Wolfgang Dekant

Summary

Country: Germany

Publications

  1. ncbi Are 4-hydroxy-2(E)-nonenal derived mercapturic acids and (1)H NMR metabonomics potential biomarkers of chemically induced oxidative stress in the kidney?
    Angela Mally
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicology 230:244-55. 2007
  2. ncbi Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation
    W Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Street 9, 97078 Wurzburg, Germany
    Toxicol Lett 124:21-36. 2001
  3. ncbi Toxicity assessment strategies, data requirements, and risk assessment approaches to derive health based guidance values for non-relevant metabolites of plant protection products
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Regul Toxicol Pharmacol 56:135-42. 2010
  4. ncbi Biosynthesis of toxic glutathione conjugates from halogenated alkenes
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Lett 144:49-54. 2003
  5. ncbi Toxicokinetics of ethers used as fuel oxygenates
    W Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Würzburg D, Germany
    Toxicol Lett 124:37-45. 2001
  6. ncbi Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Germany
    Toxicol Appl Pharmacol 228:114-34. 2008
  7. ncbi Organ-specific carcinogenicity of haloalkenes mediated by glutathione conjugation
    W Dekant
    Department of Toxicology, University of Wurzburg, Germany
    J Cancer Res Clin Oncol 125:174-81. 1999
  8. ncbi Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity
    Melanie Adler
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Carcinogenesis 30:711-9. 2009
  9. ncbi Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery
    Maximilian Sieber
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 22:1221-31. 2009
  10. ncbi Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats
    Eva Rached
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Toxicol Sci 97:288-98. 2007

Collaborators

Detail Information

Publications63

  1. ncbi Are 4-hydroxy-2(E)-nonenal derived mercapturic acids and (1)H NMR metabonomics potential biomarkers of chemically induced oxidative stress in the kidney?
    Angela Mally
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicology 230:244-55. 2007
    ....
  2. ncbi Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation
    W Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Street 9, 97078 Wurzburg, Germany
    Toxicol Lett 124:21-36. 2001
    ....
  3. ncbi Toxicity assessment strategies, data requirements, and risk assessment approaches to derive health based guidance values for non-relevant metabolites of plant protection products
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Regul Toxicol Pharmacol 56:135-42. 2010
    ..Based on the recommendations given in the SANCO guidance document and the work described in this and the accompanying paper, a concise re-evaluation of the Guidance document is proposed...
  4. ncbi Biosynthesis of toxic glutathione conjugates from halogenated alkenes
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Lett 144:49-54. 2003
    ..Beta-lyase-dependent metabolism of halovinyl cysteine S-conjugates yields electrophilic thioketenes, whose covalent binding to cellular macromolecules is likely responsible for the observed nephrotoxicity of the parent compounds...
  5. ncbi Toxicokinetics of ethers used as fuel oxygenates
    W Dekant
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Würzburg D, Germany
    Toxicol Lett 124:37-45. 2001
    ..The results suggest that reactive and potentially toxic metabolites are not formed during biotransformation of these ethers and that toxic effects of these compounds initiated by covalent binding to cellular macromolecules are unlikely...
  6. ncbi Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Germany
    Toxicol Appl Pharmacol 228:114-34. 2008
    ..1 microg/kg bw/day) for the majority of the population...
  7. ncbi Organ-specific carcinogenicity of haloalkenes mediated by glutathione conjugation
    W Dekant
    Department of Toxicology, University of Wurzburg, Germany
    J Cancer Res Clin Oncol 125:174-81. 1999
    ..The formation of reactive intermediates by cysteine-conjugate beta-lyase may play a role in the target-organ toxicity and in the possible renal tumorigenicity of several chlorinated olefins widely used in many chemical processes...
  8. ncbi Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity
    Melanie Adler
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Carcinogenesis 30:711-9. 2009
    ....
  9. ncbi Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery
    Maximilian Sieber
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 22:1221-31. 2009
    ..Use of multiple analytical platforms for metabonomics analysis may result in a more comprehensive metabolite coverage and may be applied to obtain mechanistic information from conventional rodent toxicity studies...
