Adnan Kastrati

Summary

Affiliation: Deutsches Herzzentrum
Country: Germany

Publications

  1. doi request reprint Two zotarolimus-eluting stent generations: a meta-analysis of 12 randomised trials versus other limus-eluting stents and an adjusted indirect comparison
    Salvatore Cassese
    Deutsches Herzzentrum, Technische Universitat, Lazaretstr 36, Munich 80636, Germany
    Heart 98:1632-40. 2012
  2. doi request reprint New anti-platelet agents: the end of resistance?
    Adnan Kastrati
    German Heart Center Munich, Cardiology Department, Munich, Germany
    Thromb Res 130:S53-5. 2012
  3. doi request reprint Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention
    Gjin Ndrepepa
    Deutsches Herzzentrum, Lazarettstrasse 36, Munich, Germany
    Circulation 125:1424-31. 2012
  4. ncbi request reprint Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Lancet 359:920-5. 2002
  5. ncbi request reprint Early administration of reteplase plus abciximab vs abciximab alone in patients with acute myocardial infarction referred for percutaneous coronary intervention: a randomized controlled trial
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JAMA 291:947-54. 2004
  6. ncbi request reprint Meta-analysis of randomized trials on drug-eluting stents vs. bare-metal stents in patients with acute myocardial infarction
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Lazarettstr 36, Munich 80636, Germany
    Eur Heart J 28:2706-13. 2007
  7. ncbi request reprint Bivalirudin versus unfractionated heparin during percutaneous coronary intervention
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 359:688-96. 2008
  8. ncbi request reprint Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 356:1030-9. 2007
  9. doi request reprint Abciximab and heparin versus bivalirudin for non-ST-elevation myocardial infarction
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 365:1980-9. 2011
  10. ncbi request reprint Sirolimus-eluting stents vs paclitaxel-eluting stents in patients with coronary artery disease: meta-analysis of randomized trials
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JAMA 294:819-25. 2005

Collaborators

Detail Information

Publications149 found, 100 shown here

  1. doi request reprint Two zotarolimus-eluting stent generations: a meta-analysis of 12 randomised trials versus other limus-eluting stents and an adjusted indirect comparison
    Salvatore Cassese
    Deutsches Herzzentrum, Technische Universitat, Lazaretstr 36, Munich 80636, Germany
    Heart 98:1632-40. 2012
    ..To evaluate efficacy and safety of two zotarolimus-eluting stent generations versus other limus-eluting stents (LES), and to compare Resolute zotarolimus-eluting stents (R-ZES) with Endeavor zotarolimus-eluting stents (E-ZES)...
  2. doi request reprint New anti-platelet agents: the end of resistance?
    Adnan Kastrati
    German Heart Center Munich, Cardiology Department, Munich, Germany
    Thromb Res 130:S53-5. 2012
    ....
  3. doi request reprint Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention
    Gjin Ndrepepa
    Deutsches Herzzentrum, Lazarettstrasse 36, Munich, Germany
    Circulation 125:1424-31. 2012
    ....
  4. ncbi request reprint Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Lancet 359:920-5. 2002
    ..We compared two strategies, stenting and fibrinolysis, both combined with abciximab, in terms of their ability to salvage myocardium in patients with acute myocardial infarction...
  5. ncbi request reprint Early administration of reteplase plus abciximab vs abciximab alone in patients with acute myocardial infarction referred for percutaneous coronary intervention: a randomized controlled trial
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JAMA 291:947-54. 2004
    ..The optimal pharmacological strategy for bridging the delay between admission and performance of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) is not known...
  6. ncbi request reprint Meta-analysis of randomized trials on drug-eluting stents vs. bare-metal stents in patients with acute myocardial infarction
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Lazarettstr 36, Munich 80636, Germany
    Eur Heart J 28:2706-13. 2007
    ..To compare the efficacy and safety of drug-eluting stents vs. bare-metal stents in patients with acute ST-segment elevation myocardial infarction...
  7. ncbi request reprint Bivalirudin versus unfractionated heparin during percutaneous coronary intervention
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 359:688-96. 2008
    ..Whether bivalirudin is superior to unfractionated heparin in patients with stable or unstable angina who undergo percutaneous coronary intervention (PCI) after pretreatment with clopidogrel is unknown...
  8. ncbi request reprint Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 356:1030-9. 2007
    ..The long-term effects of treatment with sirolimus-eluting stents, as compared with bare-metal stents, have not been established...
  9. doi request reprint Abciximab and heparin versus bivalirudin for non-ST-elevation myocardial infarction
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 365:1980-9. 2011
    ..We compared the two treatments in this patient population...
  10. ncbi request reprint Sirolimus-eluting stents vs paclitaxel-eluting stents in patients with coronary artery disease: meta-analysis of randomized trials
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JAMA 294:819-25. 2005
    ..Whether there are any differences in efficacy and safety between these 2 drug-eluting stents is unclear...
  11. ncbi request reprint Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JAMA 295:1531-8. 2006
    ....
  12. ncbi request reprint Sirolimus-eluting stent or paclitaxel-eluting stent vs balloon angioplasty for prevention of recurrences in patients with coronary in-stent restenosis: a randomized controlled trial
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JAMA 293:165-71. 2005
    ..It is less clear whether drug-eluting stents are superior to conventional balloon angioplasty for the treatment of patients with in-stent restenosis...
  13. ncbi request reprint Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy
    Adnan Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar Technische Universität, Munich, Germany
    Circulation 110:1916-9. 2004
    ..We performed a comparative assessment of the antiplatelet effects of a 600-mg loading dose of clopidogrel given to patients with and without chronic clopidogrel therapy...
  14. ncbi request reprint A European multicentre, randomised study of the MAR-Tyn cobalt chromium tin-coated stent in patients with de novo coronary artery lesions: study design and protocol
    Adnan Kastrati
    Department of Cardiology, Herzzentrum Munich, Germany
    EuroIntervention 5:976-80. 2010
    ..The aim of this randomised study is to evaluate the efficacy and safety of a new bare metal stents (BMS) with thin struts and a novel passive coating as compared to current standard BMS...
  15. ncbi request reprint A randomized trial comparing myocardial salvage achieved by coronary stenting versus balloon angioplasty in patients with acute myocardial infarction considered ineligible for reperfusion therapy
    Adnan Kastrati
    Deutsches Herzzentrum, Munich, Germany
    J Am Coll Cardiol 43:734-41. 2004
    ..We assessed myocardial salvage achieved by reperfusion with percutaneous coronary interventions (PCI) and compared stenting with balloon angioplasty (PTCA) in patients with acute myocardial infarction (AMI) ineligible for thrombolysis...
  16. ncbi request reprint Interlesion dependence of the risk for restenosis in patients with coronary stent placement in in multiple lesions
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 97:2396-401. 1998
    ..Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions...
  17. ncbi request reprint Predictive factors of restenosis after coronary implantation of sirolimus- or paclitaxel-eluting stents
    Adnan Kastrati
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Circulation 113:2293-300. 2006
    ..The efficacy of drug-eluting stents in reducing restenosis risk has not been uniform across patient subsets. Identifying predictive factors of restenosis may help improve outcomes after percutaneous coronary interventions...
  18. ncbi request reprint Operator volume and outcome of patients undergoing coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 32:970-6. 1998
    ..The aim of this study was to assess the relation between operator experience in coronary stent placement procedures and the clinical outcome of patients...
  19. ncbi request reprint PlA polymorphism of platelet glycoprotein IIIa and risk of restenosis after coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 99:1005-10. 1999
    ..We designed this prospective study to test the hypothesis that PlA polymorphism of glycoprotein IIIa is associated with an increased risk for restenosis after coronary stent placement...
  20. ncbi request reprint Influence of lesion length on restenosis after coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Cardiol 83:1617-22. 1999
    ..The results of this study suggest that a possible way to reduce the risk is to cover the lesion with a minimal number of nonoverlapping stents...
  21. ncbi request reprint Prognostic value of the modified american college of Cardiology/American heart association stenosis morphology classification for long-term angiographic and clinical outcome after coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 100:1285-90. 1999
    ..Lesion morphology is able to influence the restenosis process and thus the entire 1-year clinical course of these patients...
  22. ncbi request reprint Primary intracoronary stenting in acute myocardial infarction: long-term clinical and angiographic follow-up and risk factor analysis
    A Kastrati
    Deutsches Herzzentrum and Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Germany
    Am Heart J 139:208-16. 2000
    ..The aim of this study was to analyze the long-term clinical and angiographic follow-up of patients treated with primary intracoronary stenting and to identify the predictive factors of an adverse outcome...
  23. ncbi request reprint Genetic risk factors and restenosis after percutaneous coronary interventions
    A Kastrati
    Deutsches Herzzentrum Munchen
    Herz 25:34-46. 2000
    ..The results of this research will have considerable pathophysiological and therapeutical implications for the battle against restenosis...
  24. ncbi request reprint Increased risk of restenosis after placement of gold-coated stents: results of a randomized trial comparing gold-coated with uncoated steel stents in patients with coronary artery disease
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar der Technischen Universität, Munich, Germany
    Circulation 101:2478-83. 2000
    ..In this randomized trial, we assessed whether gold-coated stents were associated with a better clinical and angiographic outcome after coronary placement...
