Kirsten de Groot

Summary

Country: Germany

Publications

  1. ncbi request reprint Development and validation of a disease extent index for Wegener's granulomatosis
    K de Groot
    Department of Rheumatology, Medical University of Lubeck, and Rheumaklinik, Bad Bramstedt, Germany
    Clin Nephrol 55:31-8. 2001
  2. ncbi request reprint Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis
    Kirsten de Groot
    Medical School Hannover, Germany
    Arthritis Rheum 52:2461-9. 2005
  3. doi request reprint Renal disease in small-vessel vasculitis
    Kirsten de Groot
    Medizinische Klinik III, Klinikum Offenbach, KfH Nierenzentrum Offenbach, Starkenburgring 66, Offenbach, Germany
    Cleve Clin J Med 79:S22-6. 2012
  4. ncbi request reprint What is new in the therapy of ANCA-associated vasculitides? Take home messages from the 12th workshop on ANCA and systemic vasculitides
    K de Groot
    Department of Nephrology, Medical School, Hannover, Germany
    Clin Nephrol 64:480-4. 2005
  5. ncbi request reprint [Therapy of primary systemic vasculitis]
    K de Groot
    Abteilung für Nephrologie, Medizinische Hochschule Hannover
    Internist (Berl) 44:1541-8. 2003
  6. ncbi request reprint [Pulmonary renal syndrome]
    K de Groot
    Abteilung für Nephrologie, Medizinische Hochschule Hannover, Hannover, Germany
    Internist (Berl) 44:1140-50. 2003
  7. ncbi request reprint [Interdisciplinary consensus to management of lupus nephritis in Germany]
    K de Groot
    Medizinische Klinik III, Klinikum Offenbach GmbH, Starkenburgring 66, 63069, Offenbach Main, Germany
    Z Rheumatol 66:724, 726. 2007
  8. ncbi request reprint Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis
    K de Groot
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 56:3847-53. 2007
  9. doi request reprint [Managing comorbidities of inflammatory rheumatic diseases]
    K de Groot
    Medizinische Klinik III, Klinikum Offenbach GmbH, Starkenburgring 66, Offenbach, Germany
    Internist (Berl) 52:688-96. 2011
  10. ncbi request reprint [Initial results of multicenter, randomized, controlled therapy studies of ANCA-associated vasculitis]
    Kirsten de Groot
    Arztin für Innere Medizin, Rheumatologie, Nephrologie Abt für Nephrologie Med Hochschule Hannover Carl Neuberg Str 1 30625 Hannover, Germany
    Z Rheumatol 61:607-9. 2002

Detail Information

Publications42

  1. ncbi request reprint Development and validation of a disease extent index for Wegener's granulomatosis
    K de Groot
    Department of Rheumatology, Medical University of Lubeck, and Rheumaklinik, Bad Bramstedt, Germany
    Clin Nephrol 55:31-8. 2001
    ..We present a validation study of the Disease Extent Index (DEI)...
  2. ncbi request reprint Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis
    Kirsten de Groot
    Medical School Hannover, Germany
    Arthritis Rheum 52:2461-9. 2005
    ..This unblinded, prospective, randomized, controlled trial was undertaken to determine whether methotrexate (MTX) could replace CYC in the early treatment of AASV...
  3. doi request reprint Renal disease in small-vessel vasculitis
    Kirsten de Groot
    Medizinische Klinik III, Klinikum Offenbach, KfH Nierenzentrum Offenbach, Starkenburgring 66, Offenbach, Germany
    Cleve Clin J Med 79:S22-6. 2012
    ..Renal transplant patients with vasculitis fare as well as renal transplant patients without vasculitis. Lastly, renal vasculitis is an independent risk factor for cardiovascular events...
  4. ncbi request reprint What is new in the therapy of ANCA-associated vasculitides? Take home messages from the 12th workshop on ANCA and systemic vasculitides
    K de Groot
    Department of Nephrology, Medical School, Hannover, Germany
    Clin Nephrol 64:480-4. 2005
    ..Myfortic will be assessed for a similar indication in the future. Currently, long-term follow-up of the EUVAS patients is also sought...
  5. ncbi request reprint [Therapy of primary systemic vasculitis]
    K de Groot
    Abteilung für Nephrologie, Medizinische Hochschule Hannover
    Internist (Berl) 44:1541-8. 2003
    ..Immunosuppression in these diseases is reserved for organ- or life-threatening manifestations only...
  6. ncbi request reprint [Pulmonary renal syndrome]
    K de Groot
    Abteilung für Nephrologie, Medizinische Hochschule Hannover, Hannover, Germany
    Internist (Berl) 44:1140-50. 2003
    ..Supportive measures such as temporary ventilation and hemodialysis have further reduced mortality...
  7. ncbi request reprint [Interdisciplinary consensus to management of lupus nephritis in Germany]
    K de Groot
    Medizinische Klinik III, Klinikum Offenbach GmbH, Starkenburgring 66, 63069, Offenbach Main, Germany
    Z Rheumatol 66:724, 726. 2007
    ..In October 2006 a German ad hoc committee consisting of rheumatologists and nephrologists developed a consensus statement on the current practice in the management of lupus nephritis. The published results are summarized...
  8. ncbi request reprint Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis
    K de Groot
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 56:3847-53. 2007
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to play a pivotal role in the regeneration of damaged endothelium. The aim of this study was to investigate whether EPCs are involved in vascular repair in AAV...
  9. doi request reprint [Managing comorbidities of inflammatory rheumatic diseases]
    K de Groot
    Medizinische Klinik III, Klinikum Offenbach GmbH, Starkenburgring 66, Offenbach, Germany
    Internist (Berl) 52:688-96. 2011
    ..Effective control of the systemic inflammatory activity may serve to reduce the risk of certain cardiovascular and neoplastic comorbidities...
  10. ncbi request reprint [Initial results of multicenter, randomized, controlled therapy studies of ANCA-associated vasculitis]
    Kirsten de Groot
    Arztin für Innere Medizin, Rheumatologie, Nephrologie Abt für Nephrologie Med Hochschule Hannover Carl Neuberg Str 1 30625 Hannover, Germany
    Z Rheumatol 61:607-9. 2002
  11. ncbi request reprint Standardized neurologic evaluations of 128 patients with Wegener granulomatosis
    K de Groot
    Department of Rheumatology, University of Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Arch Neurol 58:1215-21. 2001
    ..To assess the frequency and type of neurologic involvement in a cohort of patients with generalized Wegener granulomatosis (WG)...
  12. doi request reprint [Wegener's granulomatosis and microscopic polyangiitis]
    K de Groot
    Medizinische Klinik III Innere Medizin, Nephrologie, Rheumatologie, Klinikum Offenbach GmbH, Starkenburgring 66, 63069, Offenbach
    Z Rheumatol 68:49-63; quiz 64. 2009
    ..Age > or = 50 at diagnosis, renal dysfunction and pulmonary involvement are associated with higher mortality rates. The relapse rate is approximately 50% within 5 years, being higher in WG than MPA...
  13. ncbi request reprint [Renal manifestations in rheumatic diseases]
    K de Groot
    Med Klinik III Nephrologie, Hypertensiologie, Rheumatologie, Klinikum Offenbach GmbH, 63069 Offenbach
    Internist (Berl) 48:779-85. 2007
    ..The differential diagnosis of renal abnormalities in a rheumatic patient should include drug induced renal impairment as well as infection...
  14. ncbi request reprint Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial
    Kirsten de Groot
    Klinikum Offenbach, Offenbach, Germany
    Ann Intern Med 150:670-80. 2009
    ..Current therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are limited by toxicity...
  15. doi request reprint TLR-4+ peripheral blood monocytes and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan M Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 26:1421-4. 2011
    ..Atherosclerosis is an inflammatory process mediated by circulating immune cells, including monocytes. There is accumulating evidence for the involvement of Toll-like receptor 4 (TLR-4) as a mediator of atherogenesis...
  16. pmc Endothelial progenitor cells and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e11477. 2010
    ..Endothelial progenitor cells (EPCs) mediate vascular repair and regeneration. Their number in peripheral blood is related to cardiovascular events in individuals with normal renal function...
  17. ncbi request reprint Kidney graft function determines endothelial progenitor cell number in renal transplant recipients
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, 30625 Hannover, Germany
    Transplantation 79:941-5. 2005
    ..In uremic patients, the number of functionally active EPCs is reduced. Thus, we assessed EPCs in stable patients 6 months or more after renal transplantation...
  18. ncbi request reprint [Pulmonary-renal syndrome]
    K de Groot
    Abteilung für Nephrologie, Medizinische Hochschule Hannover
    Internist (Berl) 46:769-81; quiz 782. 2005
    ..Supportive measures as temporary ventilation and hemodialysis have further reduced mortality...
  19. ncbi request reprint Erythropoietin regulates endothelial progenitor cells
    Ferdinand H Bahlmann
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Blood 103:921-6. 2004
    ..Erythropoietin increases the number of functionally active EPCs in humans. Administration of rhEPO or EPO analogs may open new therapeutic strategies in regenerative cardiovascular medicine...
  20. ncbi request reprint Uremia causes endothelial progenitor cell deficiency
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine Hannover Medical School, Hannover, Germany
    Kidney Int 66:641-6. 2004
    ..Their number in peripheral blood correlates with endothelial function and cardiovascular risk in humans. We explored whether uremia influences the number of EPCs...
  21. ncbi request reprint Erythropoietin: is it more than correcting anaemia?
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nephrol Dial Transplant 19:20-2. 2004
  22. ncbi request reprint High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate
    Eva Reinhold-Keller
    Medical University of Lubeck, Lubeck, Germany
    Arthritis Rheum 47:326-32. 2002
    ....
  23. ncbi request reprint Stem cells and progenitor cells in renal disease
    Hermann Haller
    Department of Nephrology, Hannover Medical School, Germany
    Kidney Int 68:1932-6. 2005
    ..Such animal models improve our understanding of stem cell behavior in the kidney and may eventually contribute to novel therapies...
  24. ncbi request reprint Cardiovascular disease in renal patients--a matter of stem cells?
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nephrol Dial Transplant 19:2952-4. 2004
  25. ncbi request reprint Toll-like receptor 2 and renal allograft function
    Kirsten de Groot
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Am J Nephrol 28:583-8. 2008
    ..Toll-like receptors (TLR) modulate the immune response. We analyzed the relationships between TLR expression in renal tissue with infection, rejection and graft function after kidney transplantation...
  26. ncbi request reprint Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis
    C Metzler
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Rheumatology (Oxford) 46:1087-91. 2007
    ..Results from open-label trials suggest that methotrexate (MTX) and leflunomide (LEF) are effective for maintenance of remission in Wegener's granulomatosis (WG), but data from randomized controlled clinical trails are not yet available...
  27. ncbi request reprint Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure
    Ferdinand H Bahlmann
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 110:1006-12. 2004
    ....
  28. ncbi request reprint Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 111:2356-63. 2005
    ..We therefore tested the hypothesis that similar reductions in LDL cholesterol with simvastatin and ezetimibe, a novel cholesterol absorption inhibitor, result in different effects on endothelial function...
  29. ncbi request reprint Tolerance of mycophenolate mofetil in end-stage renal disease patients with ANCA-associated vasculitis
    M Haubitz
    Department of Nephrology, University Hospital Hannover, Germany
    Clin Nephrol 57:421-4. 2002
    ..Since all the treated patients who have been reported so far had no or only moderate renal insufficiency when MMF was initiated, no data are available regarding side effects in patients with end-stage renal disease (ESRD)...
  30. ncbi request reprint The value of pulse cyclophosphamide in ANCA-associated vasculitis: meta-analysis and critical review
    K de Groot
    Department of Nephrology, Medical School Hannover, Germany
    Nephrol Dial Transplant 16:2018-27. 2001
    ....
  31. ncbi request reprint Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis
    Alexander Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, 30625, Hannover, Germany
    Lancet 361:206-10. 2003
    ..We postulated that isolation of these cells from peripheral blood might provide a novel marker of the disease and elucidate pathogenetic events...
  32. ncbi request reprint IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes
    Imke Peters
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, 30625 Germany, and Division of Pediatric Nephrology, Children s Hospital at Montefiore, Bronx, NY, USA
    J Am Soc Nephrol 17:1644-56. 2006
    ..These results demonstrate that the IGF/IGFBP axis plays an important role in the development of podocyte apoptosis by modulation of TGF-beta and BMP-7-induced pro- and antiapoptotic signals...
  33. ncbi request reprint Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmic antibodies (ANCA). A report of 3 cases and a review of the literature
    E Reinhold-Keller
    Department of Rheumatology, Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Germany
    Clin Exp Rheumatol 19:541-9. 2001
    ..The authors report 3 young patients with biopsy-proven active generalized WG who were consistently negative for ANCA over observation times ranging from 58 to 114 months...
  34. pmc Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis
    A Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Rheum Dis 65:164-8. 2006
    ..To evaluate numbers of circulating endothelial cells (CECs) in ANCA associated vasculitis and compare vasculitic relapse with limited granulomatous disease...
  35. ncbi request reprint Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study
    Elena Csernok
    Department of Rheumatology, University of Schleswig Holstein Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Rheumatology (Oxford) 43:174-80. 2004
    ..To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories...
  36. pmc Smoking habits in patients diagnosed with ANCA associated small vessel vasculitis
    M Haubitz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Rheum Dis 64:1500-2. 2005
    ..To study the prevalence of smoking at onset of symptoms in patients with small vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA)...
  37. ncbi request reprint When should patients with ANCA-associated vasculitis be switched from induction to maintenance therapy?
    Oliver Flossmann
    Addenbrooke s Hospital, Cambridge, UK
    Nat Clin Pract Nephrol 3:236-7. 2007
  38. ncbi request reprint A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies
    David Jayne
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 349:36-44. 2003
    ..We investigated whether exposure to cyclophosphamide in patients with generalized vasculitis could be reduced by substitution of azathioprine at remission...
  39. ncbi request reprint Circulating endothelial cells: life, death, detachment and repair of the endothelial cell layer
    Alexander Woywodt
    Nephrol Dial Transplant 17:1728-30. 2002
  40. pmc Development of comprehensive disease assessment in systemic vasculitis
    Oliver Flossmann
    Botnar Research Centre, University of Oxford, Oxford, UK
    Ann Rheum Dis 66:283-92. 2007
    ..The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function...
  41. ncbi request reprint Pharmacokinetics of moxifloxacin and levofloxacin in intensive care unit patients who have acute renal failure and undergo extended daily dialysis
    David Czock
    Division of Nephrology, University Hospital Ulm, Ulm, Germany
    Clin J Am Soc Nephrol 1:1263-8. 2006
    ..The levofloxacin dosage, however, should be reduced according to the intensity of renal replacement therapy...
  42. ncbi request reprint Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Hypertension 45:526-9. 2005
    ..Angiotensin II receptor antagonists increase the number of regenerative EPCs in patients with type 2 diabetes mellitus. This action may be of therapeutic relevance contributing to their beneficial cardiovascular effects...