  10. ncbi Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats
    Eva Rached
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Toxicol Sci 97:288-98. 2007
    ....
  11. ncbi Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats
    Angela Mally
    Department of Toxicology, , Germany
    Chem Res Toxicol 18:1242-52. 2005
    ..Taken together, the uncommon changes induced by OTA suggest that a unique mechanism may be involved in OTA nephrotoxicity and carcinogenicity...
  12. ncbi Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro
    Eva Rached
    Department of Toxicology, University of Wurzburg, Würzburg D 97078, Germany
    Toxicol Sci 103:371-81. 2008
    ....
  13. ncbi Furan carcinogenicity: DNA binding and genotoxicity of furan in rats in vivo
    Carolin Neuwirth
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Mol Nutr Food Res 56:1363-74. 2012
    ..However, short-term tests for genotoxicity of furan are inconclusive. The aim of this study was to assess the potential of furan to covalently bind to DNA, and to assess furan genotoxicity in rats in vivo...
  14. ncbi Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents
    Angela Mally
    Department of Toxicology, University of Wurzburg, Germany
    Mol Nutr Food Res 53:467-78. 2009
    ..The estimated intake of OTA in Europe is below this TWI for most of the population...
  15. ncbi Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity?
    Kristin Czakai
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Toxicol Sci 122:317-29. 2011
    ....
  16. ncbi Furan in heat-treated foods: formation, exposure, toxicity, and aspects of risk assessment
    Sabrina Moro
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Mol Nutr Food Res 56:1197-211. 2012
    ....
  17. ncbi Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration
    Wolfgang Völkel
    Department of Toxicology, University of Wurzburg, Versbacherstrasse 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 216:331-8. 2006
    ..Enterohepatic circulation of glucuronides derived from the two major 4-MBC metabolites may explain the slow excretion of 4-MBC metabolites with urine and the small percentage of the administered doses recovered in urine...
  18. ncbi Performance of novel kidney biomarkers in preclinical toxicity studies
    Dana Hoffmann
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Toxicol Sci 116:8-22. 2010
    ..Although Lcn2 did not appear to be specific for kidney toxicity, its rapid response to inflammation and tissue damage in general may suggest its utility in routine toxicity testing...
  19. ncbi Hepatobiliary toxicity of furan: identification of furan metabolites in bile of male f344/n rats
    Carolin Hamberger
    University of Wurzburg, Versbacher Strasse 9, Wurzburg, Germany
    Drug Metab Dispos 38:1698-706. 2010
    ....
  20. ncbi Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity
    Dana Hoffmann
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicology 277:49-58. 2010
    ..Overall, our data confirm increased sensitivity of new markers as compared to traditional clinical chemistry parameters...
  21. ncbi Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf)
    Paul Schuster
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 233:323-32. 2008
    ....
  22. ncbi Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver
    Angela Mally
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Mol Nutr Food Res 54:1556-67. 2010
    ..The aim of this study was to establish dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in livers of male F344 rats treated with furan at doses ≤2 mg/kg b.w. for 28 days...
  23. ncbi Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf) in rabbits
    Paul Schuster
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 244:247-53. 2010
    ..The differences in urinary metabolite patterns between rats and rabbits seen with HFO-1234yf are likely due to species-specific processing of glutathione S-conjugates. Rabbits also show a larger extent of biotransformation of HFO-1234yf...
  24. ncbi Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity
    Max Sieber
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Toxicol Sci 109:336-49. 2009
    ..The early increase in urine, which correlated with enhanced gene and protein expression at the site of injury, provides further support for lipocalin-2 and Kim-1 as sensitive, noninvasive biomarkers of nephrotoxicity...
  25. ncbi Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf) in male, pregnant and non-pregnant female rabbits after single high dose inhalation exposure
    Tobias Schmidt
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 263:32-8. 2012
    ..Lethality and clinical signs of toxicity were not observed in any group. The results suggest that the lethality of HFO-1234yf in pregnant rabbits unlikely is due to changes in biotransformation patterns or capacity in pregnant rabbits...
  26. ncbi Application of the "threshold of toxicological concern" to derive tolerable concentrations of "non-relevant metabolites" formed from plant protection products in ground and drinking water
    Stephanie Melching-Kollmuss
    BASF SE, GUP PP Z470, 67056 Ludwigshafen, 97078 Wurzburg, Germany
    Regul Toxicol Pharmacol 56:126-34. 2010
    ....
  27. ncbi Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Free Radic Biol Med 38:1526-36. 2005
    ....
  28. ncbi Toxicokinetics of acrylamide in rats and humans following single oral administration of low doses
    Eva Katharina Kopp
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 235:135-42. 2009
    ..7% and 49.2%, 6.3% and 6.4% and 13.2% and 14.5% of the applied dose, respectively. The obtained results suggest that the extent of AA bioactivation to GA in humans is lower than in rodents...
  29. ncbi Ochratoxin A: lack of formation of covalent DNA adducts
    Angela Mally
    , , Versbacher Strasse 9, , Germany
    Chem Res Toxicol 17:234-42. 2004
    ..In summary, the results presented here demonstrate that DNA binding of OTA is not detectable with sensitive analytical methods and is unlikely to represent a mechanism for OTA-induced tumor formation...
  30. ncbi Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro
    Angela Mally
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicology 224:108-18. 2006
    ....
  31. ncbi Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer
    Karoline Scholz
    Department of Toxicology, , Germany
    J Am Soc Mass Spectrom 16:1976-84. 2005
    ..These results show that the developed methods have a high potential to serve as both a prescreen to detect unknown MAs and to identify these analytes in complex matrix...
  32. ncbi Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry
    Wolfgang Völkel
    Department of Toxicology, University of Wurzburg, Versbacherstrasse 9, 97078 Wurzburg, Germany
    Drug Metab Dispos 33:1748-57. 2005
    ..The LOD obtained and the absence of detectable levels of BPA in samples from individuals suggests that general exposure of humans to BPA is much lower than the worst-case exposure scenario developed...
  33. ncbi Ochratoxin a causes DNA damage and cytogenetic effects but no DNA adducts in rats
    Angela Mally
    Department of Toxicology, , Germany
    Chem Res Toxicol 18:1253-61. 2005
    ....
  34. ncbi Rapid and sensitive HILIC-ESI-MS/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap column
    Eva K Kopp
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    J Agric Food Chem 56:9828-34. 2008
    ..Median concentrations in urine samples ( n = 54) of six nonsmoking human subjects were 24.0 microg/L (AAMA, 7.8-79.8 microg/L), 16.7 microg/L (AAMA-sulfoxide, 6.8-70.1 microg/L), and 3.82 microg/L (GAMA, 1.0-23.6 microg/L)...
  35. ncbi DNA adduct formation by ochratoxin A: review of the available evidence
    Angela Mally
    Department of Toxicology, , Germany
    Food Addit Contam 22:65-74. 2005
    ..The aim of this manuscript is to provide an overview of the available literature regarding DNA adduct formation by OTA...
  36. ncbi Biotransformation of trans-1,1,1,3-tetrafluoropropene (HFO-1234ze)
    Paul Schuster
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 239:215-23. 2009
    ..6 h). The obtained results suggest that HFO-1234ze is likely subjected to an addition-elimination reaction with glutathione and to a CYP 450 mediated epoxidation at low rates...
  37. ncbi Toxicokinetics of tetrabromobisphenol a in humans and rats after oral administration
    Ute M D Schauer
    Department of Toxicology, , , Germany
    Toxicol Sci 91:49-58. 2006
    ..The obtained results suggest absorption of TBBPA from the gastrointestinal tract and rapid metabolism of the absorbed TBBPA by conjugation resulting in a low systemic bioavailability of TBBPA...
  38. ncbi Quantitation of mercapturic acids from acrylamide and glycidamide in human urine using a column switching tool with two trap columns and electrospray tandem mass spectrometry
    Marco Kellert
    Department of Toxicology, , Versbacher Strasse 9, , Germany
    J Chromatogr A 1131:58-66. 2006
    ..Lower levels for AA-MA (14-102 microg/L) and GA-MA (1-11 microg/L) were detected in non-smokers (n=13)...
