbi request reprint Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting
    Klaus Tiroch
    Deutsches Herzzentrum Munchen, 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, München D 80636, Germany
    Eur Heart J 28:968-73. 2007
    ..We evaluated, whether an association existed between this polymorphism and the incidence of restenosis after coronary stenting...
  42. ncbi request reprint ABO locus O1 allele and risk of myocardial infarction
    Nicolas von Beckerath
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Blood Coagul Fibrinolysis 15:61-7. 2004
    ..00003) in a separate control group (n = 164). Carriage of the O1 allele is associated with a decreased risk of myocardial infarction, with homozygosity providing the greatest protection...
  43. ncbi request reprint P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose
    Nicolas von Beckerath
    Deutsches Herzzentrum, Technische Universitat Munchen, Lazarettstrasse 36, 80636 Munich, Germany
    Blood Coagul Fibrinolysis 16:199-204. 2005
    ..9 +/- 21.4 versus 43.2 +/- 21.1%, respectively; P = 0.77). Carriage of P2Y12 H2 haplotype does not seem to affect the platelet response to a 600 mg loading dose of clopidogrel in coronary artery disease patients prior to stenting...
  44. doi request reprint Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene
    Werner Koch
    Deutsches Herzzentrum Munchen, Munich, Germany
    Ann Hum Genet 77:47-55. 2013
    ..Thus, the findings allowed for a more precise definition of risk-associated markers: specific nucleotides in LPA instead of standard haplotypes defined by noneffective variants from the extensive SLC22A3-LPAL2-LPA region...
  45. ncbi request reprint The 5A/6A polymorphism of the stromelysin-1 gene and restenosis after percutaneous coronary interventions
    Petra Hoppmann
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Eur Heart J 25:335-41. 2004
    ..We examined the possibility that the 5A/6A promoter polymorphism of the stromelysin-1 gene is associated with restenosis after stenting or percutaneous transluminal coronary angioplasty (PTCA)...
  46. ncbi request reprint C825T polymorphism of the G-protein beta3 subunit gene and atrial fibrillation: association of the TT genotype with a reduced risk for atrial fibrillation
    Juergen Schreieck
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am Heart J 148:545-50. 2004
    ..Therefore, we investigated a possible impact of the GNB3 C825T polymorphism on atrial fibrillation in an association study...
  47. ncbi request reprint Tissue factor promotor polymorphism -603 A/G is associated with myocardial infarction
    Ilka Ott
    Deutsches Herzzentrum und 1, Medizinische Klinik der Technischen Universität, Lazarettstr 36, 80636 München, Germany
    Atherosclerosis 177:189-91. 2004
    ..Carriage of the -603 G allele is associated with an increased risk for myocardial infarction. Because higher plasma TF concentrations are found in -603 G carriers enhanced TF expression may be the mechanism underlying this association...
  48. ncbi request reprint Interferon-gamma and interferon-gamma receptor 1 and 2 gene polymorphisms and restenosis following coronary stenting
    K Tiroch
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Atherosclerosis 182:145-51. 2005
    ..61). Thus, this study does not support a clinically relevant role of the studied polymorphisms in the processes leading to in-stent restenosis...
  49. ncbi request reprint Glycoprotein Ia C807T polymorphism and risk of restenosis following coronary stenting
    N von Beckerath
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Lazarettstr 36, 80636, Munich, Germany
    Atherosclerosis 156:463-8. 2001
    ..6% for CC, 21.7% for CT and 21.2% for TT patients (P=0.98). Thus, carriage of the GP Ia T807 allele is not associated with an increased risk of restenosis or unfavorable late outcome following coronary artery stenting...
  50. ncbi request reprint Glycoprotein Ia gene C807T polymorphism and risk for major adverse cardiac events within the first 30 days after coronary artery stenting
    N von Beckerath
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Blood 95:3297-301. 2000
    ..15 (0.76-1.75). Therefore, C807T genotype has no significant influence on the major adverse events occurring after coronary artery stenting...