  25. ncbi request reprint Influence of stent design on 1-year outcome after coronary stent placement: a randomized comparison of five stent types in 1,147 unselected patients
    A Kastrati
    Deutsches Herzzentrum, Munchen, Germany
    Catheter Cardiovasc Interv 50:290-7. 2000
    ..01 +/- 0.70 mm to 1.20 +/- 0.82 mm (P = 0.085), and the incidence of restenosis varied between 25.3% and 35.9% (P = 0.145). Thus, stent design has a significant impact on the long-term results after coronary stent placement...
  26. ncbi request reprint PlA polymorphism of glycoprotein IIIa and risk of adverse events after coronary stent placement
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 36:84-9. 2000
    ..We designed this prospective study to test the hypothesis that platelet antigen (PlA) polymorphism of glycoprotein (GP) IIIa is associated with an increased risk for adverse events after coronary stent placement...
  27. ncbi request reprint A randomized trial comparing stenting with balloon angioplasty in small vessels in patients with symptomatic coronary artery disease. ISAR-SMART Study Investigators. Intracoronary Stenting or Angioplasty for Restenosis Reduction in Small Arteries
    A Kastrati
    Deutsches Herzzentrum, Lazarettstr 36, 80636 M nchen, Germany
    Circulation 102:2593-8. 2000
    ..The objective of this randomized trial was to assess whether compared with PTCA, stenting of small coronary vessels is associated with a reduction of restenosis...
  28. ncbi request reprint Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting
    A Kastrati
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 36:2168-73. 2000
    ..To test the hypothesis that interleukin-1 receptor antagonist (IL-1ra) gene polymorphism contributes to the risk of restenosis after coronary stenting...
  29. ncbi request reprint Restenosis after coronary placement of various stent types
    A Kastrati
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, and Institut für Medizinische Statistik und Epidemiologie KU, Technische Universitat, Munich, Germany
    Am J Cardiol 87:34-9. 2001
    ..Among these factors, stent design appears to play a particularly important role in the hyperplastic response of the vessel wall...
  30. ncbi request reprint Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO) trial
    A Kastrati
    Deutsches Herzzentrum, Munich, Germany
    Circulation 103:2816-21. 2001
    ..The objective of this randomized, multicenter study was to assess whether a reduced strut thickness of coronary stents is associated with improved follow-up angiographic and clinical results...
  31. ncbi request reprint A clinical trial of abciximab in elective percutaneous coronary intervention after pretreatment with clopidogrel
    Adnan Kastrati
    Deutsches Herzzentrum, Munich, Germany
    N Engl J Med 350:232-8. 2004
    ..Whether the glycoprotein IIb/IIIa inhibitor abciximab is beneficial in patients undergoing elective percutaneous coronary intervention after pretreatment with clopidogrel is unknown...
  32. ncbi request reprint Inflammatory response after intervention assessed by serial C-reactive protein measurements correlates with restenosis in patients treated with coronary stenting
    Alban Dibra
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat, Munich, Germany
    Am Heart J 150:344-50. 2005
    ....
  33. ncbi request reprint N-terminal probrain natriuretic peptide and C-reactive protein in stable coronary heart disease
    Gjin Ndrepepa
    Klinik für Herz und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, Munich, Germany
    Am J Med 119:355.e1-8. 2006
    ..The aim of the study was to investigate whether combined use of NT-proBNP and CRP improves risk stratification in these patients...
  34. ncbi request reprint Bivalirudin reduces platelet and monocyte activation after elective percutaneous coronary intervention
    Gabriele Busch
    Deutsches Herzzentrum, Lazarettstrasse 36, 80636 Munich, Germany
    Thromb Haemost 101:340-4. 2009
    ..In conclusion, our data suggest that bivalirudin may reduce platelet and monocyte activation in patients undergoing elective PCI. Thereby, bivalirudin might reduce periinterventional thrombotic complications...
  35. doi request reprint Clopidogrel response status assessed with Multiplate point-of-care analysis and the incidence and timing of stent thrombosis over six months following coronary stenting
    Dirk Sibbing
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Lazarettstrasse 36, 80636 München, Germany
    Thromb Haemost 103:151-9. 2010
    ..In the majority of clopidogrel low responders suffering ST, the ischaemic event occurs early in the course after the procedure...
  36. doi request reprint Prognostic value of a high on-clopidogrel treatment platelet reactivity in bivalirudin versus abciximab treated non-ST-segment elevation myocardial infarction patients. ISAR-REACT 4 (Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action fo
    Dirk Sibbing
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstrasse36, Munich, Germany
    J Am Coll Cardiol 60:369-77. 2012
    ....
