Valentina Vengeliene

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. doi request reprint The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats
    Valentina Vengeliene
    Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Alcohol Clin Exp Res 37:E322-8. 2013
  2. doi request reprint D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 43:626-9. 2008
  3. doi request reprint Compulsive alcohol drinking in rodents
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:384-96. 2009
  4. ncbi request reprint The effects of lamotrigine on alcohol seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    Neuropharmacology 53:951-7. 2007
  5. ncbi request reprint The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    FASEB J 20:2223-33. 2006
  6. doi request reprint Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 68:704-11. 2010
  7. doi request reprint Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 205:389-97. 2009
  8. ncbi request reprint The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
    Neuropharmacology 48:822-9. 2005
  9. ncbi request reprint Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68072 Mannheim, Germany
    J Neurosci 26:1231-8. 2006
  10. ncbi request reprint Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases
    Sören Siegmund
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 29:1139-45. 2005

Detail Information

Publications22

  1. doi request reprint The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats
    Valentina Vengeliene
    Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Alcohol Clin Exp Res 37:E322-8. 2013
    ..Here, we used a novel drinkometer system in combination with Fourier analysis to provide detailed information on drinking patterns...
  2. doi request reprint D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 43:626-9. 2008
    ..The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour...
  3. doi request reprint Compulsive alcohol drinking in rodents
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:384-96. 2009
    ..In particular, hypofunctioning of monoaminergic systems and hyperfunctioning of glutamatergic systems may play a role in compulsive alcohol drinking...
  4. ncbi request reprint The effects of lamotrigine on alcohol seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    Neuropharmacology 53:951-7. 2007
    ....
  5. ncbi request reprint The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    FASEB J 20:2223-33. 2006
    ..We therefore suggest that selective antagonists of this pharmacological target provide a specific treatment approach to reduce alcohol craving and relapse behavior...
  6. doi request reprint Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 68:704-11. 2010
    ..We therefore hypothesized that the blockade of glycine transporter 1 might interfere with compulsive alcohol consumption and relapse behavior...
  7. doi request reprint Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 205:389-97. 2009
    ..The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval...
  8. ncbi request reprint The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
    Neuropharmacology 48:822-9. 2005
    ..In summary, the results suggest that an inhibition of NMDAR function in general, rather than a particular interference with a specific binding site of this receptor, is sufficient for the reduction of relapse behavior...
  9. ncbi request reprint Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68072 Mannheim, Germany
    J Neurosci 26:1231-8. 2006
    ..In conclusion, AMPA receptors seem to be involved in the neuroplastic changes underlying alcohol seeking behavior and relapse. Thus, AMPA receptors represent a novel therapeutic target in preventing relapse...
  10. ncbi request reprint Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases
    Sören Siegmund
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 29:1139-45. 2005
    ..We investigated the magnitude of the effects of deprivation and stress on alcohol intake and the influence of these events on the alcohol drinking behavior across time...
  11. ncbi request reprint Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats
    Marc W Füllgrabe
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
    Pharmacol Biochem Behav 86:320-6. 2007
    ..In conclusion, female rats that initiate alcohol consumption during adolescence might be more susceptible to stress-induced alcohol consumption. Adolescent alcohol drinking might also result in a reduced response to acamprosate...
  12. pmc Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking
    Stephanie Perreau-Lenz
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:2121-31. 2012
    ..Our data suggest that CK1 inhibitors may be candidates for drug treatment development for alcoholism...
  13. ncbi request reprint Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 178:125-32. 2005
    ..A high comorbidity between depression and alcoholism has been reported in several studies, but the mechanisms underlying this relationship remain unknown...
  14. doi request reprint New pharmacological treatment strategies for relapse prevention
    Rainer Spanagel
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Curr Top Behav Neurosci 13:583-609. 2013
    ..However, it will still be several years before the majority of the "treatment-seeking population" will benefit from those developments...
  15. ncbi request reprint Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning
    Barbara Vollmayr
    Department of Psychiatry, Central Institute of Mental Health J5, D 68159 Mannheim, Germany
    Behav Brain Res 150:217-21. 2004
    ....
  16. ncbi request reprint A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 27:1048-54. 2003
    ..For the alcohol drinking procedure, a long-term model of alcohol self-administration originally developed for heterogeneous Wistar rats was used and was compared with different alcohol-preferring rat lines...
  17. ncbi request reprint Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Alcohol Clin Exp Res 28:1752-7. 2004
    ..To further characterize the influence of chronic ethanol exposure on the developing brain, we assessed the transcriptional and translational regulation of glutamate transporters in a less artificial in vitro system...
  18. doi request reprint Acamprosate produces its anti-relapse effects via calcium
    Rainer Spanagel
    Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
    Neuropsychopharmacology 39:783-91. 2014
    ..5 million treated patients can possibly be attributed to calcium. ..
  19. doi request reprint A systems medicine research approach for studying alcohol addiction
    Rainer Spanagel
    Insitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
    Addict Biol 18:883-96. 2013
    ....
  20. pmc Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking
    Anna Molander
    Institute of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 37:1047-56. 2012
    ..We conclude that CRH/CRHR1 extra-HPA and HPA signaling may have opposing effects on stress-related alcohol consumption. CRHR1 does not have a role in basal alcohol intake or relapse-like drinking situations with a low stress load...
  21. doi request reprint The effects of xenon and nitrous oxide gases on alcohol relapse
    Valentina Vengeliene
    Faculty of Medicine Mannheim, Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany
    Alcohol Clin Exp Res 38:557-63. 2014
    ..The aim of this study was to examine the effect of both Xe and N2 O on alcohol-seeking and relapse-like drinking behavior (measured as the alcohol deprivation effect) in Wistar rats...
  22. ncbi request reprint The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system
    Michael S Cowen
    Howard Florey Institute, University of Melbourne, Australia
    Addict Biol 10:233-42. 2005
    ....