M Christ

Summary

Country: Germany

Publications

  1. ncbi request reprint Prognostic significance of serum cholesterol levels in patients with idiopathic dilated cardiomyopathy
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie und Intensivmedizin, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Eur Heart J 27:691-9. 2006
  2. ncbi request reprint Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin
    Michael Christ
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Diabetes 51:2648-52. 2002
  3. ncbi request reprint Effects of a weight reduction program with and without aerobic exercise in the metabolic syndrome
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Int J Cardiol 97:115-22. 2004
  4. ncbi request reprint Enhancement of beta-adrenergic cAMP-signaling by the mineralocorticoid receptor
    Michael Christ
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1, D 68135 Mannheim, Germany
    Mol Cell Endocrinol 231:23-31. 2005
  5. ncbi request reprint [Arterial hypertension and metabolic syndrome]
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Angiologie, Intensivmedizin und Prävention, Philipps Universitat, Marburg, Germany
    Herz 28:674-85. 2003
  6. ncbi request reprint Preoperative and perioperative care for patients with suspected or established aortic stenosis facing noncardiac surgery
    Michael Christ
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Chest 128:2944-53. 2005
  7. ncbi request reprint Association of right ventricular dysfunction and Cheyne-Stokes respiration in patients with chronic heart failure
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps Universitat Marburg, Marburg, Germany
    J Sleep Res 12:161-7. 2003
  8. ncbi request reprint [Significance of aldosterone antagonist therapy]
    M Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps Universitat Marburg
    Internist (Berl) 45:347-54. 2004
  9. ncbi request reprint [Value of aldosterone receptor blockade in diuretic therapy of patients with chronic heart failure]
    Michael Christ
    Klinik für Innere Medizin Kardiologie, Philipps Universitat Marburg
    Herz 27:135-49. 2002
  10. ncbi request reprint Hormone replacement in postmenopausal women: impact of progestogens on autonomic tone and blood pressure regulation
    Michael Christ
    Department of Internal Medicine Cardiology, University of Marburg, Germany
    Menopause 9:127-36. 2002

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Prognostic significance of serum cholesterol levels in patients with idiopathic dilated cardiomyopathy
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie und Intensivmedizin, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Eur Heart J 27:691-9. 2006
    ..Previous studies indicate that low cholesterol levels are associated with adverse prognosis in heart failure patients, because elevated lipoprotein levels may negate bacterial endotoxin load induced by gastrointestinal congestion...
  2. ncbi request reprint Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin
    Michael Christ
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Diabetes 51:2648-52. 2002
    ..Beneficial effects of statins in diabetic patients may be explained in part by attenuation of vascular O(2)(-) formation independent of lipid lowering...
  3. ncbi request reprint Effects of a weight reduction program with and without aerobic exercise in the metabolic syndrome
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Int J Cardiol 97:115-22. 2004
    ..Patients with a similar risk profile, who declined antihypertensive therapy beyond ACE inhibition, served as controls (n = 14)...
  4. ncbi request reprint Enhancement of beta-adrenergic cAMP-signaling by the mineralocorticoid receptor
    Michael Christ
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1, D 68135 Mannheim, Germany
    Mol Cell Endocrinol 231:23-31. 2005
    ..In conclusion, our findings suggest a novel interplay between cAMP and MR signaling pathways...
  5. ncbi request reprint [Arterial hypertension and metabolic syndrome]
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Angiologie, Intensivmedizin und Prävention, Philipps Universitat, Marburg, Germany
    Herz 28:674-85. 2003
    ..Due to its adverse impact on cardiovascular disease, early detection and aggressive treatment is mandatory to ensure longlasting benefits for affected patients...
  6. ncbi request reprint Preoperative and perioperative care for patients with suspected or established aortic stenosis facing noncardiac surgery
    Michael Christ
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Chest 128:2944-53. 2005
    ..At this point, decisions should be made in an interdisciplinary manner, including the opinions/wishes of the patient and the patient's family...
  7. ncbi request reprint Association of right ventricular dysfunction and Cheyne-Stokes respiration in patients with chronic heart failure
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps Universitat Marburg, Marburg, Germany
    J Sleep Res 12:161-7. 2003
    ..In conclusion, CSR is associated with depressed systolic RV function and increased RV dimensions in CHF patients. Future studies will show whether optimized treatment of CSR will improve RV function...