  39. ncbi Ochratoxin A alters cell adhesion and gap junction intercellular communication in MDCK cells
    Angela Mally
    Department of Toxicology, University of Wurzburg, Germany
    Toxicology 223:15-25. 2006
    ..Taken together, these data support the hypothesis that disruption of cell-cell signaling may contribute to OTA toxicity and carcinogenicity...
  40. ncbi The role of biotransformation and bioactivation in toxicity
    Wolfgang Dekant
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    EXS 99:57-86. 2009
    ..The interaction of toxic products formed by biotransformation reactions with cellular macromolecules initiates the sequences resulting in cellular damage, cell death and toxicity...
  41. ncbi Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats
    A Mally
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Food Chem Toxicol 45:2254-60. 2007
    ....
  42. ncbi Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues
    E Schmitt
    Department of Toxicology, University of Wuerzburg, Versbacherstrasse 9, D 97078 Wuerzburg, Germany
    Toxicol In Vitro 15:433-9. 2001
    ..Furthermore, we demonstrated that BG-1 cells are a suitable additional cell system to investigate estrogenicity of test compounds...
  43. ncbi Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites?
    H Zepnik
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Sci 59:59-67. 2001
    ..The obtained results suggest that oxidative biotransformation of ochratoxin A occurs at low rates, is catalyzed by cytochromes P450, and is unlikely to form reactive intermediates capable of binding to DNA...
  44. ncbi Biotransformation of trans-1-chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd)
    Tobias Schmidt
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 268:343-51. 2013
    ..The low extent of biotransformation and the rapid excretion of metabolites formed are consistent with the very low potential for toxicity of trans-HCFO-1233zd in mammals...
  45. ncbi Fumonisin B1 and the kidney: modes of action for renal tumor formation by fumonisin B1 in rodents
    Stephanie Muller
    Department of Toxicology, University of Wurzburg, Germany
    Food Chem Toxicol 50:3833-46. 2012
    ....
  46. ncbi Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration
    Herbert Zepnik
    , , Versbacher Str 9, , Germany
    Toxicol Appl Pharmacol 192:36-44. 2003
    ..The high concentrations of OTA in kidneys of male rats may, in part, explain the organ- and gender-specific toxicity of OTA...
  47. ncbi Identification and pathway mapping of furan target proteins reveal mitochondrial energy production and redox regulation as critical targets of furan toxicity
    Sabrina Moro
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Toxicol Sci 126:336-52. 2012
    ....
  48. ncbi Comparison of electrospray ionization, atmospheric pressure chemical ionization, and atmospheric pressure photoionization for the analysis of dinitropyrene and aminonitropyrene LC-MS/MS
    Ellen A Straube
    Department of Toxicology, , Versbacher Strasse 9, , Germany
    J Am Soc Mass Spectrom 15:1853-62. 2004
    ..To our knowledge, this is the first time that aminonitropyrene was observed in plasma after intratracheal or oral administration directly demonstrating the reductive metabolism of dinitropyrene in vivo...
  49. ncbi Ochratoxin A: apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics?
    Eva Rached
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Toxicol Sci 92:78-86. 2006
    ..Aberrant exit from mitosis resulting in blocked or asymmetric cell division may favor the occurrence of cytogenetic abnormalities and may therefore play a critical role in renal tumor formation by OTA...
  50. ncbi Disposition and biotransformation of the estrogenic isoflavone daidzein in rats
    T Bayer
    , , Versbacher Str. 9, , Germany
    Toxicol Sci 62:205-11. 2001
    ....
  51. ncbi Metabolism and kinetics of bisphenol a in humans at low doses following oral administration
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 15:1281-7. 2002
    ..The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bisphenol A in humans following oral absorption of low doses...
  52. ncbi Enhanced sensitivity for the determination of ambiphilic polyaromatic amines by LC-MS/MS after acetylation
    Ellen Straube
    Department of Toxicology, , Versbacher Strasse 9, , Germany
    J Chromatogr A 1067:181-90. 2005
    ....
  53. ncbi Toxicokinetics of methyl tert-butyl ether and its metabolites in humans after oral exposure
    A Amberg
    , , Versbacher Str. 9, , Germany
    Toxicol Sci 61:62-7. 2001
    ..The obtained data indicate that MTBE-biotransformation and excretion after oral exposure is similar to inhalation exposure and suggest the absence of a significant first-pass metabolism of MTBE in the liver after oral administration...
