M Cristina Cardoso

Summary

Affiliation: Darmstadt University of Technology
Country: Germany

Publications

  1. pmc Direct homo- and hetero-interactions of MeCP2 and MBD2
    Annette Becker
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    PLoS ONE 8:e53730. 2013
  2. pmc Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies
    K Laurence Jost
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    PLoS ONE 6:e26499. 2011
  3. pmc 3D-Image analysis platform monitoring relocation of pluripotency genes during reprogramming
    K Laurence Jost
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    Nucleic Acids Res 39:e113. 2011
  4. pmc Targeted manipulation of heterochromatin rescues MeCP2 Rett mutants and re-establishes higher order chromatin organization
    Corella S Casas-Delucchi
    Department of Biology, Technische Universitat Darmstadt, 64287 Darmstadt, Germany
    Nucleic Acids Res 40:e176. 2012
  5. pmc Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
    Corella S Casas-Delucchi
    Department of Biology, Technische Universitat Darmstadt, 64287 Darmstadt, Germany
    Nucleic Acids Res 40:159-69. 2012
  6. pmc Cell entry of arginine-rich peptides is independent of endocytosis
    Gohar Ter-Avetisyan
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    J Biol Chem 284:3370-8. 2009
  7. pmc Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
    Gisela Lättig-Tünnemann
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nat Commun 2:453. 2011
  8. pmc Measurement of replication structures at the nanometer scale using super-resolution light microscopy
    D Baddeley
    Kirchhoff Institut für Physik, University of Heidelberg, Germany
    Nucleic Acids Res 38:e8. 2010
  9. pmc Heterochromatin and gene positioning: inside, outside, any side?
    K Laurence Jost
    Cell Biology and Epigenetics, Department of Biology, Technische Universitat Darmstadt, Schnittspahnstr 10, 64287 Darmstadt, Germany
    Chromosoma 121:555-63. 2012
  10. doi request reprint Structure, function and dynamics of nuclear subcompartments
    M Cristina Cardoso
    Department of Biology, Technische Universitat Darmstadt, Germany
    Curr Opin Cell Biol 24:79-85. 2012

Collaborators

Detail Information

Publications27

  1. pmc Direct homo- and hetero-interactions of MeCP2 and MBD2
    Annette Becker
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    PLoS ONE 8:e53730. 2013
    ..Our results strengthen the possibility that MeCP2 and MBD2 direct interactions could crosslink chromatin fibers and therefore give novel insight into the molecular mechanism of MBD mediated global heterochromatin architecture...
  2. pmc Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies
    K Laurence Jost
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    PLoS ONE 6:e26499. 2011
    ..The new MeCP2 specific monoclonal antibodies described here perform well in a large variety of immunological applications making them a very valuable set of tools for studies of MeCP2 pathophysiology in situ and in vitro...
  3. pmc 3D-Image analysis platform monitoring relocation of pluripotency genes during reprogramming
    K Laurence Jost
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    Nucleic Acids Res 39:e113. 2011
    ..Thus, our computational approach enables comparative analysis of topological relationships in spite of stark morphological variability typical of biological data sets...
  4. pmc Targeted manipulation of heterochromatin rescues MeCP2 Rett mutants and re-establishes higher order chromatin organization
    Corella S Casas-Delucchi
    Department of Biology, Technische Universitat Darmstadt, 64287 Darmstadt, Germany
    Nucleic Acids Res 40:e176. 2012
    ..This novel strategy enables specific tethering of any protein to heterochromatin and lays the ground for controlled manipulation of its composition and organization...
  5. pmc Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
    Corella S Casas-Delucchi
    Department of Biology, Technische Universitat Darmstadt, 64287 Darmstadt, Germany
    Nucleic Acids Res 40:159-69. 2012
    ..We speculate that a high histone acetylation level might increase the firing efficiency of origins and, concomitantly, advances the replication timing of distinct genomic regions...
  6. pmc Cell entry of arginine-rich peptides is independent of endocytosis
    Gohar Ter-Avetisyan
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    J Biol Chem 284:3370-8. 2009
    ..In summary, although the frequency and kinetics of TAT transduction varied between cell types, it was independent of endocytosis...
  7. pmc Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
    Gisela Lättig-Tünnemann
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nat Commun 2:453. 2011
    ..We propose that guanidinium groups are forced into maximally distant positions by cyclization. This orientation increases membrane contacts leading to enhanced cell penetration...
  8. pmc Measurement of replication structures at the nanometer scale using super-resolution light microscopy
    D Baddeley
    Kirchhoff Institut für Physik, University of Heidelberg, Germany
    Nucleic Acids Res 38:e8. 2010
    ....
  9. pmc Heterochromatin and gene positioning: inside, outside, any side?
    K Laurence Jost
    Cell Biology and Epigenetics, Department of Biology, Technische Universitat Darmstadt, Schnittspahnstr 10, 64287 Darmstadt, Germany
    Chromosoma 121:555-63. 2012
    ..In this review, we address how (hetero)chromatin structure and proximity might influence gene expression and discuss the challenges and means to unravel this fundamental biological question...
  10. doi request reprint Structure, function and dynamics of nuclear subcompartments
    M Cristina Cardoso
    Department of Biology, Technische Universitat Darmstadt, Germany
    Curr Opin Cell Biol 24:79-85. 2012
    ..Old challenges and new insights are illustrated with examples of DNA replication and nuclear protein dynamics...
  11. ncbi request reprint Live-cell analysis of cell penetration ability and toxicity of oligo-arginines
    Gisela Tunnemann
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    J Pept Sci 14:469-76. 2008
    ..Altogether, our results identified concentration windows with low toxicity and high transduction efficiency, resulting in fully bioavailable intracellular peptides...
  12. ncbi request reprint Uncoupling the replication machinery: replication fork progression in the absence of processive DNA synthesis
    Sabine M Görisch
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell Cycle 7:1983-90. 2008
    ..We, therefore, propose that the replication machinery is made up of distinct functional sub-modules that allow a flexible and dynamic response to challenges during DNA replication...
  13. pmc Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy
    Lothar Schermelleh
    Center for Integrated Protein Science, Department of Biology, Ludwig Maximilians University Munich, 82152 Planegg Martinsried, Germany
    Science 320:1332-6. 2008
    ..Multicolor 3D-SIM opens new and facile possibilities to analyze subcellular structures beyond the diffraction limit of the emitted light...
  14. pmc Visualization and targeted disruption of protein interactions in living cells
    Henry D Herce
    1 Department of Biology, Technische Universitat Darmstadt, 64287 Darmstadt, Germany 2
    Nat Commun 4:2660. 2013
    ..The availability of multiple anchor sites and the simple optical readout of this nanobody-based capture assay enable systematic and versatile analyses of protein-protein interactions in practically any cell type and species. ..
  15. pmc Histone acetylation controls the inactive X chromosome replication dynamics
    Corella S Casas-Delucchi
    Department of Biology, Technische Universitat Darmstadt, Darmstadt 64287, Germany
    Nat Commun 2:222. 2011
    ..The epigenetically controlled, highly coordinated replication of the Xi is reminiscent of embryonic genome replication in flies and frogs before genome activation and might be a common feature of transcriptionally silent chromatin...
  16. pmc MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line
    Bianca Bertulat
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    PLoS ONE 7:e47848. 2012
    ....
  17. pmc Chromatin condensation modulates access and binding of nuclear proteins
    Robert M Martin
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    FASEB J 24:1066-72. 2010
    ..Martin, R. M., Cardoso, M. C. Chromatin condensation modulates access and binding of nuclear proteins...
  18. doi request reprint Epigenetic control of DNA replication dynamics in mammals
    Corella S Casas-Delucchi
    Department of Biology, Technische Universitat Darmstadt, Germany
    Nucleus 2:370-82. 2011
    ..Here we present and discuss current knowledge on the con-trol of DNA replication dynamics in mammals and the role of chromatin modifications in this basic biological process...
  19. ncbi request reprint Cell cycle markers for live cell analyses
    Hariharan P Easwaran
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell Cycle 4:453-5. 2005
    ..These markers are new tools to directly study cell cycle dependent processes in both, fixed and living cells...
  20. doi request reprint Cube-octameric silsesquioxane-mediated cargo peptide delivery into living cancer cells
    Sebastian Hörner
    Clemens Schöpf Institute of Organic Chemistry and Biochemistry, Technische Universitat Darmstadt, Petersenstr 22, 64287 Darmstadt, Germany
    Org Biomol Chem 11:2258-65. 2013
    ..Nuclear targeting was demonstrated in HeLa cells by selective binding of released p21(Cip1/Waf1)-derived cargo peptide to PCNA, a protein involved in DNA replication and repair...
  21. pmc Organization of DNA replication
    Vadim O Chagin
    Department of Biology, Technische Universitat Darmstadt, Germany
    Cold Spring Harb Perspect Biol 2:a000737. 2010
    ..The integration of these data with time lapse microscopy analysis will give us the ability to film and dissect the replication of the genome in situ and in real time...
  22. doi request reprint Spatiotemporal visualization of DNA replication dynamics
    Marius Reinhart
    Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany
    Methods Mol Biol 1042:213-25. 2013
    ....
  23. ncbi request reprint DNA labeling in living cells
    Robert M Martin
    Max Delbruck Center for Molecular Medicine, Franz Volhard Klinik, Berlin, Germany
    Cytometry A 67:45-52. 2005
    ..Live cell fluorescence microscopy experiments often require visualization of the nucleus and the chromatin to determine the nuclear morphology or the localization of nuclear compartments...
  24. pmc Modulation of muscle contraction by a cell-permeable peptide
    Gisela Tunnemann
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125, Berlin, Germany
    J Mol Med (Berl) 85:1405-12. 2007
    ....
  25. doi request reprint Generation and characterization of a rat monoclonal antibody specific for multiple red fluorescent proteins
    Andrea Rottach
    Center for Integrated Protein Science Munich, Department of Biology, Ludwig Maximilians University Munich, Planegg Martinsried, Germany
    Hybridoma (Larchmt) 27:337-43. 2008
    ..Applying our versatile antibody, one and the same red fluorescent protein tag can be used to perform not only microscopic studies, but also multiple biochemical assays...
  26. pmc Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules
    Shashank Gupta
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 3:e1814. 2008
    ....
  27. ncbi request reprint Protein transduction: a novel tool for tissue regeneration
    M Cristina Cardoso
    Max Delbruck Center for Molecular Medicine, D 13125 Berlin, Germany
    Biol Chem 383:1593-9. 2002
    ..The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration...