Elena Csernok

Summary

Country: Germany

Publications

  1. doi Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma
    Elena Csernok
    Department of Rheumatology, University of Luebeck, Rheumaklinik Bad Bramstedt, Oskar Alexander Str 26, 24576, Bad Bramstedt, Germany
    Clin Rev Allergy Immunol 34:300-6. 2008
  2. doi Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis
    Elena Csernok
    University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Curr Opin Rheumatol 22:43-8. 2010
  3. ncbi Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway
    Elena Csernok
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, Germany
    Blood 107:4440-8. 2006
  4. ncbi Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosis
    E Csernok
    Department of Rheumatology, University Lübeck and Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 26:S112-7. 2008
  5. doi Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis
    Dorin Capraru
    University of Lubeck, Department of Rheumatology, Vasculitiscenter and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Clin Immunol 127:144-50. 2008
  6. ncbi Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis
    Peter Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Clin Immunol 108:1-7. 2003
  7. ncbi The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC
    Bo Jiang
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:56-61. 2010
  8. ncbi Distinct proteinase 3-induced cytokine patterns in Wegener´s granulomatosis, Churg-Strauss syndrome, and healthy controls
    Ursula Fagin
    University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Lubeck, Germany
    Clin Exp Rheumatol 29:S57-62. 2011
  9. ncbi Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis
    Peter Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, 23538 Luebeck, Germany
    Cell Immunol 224:1-7. 2003
  10. ncbi Expansion of CD28-CD27-NKG2D+ effector memory T cells and predominant Th1-type response during febrile attacks in tumor necrosis factor-associated periodic syndrome
    Julia U Holle
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, and Rheumaklinik Bad Bramstedt, Lubeck, Germany
    Isr Med Assoc J 8:142-4. 2006

Collaborators

Detail Information

Publications29

  1. doi Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma
    Elena Csernok
    Department of Rheumatology, University of Luebeck, Rheumaklinik Bad Bramstedt, Oskar Alexander Str 26, 24576, Bad Bramstedt, Germany
    Clin Rev Allergy Immunol 34:300-6. 2008
    ..The aim of this review was to update current basic and clinical research on ANCA in the pathophysiology of AAV and to point out and discuss limitations and inconsistencies of the clinical and experimental evidence...
  2. doi Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis
    Elena Csernok
    University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Curr Opin Rheumatol 22:43-8. 2010
    ..This review summarizes the most recent findings in this field...
  3. ncbi Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway
    Elena Csernok
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, Germany
    Blood 107:4440-8. 2006
    ..Wegener autoantigen interacts with a "gateway" receptor (PAR-2) on iDCs in vitro triggering their maturation and licenses them for a T helper 1 (Th1)-type response potentially favoring granuloma formation in WG...
  4. ncbi Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosis
    E Csernok
    Department of Rheumatology, University Lübeck and Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 26:S112-7. 2008
    ....
  5. doi Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis
    Dorin Capraru
    University of Lubeck, Department of Rheumatology, Vasculitiscenter and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Clin Immunol 127:144-50. 2008
    ....
  6. ncbi Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis
    Peter Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Clin Immunol 108:1-7. 2003
    ..Expansion of Th-1-type CD4(+)CD28(-)CCR5(+) effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation...
  7. ncbi The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC
    Bo Jiang
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:56-61. 2010
    ....
  8. ncbi Distinct proteinase 3-induced cytokine patterns in Wegener´s granulomatosis, Churg-Strauss syndrome, and healthy controls
    Ursula Fagin
    University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Lubeck, Germany
    Clin Exp Rheumatol 29:S57-62. 2011
    ..To analyse whether a specific cytokine pattern is elicited in response to the autoantigen proteinase 3 (PR3) in active Wegener's granulomatosis (WG)...
  9. ncbi Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis
    Peter Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, 23538 Luebeck, Germany
    Cell Immunol 224:1-7. 2003
    ..Our results might reflect profound generalized changes in the CD8+ T-cell compartment also affecting virus-specific T-cell responses in WG...
  10. ncbi Expansion of CD28-CD27-NKG2D+ effector memory T cells and predominant Th1-type response during febrile attacks in tumor necrosis factor-associated periodic syndrome
    Julia U Holle
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, and Rheumaklinik Bad Bramstedt, Lubeck, Germany
    Isr Med Assoc J 8:142-4. 2006
  11. ncbi Diagnostic significance of ANCA in vasculitis
    Elena Csernok
    Department of Rheumatology, University Hospital of Schleswig Holstein, Lubeck, Germany
    Nat Clin Pract Rheumatol 2:174-5. 2006
  12. ncbi Lower numbers of FoxP3 and CCR4 co-expressing cells in an elevated subpopulation of CD4+CD25high regulatory T cells from Wegener's granulomatosis
    Sebastian Klapa
    University of Lubeck, Department of Rheumatology and Vasculitis Centre University Hospital Schleswig Holstein, Lubeck, and Clinical Centre Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:72-80. 2010
    ..The results indicate upregulated numbers of Treg cells in PB and nasal mucosa as well as phenotypical and functional alterations of PB Treg cells in WG, some presumably mediated through PR3 and IFN-alpha...
  13. ncbi Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses
    Antje Muller
    Department of Rheumatology, University of Luebeck, Germany
    Ann N Y Acad Sci 1109:84-92. 2007
    ..Altogether, there are a number of (auto)molecules that bind to PR3, some of them even competitive and each binding interaction seems to have specific implications...
  14. ncbi Transfer of human leukocytes into double-knockout Pfp-/-Rag2-/- mice grafted with human skin: increased accumulation of neutrophils in human dermal microvessels
    Sebastian Ullrich
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lübeck and Rheumaklinik Bad Bramstedt, Ratzeburger Alle 160, 23538 Lubeck, Germany
    Transplantation 78:1557-9. 2004
    ..Thus, a xenograft model of vasculitis with predominant huPMNs infiltration has been established for the first time...
  15. ncbi Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study
    Elena Csernok
    Department of Rheumatology, University of Schleswig Holstein Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Rheumatology (Oxford) 43:174-80. 2004
    ..To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories...
  16. ncbi Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitides
    Elena Csernok
    Department of Rheumatology, University of Lubeck, Oskar Alexander Str 26, 24576 Bad Bramstedt, Germany
    Autoimmun Rev 2:158-64. 2003
    ..We now know that a passive transfer of ANCA is sufficient to induce disease, but it remains to be discovered how the autoantibodies to neutrophil antigens might triggered...
  17. pmc Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosis
    Peter Lamprecht
    Department of Rheumatology, University of Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Arthritis Res Ther 5:R25-31. 2003
    ..CCR5 and CCR3 expression on CD4+ and CD8+ memory T cells indicates a potential to respond to chemotactic gradients and might be important in T cell migration contributing to granuloma formation and vasculitis in WG...
  18. pmc Peripheral blood and granuloma CD4(+)CD28(-) T cells are a major source of interferon-gamma and tumor necrosis factor-alpha in Wegener's granulomatosis
    Andras Komocsi
    Department of Rheumatology, University of Luebeck, Luebeck, Germany
    Am J Pathol 160:1717-24. 2002
    ..CD4(+)CD28(-) T cells may be recruited into granulomatous lesions from the blood via CD18 interaction, and may subsequently promote monocyte accumulation and granuloma formation through their cytokine secretion in WG...
  19. doi Current understanding of the pathogenesis of granulomatosis with polyangiitis (Wegener's)
    Elena Csernok
    Department of Rheumatology, University of Schleswig Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Oskar Alexanderstr 26, 24576 Bad Bramstedt GmBH, Germany
    Expert Rev Clin Immunol 9:641-8. 2013
    ..New data unexpectedly suggest that the destruction of nasal cartilage in GPA is mainly mediated by fibroblasts that can be blocked by corticosteroids. ..
  20. pmc Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4
    Philipp H Reichel
    Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt, Germany
    Clin Diagn Lab Immunol 10:473-5. 2003
    ....
  21. pmc Selective killing of B-cell hybridomas targeting proteinase 3, Wegener's autoantigen
    Katrin S Reiners
    Department of Internal Medicine I, University Hospital Cologne, Cologne, Germany
    Immunology 112:228-36. 2004
    ..The data indicate that autoantigen-toxins are promising tools in the treatment or co-treatment of autoimmune diseases in which the antigen is known...
  22. ncbi The PTPN22 620W allele is a risk factor for Wegener's granulomatosis
    Peter Jagiello
    Ruhr University, Bochum, Germany
    Arthritis Rheum 52:4039-43. 2005
    ..This study therefore examined whether the functionally relevant PTPN22 polymorphism is associated with Wegener's granulomatosis (WG)...
  23. ncbi Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation
    Katja Hattar
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Leukoc Biol 71:996-1004. 2002
    ..These mechanisms may contribute to inflammatory tissue injury in WG...
  24. ncbi Vitronectin- and fibronectin-containing immune complexes in primary systemic vasculitis
    Karen Maehnss
    University of Kiel, Germany
    J Autoimmun 18:239-50. 2002
    ..However, their involvement in the pathogenesis of the disease is not clearly defined. Our data suggest that there are preformed IC present in sera of patients with CSS and WG that contain VN and FN and bind to endothelial cells...
  25. ncbi 20 years with ANCA (antineutrophil cytoplasmic autoantibodies): from seromarker to a major pathogenic player in vasculitis
    Bernhard Hellmich
    J Leukoc Biol 74:1-2. 2003
  26. ncbi Frequency of proteinase 3 (PR3)-specific autoreactive T cells determined by cytokine flow cytometry in Wegener's granulomatosis
    Jolanta Winek
    Third Department of Tuberculosis and Lung Diseases, Institute of Tuberculosis and Lung Diseases, Plocka 26, 01 138 Warsaw, Poland
    J Autoimmun 22:79-85. 2004
    ..We tested immunogenicity of PR3-derived peptides and determined frequencies of PR3-specific T cells using cytokine flow cytometry in Wegener's granulomatois (WG)...
  27. ncbi New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes
    Peter Jagiello
    Department of Human Genetics, Ruhr University, Universitätstrasse 150, 44801 Bochum, Germany
    Hum Genet 114:468-77. 2004
    ..Thus, our data demonstrate that EAS may be a valuable alternative approach for determining genetic predisposition factors in multifactorial diseases...
  28. ncbi Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation
    Katja Hattar
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Leukoc Biol 78:992-1000. 2005
    ..The resulting enhanced responsiveness to bacterial pathogens may contribute to the development and maintenance of inflammatory lesions during active WG...
  29. pmc Association study with Wegener granulomatosis of the human phospholipase Cgamma2 gene
    Peter Jagiello
    Department of Human Genetics, Ruhr University Bochum Germany
    J Negat Results Biomed 4:1. 2005
    ..In addition, we screened indirectly for disease association via 4 microsatellites with pooled DNA in the PLCgamma-2 gene...