Janaky Coomaraswamy

Summary

Country: Germany

Publications

  1. pmc Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
    Janaky Coomaraswamy
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:7969-74. 2010
  2. ncbi Cystatin C modulates cerebral beta-amyloidosis
    Stephan A Kaeser
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    Nat Genet 39:1437-9. 2007
  3. pmc BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE)
    Ellen Kilger
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 286:37446-57. 2011
  4. ncbi Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
    Melanie Meyer-Luehmann
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Science 313:1781-4. 2006
  5. pmc Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    Rebecca Radde
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    EMBO Rep 7:940-6. 2006
  6. ncbi Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice
    Anna K Stalder
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 25:11125-32. 2005

Collaborators

Detail Information

Publications6

  1. pmc Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
    Janaky Coomaraswamy
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:7969-74. 2010
    ..Our results support the concept of the amyloid hypothesis for AD and related dementias, and suggest that different proteins prone to amyloid formation can drive strikingly similar pathogenic pathways in the brain...
  2. ncbi Cystatin C modulates cerebral beta-amyloidosis
    Stephan A Kaeser
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    Nat Genet 39:1437-9. 2007
    ..Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions...
  3. pmc BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE)
    Ellen Kilger
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 286:37446-57. 2011
    ..Targeting the regulation of IDE may be a promising therapeutic approach to sporadic AD...
  4. ncbi Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
    Melanie Meyer-Luehmann
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Science 313:1781-4. 2006
    ..The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Abeta strains with varying biological activities reminiscent of prion strains...
  5. pmc Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    Rebecca Radde
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    EMBO Rep 7:940-6. 2006
    ....
  6. ncbi Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice
    Anna K Stalder
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 25:11125-32. 2005
    ..The observation that hematopoietic cells invade the brain in response to cerebral amyloidosis may hold an unrecognized therapeutic potential...