Research Topics
| B WeberSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Detail Information
Publications
Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depressionB Weber
Central Institute of Mental Health, PO Box 122120, 68072, Mannheim, Germany
Psychoneuroendocrinology 25:765-71. 2000..These findings are best explained as a consequence of an overstimulation of the adrenal glands through pituitary and hypothalamic sites of the HPA-system...- Major depression and impaired glucose toleranceB Weber
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
Exp Clin Endocrinol Diabetes 108:187-90. 2000..Insulin and glucose responses to the test meal were significantly increased in hypercortisolemic patients compared to controls. Hence, patients with major depression have an impaired insulin sensitivity... - Pulse-dosing and conventional application of doxepin: effects on psychopathology and hypothalamus-pituitary-adrenal (HPA) systemM Deuschle
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
J Clin Psychopharmacol 17:156-60. 1997..02. We conclude that CONV application of DOX is clinically superior compared with PD and that both modes of application have attenuating effects on hypothalamus-pituitary-adrenal system activity... - Insulin-like growth factor-I (IGF-I) plasma concentrations are increased in depressed patientsM Deuschle
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
Psychoneuroendocrinology 22:493-503. 1997..After treatment only patients in remission had attenuated IGF-I plasma concentrations. We conclude that plasma IGF-I is increased in acutely depressed patients similar to other states of hypercortisolemia... - Corticosteroid-binding globulin is not decreased in depressed patientsM Deuschle
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
Psychoneuroendocrinology 21:645-9. 1996..However, the exaggerated activity of the hypothalamus-pituitary-adrenocortical system in healthy and depressed females is associated with an increase in plasma CBG... - Mineralocorticoid receptor also modulates basal activity of hypothalamus-pituitary-adrenocortical system in humansM Deuschle
Central Institute of Mental Health, J5, Mannheim, Germany
Neuroendocrinology 68:355-60. 1998..These findings are similar to the effects of aging upon the HPA system. However, the effect of spironolactone treatment was small, suggesting that the HPA system activity in humans is modulated but not regulated by the hippocampal MR... - Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation studyM Deuschle
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Stress 2:281-7. 1998..This finding is in line with the observation that in both conditions medical problems triggered and/or maintained by glucocorticoids (e.g. osteoporosis) are frequently seen... - Testosterone, gonadotropin, and cortisol secretion in male patients with major depressionU Schweiger
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
Psychosom Med 61:292-6. 1999..The objective of this study was to explore whether major depressive episodes are indeed associated with an alteration of gonadal function... - Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patientsI Heuser
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
J Clin Endocrinol Metab 83:3130-3. 1998.... - The role of mineralocorticoid receptors in the circadian activity of the human hypothalamus-pituitary-adrenal system: effect of ageI Heuser
Central Institute of Mental Health, J5, 68159, Mannheim, Germany
Neurobiol Aging 21:585-9. 2000.... - Plasma leptin in depressed patients and healthy controlsM Deuschle
Max Planck Institute of Psychiatry, Clinical Institute, , Germany
Horm Metab Res 28:714-7. 1996..We conclude that leptin plasma concentrations are unchanged in depression and that there is no evidence for leptin playing a major role in loss of appetite and body weight in depressed patients... - Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactoneI Heuser
Max Planck Institute of Psychiatry, Clinical Institute, Kraepelinstr 10, 80804, Munich, Germany
Psychoneuroendocrinology 25:513-8. 2000.... - Lumbar bone mineral density in patients with major depression: evidence of increased bone loss at follow-upU Schweiger
Max Planck Institute of Psychiatry, Munich, Germany
Am J Psychiatry 157:118-20. 2000..This study investigated whether an increase in the loss of bone mineral density occurs with major depression... - The glutamate antagonist riluzole and its effects upon basal and stress-induced activity of the human hypothalamus-pituitary-adrenocortical system in elderly subjectsA Kniest
Central Institute of Mental Health, Mannheim, Germany
Neuropsychobiology 43:91-5. 2001..However, a trend for dampening the endocrine response to physical stress emerged... - Dreaming and insomnia: dream recall and dream content of patients with insomniaM Schredl
Sleep Laboratory, Central Institute of Mental Health, Mannheim, Germany
J Sleep Res 7:191-8. 1998..It is suggested that future studies should use more dreams per subject in order to reduce error variance of the dream content measures and more detailed measures of waking life stress... - Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy personsM Schredl
Sleep Laboratory, Central Institute of Mental Health, P O Box 122120, 68072, Mannheim, Germany
Exp Gerontol 36:353-61. 2001..Based on these findings, we conclude that there is an interrelationship between cognitive performance and amount of REM sleep in elderly humans as has been previously shown in animals and young adults...