  51. ncbi request reprint G protein beta3 subunit polymorphism and risk of thrombosis and restenosis following coronary stent placement
    N von Beckerath
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Lazarettstr 36, 80636, Munich, Germany
    Atherosclerosis 149:151-5. 2000
    ..4% CC, 44.6% CT, 10.0% TT; P = 0.644). In conclusion, C825T polymorphism has no appreciable impact on the mechanisms leading to thrombosis and restenosis following coronary stent placement...
  52. ncbi request reprint PlA polymorphism of platelet glycoprotein IIIa and risk of restenosis after coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 99:1005-10. 1999
    ..We designed this prospective study to test the hypothesis that PlA polymorphism of glycoprotein IIIa is associated with an increased risk for restenosis after coronary stent placement...
  53. ncbi request reprint Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells
    M Gawaz
    Medizinische Klinik und Deutsches Herzzentrum and Institut für klinische Chemie und Pathobiologie, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    Circulation 98:1164-71. 1998
    ..The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed...
  54. ncbi request reprint PlA polymorphism of glycoprotein IIIa and risk of adverse events after coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 36:84-9. 2000
    ..We designed this prospective study to test the hypothesis that platelet antigen (PlA) polymorphism of glycoprotein (GP) IIIa is associated with an increased risk for adverse events after coronary stent placement...
  55. ncbi request reprint Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting
    A Kastrati
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 36:2168-73. 2000
    ..To test the hypothesis that interleukin-1 receptor antagonist (IL-1ra) gene polymorphism contributes to the risk of restenosis after coronary stenting...
  56. ncbi request reprint Previous cytomegalovirus infection and restenosis after coronary stent placement
    F J Neumann
    1. Medizinische Klinik, Deutsches Herzzentrum, , Immunologie und Hygiene, , Munich, Germany
    Circulation 104:1135-9. 2001
    ..78 [0.52 to 1.19]). CONCLUSIONS: Previous cytomegalovirus infection does not carry an increased risk of restenosis after stenting...
  57. doi request reprint P27 and P53 gene polymorphisms and restenosis following coronary implantation of drug-eluting stents
    K Tiroch
    Deutsches Herzzentrum Munchen, Munchen, Germany
    Cardiology 112:263-9. 2009
    ..We hypothesized that genetic variants of P27 and P53 influence the development of restenosis and the clinical outcome of patients receiving DES...
  58. ncbi request reprint Induction of cytokine expression in leukocytes in acute myocardial infarction
    N Marx
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 30:165-70. 1997
    ..This study sought to investigate whether cytokine expression in leukocytes may be induced by plasma from the reperfused heart of patients with an acute myocardial infarction (MI)...
  59. ncbi request reprint Leucine 7 to proline 7 polymorphism of the preproneuropeptide Y gene is not associated with restenosis after coronary stenting
    Ullamari Pesonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, PharmaCity, Turku, Finland
    J Endovasc Ther 10:566-72. 2003
    ..The Pro7 allele of the preproNPY gene affects the plasma levels of human neuropeptide Y, a potent mitogen of vascular smooth muscle cells...
  60. ncbi request reprint Apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphism and myocardial infarction: case-control study in a large population sample
    Werner Koch
    Int J Cardiol 125:116-7. 2008
    ..The epsilon2 allele and epsilon2epsilon3 genotype showed trends towards lower risks of myocardial infarction than the epsilon3epsilon3 genotype...
  61. ncbi request reprint Glycoprotein VI polymorphisms and outcome after percutaneous coronary interventions
    Corinna Boettiger
    Thromb Haemost 97:673-4. 2007
  62. ncbi request reprint Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension
    Andreas Lazar
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Clin Exp Hypertens 28:645-53. 2006
    ..This study further suggests a function of OCT2 in blood pressure homeostasis and points to the potential role of the transporter in the development of essential hypertension...
  63. ncbi request reprint Haptoglobin genotype is predictive of major adverse cardiac events in the 1-year period after percutaneous transluminal coronary angioplasty in individuals with diabetes
    Ariel Roguin
    Technion Israel Institute of Technology, Haifa, Israel
    Diabetes Care 26:2628-31. 2003
    ..The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes...