Evelyna Derhovanessian

Summary

Country: Germany

Publications

  1. doi Immunosenescence and cancer
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Clinical School, Waldhornlestr 22, D 72072 Tubingen, Germany
    Crit Rev Oncol Hematol 75:165-72. 2010
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  3. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
  4. pmc Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people
    Evelyna Derhovanessian
    Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, Waldhornlestrasse 22, 72072, Tubingen, Germany
    Age (Dordr) 35:1387-99. 2013
  5. doi Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans
    Evelyna Derhovanessian
    Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, Tubingen, Germany
    J Gen Virol 92:2746-56. 2011
  6. doi Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    Evelyna Derhovanessian
    Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, 72072 Tubingen, Germany
    Vaccine 31:685-90. 2013
  7. doi Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients
    Evelyna Derhovanessian
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tubingen, Germany
    Int J Cancer 125:1372-9. 2009
  8. doi Hallmark features of immunosenescence are absent in familial longevity
    Evelyna Derhovanessian
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tubingen, Germany
    J Immunol 185:4618-24. 2010
  9. doi Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis
    Benjamin Weide
    University Medical Center, University of Tubingen, Tubingen, Germany
    J Clin Oncol 30:1835-41. 2012
  10. doi Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    Evelyna Derhovanessian
    Center for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    Curr Opin Immunol 21:440-5. 2009

Collaborators

Detail Information

Publications20

  1. doi Immunosenescence and cancer
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Clinical School, Waldhornlestr 22, D 72072 Tubingen, Germany
    Crit Rev Oncol Hematol 75:165-72. 2010
    ..This review weighs some of the evidence for and against this possibility...
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  3. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
    ..abstract:..
  4. pmc Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people
    Evelyna Derhovanessian
    Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, Waldhornlestrasse 22, 72072, Tubingen, Germany
    Age (Dordr) 35:1387-99. 2013
    ....
  5. doi Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans
    Evelyna Derhovanessian
    Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, Tubingen, Germany
    J Gen Virol 92:2746-56. 2011
    ..We conclude that these hallmarks of age-associated alterations to immune signatures are indeed observed in the general population in people infected with CMV and not those infected with a different persistent herpesvirus...
  6. doi Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    Evelyna Derhovanessian
    Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, 72072 Tubingen, Germany
    Vaccine 31:685-90. 2013
    ..Thus, latent CMV infection has a deleterious effect on influenza antibody responses in the elderly, which might be mediated through CD4 T-cells lacking CCR7, CD27 and CD28 and re-expressing CD45RA...
  7. doi Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients
    Evelyna Derhovanessian
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tubingen, Germany
    Int J Cancer 125:1372-9. 2009
    ....
  8. doi Hallmark features of immunosenescence are absent in familial longevity
    Evelyna Derhovanessian
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tubingen, Germany
    J Immunol 185:4618-24. 2010
    ....
  9. doi Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis
    Benjamin Weide
    University Medical Center, University of Tubingen, Tubingen, Germany
    J Clin Oncol 30:1835-41. 2012
    ..To analyze the prognostic relevance of circulating T cells responding to NY-ESO-1, Melan-A, MAGE-3, and survivin in patients with melanoma with distant metastasis...
  10. doi Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    Evelyna Derhovanessian
    Center for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    Curr Opin Immunol 21:440-5. 2009
    ....
  11. pmc Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters
    Christopher Shipp
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology, Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, Waldhornlestr 22, 72072 Tubingen, Germany
    Cell Stress Chaperones 18:145-54. 2013
    ..This study provides further evidence for the importance of hsps in melanoma and for their use as therapeutic targets and biomarkers, but larger-scale follow-up studies are required to confirm these results...
  12. doi The impact of CMV infection on survival in older humans
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Clinical School, Waldhoernlestr 22, D 72072 Tuebingen, Germany
    Curr Opin Immunol 24:507-11. 2012
    ..Infection with this persistent β-herpesvirus may therefore indirectly impact on survival in the elderly. Recent evidence pertaining to this controversial proposal is reviewed here...
  13. doi Immune profiling of Alzheimer patients
    Mariavaleria Pellicano
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tübingen Aging and Tumor Immunology Group, Waldhornlestr 22, 72072 Tubingen, Germany
    J Neuroimmunol 242:52-9. 2012
    ..Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease...
  14. doi Cytomegalovirus and human immunosenescence
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rev Med Virol 19:47-56. 2009
    ..Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review...
  15. pmc Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines
    Christopher Shipp
    Tubingen Ageing and Tumour Immunology Group, Department of Internal Medicine II, Centre for Medical Research, University of Tubingen, Tubingen, Baden Wurttemberg, Germany
    PLoS ONE 7:e37475. 2012
    ..This study examined the effect of different oxygen concentrations on the expression of hsps in melanoma cell lines...
  16. doi Role of CMV in immune senescence
    Graham Pawelec
    Section for Transplantation Immunology, 2nd Dept of Internal Medicine, University of Tübingen Center for Medical Research, Tubingen Ageing and Tumour Immunology Group, Waldhornlestr 22, D 72072 Tubingen, Germany
    Virus Res 157:175-9. 2011
    ..Here we review the impact of CMV on "immune senescence" in humans...
  17. doi High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma
    Benjamin Weide
    Department of Dermatology, Center of Dermato Oncology, University of Tuebingen, Tuebingen, Germany
    Cancer 116:4139-46. 2010
    ..The objectives of the current study were to confirm those results in a larger cohort and to identify patient or regimen characteristics associated with response...
  18. doi Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients
    Benjamin Weide
    Department of Dermatology, Division of Dermatooncology, University of Tubingen, Tubingen, Germany
    J Immunother 32:498-507. 2009
    ....
  19. doi Vaccination in the elderly
    Evelyna Derhovanessian
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tubingen Medical School, Waldhornlestr 22, D 72072 Tubingen, Germany
    Microb Biotechnol 5:226-32. 2012
    ..We will consider these three options, focusing on influenza vaccination, in this mini-review...
  20. doi Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
    Anis Larbi
    Center for Medical Research, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 17:91-103. 2009
    ....