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Genomes and Genes | Martin H DeiningerSummaryCountry: Germany Publications
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Publications
Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progressionM H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
Brain Res 885:111-6. 2000..0471) lower in primary oligodendrogliomas than in high grade oligodendroglioma relapses. These data provide convincing evidence for the differential accumulation of cyclooxygenase isoforms during oligodendroglioma progression in vivo...- Cortical neurons of Creutzfeldt-Jakob disease patients express the urokinase-type plasminogen activator receptorM H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Calwer Strasse 3, 72076, Germany
Neurosci Lett 324:80-2. 2002..These data provide the pathophysiological basis for detailed analyses of the role of the plasminogen activator system in CJD and related diseases... - The allograft inflammatory factor-1 family of proteinsMartin H Deininger
Institute of Brain Research, University of Tubingen, Calwer Str 3, D 72076 Tubingen, Germany
FEBS Lett 514:115-21. 2002..In this review, genomic and functional characteristics of AIF-1-related proteins are summarized and a common nomenclature is proposed... - Macrophage/microglial cell subpopulations in glioblastoma multiforme relapses are differentially altered by radiochemotherapyM H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Germany
J Neurooncol 55:141-7. 2001..The lacking increase of CD68 expressing cells in patients with radiochemotherapy suggests depletion of this cell type by postsurgical therapy... - Galectin-3 labeling correlates positively in tumor cells and negatively in endothelial cells with malignancy and poor prognosis in oligodendroglioma patientsMartin H Deininger
Institute of Brain Research, University of Tuebingen, Medical School Tuebingen, Germany
Anticancer Res 22:1585-92. 2002..Galectin-3 modulates cell growth, transformation and metastasis in a wide range of neoplasms... - Release of regulators of angiogenesis following Hypocrellin-A and -B photodynamic therapy of human brain tumor cellsMartin H Deininger
Institute of Brain Research, University of Tubingen, Calwer Strasse 3, D 72076 Tubingen, Germany
Biochem Biophys Res Commun 298:520-30. 2002..However, VEGF release is also induced thus suggesting both favorable and deleterious effects on tumor outgrowth... - Accumulation of endostatin/collagenXVIII in brains of patients who died with cerebral malariaMartin H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Calwer Str 3, Tubingen, Germany
J Neuroimmunol 131:216-21. 2002..Focal accumulation of endostatin/collagenXVIII in granulomas but not in ring hemorrhages of CM brains suggests a novel process that is involved in the destruction of endothelial cells at the time of Dürck's granuloma formation... - Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer's diseaseMartin H Deininger
Institute of Brain Research, University of Tuebingen Medical School, D 72076 Tuebingen, Germany
J Neurosci 22:10621-6. 2002.... - Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob diseaseMartin H Deininger
Institute of Brain Research, University of Tuebingen Medical School, Tuebingen, Germany
J Mol Neurosci 20:25-30. 2003..These data show that accumulation of COX-1-expressing macrophages/microglial cells and COX-2-expressing neurons might represent important regulatory mechanisms in the complex process of neuronal degeneration in CJD patients... - Endothelial endostatin release is induced by general cell stress and modulated by the nitric oxide/cGMP pathwayMartin H Deininger
Institute of Brain Research, University of Tuebingen Medical School, Calwer Str 3, D 72076 Tuebingen, Germany
FASEB J 17:1267-76. 2003..These results describe the modulation of endostatin release by the NO signaling cascade and provide important new pharmacological information for the systemic induction of endogenous endostatin release by common NO donor pharmacotherapy... - Expression and release of CD14 in astrocytic brain tumorsMartin H Deininger
Institute of Brain Research, University of Tubingen Medical School, Calwer Str 3, 72076 Tubingen, Germany
Acta Neuropathol 106:271-7. 2003..These results demonstrate that CD14 is expressed, and more importantly released, from a subset of human glioma cells and infiltrating macrophages/microglial cells that may contribute to immunodepletion observed in these patients... - The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brainsM H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
Neuropathol Appl Neurobiol 29:389-99. 2003..Parallel reverse transcriptase polymerase chain reaction and sequencing was used to confirm AIF-1 mRNA expression... - Angiogenic proteins in brains of patients who died with cerebral malariaMartin H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Calwer Str 3, D 72076 Tubingen, Germany
J Neuroimmunol 142:101-11. 2003..These data demonstrate the activation of the proangiogenic VEGF signaling cascade in patients with CM, probably reflecting compensatory mechanisms of general and focal brain hypoxia observed in these patients... - Tako-tsubo cardiomyopathy: reversible heart failure with favorable outcome in patients with intracerebral hemorrhage. Case reportMartin H Deininger
Department of Neurosurgery, University of Freiburg Medical School, Freiburg, Germany
J Neurosurg 105:465-7. 2006..This characteristic must be taken into consideration when treating patients with intracerebral hemorrhage to avoid misclassification of the disease... - Cerebral vasospasm in shunt infectionMartin H Deininger
Department of General Neurosurgery, University of Freiburg Medical School, Breisacher Str 64, Freiburg 79106, Germany
Neurocrit Care 7:27-30. 2007..In bacterial shunt infection, CNS inflammation is a frequently observed complication that may cause vascular complications including vasospasms. Here, we describe the first patient with shunt infection-induced cerebral vasospasms... - Endostatin/collagen XVIII accumulates in patients with traumatic brain injuryMartin H Deininger
Department of Neurosurgery, University of Freiburg Medicsal School, Freiburg, Germany
J Neurotrauma 23:1103-10. 2006..Common NO synthase inhibitor pharmacotherapy with aminoguanidine and L-NAME completely abolished endostatin release from microglial cells, raising hopes of altering endostatin release in vivo... - Macrophages/microglial cells in patients with cerebral malariaMartin H Deininger
Institute of Brain Research, University of Tuebingen Medical School, Calwer Str 3, D 72076 Tuebingen, Germany
Eur Cytokine Netw 13:173-85. 2002..In this review, recent advances in the understanding of the involvement of macrophages/microglial cells in the development of cerebral malaria are summarized... - Multiple epitope labeling by the exclusive use of alkaline phosphatase conjugates in immunohistochemistryM H Deininger
Institute of Brain Research, University of Tuebingen, Germany
Histochem Cell Biol 110:425-30. 1998.... - Galectin-3: cellular distribution and correlation with WHO-grade in human gliomasH M Strik
Institute of Brain Research, Medical School, University of Tubingen, Germany
J Neurooncol 53:13-20. 2001..The differential expression on endothelial cells raises the question if galectin-3 plays a role in tumor angiogenesis of human gliomas... - Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and gliomaM H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Germany
J Neuroimmunol 95:202-8. 1999.... - CP-10, a chemotactic peptide, is expressed in lesions of experimental autoimmune encephalomyelitis, neuritis, uveitis and in C6 gliomasM H Deininger
Institute of Brain Research, University of Tubingen, Germany
J Neuroimmunol 93:156-63. 1999..Using double labeling experiments, other cells participating in the inflammatory reaction were found to express CP-10, like few lymphoblastic W3/13+ cells in the vicinity of the inflammatory infiltrate... - Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivoM H Deininger
Institute of Brain Research, University of Tuebingen Medical School, Germany
Acta Neuropathol 98:240-4. 1999..Further studies are required to determine whether COX-2 is involved in the development of necrosis or, more likely, whether COX-2 is a part of the tumor tissue response to necrosis... - Focal accumulation of cyclooxygenase-1 (COX-1) and COX-2 expressing cells in cerebral malariaM H Deininger
Institute of Brain Research, University of Tuebingen Medical School, Calwer Str 3, D 72076, Tuebingen, Germany
J Neuroimmunol 106:198-205. 2000..The restricted expression and accumulation of COX-1 and COX-2 in CM brains adds convincing evidence for the participation of cyclooxygenases in the formation of fever, inflammation and granuloma in these patients... - Differential cellular accumulation of transforming growth factor-beta1, -beta2, and -beta3 in brains of patients who died with cerebral malariaM H Deininger
Institute of Brain Research, University of Tubingen, Medical School, D 72076 Tubingen, Germany
J Infect Dis 181:2111-5. 2000.... - Heme oxygenase (HO)-1 expressing macrophages/microglial cells accumulate during oligodendroglioma progressionM H Deininger