  37. ncbi request reprint 2-year clinical and angiographic outcomes from a randomized trial of polymer-free dual drug-eluting stents versus polymer-based Cypher and Endeavor [corrected] drug-eluting stents
    Robert A Byrne
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    J Am Coll Cardiol 55:2536-43. 2010
    ..The aim of the current study was to investigate the comparative clinical and angiographic effectiveness of SES, Dual-DES, and ZES between 1 and 2 years...
  38. ncbi request reprint Predictive value of basal C-reactive protein levels for myocardial salvage in patients with acute myocardial infarction is dependent on the type of reperfusion treatment
    Alban Dibra
    Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Eur Heart J 24:1128-33. 2003
    ..To evaluate whether C-reactive protein (CRP) levels on admission are predictive of myocardial salvage achieved with different reperfusion strategies in patients with acute myocardial infarction (AMI)...
  39. doi request reprint Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    Dirk Sibbing
    Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 München, Germany
    Circulation 121:512-8. 2010
    ..The aim of this study was to assess the impact of CYP2C19*17 on ADP-induced platelet aggregation, the risk of bleeding, and stent thrombosis in clopidogrel-treated patients undergoing percutaneous coronary intervention...
  40. ncbi request reprint Impact of diabetes mellitus on long-term outcomes in the drug-eluting stent era
    Raisuke Iijima
    Deutsches Herzzentrum, Technische Universtität, Munich, Germany
    Am Heart J 154:688-93. 2007
    ..Little is known about the late outcome of patients with diabetes mellitus who receive drug-eluting stents (DES)...
  41. doi request reprint 5-year prognostic value of no-reflow phenomenon after percutaneous coronary intervention in patients with acute myocardial infarction
    Gjin Ndrepepa
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    J Am Coll Cardiol 55:2383-9. 2010
    ..This impact was also assessed in relation to infarct size...
  42. ncbi request reprint Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans
    Werner Koch
    Deutsches Herzzentrum Munchen, 80636 Munich, Germany
    Hum Mol Genet 16:1821-7. 2007
    ..98, 95% CI 0.83-1.16; P = 0.84). Our finding that protective effects are linked with minor homozygous genotypes and haplotype 1 of the BAT1-NFKBIL1-LTA region in Europeans is opposite to the observation of associated risks in Japanese...
  43. doi request reprint No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting
    Dirk Sibbing
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, Munich, Germany
    Eur Heart J 32:1605-13. 2011
    ..The aim of this study was to assess the impact of the PON1 Q192R genotype in parallel to that of CYP2C19*2 on the antiplatelet effect of clopidogrel and the risk of ST in clopidogrel-treated patients...
  44. ncbi request reprint Randomized clinical trial of abciximab in diabetic patients undergoing elective percutaneous coronary interventions after treatment with a high loading dose of clopidogrel
    Julinda Mehilli
    Deutsches Herzzentrum, Lazarettstrasse 36, 80636 Munich, Germany
    Circulation 110:3627-35. 2004
    ....
  45. doi request reprint No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents
    Petra Hoppmann
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    JACC Cardiovasc Interv 2:1149-55. 2009
    ..3 is a genetic factor for coronary heart disease, we investigated whether this locus influenced the clinical and angiographic outcomes after implantation of drug-eluting stents in coronary arteries...
  46. doi request reprint Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease
    Julinda Mehilli
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    J Am Coll Cardiol 53:1760-8. 2009
    ..The aim of this trial was to compare the safety and efficacy of paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) for treatment of unprotected left main coronary artery (uLMCA) disease...
  47. doi request reprint Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment
    Isabell Bernlochner
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Thromb Haemost 104:1193-200. 2010
    ..Whether a direct relation between platelets and inflammation exists, as well as the clinical impact of our results, warrants further investigations...
  48. ncbi request reprint Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel
    Dirk Sibbing
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Thromb Haemost 101:714-9. 2009
    ..Specifically designed and randomized clinical studies are needed to define the impact of concomitant PPI treatment on adverse events after percutaneous coronary intervention...
  49. ncbi request reprint Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients
    Alban Dibra
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    N Engl J Med 353:663-70. 2005
    ..It is not known whether there are differences in the effectiveness of currently approved drug-eluting stents in the high-risk subgroup of patients with diabetes mellitus...
  50. ncbi request reprint Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial
    Franz Josef Neumann
    Medizinische Klinik, Technische Universitat Munchen, Munich, Germany
    JAMA 290:1593-9. 2003
    ..In unstable coronary syndromes, catheter intervention is frequently preceded by antithrombotic treatment to reduce periprocedural risk; however, evidence from clinical trials to support antithrombotic pretreatment is sparse...
  51. doi request reprint No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting
    Juliane Jaitner
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circ Cardiovasc Interv 5:82-8, S1-2. 2012
    ....
  52. ncbi request reprint Thrombolysis in myocardial infarction myocardial perfusion grade in angiography correlates with myocardial salvage in patients with acute myocardial infarction treated with stenting or thrombolysis
    Alban Dibra
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, 80 636 Munich, Germany
    J Am Coll Cardiol 41:925-9. 2003
    ..We sought to assess the relationship between the Thrombolysis In Myocardial Infarction (TIMI) myocardial perfusion (TMP) grade and myocardial salvage as well as the usefulness of TMP grade in comparing two different reperfusion strategies...
  53. ncbi request reprint Sustained increased risk of adverse cardiac events over 5 years after implantation of gold-coated coronary stents
    Jürgen Pache
    Deutsches Herzzentrum, Lazarettstr 36, 80636 München, Germany
    Catheter Cardiovasc Interv 68:690-5. 2006
    ..To study the 5-year outcome of patients treated with gold-coated stent placement...
  54. ncbi request reprint Impact of bivalirudin or unfractionated heparin on platelet aggregation in patients pretreated with 600 mg clopidogrel undergoing elective percutaneous coronary intervention
    Dirk Sibbing
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur Heart J 29:1504-9. 2008
    ....
  55. ncbi request reprint One year outcomes with abciximab vs. placebo during percutaneous coronary intervention after pre-treatment with clopidogrel
    Albert Schomig
    Deutsches Herzzentrum, Lazarettstr 36, 80636 Munich, Germany
    Eur Heart J 26:1379-84. 2005
    ..We assessed whether there was any clinical benefit from abciximab at 1 year follow-up...
  56. doi request reprint Five-year clinical outcomes of sirolimus-eluting versus paclitaxel-eluting stents in high-risk patients
    K Anette Birkmeier
    Deutsches Herzzentrum, Technische Universitat, Munich
    Catheter Cardiovasc Interv 77:494-501. 2011
    ..We compared the five-year clinical efficacy and safety of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in a population of high-risk patients...
  57. ncbi request reprint One-year outcomes with abciximab and unfractionated heparin versus bivalirudin during percutaneous coronary interventions in patients with non-ST-segment elevation myocardial infarction: updated results from the ISAR-REACT 4 trial
    Stefanie Schulz
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    EuroIntervention 9:430-6. 2013
    ..A longer follow-up may be required to assess the whole potential benefit of a periprocedural antithrombotic therapy...
  58. ncbi request reprint Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease
    Klaus Kölling
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar der Technischen, Universität Munich, Lazarettstrasse 36, 80636 Munich, Germany
    Am J Cardiol 93:1201-6. 2004
    ..Although there is an apparent association between elevated levels of homocysteine and CAD, this association is not independent of conventional cardiovascular risk factors...
  59. doi request reprint Long-term risk of adverse outcomes and new malignancies in patients treated with oral sirolimus for prevention of restenosis
    Sebastian Kufner
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    JACC Cardiovasc Interv 2:1142-8. 2009
    ..We sought to investigate the long-term efficacy of oral sirolimus therapy and its impact on the incidence of de novo malignancies in the OSIRIS (Oral Sirolimus to Inhibit Recurrent In-Stent Stenosis) trial population...
  60. ncbi request reprint Troponin level and efficacy of abciximab in patients with acute coronary syndromes undergoing early intervention after clopidogrel pretreatment
    Raisuke Iijima
    Deutsches Herzzentrum, Technische Universitat, Lazarettstr 36, 80636, Munich, Germany
    Clin Res Cardiol 97:160-8. 2008
    ....
  61. ncbi request reprint N-terminal pro-brain natriuretic peptide on admission in patients with acute myocardial infarction and correlation with scintigraphic infarct size, efficacy of reperfusion, and prognosis
    Gjin Ndrepepa
    Klinik für Herz und Kreislauferkrankungen, Munich, Germany
    Am J Cardiol 97:1151-6. 2006
    ..In conclusion, NT-pro-BNP measured on admission in patients with AMI correlates with scintigraphic area at risk and predicts prognosis but does not predict the efficacy of mechanical reperfusion by stenting or angioplasty...
  62. doi request reprint Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial
    Julinda Mehilli
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Circulation 119:1933-40. 2009
    ..However, it is not known whether abciximab remains beneficial after adequate clopidogrel loading in patients with acute ST-segment-elevation myocardial infarction...
  63. doi request reprint Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events
    Klaus A Tiroch
    Deutsches Herzzentrum Munchen, Rechts der Isar, Technische Universitat, Germany
    Am Heart J 160:506-12. 2010
    ..Reduced-function alleles have been associated with an increase in cardiovascular events...