  8. ncbi request reprint [Significance of aldosterone antagonist therapy]
    M Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps Universitat Marburg
    Internist (Berl) 45:347-54. 2004
    ..In conclusion, an old-fashioned, previously abandoned treatment strategy is currently celebrating its revival...
  9. ncbi request reprint [Value of aldosterone receptor blockade in diuretic therapy of patients with chronic heart failure]
    Michael Christ
    Klinik für Innere Medizin Kardiologie, Philipps Universitat Marburg
    Herz 27:135-49. 2002
    ..Elevated levels of those neurohormones detrimentally modulate renal function. Subsequently, renal salt and volume retention occurs leading to the main symptoms of heart failure, edema formation and dyspnea...
  10. ncbi request reprint Hormone replacement in postmenopausal women: impact of progestogens on autonomic tone and blood pressure regulation
    Michael Christ
    Department of Internal Medicine Cardiology, University of Marburg, Germany
    Menopause 9:127-36. 2002
    ..While hormone replacement therapy (HRT) with estrogens beneficially modulates autonomic tone and blood pressure (BP) regulation in postmenopausal women, the impact of concomitant treatment with progestogens remains unclear...
  11. ncbi request reprint Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system
    B M Schmidt
    Institute of Clinical Pharmacology, University Hospital of Mannheim, Faculty for Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Clin Endocrinol Metab 86:761-7. 2001
    ..Furthermore, aldosterone blunts the blood pressure-lowering effect of the beta-blocking agent esmolol by a nongenomic mechanism...
  12. ncbi request reprint Effect of oral contraceptives and ovarian cycle on platelet function
    A Roell
    Faculty of Clinical Medicine Mannheim, Institute of Clinical Pharmacology, University of Heidelberg, Germany
    Platelets 18:165-70. 2007
    ..As for OCs, the main factor seems to be the progestagen. During the female cycle, the main impact on platelet function might be mediated by progesterone...
  13. ncbi request reprint Acute effects of a single oral dose of carvedilol on cardiac sympathovagal balance in man
    K Haseroth
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Munich, Germany
    Int J Clin Pharmacol Ther 39:315-21. 2001
    ..Interpretation of the latter results, in particular, requires further investigation...
  14. ncbi request reprint Nongenomic effects of aldosterone on human renal cells
    H Koppel
    V Medizinische Universitätsklinik, Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Clin Endocrinol Metab 88:1297-302. 2003
    ..As these effects occur at concentrations close to free plasma aldosterone levels in man, they may be of physiological relevance and may contribute to renal injury...
  15. ncbi request reprint Alterations in platelet function during the ovarian cycle
    M Feuring
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany
    Blood Coagul Fibrinolysis 13:443-7. 2002
    ..This study indicates that platelet function is periodically altered during the ovarian cycle due to the influence of progesterone and estrogen on von Willebrand factor concentrations...
  16. ncbi request reprint Rapid nongenomic effects of aldosterone in mineralocorticoid-receptor-knockout mice
    K Haseroth
    Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Biochem Biophys Res Commun 266:257-61. 1999
    ..The study, thus, proves that a receptor different from the classic intracellular receptor is involved in rapid aldosterone signaling...
  17. ncbi request reprint Hypoxia modulates rapid effects of aldosterone on oxidative metabolism in human calf muscle
    M Christ
    Institute of Clinical Pharmacology, Klinikum Mannheim, University of Heidelberg, Germany
    J Endocrinol Invest 24:587-97. 2001
    ..We hypothesize that aldosterone rapidly interferes with oxidative metabolism probably by direct modulation of ATP-turnover, which is induced by an oxygen-dependent imbalance of the ATP-synthesis and utilization rate...
  18. ncbi request reprint [Extracardiac causes of right ventricular insufficiency]
    B Maisch
    Klinik fur Innere Medizin, Philipps Universitat Marburg
    Internist (Berl) 45:1136-46. 2004
    ..Cardiac surgery with pericardiolysis and (partial) pericardial resection remains the method of choice for symptomatic constrictive pericarditis...
  19. ncbi request reprint Tumour necrosis factor-related apoptosis-inducing ligand and osteoprotegerin serum levels in psoriatic arthritis
    L C Hofbauer
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Rheumatology (Oxford) 45:1218-22. 2006
    ....
  20. ncbi request reprint Arrhythmia risk prediction in idiopathic dilated cardiomyopathy based on heart rate variability and baroreflex sensitivity
    Wolfram Grimm
    Department of Cardiology, Hospital of the Philipps University of Marburg, Germany
    Pacing Clin Electrophysiol 28:S202-6. 2005
    ..3 ms/mmHg, ns) were both similar in patients with versus without MAE during follow-up. In contrast, left ventricular ejection fraction was significantly lower in patients with versus without MAE (24%+/- 7% vs 31%+/- 10%, P < 0.019...
  21. pmc QRS and QTc interval prolongation in the prediction of long-term mortality of patients with acute destabilised heart failure
    Tobias Breidthardt
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    Heart 93:1093-7. 2007
    ..To quantify the prognostic utility of QRS and QTc interval prolongation in patients presenting with acute destabilised heart failure (ADHF) to the emergency department (ED)...
  22. ncbi request reprint Brain natriuretic peptide for prediction of Cheyne-Stokes respiration in heart failure patients
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie Philipps Universität Marburg, Germany
    Int J Cardiol 116:62-9. 2007
    ..Specifically, BNP levels are associated with the severity of cardiac and sleep-related disease, and may be helpful in the diagnosis of CSR and more appropriate use of polysomnography in CHF patients...
  23. ncbi request reprint Long runs of non-sustained ventricular tachycardia on 24-hour ambulatory electrocardiogram predict major arrhythmic events in patients with idiopathic dilated cardiomyopathy
    Wolfram Grimm
    Department of Cardiology, Hospital of the Philipps University of Marburg, Germany
    Pacing Clin Electrophysiol 28:S207-10. 2005
    ..The presence of NSVT with >/=10 beat runs on ambulatory ECG was associated with a particularly high risk of major arrhythmic events...
  24. ncbi request reprint Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction: role of vascular superoxide anion formation and endothelial nitric oxide synthase expression
    Johann Bauersachs
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg
    J Am Coll Cardiol 39:351-8. 2002
    ..We sought to investigate the effects of adding spironolactone (SP) to angiotensin-converting enzyme (ACE) inhibition on endothelium-dependent vasodilation in rats with chronic heart failure (CHF)...
  25. ncbi request reprint Nongenomic cardiovascular effects of triiodothyronine in euthyroid male volunteers
    Bernhard M W Schmidt
    Institute of Clinical Pharmacology, University Hospital of Mannheim, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    J Clin Endocrinol Metab 87:1681-6. 2002
    ..After pretreatment with esmolol, the effects on SVR and LF/HF ratio were reversed. Our data show, for the first time, nongenomic cardiovascular effects of T(3) in humans...
  26. ncbi request reprint Value of heart rate variability to predict ventricular arrhythmias in recipients of prophylactic defibrillators with idiopathic dilated cardiomyopathy
    Wolfram Grimm
    Department of Cardiology, Hospital of the Philipps University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Pacing Clin Electrophysiol 26:411-5. 2003
    ..These findings do not support the use of HRV measured as SDNN on 24-hour ambulatory ECG to select patients with IDC for prophylactic ICD therapy...
  27. ncbi request reprint Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition
    Andreas Schafer
    Medizinische Universitatsklinik, Wurzburg, Germany
    Thromb Haemost 89:1024-30. 2003
    ..Increased nitric oxide bioavailability can only partially explain the reduced platelet activation by eplerenone and ACE inhibition...
  28. ncbi request reprint Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy Study
    Wolfram Grimm
    Department of Cardiology, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Circulation 108:2883-91. 2003
    ..Arrhythmia risk stratification with regard to prophylactic implantable cardioverter-defibrillator therapy is a completely unsolved issue in idiopathic dilated cardiomyopathy (IDC)...
  29. ncbi request reprint Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik der Julius Maximilians Universität Würzburg, Wurzburg, Germany
    J Am Coll Cardiol 42:1666-73. 2003
    ....
  30. ncbi request reprint Early aldosterone up-regulated genes: new pathways for renal disease?
