Henrik Daub

Summary

Country: Germany

Publications

  1. ncbi Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
    Henrik Daub
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell 31:438-48. 2008
  2. ncbi Characterisation of kinase-selective inhibitors by chemical proteomics
    Henrik Daub
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinried, Germany
    Biochim Biophys Acta 1754:183-90. 2005
  3. ncbi Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry
    Josef Wissing
    Department of Cell Biology, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Mol Cell Proteomics 6:537-47. 2007
  4. ncbi An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling
    Thiemo B Schreiber
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 9:1047-62. 2010
  5. ncbi Large-scale proteomics analysis of the human kinome
    Felix S Oppermann
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Cell Proteomics 8:1751-64. 2009
  6. ncbi Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics
    Cuiping Pan
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried near Munich, Germany
    Mol Cell Proteomics 8:2796-808. 2009
  7. ncbi Quantitative analysis of kinase-proximal signaling in lipopolysaccharide-induced innate immune response
    Kirti Sharma
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteome Res 9:2539-49. 2010
  8. ncbi Proteomics strategy for quantitative protein interaction profiling in cell extracts
    Kirti Sharma
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Nat Methods 6:741-4. 2009
  9. ncbi Proteomics analysis of cellular imatinib targets and their candidate downstream effectors
    Susanne B Breitkopf
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteome Res 9:6033-43. 2010
  10. ncbi Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression
    Kalyan Dulla
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 9:1167-81. 2010

Collaborators

  • Matthias Mann
  • Jürgen Cox
  • Florian Gnad
  • Christoph Schaab
  • Oliver J Gruss
  • Erich A Nigg
  • Olaf Stemmann
  • Kalyan Dulla
  • Matt Cotten
  • Thiemo B Schreiber
  • Nina Mäusbacher
  • Gyorgy Keri
  • Klaus Godl
  • Felix S Oppermann
  • Josef Wissing
  • Kirti Sharma
  • Dirk Brehmer
  • Stephanie Blencke
  • Susanne B Breitkopf
  • Jesper V Olsen
  • Axel Ullrich
  • Christoph Weber
  • Martina Weber
  • Chanchal Kumar
  • Kathrin Grundner-Culemann
  • Zoltan Greff
  • Cuiping Pan
  • Yi Xiang Zhang
  • Renate Hornberger
  • Philipp Mertins
  • Birgit Zech
  • Alexander Kurtenbach
  • Peter Habenberger
  • Matthias Stein-Gerlach
  • Andrea Missio
  • Joanna Soroka
  • Prasad V Jallepalli
  • Sebastian K Wandinger
  • Johannes Buchner
  • Manuela Machatti
  • Markus Grammel
  • Michaela Bairlein
  • Peter G Knyazev
  • Yuri V Cheburkin
  • Jörg Renkawitz
  • Yuri P Knyazev
  • Michel L Tremblay
  • H Christian Eberl
  • Laszlo Orfi
  • István Szabadkai
  • Yi-Xiang Zhang
  • Manfred Nimtz
  • Lothar Jänsch
  • Jurgen Wehland
  • Guido Dieterich
  • Heidrun Degen
  • Jan Eickhoff
  • Bert Klebl
  • Ola Engkvist
  • Kostadinos Salassidis
  • Heidrun Gutbrod

Detail Information

Publications29

  1. ncbi Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
    Henrik Daub
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell 31:438-48. 2008
    ..These results provide a vastly extended knowledge base for functional studies on kinases and their regulation through site-specific phosphorylation...
  2. ncbi Characterisation of kinase-selective inhibitors by chemical proteomics
    Henrik Daub
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinried, Germany
    Biochim Biophys Acta 1754:183-90. 2005
    ..Importantly, these chemical proteomic methods permit the direct analysis of kinase inhibitor selectivity in biological systems and have led to new insights into the cellular modes of action of kinase-selective small molecule antagonists...
  3. ncbi Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry
    Josef Wissing
    Department of Cell Biology, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Mol Cell Proteomics 6:537-47. 2007
    ....
  4. ncbi An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling
    Thiemo B Schreiber
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 9:1047-62. 2010
    ....
  5. ncbi Large-scale proteomics analysis of the human kinome
    Felix S Oppermann
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Cell Proteomics 8:1751-64. 2009
    ..In conclusion, the straightforward experimental procedures described here enable different implementations of kinase-selective proteomics with considerable potential for future signal transduction and kinase drug target analysis...
  6. ncbi Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics
    Cuiping Pan
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried near Munich, Germany
    Mol Cell Proteomics 8:2796-808. 2009
    ..Our assay is streamlined and generic and could become a useful tool in kinase drug development...
  7. ncbi Quantitative analysis of kinase-proximal signaling in lipopolysaccharide-induced innate immune response
    Kirti Sharma
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteome Res 9:2539-49. 2010
    ..Thus, our data expands previous knowledge for functional analyses of innate immune response...
  8. ncbi Proteomics strategy for quantitative protein interaction profiling in cell extracts
    Kirti Sharma
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Nat Methods 6:741-4. 2009
    ..We demonstrate the general utility of this methodology in interaction studies involving small-molecule kinase inhibitors, a tyrosine-phosphorylated peptide and an antibody as affinity ligands...
  9. ncbi Proteomics analysis of cellular imatinib targets and their candidate downstream effectors
    Susanne B Breitkopf
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteome Res 9:6033-43. 2010
    ..Our approach is rather generic and may have various applications in kinase drug discovery...
  10. ncbi Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression
    Kalyan Dulla
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 9:1167-81. 2010
    ..Thus, the results of this study provide a valuable resource for cell biologists and provide insight into the system properties of the mitotic phosphokinome...
  11. ncbi Combination of chemical genetics and phosphoproteomics for kinase signaling analysis enables confident identification of cellular downstream targets
    Felix S Oppermann
    Cell Signaling Group, Department of Molecular Biology, 82152 Martinsried, Germany
    Mol Cell Proteomics 11:O111.012351. 2012
    ..We anticipate the described strategies to be of general utility for systematic and confident identification of cellular protein kinase substrates...
  12. ncbi Global analysis of phosphoproteome regulation by the Ser/Thr phosphatase Ppt1 in Saccharomyces cerevisiae
    Thiemo B Schreiber
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteome Res 11:2397-408. 2012
    ..These results demonstrate the utility of large-scale and quantitative phosphoproteomics to identify cellular sites of serine/threonine phosphatase action in an unbiased manner...
  13. ncbi Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells
    Christoph Weber
    Project Group Cell Signaling, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteomics 75:1343-56. 2012
    ..Taken together, our data suggest that cellular perturbation of SFKs and/or Btk translates into rather specific signal transduction inhibition, which in turn contributes to the antileukemic activity of erlotinib and gefitinib in AML...
  14. ncbi Quantitative phosphoproteomics--an emerging key technology in signal-transduction research
    Thiemo B Schreiber
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Proteomics 8:4416-32. 2008
    ..Here, we provide an overview of these exciting developments and their potential to transform signal-transduction research into a technology-driven, high-throughput science...
  15. ncbi Glycoprotein capture and quantitative phosphoproteomics indicate coordinated regulation of cell migration upon lysophosphatidic acid stimulation
    Nina Mäusbacher
    Project Group Cell Signaling, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Germany
    Mol Cell Proteomics 9:2337-53. 2010
    ..In conclusion, the glycoproteome phosphoproteomics strategy described here sheds light on incompletely understood mechanisms in LPA-induced cell migratory behavior...
  16. ncbi Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics
    Philipp Mertins
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 7:1763-77. 2008
    ..Importantly the MS-based strategies described here are entirely generic and can be used to address the poorly understood aspects of cellular PTP function...
  17. ncbi AXL is a potential target for therapeutic intervention in breast cancer progression
    Yi Xiang Zhang
    Max Planck Institute of Biochemistry, Martinsried, Germany
    Cancer Res 68:1905-15. 2008
    ....
  18. ncbi Proteome-wide analysis of temporal phosphorylation dynamics in lysophosphatidic acid-induced signaling
    Nina Mäusbacher
    Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Proteomics 12:3485-98. 2012
    ..Finally, we detected regulation of functionally characterized phosphorylation sites not yet implicated in LPA signaling, which may foster a better understanding how LPA regulates cellular physiology on the molecular level...
  19. ncbi Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein
    Henrik Daub
    Axxima Pharmaceuticals AG, 82152 Martinsried, Germany
    J Virol 76:8124-37. 2002
    ....
  20. ncbi Evaluation of kinase inhibitor selectivity by chemical proteomics
    Henrik Daub
    Axxima Pharmaceuticals AG, Munchen, Germany
    Assay Drug Dev Technol 2:215-24. 2004
    ....
  21. ncbi Cellular targets of gefitinib
    Dirk Brehmer
    Axxima Pharmaceuticals AG, Munich, Germany
    Cancer Res 65:379-82. 2005
    ..Our data suggest alternative cellular modes of action for gefitinib and provide rationales for the development of related drugs...
  22. ncbi Exploiting features of adenovirus replication to support mammalian kinase production
    Matt Cotten
    Axxima Pharmaceuticals AG, Max Lebsche Platz 32, 81377 Munchen, Germany
    Nucleic Acids Res 31:e128. 2003
    ..Thus, the utility of adenovirus-mediated enzyme expression as a versatile alternative to established protein production technologies is demonstrated...
  23. ncbi Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors
    Josef Wissing
    Axxima Pharmaceuticals AG, , Germany
    Mol Cell Proteomics 3:1181-93. 2004
    ..Thus, our data demonstrate the utility of proteomic methods employing immobilized kinase inhibitors for identifying new targets linked to previously unrecognized therapeutic applications...
  24. ncbi An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
    Klaus Godl
    Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 100:15434-9. 2003
    ..Based on the procedures described here, efficient affinity purification techniques can be developed for other protein kinase inhibitors, providing crucial information about their cellular modes of action...
  25. ncbi Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors
    Dirk Brehmer
    Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 Munich, Germany
    Mol Cell Proteomics 3:490-500. 2004
    ....
  26. ncbi Proteomic analysis of kinase inhibitor selectivity and function
    Klaus Godl
    Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, , Germany
    Cell Cycle 3:393-5. 2004
    ....
  27. ncbi Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
    Stephanie Blencke
    Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 Munich, Germany
    Chem Biol 11:691-701. 2004
    ..Our data establish a conserved structural determinant of protein kinase sensitivity relevant for both signal transduction research and drug development...
  28. ncbi Strategies to overcome resistance to targeted protein kinase inhibitors
    Henrik Daub
    Axxima Pharmaceuticals AG, Max Lebsche Platz 32, 81377 Munchen, Germany
    Nat Rev Drug Discov 3:1001-10. 2004
    ....
  29. ncbi Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling
    Klaus Godl
    Axxima Pharmaceuticals AG, Munich, Germany
    Cancer Res 65:6919-26. 2005
    ....