Genomes and Genes
- Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granulomaElena Csernok
Department of Rheumatology, University of Luebeck, Rheumaklinik Bad Bramstedt, Oskar Alexander Str 26, 24576, Bad Bramstedt, Germany
Clin Rev Allergy Immunol 34:300-6. 2008..The aim of this review was to update current basic and clinical research on ANCA in the pathophysiology of AAV and to point out and discuss limitations and inconsistencies of the clinical and experimental evidence...
- Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitisElena Csernok
University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
Curr Opin Rheumatol 22:43-8. 2010..This review summarizes the most recent findings in this field...
- Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathwayElena Csernok
Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, Germany
Blood 107:4440-8. 2006..Wegener autoantigen interacts with a "gateway" receptor (PAR-2) on iDCs in vitro triggering their maturation and licenses them for a T helper 1 (Th1)-type response potentially favoring granuloma formation in WG...
- Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosisE Csernok
Department of Rheumatology, University Lübeck and Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany
Clin Exp Rheumatol 26:S112-7. 2008....
- Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosisDorin Capraru
University of Lubeck, Department of Rheumatology, Vasculitiscenter and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
Clin Immunol 127:144-50. 2008....
- Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosisPeter Lamprecht
Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
Clin Immunol 108:1-7. 2003..Expansion of Th-1-type CD4(+)CD28(-)CCR5(+) effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation...
- Distinct proteinase 3-induced cytokine patterns in Wegener´s granulomatosis, Churg-Strauss syndrome, and healthy controlsUrsula Fagin
University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Lubeck, Germany
Clin Exp Rheumatol 29:S57-62. 2011..To analyse whether a specific cytokine pattern is elicited in response to the autoantigen proteinase 3 (PR3) in active Wegener's granulomatosis (WG)...
- The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DCBo Jiang
Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
Clin Exp Rheumatol 28:56-61. 2010....
- Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosisPeter Lamprecht
Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, 23538 Luebeck, Germany
Cell Immunol 224:1-7. 2003..Our results might reflect profound generalized changes in the CD8+ T-cell compartment also affecting virus-specific T-cell responses in WG...
- Expansion of CD28-CD27-NKG2D+ effector memory T cells and predominant Th1-type response during febrile attacks in tumor necrosis factor-associated periodic syndromeJulia U Holle
Department of Rheumatology, University Hospital of Schleswig-Holstein, , and Rheumaklinik Bad Bramstedt, , Germany
Isr Med Assoc J 8:142-4. 2006
- Diagnostic significance of ANCA in vasculitisElena Csernok
Department of Rheumatology, University Hospital of Schleswig-Holstein, , Germany
Nat Clin Pract Rheumatol 2:174-5. 2006
- Lower numbers of FoxP3 and CCR4 co-expressing cells in an elevated subpopulation of CD4+CD25high regulatory T cells from Wegener's granulomatosisSebastian Klapa
University of Lubeck, Department of Rheumatology and Vasculitis Centre University Hospital Schleswig Holstein, Lubeck, and Clinical Centre Bad Bramstedt, Bad Bramstedt, Germany
Clin Exp Rheumatol 28:72-80. 2010..The results indicate upregulated numbers of Treg cells in PB and nasal mucosa as well as phenotypical and functional alterations of PB Treg cells in WG, some presumably mediated through PR3 and IFN-alpha...
- Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responsesAntje Muller
Department of Rheumatology, University of Luebeck, Germany
Ann N Y Acad Sci 1109:84-92. 2007..Altogether, there are a number of (auto)molecules that bind to PR3, some of them even competitive and each binding interaction seems to have specific implications...
- Transfer of human leukocytes into double-knockout Pfp-/-Rag2-/- mice grafted with human skin: increased accumulation of neutrophils in human dermal microvesselsSebastian Ullrich
Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lübeck and Rheumaklinik Bad Bramstedt, Ratzeburger Alle 160, 23538 Lubeck, Germany
Transplantation 78:1557-9. 2004..Thus, a xenograft model of vasculitis with predominant huPMNs infiltration has been established for the first time...
- Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre studyElena Csernok
Department of Rheumatology, University of Schleswig Holstein Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
Rheumatology (Oxford) 43:174-80. 2004..To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories...
- Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosisPeter Lamprecht
Department of Rheumatology, University of Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
Arthritis Res Ther 5:R25-31. 2003..CCR5 and CCR3 expression on CD4+ and CD8+ memory T cells indicates a potential to respond to chemotactic gradients and might be important in T cell migration contributing to granuloma formation and vasculitis in WG...
- Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitidesElena Csernok
Department of Rheumatology, University of Lubeck, Oskar Alexander Str 26, 24576 Bad Bramstedt, Germany
Autoimmun Rev 2:158-64. 2003..We now know that a passive transfer of ANCA is sufficient to induce disease, but it remains to be discovered how the autoantibodies to neutrophil antigens might triggered...
- Peripheral blood and granuloma CD4(+)CD28(-) T cells are a major source of interferon-gamma and tumor necrosis factor-alpha in Wegener's granulomatosisAndras Komocsi
Department of Rheumatology, University of Luebeck, Luebeck, Germany
Am J Pathol 160:1717-24. 2002..CD4(+)CD28(-) T cells may be recruited into granulomatous lesions from the blood via CD18 interaction, and may subsequently promote monocyte accumulation and granuloma formation through their cytokine secretion in WG...
- Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4Philipp H Reichel
Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt, Germany
Clin Diagn Lab Immunol 10:473-5. 2003....
- Selective killing of B-cell hybridomas targeting proteinase 3, Wegener's autoantigenKatrin S Reiners
Department of Internal Medicine I, University Hospital Cologne, Cologne, Germany
Immunology 112:228-36. 2004..The data indicate that autoantigen-toxins are promising tools in the treatment or co-treatment of autoimmune diseases in which the antigen is known...
- The PTPN22 620W allele is a risk factor for Wegener's granulomatosisPeter Jagiello
Ruhr University, Bochum, Germany
Arthritis Rheum 52:4039-43. 2005..This study therefore examined whether the functionally relevant PTPN22 polymorphism is associated with Wegener's granulomatosis (WG)...
- Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activationKatja Hattar
Department of Internal Medicine, Justus Liebig University, Giessen, Germany
J Leukoc Biol 71:996-1004. 2002..These mechanisms may contribute to inflammatory tissue injury in WG...
- Vitronectin- and fibronectin-containing immune complexes in primary systemic vasculitisKaren Maehnss
University of Kiel, Germany
J Autoimmun 18:239-50. 2002..However, their involvement in the pathogenesis of the disease is not clearly defined. Our data suggest that there are preformed IC present in sera of patients with CSS and WG that contain VN and FN and bind to endothelial cells...
- 20 years with ANCA (antineutrophil cytoplasmic autoantibodies): from seromarker to a major pathogenic player in vasculitisBernhard Hellmich
J Leukoc Biol 74:1-2. 2003
- Frequency of proteinase 3 (PR3)-specific autoreactive T cells determined by cytokine flow cytometry in Wegener's granulomatosisJolanta Winek
Third Department of Tuberculosis and Lung Diseases, Institute of Tuberculosis and Lung Diseases, Plocka 26, 01-138 Warsaw, Poland
J Autoimmun 22:79-85. 2004..Additional factors such as the influence of proinflammatory or regulatory T cells might be important for the induction of autoimmunity in WG...
- New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genesPeter Jagiello
Department of Human Genetics, Ruhr University, Universitätstrasse 150, 44801 Bochum, Germany
Hum Genet 114:468-77. 2004..Thus, our data demonstrate that EAS may be a valuable alternative approach for determining genetic predisposition factors in multifactorial diseases...
- Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activationKatja Hattar
Department of Internal Medicine, Justus-Liebig-University, Giessen, Germany
J Leukoc Biol 78:992-1000. 2005..The resulting enhanced responsiveness to bacterial pathogens may contribute to the development and maintenance of inflammatory lesions during active WG...
- Association study with Wegener granulomatosis of the human phospholipase Cgamma2 genePeter Jagiello
Department of Human Genetics, Ruhr University Bochum Germany
J Negat Results Biomed 4:1. 2005..In addition, we screened indirectly for disease association via 4 microsatellites with pooled DNA in the PLCgamma-2 gene...