  54. ncbi Genotoxic activity of four metabolites of the soy isoflavone daidzein
    Elmar Schmitt
    Institute of Pharmacology and Toxicology, University of Wuerzburg, Versbacher Strasse 9, D-97078 Wuerzburg, Germany
    Mutat Res 542:43-8. 2003
    ..2-fold induction at 100 microM) induced micronuclei in a concentration-dependent manner. Thus, both reductive and oxidative metabolites of the soy isoflavone daidzein exhibit genotoxic potential in vitro...
  55. ncbi Biotransformation of 1,1,1,3,3-Pentafluoropropane (HFC-245fa)
    Tanja Bayer
    , , Versbacher Strasse 9, 97078, Germany
    Chem Res Toxicol 15:723-33. 2002
    ..The toxic effects of 1,1,1,3,3-pentafluoropropane may be associated with the formation of the minor metabolite 3,3,3-trifluoropropanoic acid, which is highly toxic in rats...
  56. ncbi Toxicology of chlorofluorocarbon replacements
    W Dekant
    Department of Toxicology, University of Wurzburg, Germany
    Environ Health Perspect 104:75-83. 1996
    ..The chronic toxicity of the CFC replacements studied is unlikely to be of relevance for humans exposed during production and application of CFC replacements...
  57. ncbi Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins
    W Völkel
    Department of Toxicology, University of Wurzburg, Germany
    J Chromatogr A 847:35-46. 1999
    ....
  58. ncbi Biotransformation and nephrotoxicity of ochratoxin B in rats
    Angela Mally
    , , , Germany
    Toxicol Appl Pharmacol 206:43-53. 2005
    ..OTB is more extensively metabolized and more rapidly eliminated than OTA. The lack of specific retention of OTB in the kidneys and the differences in toxicokinetics may therefore provide an explanation for the lower toxicity of OTB...
  59. ncbi Absence of 2'-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS
    Thierry Delatour
    Institut fur Toxikologie, Universitat Wurzburg, Wurzburg, Germany
    Mol Nutr Food Res 52:472-82. 2008
    ..5 dGuoOTA/10(9) nucleotides. These data are consistent with previous results showing lack of DNA adduct formation by OTA and demonstrate that dGuoOTA is not formed in biologically relevant amounts under physiological conditions in vivo...
  60. ncbi Specificity of aminoacylase III-mediated deacetylation of mercapturic acids
    Debra Newman
    Division of Nephrology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 7 155 Factor Building, Los Angeles, CA 90095 1689, USA
    Drug Metab Dispos 35:43-50. 2007
    ..Our results indicate that in proximal tubule cells, AAIII plays an important role in deacetylating several halogenated mercapturic acids, and this process may be involved in their cyto- and nephrotoxicity...
  61. ncbi Exposure of an adult population to perfluorinated substances using duplicate diet portions and biomonitoring data
    Hermann Fromme
    Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterindiirstrasse 2, D 85764 Oberschleissheim, Germany
    Environ Sci Technol 41:7928-33. 2007
    ..Biomonitoring data predict an exposure in a comparable range. We suppose that, normally, food intake is the main source of exposure of the general population to PFOS and PFOA...
  62. ncbi Kinetics of 3-(4-methylbenzylidene)camphor in rats and humans after dermal application
    Ute M D Schauer
    Institute of Toxicology, University of Wuerzburg, Versbacherstrasse 9, 97078 Wuerzburg, Germany
    Toxicol Appl Pharmacol 216:339-46. 2006
    ..The obtained results suggest a more intensive biotransformation of 4-MBC in rats as compared to humans after dermal application and a poor absorption of 4-MBC through human skin...
  63. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells
    Stefanie Knerr
    Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Germany
    Mol Nutr Food Res 50:378-84. 2006
    ..Both effects were in good agreement with the extent of induction of CYP1A1 protein and EROD activity, suggesting that CYP1 induction is a major source of ROS formation in TCDD-treated hepatocytes...