Johannes F Coy

Summary

Country: Germany

Publications

  1. ncbi request reprint Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer
    Johannes F Coy
    R Biopharm AG, Landwehrstrasse 54, 64293 Darmstadt, Germany
    Clin Lab 51:257-73. 2005
  2. ncbi request reprint Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases
    Monica Zerilli
    Department of Human Pathology, University of Palermo, Palermo, Italy
    Cancer 113:936-44. 2008
  3. pmc Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
    S Langbein
    Department of Urology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Br J Cancer 94:578-85. 2006
  4. pmc The role of glucose metabolism and glucose-associated signalling in cancer
    Rainer Wittig
    R Biopharm AG, Landwehrstrasse 54, 64293 Darmstadt, Germany
    Perspect Medicin Chem 1:64-82. 2008
  5. doi request reprint Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis
    Natalie Jansen
    TAVARLIN AG, Landwehrstrasse 54, D 64293 Darmstadt, Germany
    Future Oncol 9:605-9. 2013
  6. doi request reprint EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies
    Oliver Feyen
    TAVARLIN AG, Landwehrstrasse 54, D 64293 Darmstadt, Germany
    Future Oncol 8:1349-59. 2012
  7. ncbi request reprint Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer
    Wilko I Staiger
    Department of Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
    Oncol Rep 16:657-61. 2006
  8. doi request reprint Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer
    Sigrun Langbein
    Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Int J Cancer 122:2422-8. 2008
  9. ncbi request reprint Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer
    Martha Földi
    Department of Obstetrics and Gynaecology, University Hospital Freiburg, D 79106 Freiburg, Germany
    Oncol Rep 17:841-5. 2007
  10. ncbi request reprint Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms
    Johannes F Coy
    German Cancer Research Center, Division of Molecular Genomeanalysis, Im Neuenheimer Feld 280, Heidelberg, Germany
    Gene 290:73-94. 2002

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer
    Johannes F Coy
    R Biopharm AG, Landwehrstrasse 54, 64293 Darmstadt, Germany
    Clin Lab 51:257-73. 2005
    ..We furthermore postulate a novel metabolic concept for the understanding, prevention and therapy of neurodegenerative diseases, diabetes and cancer...
  2. ncbi request reprint Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases
    Monica Zerilli
    Department of Human Pathology, University of Palermo, Palermo, Italy
    Cancer 113:936-44. 2008
    ..A mutated transketolase transcript (TKTL1) has been found up-regulated in different human malignancies, and strong TKTL1 protein expression has been associated with aggressiveness and poor patient survival in several epithelial cancers...
  3. pmc Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
    S Langbein
    Department of Urology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Br J Cancer 94:578-85. 2006
    ..We suggest an individualised cancer therapy based on the determination of metabolic changes in tumours that might enable the targeted inhibition of invasion and metastasis...
  4. pmc The role of glucose metabolism and glucose-associated signalling in cancer
    Rainer Wittig
    R Biopharm AG, Landwehrstrasse 54, 64293 Darmstadt, Germany
    Perspect Medicin Chem 1:64-82. 2008
    ..These results place glucose metabolism to the centre of pathogenesis of several civilisation related diseases and raise concerns about the high glycaemic index of various food components commonly consumed in western diets...
  5. doi request reprint Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis
    Natalie Jansen
    TAVARLIN AG, Landwehrstrasse 54, D 64293 Darmstadt, Germany
    Future Oncol 9:605-9. 2013
    ....
  6. doi request reprint EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies
    Oliver Feyen
    TAVARLIN AG, Landwehrstrasse 54, D 64293 Darmstadt, Germany
    Future Oncol 8:1349-59. 2012
    ..To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies...
  7. ncbi request reprint Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer
    Wilko I Staiger
    Department of Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
    Oncol Rep 16:657-61. 2006
    ..Since molecular targeted inhibition of transketolase enzyme reactions suppresses tumor growth and metastasis, TKTL1 could be a relevant target for anti-transketolase therapies in gastric cancer...
  8. doi request reprint Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer
    Sigrun Langbein
    Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Int J Cancer 122:2422-8. 2008
    ..The coexistence of cancer cells with differentially regulated energy supplies provides new insights in carcinogenesis and novel anticancer targets...
  9. ncbi request reprint Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer
    Martha Földi
    Department of Obstetrics and Gynaecology, University Hospital Freiburg, D 79106 Freiburg, Germany
    Oncol Rep 17:841-5. 2007
    ....
  10. ncbi request reprint Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms
    Johannes F Coy
    German Cancer Research Center, Division of Molecular Genomeanalysis, Im Neuenheimer Feld 280, Heidelberg, Germany
    Gene 290:73-94. 2002
    ....