Institute of Brain Research, University of Tuebingen, Medical School, Calwer Strasse 3, D 72076, Tuebingen, Germany
Brain Res 882:1-8. 2000..We conclude from these data that HO-1 expressing macrophages/microglial cells accumulate during oligodendroglioma progression in areas of focal necrosis. However, overall biological function of this phenomenon remains to be determined... - Allograft inflammatory factor-1 defines a distinct subset of infiltrating macrophages/microglial cells in rat and human gliomasM H Deininger
Institute of Brain Research, University of Tuebingen, Germany
Acta Neuropathol 100:673-80. 2000..0001). These results suggest that AIF-1 defines a distinct subset of tumor-associated activated macrophages/ microglial cells... - Distinct radiochemotherapy protocols differentially influence cellular proliferation and expression of p53 and Bcl-2 in glioblastoma multiforme relapses in vivoM H Deininger
Institute of Brain Research, University of Tuebingen Medical School, Germany
J Neurooncol 48:121-9. 2000..Furthermore, we show that ISNT, DO-I and TGase II labeling scores are therapy-specific predictors of time to progression in GBM patients... - Heat shock protein expression in human gliomasH M Strik
Institute of Brain Research, Medical School, University of Tubingen, Calwer Str 3, D 72076 Tubingen, Germany
Anticancer Res 20:4457-62. 2000..Here, we asked whether the differential response to radiochemotherapy and different overall prognosis for astrocytic and oligodendroglial tumours can be accounted for by differences in HSP expression... - In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor gradeM W Elmlinger
Pediatric Endocrinology, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
Endocrinology 142:1652-8. 2001..The results suggest cell type-specific accumulation of IGFBP-1, -2, and -3 in human glial tumors of the brain. The increase in IGFBP-2 expression with this malignancy suggests a role of IGFBP-2 in the biology of human gliomas... 
Minimally invasive dorsal percutaneous spondylodesis for the treatment of adult pyogenic spondylodiscitisMartin H Deininger
Department of General Neurosurgery, University of Freiburg Medical School, 79106 Freiburg, Germany
Acta Neurochir (Wien) 151:1451-7. 2009..If surgical intervention is required, a combined anterior and posterior approach for debridement and fusion with autologous bone graft or titanium mesh cage is usually performed...- Localization of endostatin in rat and human gliomasH M Strik
Institute of Brain Research, Medical School, University of Tuebingen, Germany
Cancer 91:1013-9. 2001..Its occurrence and localization has not yet been examined in human brain tumors. The authors report the production of a monoclonal antibody and detection of endostatin in rat and human gliomas by immunohistochemistry... - Bedside catheter evacuation of predominantly isolated traumatic supratentorial hemorrhageMartin H Deininger
Department of Neurosurgery, University of Freiburg Medical School, Freiburg, Germany
J Trauma 65:1194-9. 2008..Predominantly isolated intracerebral hemorrhage (ICH) is a rare complication after traumatic brain injury that tends to occur in patients with coagulation disorders... - Gravitational valves in supine patients with ventriculo-peritoneal shuntsMartin H Deininger
Department of Neurosurgery, University of Freiburg Medical School, Breisacher Str 64, D 79106 Freiburg, Germany
Acta Neurochir (Wien) 151:705-9; discussion 709. 2009..In the subgroup of bedridden hydrocephalic patients with ventriculo-peritoneal shunts and gravitational valves, we occasionally observed persisting hydrocephalic complaints even when mechanical or infection-related obstruction was excluded... - Transient intradural catheter lysis in a patient with a diffuse and elongated subdural hematoma of the spine due to trauma. Case reportMartin H Deininger
Department of General Neurosurgery, University of Freiburg Medical School, Freiburg, Germany
J Neurosurg Spine 6:570-3. 2007..A larger series needs to be analyzed, however, to address the indications and limitations of the technique compared with conventional open surgery. Such evaluation should include serial MR imaging and electrophysiological examination... - Free-hand bedside catheter evacuation of cerebellar hemorrhageM H Deininger
Department of Neurosurgery, University of Freiburg Medical School, Freiburg, Germany
Minim Invasive Neurosurg 51:57-60. 2008..To sufficiently treat these patients, we have developed a minimally-invasive, free-hand, bedside catheter evacuation technique...