A Dendorfer

Summary

Country: Germany

Publications

  1. ncbi request reprint Comparison of the vascular and antiadrenergic activities of four angiotensin II type 1 antagonists in the pithed rat
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Hypertens 20:1151-6. 2002
  2. ncbi request reprint Peripheral sympatholytic actions of four AT1 antagonists: are they relevant for long-term antihypertensive efficacy?
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    J Hypertens 23:1861-7. 2005
  3. ncbi request reprint Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Free Radic Biol Med 38:117-24. 2005
  4. ncbi request reprint Potentiation of kinin analogues by ramiprilat is exclusively related to their degradation
    A Dendorfer
    Medical University of Lubeck, Institute of Experimental and Clinical Pharmacology and Toxicology, Lubeck, Germany
    Hypertension 38:142-6. 2001
  5. ncbi request reprint Angiotensin II induces catecholamine release by direct ganglionic excitation
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Luebeck, Luebeck, Germany
    Hypertension 40:348-54. 2002
  6. ncbi request reprint Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats
    A Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, D 23538 Lubeck, Germany
    Am J Physiol Heart Circ Physiol 280:H2182-8. 2001
  7. pmc Inhibition of kinin breakdown prolongs retention and action of bradykinin in a myocardial B2 receptor compartment
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Br J Pharmacol 138:310-6. 2003
  8. ncbi request reprint Potentiation of the vascular response to kinins by inhibition of myocardial kininases
    A Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Lubeck, Germany
    Hypertension 35:32-7. 2000
  9. ncbi request reprint Structural requirements for B2-agonists with improved degradation stability
    A Dendorfer
    Institute of Pharmacology, Medical University of Lubeck, Germany
    Immunopharmacology 45:199-205. 1999
  10. ncbi request reprint Mechanisms of bradykinin-induced catecholamine release in pithed spontaneously hypertensive rats
    A Dendorfer
    Institute of Pharmacology, Medical University of Lubeck, Germany
    Immunopharmacology 44:99-104. 1999

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Comparison of the vascular and antiadrenergic activities of four angiotensin II type 1 antagonists in the pithed rat
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Hypertens 20:1151-6. 2002
    ....
  2. ncbi request reprint Peripheral sympatholytic actions of four AT1 antagonists: are they relevant for long-term antihypertensive efficacy?
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    J Hypertens 23:1861-7. 2005
    ..AT1 receptor antagonists attenuate all these actions, but display some evidence of substance-related selectivities...
  3. ncbi request reprint Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Free Radic Biol Med 38:117-24. 2005
    ..Enhancement of superoxide activity by DFO could be demonstrated in vitro. Acute and prolonged myocardial preconditioning is triggered by DFO in response to accumulation of oxygen radicals and activation of protein kinase C...
  4. ncbi request reprint Potentiation of kinin analogues by ramiprilat is exclusively related to their degradation
    A Dendorfer
    Medical University of Lubeck, Institute of Experimental and Clinical Pharmacology and Toxicology, Lubeck, Germany
    Hypertension 38:142-6. 2001
    ..As such, no evidence of degradation-independent potentiating actions of ACE inhibitors could be obtained...
  5. ncbi request reprint Angiotensin II induces catecholamine release by direct ganglionic excitation
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Luebeck, Luebeck, Germany
    Hypertension 40:348-54. 2002
    ..In both the absence and presence of preganglionic sympathetic activity, this mechanism contributes significantly to ANG-induced enhancement of catecholamine release...
  6. ncbi request reprint Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats
    A Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, D 23538 Lubeck, Germany
    Am J Physiol Heart Circ Physiol 280:H2182-8. 2001
    ..No differences of kinin degradation were found between WKY and SHR. The identical conditions of kinin degradation in WKY and SHR suggest no pathogenic role of kininases in the SHR model of genetic hypertension...
  7. pmc Inhibition of kinin breakdown prolongs retention and action of bradykinin in a myocardial B2 receptor compartment
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Br J Pharmacol 138:310-6. 2003
    ..This is the kinetic and functional consequence of a colocalization of kininases and B(2)-receptors in a compartment constituted by endothelial membrane vesicles...
  8. ncbi request reprint Potentiation of the vascular response to kinins by inhibition of myocardial kininases
    A Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Lubeck, Germany
    Hypertension 35:32-7. 2000
    ....
  9. ncbi request reprint Structural requirements for B2-agonists with improved degradation stability
    A Dendorfer
    Institute of Pharmacology, Medical University of Lubeck, Germany
    Immunopharmacology 45:199-205. 1999
    ..Finally, the kinin derivatives D-Arg0-[Hyp3, Thi5, epsilonSer(betaPh)8]-BK and D-Arg0-[Hyp3, Thi5, epsilonAbu(betaPh)8]-BK proved to be potent B2-agonists with extensive stability against rat serum kininases...
  10. ncbi request reprint Mechanisms of bradykinin-induced catecholamine release in pithed spontaneously hypertensive rats
    A Dendorfer
    Institute of Pharmacology, Medical University of Lubeck, Germany
    Immunopharmacology 44:99-104. 1999
    ..A minor stimulating effect of bradykinin on plasma adrenaline is provoked independently of B2-receptors via histamine acting on H1-receptors...
  11. pmc Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway
    S Wolfrum
    Medical Clinic II, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Br J Pharmacol 134:370-4. 2001
    ..Cardioprotection achieved by this selective inhibitor of APP is mediated by bradykinin. Combined inhibition of APP and ACE did not result in a more pronounced reduction of IS than APP-inhibition alone...
  12. ncbi request reprint Adrenal expression of orexin receptor subtypes is differentially regulated in experimental streptozotocin induced type-1 diabetes
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Peptides 27:2764-9. 2006
    ..In adrenals, OX(1) receptor mRNA levels were significantly elevated in STZ rats while OX(2) receptors were significantly reduced. Our results imply distinct functions of adrenal orexin receptor subtypes during type-1 like diabetes...
  13. ncbi request reprint Angiotensin I-converting enzyme inhibition increases cardiac catecholamine content and reduces monoamine oxidase activity via an angiotensin type 1 receptor-mediated mechanism
    Walter Raasch
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Germany
    J Pharmacol Exp Ther 300:428-34. 2002
    ..This action contributes to an increase in cardiac catecholamine content that may improve cardiac sympathetic control during therapy...
  14. ncbi request reprint Impairment of presynaptic alpha2-adrenoceptor-regulated norepinephrine overflow in failing hearts from Zucker diabetic fatty rats
    Christof Burgdorf
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Cardiovasc Pharmacol 47:256-62. 2006
    ..In conclusion, cardiac norepinephrine overflow is inhibited in failing hearts from ZDF-fa/fa rats. This inhibition may result from a hyperactive status of presynaptic alpha2-adrenoceptors...
  15. ncbi request reprint Effects of intracoronary low-dose enalaprilat as an adjunct to primary percutaneous transluminal coronary angiography in acute myocardial infarction
    T Kurz
    Medizinische Klinik II, Universitatsklinikum Lubeck, Lubeck, Germany
    Am J Cardiol 88:1351-7. 2001
    ..Effective cardiac ACE inhibition can be achieved by low-dose intracoronary enalaprilat, which primarily causes a potentiation of bradykinin...
  16. ncbi request reprint Brain nitric oxide synthase activity in spontaneously hypertensive rats during the development of hypertension
    Fatimunnisa Qadri
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany
    J Hypertens 21:1687-94. 2003
    ..Therefore, we measured NOS activity in different brain regions in SHR at prehypertensive, onset and established hypertension, and compared with age-matched Wistar-Kyoto (WKY) rats...
  17. ncbi request reprint Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    Brain Res 1184:160-7. 2007
    ..This dysregulation of the HPA axis may eventually lead, in combination with leptin resistance, to the development of diabetes in ZDF rats...
  18. ncbi request reprint Angiotensin converting enzyme inhibition improves cardiac neuronal uptake of noradrenaline in spontaneously hypertensive rats
    W Raasch
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Luebeck, Germany
    J Hypertens 19:1827-33. 2001
    ....
  19. ncbi request reprint Angiotensin converting enzyme inhibition by captopril influences cardiac work in healthy hearts
    I Derad
    Department of Internal Medicine, University of Lubeck, Germany
    Am J Hypertens 11:1290-6. 1998
    ..From these influences of the drug on cardiac work and metabolism in healthy hearts, a protective influence of captopril in acute, critical situations of cardiac malnourishment or cardiac overload may be derived...
  20. ncbi request reprint Effects of selective angiotensin II receptor blockade on sympathetic nerve activity in primary hypertensive subjects
    Jan Struck
    Department of Internal Medicine I, and cInstitute of Pharmacology, Medical University of Lubeck, Lubeck, Germany
    J Hypertens 20:1143-9. 2002
    ..Results were compared with the effects of the peripherally acting calcium antagonist amlodipine...
  21. ncbi request reprint Calcitonin gene related peptide mediates cardioprotection by remote preconditioning
    Sebastian Wolfrum
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Regul Pept 127:217-24. 2005
    ..In conclusion, CGRP protects the heart from ischemic injury and is involved in RPC, presumably by activating myocardial PKCepsilon...
  22. ncbi request reprint Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia
    Christof Burgdorf
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Regul Pept 125:99-102. 2005
    ..At normal flow, exogenous CGRP (5 micromol l-1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia...
  23. ncbi request reprint Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?
    Walter Raasch
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic of Schleswig Holstein, Campus Lubeck, Germany
    J Hypertens 23:1597-604. 2005
    ..Since angiotensin (ANG) II availability is decreased by ACE inhibition but is increased by NEP inhibition, we evaluated the influence of the vasopeptidase inhibitor omapatrilat on ANG II-dependent noradrenaline (NA) release...
  24. doi request reprint Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells
    Jan Wenzel
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany
    Am J Physiol Regul Integr Comp Physiol 297:R1601-9. 2009
    ..In conclusion, orexins may influence adrenal steroidogenesis by differential regulation of the expression of steroidogenic enzymes involving Ca(2+), as well as PKC-ERK1/2 signaling...
  25. ncbi request reprint Interactions of ligands at angiotensin II-receptors and imidazoline receptors
    U Wethmar
    Institute of Experimental and Clinical Pharmacology and Toxicology, , Germany
    Jpn J Pharmacol 85:167-74. 2001
    ..Hence, the tested substances showed no cross-reactivity at the corresponding AT- and I-receptors up to 100 microM, a concentration markedly higher than the plasma concentrations achieved after therapeutic application...
  26. ncbi request reprint Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic Lübeck, D 23538 Lubeck, Germany
    Endocrinology 144:1219-25. 2003
    ....
  27. ncbi request reprint Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Cardiovasc Res 78:108-15. 2008
    ..Since mitogen-activated protein kinases (MAPKs) were found to be implicated in the signalling of ischaemic preconditioning (IPC), we tested the hypothesis of a contribution of these protein kinases to remote preconditioning (RPC)...
  28. ncbi request reprint Hypoxia rapidly activates HIF-3alpha mRNA expression
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    FASEB J 17:1541-3. 2003
    ..Our results suggest that induction at the transcriptional level is a unique feature of HIF-3alpha, which therefore may represent a rapidly reacting component of the HIF system in protection against hypoxic damage...
  29. ncbi request reprint Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats
    Walter Raasch
    Institute of Experimental and Clinical Pharmacology, University Clinic of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Endocrinology 147:3539-46. 2006
    ..Both a reduced pituitary sensitivity to CRH and a down-regulation of hypothalamic CRH expression have the potential to reduce HPA axis activity during chronic AT(1) blockade or angiotensin-converting enzyme inhibition...
  30. ncbi request reprint Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform
    Sebastian Wolfrum
    Institute for Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Germany
    Cardiovasc Res 55:583-9. 2002
    ..Furthermore, we tried to delineate the mechanisms by which RPC is transduced to the heart with respect to the possible contribution of kinins and neuronal reflexes...
  31. ncbi request reprint Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Biochem Biophys Res Commun 352:437-43. 2007
    ..Transcriptional up-regulation of HIF-3alpha represents a typical response to in vivo hypoglycaemia and glucoprivation. These data suggest an involvement of the HIF system in metabolic derangements as for instance caused by diabetes...
  32. ncbi request reprint Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway
    Sebastian Wolfrum
    Medical Clinic II, University of Schleswig Holstein, Campus Lubeck, Germany
    J Cardiovasc Pharmacol 44:348-55. 2004
    ..This is the first study demonstrating short-term cardioprotective effects of simvastatin in an in vivo model of ischemia/reperfusion...
  33. ncbi request reprint Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation
    Walter Raasch
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Hypertension 44:346-51. 2004
    ..These newly identified mechanisms may contribute to the antihypertensive and protective actions of AT1 blockers...
  34. ncbi request reprint Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats
    Fatimunnisa Qadri
    Institute of Experimental and Clinical Pharmacology and Toxicolgy, University Clinic of Schleswig Holstein, Lubeck, Germany
    Int Immunopharmacol 4:571-6. 2004
    ..Enhanced pituitary B2 mRNA in type 2 and reduced adrenal in type 1 diabetes account for a differential pattern in release of transmitters...
  35. ncbi request reprint Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Hypertension 41:984-90. 2003
    ....
  36. ncbi request reprint Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase
    Sebastian Wolfrum
    Medical Clinic II, University of Lubeck, Germany
    J Cardiovasc Pharmacol 41:474-80. 2003
    ..Therefore, statins may protect the heart not only by reducing the incidence of ischemic events, but also by limiting cell damage during acute myocardial infarction...
  37. ncbi request reprint Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats
    O Johren
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Lubeck, D 23538 Lubeck, Germany
    Endocrinology 142:3324-31. 2001
    ..Moreover, the sexually dimorphic expression of OX(1) and OX(2) receptors in the hypothalamus, pituitary, and adrenal glands suggests gender-specific roles of orexins in the control of endocrine functions...
  38. ncbi request reprint Cardiovascular and renal function of angiotensin II type-2 receptors
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Cardiovasc Res 62:460-7. 2004
    ..The question whether AT(2) receptors are activated in patients with elevated ANG levels when treated with AT(1) receptor antagonists and whether these effects are relevant awaits further clarification...
  39. ncbi request reprint Impaired coronary flow and left ventricular dysfunction after mechanical recanalization in acute myocardial infarction: role of neurohumoral activation?
    Ulrich Schäfer
    Medizinische Klinik II, Universitätsklinik Lübeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Basic Res Cardiol 97:399-408. 2002
    ....
  40. ncbi request reprint Adenylyl cyclase-dependent inhibition of myocardial norepinephrine release by presynaptic adenosine A1-receptors
    Christof Burgdorf
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Lubeck, Germany
    J Cardiovasc Pharmacol 45:1-3. 2005
    ..These findings suggest a Gi-protein-independent but AC-dependent inhibition of NE release following adenosine A1-receptor activation...
  41. ncbi request reprint Role of neuronal KATP channels and extraneuronal monoamine transporter on norepinephrine overflow in a model of myocardial low flow ischemia
    Christof Burgdorf
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Pharmacol Exp Ther 309:42-8. 2004
    ..K(ATP) channels impair NE release directly at presynaptic nerve endings, whereas EMT increases NE elimination in a manner independent of K(ATP) channels...
  42. ncbi request reprint Organ-specific extravasation of albumin-bound Evans blue during nonresuscitated hemorrhagic shock in rats
    Jan Schumacher
    Department of Anesthesiology, University of Luebeck, Luebeck, Germany
    Shock 20:565-8. 2003
    ..We conclude that despite the absence of fluid resuscitation and reperfusion, microvascular damage in lung and kidney is evident within the first thirty minutes of hemorrhagic shock...
  43. ncbi request reprint Prophylactic gamma radiation of unaffected vein grafts failed to prevent vein graft disease in a chronic hypercholesterolemic porcine model
    Claus Bartels
    Clinic for Cardiac Surgery, Medical University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Eur J Cardiothorac Surg 24:92-7. 2003
    ..The value of prophylactic brachytherapy on vein graft disease is unknown...
  44. doi request reprint Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Biol Chem 389:719-23. 2008
    ..However, ACE inhibition is sufficient to improve LV function despite kininogen deficiency...
  45. pmc Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection
    Sebastian Wolfrum
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
    Arterioscler Thromb Vasc Biol 24:1842-7. 2004
    ..Rho-kinase activity is increased in cardiovascular diseases and in patients with cardiovascular risk factors. However, it is not known whether inhibition of Rho-kinase could lead to cardiovascular protection and, if so, by what mechanism...
  46. ncbi request reprint Bradykinin, angiotensin-(1-7), and ACE inhibitors: how do they interact?
    Beril Tom
    Department of Pharmacology, Room EE1418b, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Int J Biochem Cell Biol 35:792-801. 2003
    ..The levels of angiotensin-(1-7) are increased during ACE inhibition, and most studies suggest that its hypotensive effects are mediated in a bradykinin-dependent manner...
  47. ncbi request reprint Inhibition of the renin-angiotensin system and the prevention of stroke
    Joachim Schrader
    St Josef s Hospital, Cloppenburg, Germany
    Am J Cardiovasc Drugs 7:25-37. 2007
    ..Therefore, ongoing trials will further define the exact role of inhibitors of the RAS and are urgently needed in secondary prevention, in acute stroke, and in the prevention of cognitive decline...
  48. ncbi request reprint Inhibition of nonexocytotic norepinephrine release by desipramine reduces myocardial infarction size
    Doreen Richardt
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Germany
    Can J Physiol Pharmacol 84:1185-9. 2006
    ....
  49. ncbi request reprint Cardiac kinin level in experimental diabetes mellitus: role of kininases
    Matthias Koch
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Am J Physiol Heart Circ Physiol 285:H418-23. 2003
    ....
  50. ncbi request reprint Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Eur J Pharmacol 550:143-8. 2006
    ..Further studies have to show whether these results can be caused by other therapeutically options. Long acting bradykinin receptor agonists might be an alternative option to improve ischemic heart disease...
  51. ncbi request reprint Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    FASEB J 18:1967-9. 2004
    ..An increased phosphorylation of the SERCA2 regulatory protein phospholamban at threonine17 via a B2 receptor-mediated mechanism is thereby involved...
  52. ncbi request reprint AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats
    Thomas Walther
    Department of Cardiology and Pneumology, Free University of Berlin, Berlin, Germany
    FASEB J 16:1237-41. 2002
    ..Our data suggest that NEP is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of AT1 antagonists...
  53. ncbi request reprint Effect of ACE-inhibitor ramiprilat and AT1-receptor antagonist candesartan on cardiac norepinephrine release: comparison between ischemic and nonischemic conditions
    Doreen Richardt
    Medizinische Klinik II and Institut für experimentelle und klinische Pharmakologie und Toxikologie, Universitatsklinikum Lubeck, Germany
    J Cardiovasc Pharmacol 40:641-6. 2002
    ..Regarding the AT -receptor antagonist, AT -receptor activation is also involved in bradykinin-mediated prejunctional stimulation...
  54. pmc Bradykinin potentiation by ACE inhibitors: a matter of metabolism
    Beril Tom
    Department of Pharmacology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Br J Pharmacol 137:276-84. 2002
    ..NEP does not appear to affect the bradykinin levels in close proximity to B(2) receptors, and the ACE inhibitor-induced bradykinin potentiation precedes B(2) receptor coupling to eNOS in caveolae...
  55. ncbi request reprint Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure
    Jens Fielitz
    Klinik fur Herz, Gefäss und Thoraxchirurgie, DHZB R P, H R Z, R H, V R Z, Berlin, Germany
    Circulation 105:286-9. 2002
    ..It increased 3.6-fold in AS (P<0.02) and 4-fold in DCM (P<0.002). NEP was localized in the myocardium by immunofluorescence microscopy and in situ PCR to myocytes and nonmyocyte areas and cells...