E Christophers

Summary

Country: Germany

Publications

  1. ncbi request reprint Sentinel node biopsy in melanoma
    A Hauschild
    Department of Dermatology, University of Kiel, Germany
    Virchows Arch 438:99-106. 2001
  2. ncbi request reprint Targeting T-cell subsets to achieve remission
    E Christophers
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Eur Acad Dermatol Venereol 17:6-11. 2003
  3. ncbi request reprint Psoriasis--epidemiology and clinical spectrum
    E Christophers
    Klinik fur Dermatologie, Venerologie und Allerologie, Universitatsklinikum Kiel, Schittenhelmstrasse 7, 21405 Kiel, Germany
    Clin Exp Dermatol 26:314-20. 2001
  4. ncbi request reprint The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion
    U Mrowietz
    Department of Dermatology, University of Kiel, Germany
    Br J Dermatol 139:992-6. 1998
  5. ncbi request reprint Treatment of psoriasis with fumaric acid esters: results of a prospective multicentre study. German Multicentre Study
    U Mrowietz
    Department of Dermatology, University of Kiel, Germany
    Br J Dermatol 138:456-60. 1998
  6. ncbi request reprint Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis
    R Fölster-Holst
    Department of Dermatology, University of Kiel, Kiel, Germany
    Br J Dermatol 155:1256-61. 2006
  7. doi request reprint Dermal fibroblasts from acute inflamed atopic dermatitis lesions display increased eotaxin/CCL11 responsiveness to interleukin-4 stimulation
    N Gahr
    Clinical Research Unit, Department of Dermatology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Br J Dermatol 164:586-92. 2011
  8. ncbi request reprint SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
    T Luger
    Department of Dermatology, University of Muenster, Germany
    Br J Dermatol 144:788-94. 2001
  9. ncbi request reprint Successful treatment of actinic keratosis with imiquimod cream 5%: a report of six cases
    E Stockfleth
    Department of Dermatology, University of Kiel, Schittenhelmstrasse 7, D 24105 Kiel, Germany
    Br J Dermatol 144:1050-3. 2001
  10. ncbi request reprint Explaining phenotype heterogeneity in patients with psoriasis
    E Christophers
    Department of Dermatology, Schleswig Holstein University Clinic, Kiel, Germany
    Br J Dermatol 158:437-41. 2008

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Sentinel node biopsy in melanoma
    A Hauschild
    Department of Dermatology, University of Kiel, Germany
    Virchows Arch 438:99-106. 2001
    ..The clinical value of reverse-transcriptase polymerase chain reaction (RT-PCR)based search for minimal melanoma disease in lymph nodes remains unclear...
  2. ncbi request reprint Targeting T-cell subsets to achieve remission
    E Christophers
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Eur Acad Dermatol Venereol 17:6-11. 2003
    ..This correlation indicates a relationship between a specific T-cell subset reduction (CD45RO+) and clinical outcome in psoriasis...
  3. ncbi request reprint Psoriasis--epidemiology and clinical spectrum
    E Christophers
    Klinik fur Dermatologie, Venerologie und Allerologie, Universitatsklinikum Kiel, Schittenhelmstrasse 7, 21405 Kiel, Germany
    Clin Exp Dermatol 26:314-20. 2001
    ..As the psoriatic immune response pattern relates to activated Th-1 cells, psoriasis and atopic dermatitis appear to be mutually exclusive due to the Th-1/Th-2 dichotomy...
  4. ncbi request reprint The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion
    U Mrowietz
    Department of Dermatology, University of Kiel, Germany
    Br J Dermatol 139:992-6. 1998
    ..We conclude from our results that the new macrolactam SDZ ASM 981 (1%) is similar to clobetasol-17-propionate (0.05%) in plaque-type psoriasis when applied topically under occlusion for 2 weeks using the microplaque assay...