    Markus Kellner
    Institute of Clinical Pharmacology, Faculty of Clinical Medicine at Mannheim, University of Heidelberg, Germany
    Kidney Int 64:1199-207. 2003
    ..This leads to the conclusion that mechanisms independent of the classical aldosterone/mineralocorticoid receptor system may contribute to the pathogenesis of cardiac and renal disease...
  31. ncbi request reprint Prognostic significance of morphometric endomyocardial biopsy analysis in patients with idiopathic dilated cardiomyopathy
    Wolfram Grimm
    Department of Cardiology, Hospital of the Philipps University of Marburg, Marburg, Germany
    Am Heart J 146:372-6. 2003
    ..To date, considerable controversy exists on the prognostic significance of morphometric endomyocardial biopsy findings in patients with idiopathic dilated cardiomyopathy (IDC)...
  32. ncbi request reprint The integration of BNP and NT-proBNP into clinical medicine
    Christian Mueller
    Department of Internal Medicine, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Swiss Med Wkly 137:4-12. 2007
    ....
  33. ncbi request reprint Neurohormonal activation and left ventricular ejection fraction in patients with suspected myocardial ischemia
    Juerg Wermuth
    Department of Internal Medicine, Medical Division A, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Int J Cardiol 120:248-53. 2007
    ..Unfortunately, there is very limited data regarding the association between BNP and LVEF...
  34. ncbi request reprint B-type natriuretic peptide levels predict event-free survival in patients with implantable cardioverter defibrillators
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Germany
    Eur J Heart Fail 9:272-9. 2007
    ....
  35. ncbi request reprint Acute effects of aldosterone on intracardiac monophasic action potentials
    Hanns Christian Tillmann
    Faculty of Clinical Medicine Mannheim, Institute of Clinical Pharmacology, Heidelberg University, Theodor Kutzer Ufer, 68135, Mannheim, Germany
    Int J Cardiol 84:33-9; discussion 39-40. 2002
    ..So far, the electrophysiological properties of aldosterone have not been thoroughly characterized. In the present study, the effects of aldosterone on intracardiac monophasic action potentials were investigated in humans...
  36. ncbi request reprint An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia
    Ruediger R Noppens
    Department of Anesthesiology, Johannes Gutenberg University Mainz, Germany
    Crit Care Med 34:2194-200. 2006
    ..In addition, we evaluated the therapeutic window for hypertonic saline treatment (early vs. delayed application)...
  37. ncbi request reprint Gender differences in acute congestive heart failure
    Myriam Ritter
    University of Basel, University Hospital, Department of Internal Medicine, Switzerland
    Swiss Med Wkly 136:311-7. 2006
    ..Little is known about sex differences in baseline characteristics and outcomes in patients with acute congestive heart failure (CHF)...
  38. ncbi request reprint TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, D 35033 Marburg, Germany
    Biochem Biophys Res Commun 338:1745-50. 2005
    ..001 vs. controls). In conclusion, myocardial overexpression of antiapoptotic OPG in DCM patients may represent a compensatory mechanism to limit systemic activation of TRAIL in patients with congestive heart disease...
  39. ncbi request reprint Prognostic significance of heart rate turbulence following ventricular premature beats in patients with idiopathic dilated cardiomyopathy
    Wolfram Grimm
    Department of Cardiology, Hospital of the Philipps University of Marburg, Marburg, Germany
    J Cardiovasc Electrophysiol 14:819-24. 2003
    ..Heart Rate Turbulence in Dilated Cardiomyopathy...
  40. ncbi request reprint Effects of synthetic progestagens on autonomic tone, neurohormones and C-reactive protein levels in young healthy females in reproductive age
    Per Otto Schueller
    Department of Cardiology, Heinrich Heine University Dusseldorf, Germany
    Int J Cardiol 111:42-8. 2006
    ....
  41. ncbi request reprint Heart rate turbulence following ventricular premature beats in healthy controls
    Wolfram Grimm
    Department of Cardiology, Munich University of Technology, Germany
    Ann Noninvasive Electrocardiol 8:127-31. 2003
    ....
  42. doi request reprint New definition of myocardial infarction: impact on long-term mortality
    Willibald Hochholzer
    Herz Zentrum, Bad Krozingen, Germany
    Am J Med 121:399-405. 2008
    ....