  64. ncbi request reprint Clopidogrel therapy in patients undergoing coronary stenting: value of a high-loading-dose regimen
    Jürgen Pache
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat, Munich, Germany
    Catheter Cardiovasc Interv 55:436-41. 2002
    ....
  65. doi request reprint Risk of drug-eluting stent thrombosis in patients receiving proton pump inhibitors
    Nikolaus Sarafoff
    Deutsches Herzzentrum Munchen, Klinik für Herz und Kreislauferkrankungen Lazarettstr 3680636 Munich, Germany
    Thromb Haemost 104:626-32. 2010
    ..The higher mortality is probably due to confounding as patients on PPIs had a higher risk profile at baseline...
  66. ncbi request reprint Prognostic value of myocardial salvage achieved by reperfusion therapy in patients with acute myocardial infarction
    Gjin Ndrepepa
    Deutsches Herzzentrum, Munich, Germany
    J Nucl Med 45:725-9. 2004
    ..The prognostic value of myocardial salvage index in patients with acute myocardial infarction after reperfusion therapy has not, however, been investigated...
  67. doi request reprint Profile of bleeding and ischaemic complications with bivalirudin and unfractionated heparin after percutaneous coronary intervention
    Raisuke Iijima
    Deutsches Herzzentrum, Technische Universitat, Lazarettstr 36, 80636 Munich, Germany
    Eur Heart J 30:290-6. 2009
    ....
  68. doi request reprint Rationale and design of a randomized, double-blind, placebo-controlled trial of 6 versus 12 months clopidogrel therapy after implantation of a drug-eluting stent: The Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual
    Robert A Byrne
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Am Heart J 157:620-4.e2. 2009
    ..In fact, the corroboration of an increased rate of late thrombotic events remains outstanding, and these clinical practice guidelines are limited by an inadequate evidence base on which to ground their recommendations...
  69. ncbi request reprint Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial
    Albert Schomig
    Deutsches Herzzentrum, 1 Medizinische Klinik rechts der Isar, Technische Universitat, Munich, Germany
    JAMA 293:2865-72. 2005
    ..Current guidelines do not recommend reperfusion treatment in these patients...
  70. ncbi request reprint Myocardial perfusion grade, myocardial salvage indices and long-term mortality in patients with acute myocardial infarction and full restoration of epicardial blood flow after primary percutaneous coronary intervention
    Gjin Ndrepepa
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Rev Esp Cardiol 63:770-8. 2010
    ....
  71. ncbi request reprint Comparative characterization of cellular and molecular anti-restenotic profiles of paclitaxel and sirolimus. Implications for local drug delivery
    Rainer Wessely
    Deutsches Herzzentrum, Department of Cardiology 1 Medizinische Klinik rechts der Isar, University of Technology, Munich, Germany
    Thromb Haemost 97:1003-12. 2007
    ..In comparison with PTX, SRL shows minor interference with endothelial cell proliferation and migration, lower levels of cytotoxicity and apoptosis, a broader therapeutic range and distinctive immunosuppressive properties...
  72. doi request reprint Peak cardiac troponin-T level, scintigraphic myocardial infarct size and one-year prognosis in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
    Robert A Byrne
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Am J Cardiol 106:1212-7. 2010
    ..Compared to peak CK-MB, peak TnT shows similar correlation with scintigraphic infarct size, although scintigraphic infarct size remains a better correlate of 1-year mortality than either biomarker...
  73. ncbi request reprint Randomized trial of paclitaxel- versus sirolimus-eluting stents for treatment of coronary restenosis in sirolimus-eluting stents: the ISAR-DESIRE 2 (Intracoronary Stenting and Angiographic Results: Drug Eluting Stents for In-Stent Restenosis 2) study
    Julinda Mehilli
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    J Am Coll Cardiol 55:2710-6. 2010
    ....
  74. ncbi request reprint A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy
    Jürgen Pache
    Medizinische Klinik rechts der Isar, Munich, Germany
    Am Heart J 148:e3. 2004
    ..The objective of this randomized trial was to assess for the first time whether GIK improves myocardial salvage in patients with AMI...
  75. ncbi request reprint Vessel size and outcome after coronary drug-eluting stent placement: results from a large cohort of patients treated with sirolimus- or paclitaxel-eluting stents
    Shpend Elezi
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    J Am Coll Cardiol 48:1304-9. 2006
    ..This study sought to investigate the influence of vessel size on the outcomes of patients after drug-eluting stent (DES) implantation...
  76. ncbi request reprint Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention
    Julinda Mehilli
    Deutsches Herzzentrum, Lazarettstrasse 36, 80636 Munich, Germany
    JAMA 287:210-5. 2002
    ..It is not clear, however, whether sex is an independent predictor of death among patients systematically treated with aggressive reperfusion and medical strategies...
