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trypanosoma variant surface glycoproteins
directed molecular evolution
H Ulrich Göringer
Darmstadt University of Technology
Homann M, Lorger M, Engstler M, Zacharias M, Göringer H. Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes. Comb Chem High Throughput Screen. 2006;9:491-9
..We demonstrate that antigen-tagged preparations of the aptamer can bind to live trypanosomes and that they can be used to re-direct immunoglobulins to the parasite surface. ..
Göringer H. Parasite-specific aptamers as biosynthetic reagents and potential pharmaceuticals. Trends Parasitol. 2012;28:106-13
..Here the published examples of aptamers that target Leishmania-, Trypanosoma- and Plasmodia-specific molecules are reviewed. ..
Göringer H. 'Gestalt,' composition and function of the Trypanosoma brucei editosome. Annu Rev Microbiol. 2012;66:65-82
..Special emphasis is placed on the molecular morphology of the editing complex in order to correlate structural features with functional characteristics. ..
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