L Danielyan

Summary

Country: Germany

Publications

  1. ncbi request reprint The blockade of endothelin A receptor protects astrocytes against hypoxic injury: common effects of BQ-123 anderythropoietin on the rejuvenation of the astrocyte population
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Otfried Müller Strasse 45, D 72076 Tubingen, Germany
    Eur J Cell Biol 84:567-79. 2005
  2. pmc Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietin
    Ali Lourhmati
    Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tuebingen, Tuebingen, Germany
    PLoS ONE 8:e77182. 2013
  3. ncbi request reprint Similar protective effects of BQ-123 and erythropoietin on survival of neural cells and generation of neurons upon hypoxic injury
    Lusine Danielyan
    Division of Clinical Pharmacology, Institute of Pharmacology and Toxicology, University Hospital of Tubingen, Germany
    Eur J Cell Biol 84:907-13. 2005
  4. ncbi request reprint Common neuroprotective effects of endothelin receptor a blockade and erythropoietin during hypoxia-associated cell injury. Perspectives of combined treatment
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Str 45, D 72076 Tuebingen, Germany
    ScientificWorldJournal 6:449-51. 2006
  5. doi request reprint Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Tubingen, Germany
    Rejuvenation Res 14:3-16. 2011
  6. ncbi request reprint Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Strasse 45, 72076 Tuebingen, Germany
    Neurochem Res 32:1489-98. 2007
  7. doi request reprint Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Tubingen, Germany
    Rejuvenation Res 13:195-201. 2010
  8. doi request reprint Intranasal delivery of cells to the brain
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Str 45, D 72076 Tuebingen, Germany
    Eur J Cell Biol 88:315-24. 2009
  9. doi request reprint Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin
    L Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, 72076 Tubingen, Germany
    Cell Death Differ 16:1599-614. 2009
  10. ncbi request reprint Characterization of the cAMP binding site of purified S-adenosyl-homocysteine hydrolase from bovine kidney
    Doris Kloor
    Department of Pharmacology, Faculty of Medicine, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    Biochem Pharmacol 64:1201-6. 2002

Detail Information

Publications13

  1. ncbi request reprint The blockade of endothelin A receptor protects astrocytes against hypoxic injury: common effects of BQ-123 anderythropoietin on the rejuvenation of the astrocyte population
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Otfried Müller Strasse 45, D 72076 Tubingen, Germany
    Eur J Cell Biol 84:567-79. 2005
    ..The benefits in the functional states of astrocytes obtained by combined treatment of HC with BQ-123 and EPO suggest a new therapeutic strategy in treatment of hypoxic brain injury...
  2. pmc Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietin
    Ali Lourhmati
    Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tuebingen, Tuebingen, Germany
    PLoS ONE 8:e77182. 2013
    ..The clinical relevance of EPO and EPOR as markers of brain cells vulnerability during aging and neurodegeneration is evidenced by remarkable changes in their expression levels in a transgenic model of AD and their WT controls...
  3. ncbi request reprint Similar protective effects of BQ-123 and erythropoietin on survival of neural cells and generation of neurons upon hypoxic injury
    Lusine Danielyan
    Division of Clinical Pharmacology, Institute of Pharmacology and Toxicology, University Hospital of Tubingen, Germany
    Eur J Cell Biol 84:907-13. 2005
    ..These data hint at a neuroprotective therapeutic potency of ETA-R blockade, which either alone or in combination with EPO may improve the survival of astroglial and neuronal cells upon hypoxic injury...
  4. ncbi request reprint Common neuroprotective effects of endothelin receptor a blockade and erythropoietin during hypoxia-associated cell injury. Perspectives of combined treatment
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Str 45, D 72076 Tuebingen, Germany
    ScientificWorldJournal 6:449-51. 2006
  5. doi request reprint Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Tubingen, Germany
    Rejuvenation Res 14:3-16. 2011
    ..IN administration provides a highly promising noninvasive alternative to the traumatic surgical procedure of transplantation and allows targeted delivery of cells to the brain with the option of chronic application...
  6. ncbi request reprint Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Strasse 45, 72076 Tuebingen, Germany
    Neurochem Res 32:1489-98. 2007
    ..These data suggest that AT1-R may decrease the susceptibility of astrocytes to hypoxic injury and their propensity to release TNF-alpha. AT1-R antagonists may therefore be of therapeutic value during hypoxia-associated neurodegeneration...
  7. doi request reprint Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Tubingen, Germany
    Rejuvenation Res 13:195-201. 2010
    ..Therefore, intranasal losartan and potentially other ARBs, at concentrations below their threshold for altering systemic blood pressure, offer a new approach for the treatment of AD...
  8. doi request reprint Intranasal delivery of cells to the brain
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Str 45, D 72076 Tuebingen, Germany
    Eur J Cell Biol 88:315-24. 2009
    ..The delivery of cells was enhanced by hyaluronidase treatment applied intranasally 30 min prior to the application of cells. Intranasal delivery provides a new non-invasive method for cell delivery to the CNS...
  9. doi request reprint Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin
    L Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, 72076 Tubingen, Germany
    Cell Death Differ 16:1599-614. 2009
    ....
  10. ncbi request reprint Characterization of the cAMP binding site of purified S-adenosyl-homocysteine hydrolase from bovine kidney
    Doris Kloor
    Department of Pharmacology, Faculty of Medicine, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    Biochem Pharmacol 64:1201-6. 2002
    ..Our data indicate that the binding site for nanomolar concentrations of cAMP and adenosine at the AdoHcyase appears to be identical. The physiological implications of a cAMP binding site at the AdoHcyase remain to be established...
  11. ncbi request reprint Impaired synthesis of erythropoietin, glutamine synthetase and metallothionein in the skin of NOD/SCID/gamma(c)(null) and Foxn1 nu/nu mice with misbalanced production of MHC class II complex
    L Danielyan
    Department of Clinical Pharmacology, University Hospital of Tuebingen, Otfried Mueller Str 45, 72076, Tuebingen, Germany
    Neurochem Res 35:899-908. 2010
    ....
  12. ncbi request reprint Colocalization of glial fibrillary acidic protein, metallothionein, and MHC II in human, rat, NOD/SCID, and nude mouse skin keratinocytes and fibroblasts
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany
    J Invest Dermatol 127:555-63. 2007
    ....
  13. pmc Keratinocytes as depository of ammonium-inducible glutamine synthetase: age- and anatomy-dependent distribution in human and rat skin
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Tubingen, Germany
    PLoS ONE 4:e4416. 2009
    ..Such a depository of glutamine-generating enzyme seems essential for continuous renewal of epidermal permeability barrier and during pathological processes accompanied by hyperammonemia...