  5. ncbi request reprint Treatment of psoriasis with fumaric acid esters: results of a prospective multicentre study. German Multicentre Study
    U Mrowietz
    Department of Dermatology, University of Kiel, Germany
    Br J Dermatol 138:456-60. 1998
    ..Transient eosinophilia seems to be a characteristic feature of FAE therapy, while lymphocytopenia is usually mild. Adverse effects are dose-related and consist mainly of gastrointestinal complaints and flushing...
  6. ncbi request reprint Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis
    R Fölster-Holst
    Department of Dermatology, University of Kiel, Kiel, Germany
    Br J Dermatol 155:1256-61. 2006
    ..A reduction of symptoms of atopic dermatitis (AD) in small infants by the administration of Lactobacillus rhamnosus has been reported in a few studies. One study with older children and adolescents failed to show any effect...
  7. doi request reprint Dermal fibroblasts from acute inflamed atopic dermatitis lesions display increased eotaxin/CCL11 responsiveness to interleukin-4 stimulation
    N Gahr
    Clinical Research Unit, Department of Dermatology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Br J Dermatol 164:586-92. 2011
    ..CCL11 is a potent chemoattractant and activator of human eosinophils and interleukin (IL)-4 is a potent inducer of CCL11 expression in dermal fibroblasts...
  8. ncbi request reprint SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
    T Luger
    Department of Dermatology, University of Muenster, Germany
    Br J Dermatol 144:788-94. 2001
    ..SDZ ASM 981 is a selective inhibitor of the production of pro-inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases...
  9. ncbi request reprint Successful treatment of actinic keratosis with imiquimod cream 5%: a report of six cases
    E Stockfleth
    Department of Dermatology, University of Kiel, Schittenhelmstrasse 7, D 24105 Kiel, Germany
    Br J Dermatol 144:1050-3. 2001
    ..Actinic keratoses (AK) are premalignant lesions, which are routinely treated by destructive procedures such as cryotherapy, electrodessication or topical 5-fluorouracil...
  10. ncbi request reprint Explaining phenotype heterogeneity in patients with psoriasis
    E Christophers
    Department of Dermatology, Schleswig Holstein University Clinic, Kiel, Germany
    Br J Dermatol 158:437-41. 2008
    ..Within this framework not a single 'antigen' but various causative agents play a key role...
  11. doi request reprint The risk of psoriatic arthritis remains constant following initial diagnosis of psoriasis among patients seen in European dermatology clinics
    E Christophers
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Eur Acad Dermatol Venereol 24:548-54. 2010
    ..Estimates of psoriatic arthritis (PsA) prevalence among psoriasis patients vary widely (5-40%). The time to development of PsA in patients with plaque psoriasis also remains unclear...
  12. ncbi request reprint Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference
    U Mrowietz
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Br J Dermatol 141:424-9. 1999
    ..This article reviews the experimental and clinical information on FAEs in psoriasis and provides guidelines for the clinical use of FAEs derived from a consensus meeting of leading experts...
  13. ncbi request reprint Body-weight-independent dosing of cyclosporine micro-emulsion and three times weekly maintenance regimen in severe psoriasis. A randomised study
    D Thaci
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Dermatology 205:383-8. 2002
    ..Body-weight-dependent (BWD) treatment of psoriasis with cyclosporine A (CsA is well established. It has recently been reported that this is not necessary for the treatment of atopic dermatitis...
  14. doi request reprint Epidemiology and comorbidity of psoriasis in children
    M Augustin
    CVderm German Center for Health Services Research in Dermatology, Department of Dermatology, University Clinics of Hamburg, Hamburg, Germany
    Br J Dermatol 162:633-6. 2010
    ..Psoriasis is a common disease affecting all age groups. In contrast to adult psoriasis, only few studies on the epidemiology of childhood psoriasis have been published...
  15. ncbi request reprint Cercarial dermatitis contracted via contact with an aquarium: case report and review
    R Fölster-Holst
    Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Br J Dermatol 145:638-40. 2001
    ..It is commonly contracted while swimming or wading in lakes. We report a biology teacher who developed the dermatitis after cleaning the school aquarium in which he kept a water snail and some fish...