  77. ncbi request reprint Value of serum ferritin and soluble transferrin receptor for prediction of coronary artery disease and its clinical presentations
    Siegmund Braun
    Institut für Laboratoriumsmedizin, Deutsches Herzzentrum Munchen, Technische Universitat, Lazarettstrasse 36, 80636 München, Germany
    Atherosclerosis 174:105-10. 2004
    ..In subjects with pre-existing CAD, those with more severe disease had increased levels of sTfR. Patients with CAD presenting with acute coronary syndromes showed increased levels of serum ferritin...
  78. ncbi request reprint Association between C-reactive protein levels and subsequent cardiac events among patients with stable angina treated with coronary artery stenting
    Alban Dibra
    Deutsches Herzzentrum and Medizinische Klinik rechts der Isar, Technische Universität Mnchen, Munich, Germany
    Am J Med 114:715-22. 2003
    ..To investigate the prognostic value of elevated C-reactive protein levels in patients with stable angina who underwent coronary stenting...
  79. doi request reprint Impact of myocardial salvage assessed by (99m)Tc-sestamibi scintigraphy on cardiac autonomic function in patients undergoing mechanical reperfusion therapy for acute myocardial infarction
    Axel Bauer
    1 Medizinische Klinik und Deutsches Herzzentrum München, Munchen, Germany
    JACC Cardiovasc Imaging 2:449-57. 2009
    ..The purpose of this study was to analyze the impact of myocardial salvage on cardiac autonomic function in patients undergoing mechanical reperfusion therapy for acute myocardial infarction (MI)...
  80. ncbi request reprint Thoracic radiotherapy in patients with lymphoma and restenosis after coronary stent placement
    Kathrin Schömig
    Deutsches Herzzentrum, Technische Universität Munich, Munich, Germany
    Catheter Cardiovasc Interv 70:359-65. 2007
    ..The aim of this study was to assess the incidence of restenosis after coronary stenting in patients with lymphoma treated with thoracic radiation...
  81. ncbi request reprint Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial
    Dietlind Zohlnhofer
    Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    JAMA 295:1003-10. 2006
    ..Granulocyte colony-stimulating factor (G-CSF) induces mobilization of bone marrow stem cells...
  82. ncbi request reprint Gender and restenosis after coronary artery stenting
    Julinda Mehilli
    Medizinische Klinik rechts der Isar der Technischen Universität, Munich, Germany
    Eur Heart J 24:1523-30. 2003
    ..To examine the impact of sex on restenosis in a large cohort of consecutive patients undergoing coronary stenting and systematic angiographic and clinical follow-up...
  83. doi request reprint Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point
    Gjin Ndrepepa
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    J Am Coll Cardiol 51:690-7. 2008
    ....
  84. ncbi request reprint Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting
    Klaus Tiroch
    Deutsches Herzzentrum Munchen, 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, München D 80636, Germany
    Eur Heart J 28:968-73. 2007
    ..We evaluated, whether an association existed between this polymorphism and the incidence of restenosis after coronary stenting...
  85. doi request reprint A polymer-free dual drug-eluting stent in patients with coronary artery disease: a randomized trial vs. polymer-based drug-eluting stents
    Robert A Byrne
    ISAR Centre, Deutsches Herzzentrum, Technische Universitat, Lazarettstrasse 36, 80636 Munich, Germany
    Eur Heart J 30:923-31. 2009
    ....
  86. ncbi request reprint Cost analysis from two randomized trials of sirolimus-eluting stents versus paclitaxel-eluting stents in high-risk patients with coronary artery disease
    Shpend Elezi
    Deutsches Herzzentrum, Technische Universität Munich, Germany
    J Am Coll Cardiol 48:262-7. 2006
    ..This study sought to analyze the cost of percutaneous coronary interventions with use of sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES) in patients at high risk of restenosis...
  87. doi request reprint Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
    Dirk Sibbing
    Department of Cardiology, Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur Heart J 30:916-22. 2009
    ..The aim of this study was to assess the impact of the CYP2C19 681G>A loss-of-function polymorphism on ST following PCI performed after pre-treatment with clopidogrel...
  88. ncbi request reprint Plasminogen activator inhibitor-1 4G/5G polymorphism and efficacy of reperfusion therapy in acute myocardial infarction
    Dirk Sibbing
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Blood Coagul Fibrinolysis 16:511-5. 2005
    ..The PAI-1 4G/5G polymorphism has no impact on the amount of myocardial salvage achieved by reperfusion with stenting or thrombolysis in patients with AMI...
  89. ncbi request reprint Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect)
    Nicolas von Beckerath
    Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Circulation 112:2946-50. 2005
    ..It is unknown, though, whether loading doses higher than 600 mg exert additional suppression of platelet function...
  90. ncbi request reprint Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement
    Olga Gorchakova
    Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Lazarettstrasse 36, 80636 München, Germany
    Eur Heart J 24:820-7. 2003
    ..We investigated the possibility that the 894 TT genotype has an unfavorable impact on the angiographic and clinical outcome after the placement of stents in coronary arteries...
  91. ncbi request reprint Five-year outcome of patients with acute myocardial infarction enrolled in a randomised trial assessing the value of abciximab during coronary artery stenting
    Gjin Ndrepepa
    Deutsches Herzzentrum and Medizinische Klinik rechts der Isar, Technische Universitat, Lazarettstr 36, 80636 Munich, Germany
    Eur Heart J 25:1635-40. 2004
    ..METHODS and..
  92. ncbi request reprint Comparison of stenting with balloon angioplasty for lesions of small coronary vessels in patients with diabetes mellitus
    Julinda Mehilli
    Deutsches Herzzentrum, Munich, Germany
    Am J Med 112:13-8. 2002
    ..We sought to assess whether stenting is a better treatment strategy than percutaneous transluminal coronary angioplasty (PTCA) for lesions in small coronary vessels of diabetic patients...
  93. ncbi request reprint PlA polymorphism of the glycoprotein IIIa and efficacy of reperfusion therapy in patients with acute myocardial infarction
    Olga Gorchakova
    Deutsches Herzzentrum, I Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Thromb Haemost 91:141-5. 2004
    ..Thus, these findings show that the functional Pl(A) polymorphism of platelet glycoprotein IIIa has no influence on the degree of myocardial salvage achieved by reperfusion therapies in patients with acute myocardial infarction...
  94. ncbi request reprint Randomized trial of a nonpolymer-based rapamycin-eluting stent versus a polymer-based paclitaxel-eluting stent for the reduction of late lumen loss
    Julinda Mehilli
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Circulation 113:273-9. 2006
    ..Recently, we showed that a nonpolymer on-site coating with rapamycin not only is feasible and safe but also leads to a dose-dependent reduction in restenosis...
  95. ncbi request reprint Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels
    Julinda Mehilli
    Deutsches Herzzentrum, Technische Universitat, Lazarettstr 36, 80636 Munich, Germany
    Eur Heart J 27:260-6. 2006
    ..Sirolimus- and paclitaxel-eluting stents effectively reduce restenosis in small coronary vessels. The relative efficacy of these drug-eluting stents in this high-risk subset is not known...
  96. ncbi request reprint Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting
    Olga Gorchakova
    Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur Heart J 25:1898-902. 2004
    ..To test prospectively whether the antiplatelet effect of a 600 mg loading dose of clopidogrel is attenuated in patients receiving atorvastatin and simvastatin for at least 4 weeks prior to coronary artery stenting...
  97. ncbi request reprint Local statin therapy differentially interferes with smooth muscle and endothelial cell proliferation and reduces neointima on a drug-eluting stent platform
    Birgit Jaschke
    Deutsches Herzzentrum and 1 Medizinische Klinik, Technische Universitat, Munich, Germany
    Cardiovasc Res 68:483-92. 2005
    ..Accordingly, identification of compounds that differentially inhibit smooth muscle and endothelial cell migration and proliferation could be of substantial clinical usefulness...
  98. ncbi request reprint Tissue factor pathway inhibitor on circulating microparticles in acute myocardial infarction
    Birgit Steppich
    Deutsches Herzzentrum, Lazarettstrasse 36, 80636 München, Germany
    Thromb Haemost 93:35-9. 2005
    ..After thrombolysis but not after stenting MPTFPI is degraded and may induce thrombin generation due to unopposed tissue factor activity. Anti-TF therapies during thrombolysis may reduce thrombin generation in AMI...
  99. ncbi request reprint Early resolution of ST-segment elevation correlates with myocardial salvage assessed by Tc-99m sestamibi scintigraphy in patients with acute myocardial infarction after mechanical or thrombolytic reperfusion therapy
    Jun Dong
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 105:2946-9. 2002
    ..Whether this correlation is an expression of initial infarct characteristics or degree of myocardial salvage achieved with reperfusion therapy is unclear...
  100. ncbi request reprint Platelet function in clopidogrel-treated patients with acute coronary syndrome
    Dirk Sibbing
    Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Blood Coagul Fibrinolysis 18:335-9. 2007
    ..0001). Patients with ACS continue to exhibit increased platelet activation after pretreatment with 600 mg clopidogrel. This finding supports the need for additional platelet function inhibition during PCI in patients with ACS...