Andrew Chan

Summary

Country: Germany

Publications

  1. ncbi request reprint Neuropsychological/-psychiatric deficits in immune-mediated neuropathies
    Andrew Chan
    Department of Neurology, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791, Bochum, Germany
    J Neurol 254:II93-5. 2007
  2. ncbi request reprint ATP-binding cassette transporters in inflammatory brain disease
    A Chan
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Curr Pharm Des 17:2803-7. 2011
  3. doi request reprint Mitoxantrone-related acute leukemia in MS: an open or closed book?
    Andrew Chan
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Neurology 80:1529-33. 2013
  4. doi request reprint Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort
    A K Trampe
    Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany
    Neurology 78:1736-42. 2012
  5. doi request reprint Pharmacogenomics in neurology: current state and future steps
    Andrew Chan
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Ann Neurol 70:684-97. 2011
  6. doi request reprint Immunosuppression in clinical practice: approaches to individualized therapy
    Andrew Chan
    Department of Neurology, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791 Bochum, Germany
    J Neurol 255:22-7. 2008
  7. pmc Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients
    Stefanie Dahlhaus
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 84:1068-74. 2013
  8. doi request reprint Natalizumab-associated reversible encephalopathy syndrome mimicking progressive multifocal leukoencephalopathy
    Bernhard F Décard
    Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
    Mult Scler 19:249-51. 2013
  9. doi request reprint Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients
    Linda K Rey
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Mol Cell Probes 25:255-9. 2011
  10. doi request reprint Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects
    Christina M Lill
    Department of Neurology, Focus Program Translational Neuroscience, corrected University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    J Med Genet 49:558-62. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Neuropsychological/-psychiatric deficits in immune-mediated neuropathies
    Andrew Chan
    Department of Neurology, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791, Bochum, Germany
    J Neurol 254:II93-5. 2007
    ..Fatigue may result in a major restriction of quality of life long after the acute phase of GBS and is also a major debilitating factor in chronic inflammatory neuropathies. Symptomatic treatment remains largely empirical...
  2. ncbi request reprint ATP-binding cassette transporters in inflammatory brain disease
    A Chan
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Curr Pharm Des 17:2803-7. 2011
    ..g. neurodegenerative, and neurovascular) where neuroinflammatory mechanisms have gained considerable attention as important contributors to pathogenesis...
  3. doi request reprint Mitoxantrone-related acute leukemia in MS: an open or closed book?
    Andrew Chan
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Neurology 80:1529-33. 2013
    ..This is of particular importance, since treatment alternatives, especially in secondary progressive MS, are sparse...
  4. doi request reprint Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort
    A K Trampe
    Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany
    Neurology 78:1736-42. 2012
    ....
  5. doi request reprint Pharmacogenomics in neurology: current state and future steps
    Andrew Chan
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Ann Neurol 70:684-97. 2011
    ..In time, this is likely to lead to improvements in the benefit-harm balance of neurological therapies, cost efficiency, and identification of new drugs...
  6. doi request reprint Immunosuppression in clinical practice: approaches to individualized therapy
    Andrew Chan
    Department of Neurology, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791 Bochum, Germany
    J Neurol 255:22-7. 2008
    ..Here, we will review practical aspects in the clinical use of immunosuppressants in MS and discuss approaches to individualized treatment schemes, including novel pharmacogenetic strategies...
  7. pmc Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients
    Stefanie Dahlhaus
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 84:1068-74. 2013
    ..We evaluated retrospectively 15 patients with natalizumab-associated PML treated at our centre...
  8. doi request reprint Natalizumab-associated reversible encephalopathy syndrome mimicking progressive multifocal leukoencephalopathy
    Bernhard F Décard
    Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
    Mult Scler 19:249-51. 2013
    ..To our knowledge, this is the first case of its kind. Our case suggests that awareness ought to be sharpened for reversible leukoencephalopathy syndrome in the follow-up of natalizumab treated multiple sclerosis patients...
  9. doi request reprint Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients
    Linda K Rey
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Mol Cell Probes 25:255-9. 2011
    ..However, a modest effect of GHSR variation cannot be ruled out and needs to be further evaluated in future studies...
  10. doi request reprint Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects
    Christina M Lill