  16. ncbi request reprint Low prevalence of the intrinsic form of atopic dermatitis among adult patients
    R Fölster-Holst
    Department of Dermatology, University Hospital of Schleswig Holstein, University of Kiel, Kiel, Germany
    Allergy 61:629-32. 2006
    ..Accordingly, these patients are assigned to a nonallergic (intrinsic) form of the disease...
  17. ncbi request reprint Distribution of HPV 53, HPV 73 and CP8304 in genital epithelial lesions with different grades of dysplasia
    T Meyer
    Institute of Immunology, Pathology and Molecular Biology IPM Hamburg, and Department of Dermatology, University of Kiel, Germany
    Int J Gynecol Cancer 11:198-204. 2001
    ..Moreover, in contrast to HPV73, these viruses have never been detected in cancer specimens. Thus, HPV53 and CP8304 infections are probably not associated with a high risk of carcinogenesis, while HPV73 could be another HR-HPV type...
  18. ncbi request reprint Psoriasis scales contain C5a as the predominant chemotaxin for monocyte-derived dendritic cells
    U Mrowietz
    Dept of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Exp Dermatol 10:238-45. 2001
    ..Our results provide evidence that C5a/C5adesarg although not specific for dendritic cells seems to be the major chemoattractant for these cells in lesional psoriasis skin...
  19. ncbi request reprint The unmet treatment need for moderate to severe psoriasis: results of a survey and chart review
    E Christophers
    University of Kiel, Kiel, Germany
    J Eur Acad Dermatol Venereol 20:921-5. 2006
    ..Conventional systemic therapies and phototherapy for psoriasis are limited by safety concerns that may preclude long-term treatment with these agents...
  20. ncbi request reprint Linkage disequilibrium analysis of familial psoriasis: identification of multiple disease-associated MHC haplotypes
    S Jenisch
    Department of Immunology, University of Kiel, Germany
    Tissue Antigens 53:135-46. 1999
    ..These results identify a major PsV susceptibility locus in the immediate vicinity of, but distinct from HLA-B or HLA-C, and suggest that multiple disease alleles have arisen during human evolution...
  21. ncbi request reprint Complete remission of a radio-resistant cutaneous angiosarcoma of the scalp by systemic treatment with liposomal doxorubicin
    S Eiling
    Department of Dermatology, University of Kiel, Schittenhelmstrasse 7, Germany
    Br J Dermatol 147:150-3. 2002
    ..Caelyx(R) appears to be a promising alternative to conventional treatment of cutaneous angiosarcoma...
  22. ncbi request reprint [Temozolomide as therapeutic option for patients with metastatic melanoma and poor prognosis]
    S Frick
    Klinik fur Dermatologie, Venerologie und Allergologie der Christian Albrechts Universität zu Kiel, Germany
    Hautarzt 53:659-65. 2002
    ..We treated 25 stage IV patients with temozolomide - a cytostatic drug with 100% oral bioavailability and considerable penetration of CNS tissue...
  23. ncbi request reprint Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris
    S Jenisch
    Department of Immunology, University of Kiel, Germany
    Tissue Antigens 54:439-49. 1999
    ..Due to its biologic function, cellular location and disease association, the CD gene appears to be an excellent candidate gene for PSORS1, the HLA-linked determinant of psoriasis vulgaris...
  24. ncbi request reprint Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment
    E Stockfleth
    Department of Dermatology, Christian Albrechts University, Kiel, Germany
    Recent Results Cancer Res 160:251-8. 2002
    ..The drug has been shown to have both antiviral and antitumor activity. Application of immune response activators or modifiers such as imiquimod might be premising in the case of transplant recipients...
  25. ncbi request reprint Remarkable remission of a follicular lymphoma treated with rituximab and polychemotherapy (CHOP)
    T Schmook
    Department of Dermatology, University of Kiel, Germany
    Clin Exp Dermatol 28:31-3. 2003
    ..Follow-up biopsies on the forehead showed no evidence of CD20 positive lymphoma cells, now. Despite mild leucocytopaenia therapy was well tolerated...