    Department of Neurology, Focus Program Translational Neuroscience, corrected University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    J Med Genet 49:558-62. 2012
    ..As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently...
  11. doi request reprint Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample
    Christina M Lill
    Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131, Mainz, Germany
    Neurogenetics 13:83-6. 2012
    ..09, P = 0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS...
  12. doi request reprint Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis
    Bernhard F Décard
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Neurol Neurosurg Psychiatry 83:1170-3. 2012
    ..We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 individuals before the first clinical manifestation of MS...
  13. pmc PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University Bochum, Germany
    Mol Neurodegener 6:32. 2011
    ..abstract:..
  14. doi request reprint A newborn with Pierre Robin sequence after preconceptional mitoxantrone exposure of a female with multiple sclerosis
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Neurol Sci 307:164-5. 2011
    ..PRS is a very rare defect and therefore a causal relation with MIX seems possible...
  15. doi request reprint 1H-magnetic resonance spectroscopy in diffuse and focal cervical cord lesions in multiple sclerosis
    Barbara Bellenberg
    Department of Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University of Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Eur Radiol 23:3379-92. 2013
    ..5 T in comparison to quantitative MR imaging of the upper cervical cord area and T2 relaxometry at baseline and follow-up...
  16. doi request reprint Potassium channel KIR4.1 as an immune target in multiple sclerosis
    Rajneesh Srivastava
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat, Munich, Germany
    N Engl J Med 367:115-23. 2012
    ..Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known...
  17. doi request reprint Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy
    Ilya Ayzenberg
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    JAMA Neurol 70:394-7. 2013
    ..To report first experiences with interleukin 6 receptor inhibition in therapy-resistant neuromyelitis optica (NMO)...
  18. pmc Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulation
    Martin N Stienen
    Institute of Neuroanatomy, Ruhr University, Bochum, Germany
    Br J Pharmacol 162:491-507. 2011
    ..Evidence so far suggests a mode of action different from that of classical AEDs. We have shown that LEV restored functional gap junction coupling and basic membrane properties in an astrocytic inflammatory model in vitro...
  19. pmc Immunomodulation and postpartum relapses in patients with multiple sclerosis
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Ther Adv Neurol Disord 2:7-11. 2009
    ..013). The results suggest that IVIG could be an option to prevent postpartum relapse of MS...
  20. doi request reprint L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients
    Nicholas Schwab
    Department of Neurology, University of Munster, Germany
    Neurology 81:865-71. 2013
    ..To find biomarkers identifying patients at risk for the development of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment...
  21. pmc Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report
    Anke Stroet
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Ther Adv Neurol Disord 6:199-203. 2013
    ..Add-on cannabinoid therapy was effective in therapy-refractory spasticity with supra-additive effect in combining intrathecal baclofen and nabiximols, hypothetically explained by mutually complementing mechanisms of action...
  22. doi request reprint Mitochondrial haplogroup H correlates with ATP levels and age at onset in Huntington disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780, Bochum, Germany
    J Mol Med (Berl) 88:431-6. 2010
    ..Our data suggest that an evolutionarily advantageous mitochondrial haplogroup is associated with functional mitochondrial alterations and may modify disease phenotype in the context of neurodegenerative conditions such as HD...
  23. pmc Functional energetics of CD4+-cellular immunity in monoclonal antibody-associated progressive multifocal leukoencephalopathy in autoimmune disorders
    Aiden Haghikia
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 6:e18506. 2011
    ..We investigated whether iATP may assist in individualized risk stratification for opportunistic infections during mAb-treatment...
  24. doi request reprint Allergic and nonallergic delayed infusion reactions during natalizumab therapy
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Arch Neurol 65:656-8. 2008
    ..Delayed infusion reactions resembling serum sickness-type reactions (type III reaction) are commonly reported in other monoclonal antibody therapies (eg, infliximab and rituximab), but are not described yet for natalizumab...
  25. pmc Standard and escalating treatment of chronic inflammatory demyelinating polyradiculoneuropathy
    Min Suk Yoon
    Department of Neurology, Ruhr University Bochum, St Josef Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Ther Adv Neurol Disord 4:193-200. 2011
    ..Large placebo-controlled trials with alternative immunosuppressive compounds, e.g. mycophenolate mofetil, cyclosporine, cyclophosphamide, or monoclonal antibodies, are lacking...