  26. ncbi request reprint Oral lichenoid reactions associated with amalgam: improvement after amalgam removal
    A Dunsche
    Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Str 16, Germany
    Br J Dermatol 148:70-6. 2003
    ..The pathogenetic relationship between oral lichenoid reactions (OLR) and dental amalgam fillings is still a matter of controversy...
  27. ncbi request reprint Alefacept in the treatment of psoriasis in patients for whom conventional therapies are inadequate
    P Van De Kerkhof
    Department of Dermatology, UMC St Radboud, Nijmegen, The Netherlands
    Dermatology 211:256-63. 2005
    ..Many patients with moderate to severe chronic plaque psoriasis fail to respond to or are not appropriate candidates for conventional systemic therapies and/or phototherapy...
  28. ncbi request reprint Topical calcipotriol plus oral fumaric acid is more effective and faster acting than oral fumaric acid monotherapy in the treatment of severe chronic plaque psoriasis vulgaris
    H Gollnick
    Department of Dermatology and Venereology, Otto von Guericke University, Magdeburg, Germany
    Dermatology 205:46-53. 2002
    ..Calcipotriol is an established topical therapy for psoriasis vulgaris...
  29. ncbi request reprint Calcitriol 3 microg g-1 ointment in combination with ultraviolet B phototherapy for the treatment of plaque psoriasis: results of a comparative study
    J Ring
    University Hospital of Dermatology, Hamburg, Germany
    Br J Dermatol 144:495-9. 2001
    ..CONCLUSIONS: Calcitriol 3 microg g-1 ointment and UVB phototherapy in combination provides a promising therapy for managing chronic plaque psoriasis...
  30. ncbi request reprint Immune response profiles in human skin
    T Meyer
    Institute for Immunology, Clinical Pathology and Molecular Medicine, Lademannbogen 61, 22339 Hamburg, Germany
    Br J Dermatol 157:1-7. 2007
    ..Recent improvements of our knowledge of dysregulated immune pathways associated with inflammatory skin diseases represent an important basis of novel immunomodulatory treatment modalities...
  31. ncbi request reprint S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis
    S W Stoll
    The Department of The Department of Dermatology, University of Michigan Medical School, MI, USA
    Clin Exp Dermatol 26:79-83. 2001
    ..00 by Fisher's exact test). Our data explain conflicting results in the literature regarding the sequence of S100A2 but provide no support for a direct causal role for S100A2 in psoriasis...
  32. ncbi request reprint A classification of psoriasis vulgaris according to phenotype
    C E M Griffiths
    Dermatology Centre, The University of Manchester, Hope Hospital, Salford, Manchester, UK
    Br J Dermatol 156:258-62. 2007
    ..A meeting of the International Psoriasis Council produced a consensus on clinical phenotypes of psoriasis equally relevant to clinical practitioners and psoriasis researchers...
  33. ncbi request reprint Cyclosporine in severe psoriasis. Results of a meta-analysis in 579 patients
    L Faerber
    Department of Pharmacology, University of Regensburg, Regensburg, Germany
    Am J Clin Dermatol 2:41-7. 2001
    ..An increase in serum creatinine level that required intervention occurred in 3.4% of cyclosporine treatment cycles. CONCLUSION: Cyclosporine is highly effective and well tolerated in the short term treatment of severe psoriasis...
  34. ncbi request reprint What is the 'true' function of skin?
    C M Chuong
    Department of Pathology, University of Southern California, Los Angeles, 90033, USA
    Exp Dermatol 11:159-87. 2002
    ....
  35. pmc Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage
    P Stuart
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Med Genet 43:12-7. 2006
    ..Another study found an association with SNPs in the RAPTOR gene, but not with the RUNX1 binding site polymorphism...
  36. ncbi request reprint Biological therapies in the systemic management of psoriasis: International Consensus Conference
    W Sterry
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    Br J Dermatol 151:3-17. 2004
    ..The limitations of current psoriasis therapies, the value of biological therapies for psoriasis, and guidance regarding the incorporation of biological therapies into clinical practice are discussed...
  37. ncbi request reprint A peptide antibiotic from human skin
    J Harder
    Nature 387:861. 1997