Research Topics
Genomes and Genes | Valentina VengelieneSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Publications
The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in ratsValentina Vengeliene
Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
Alcohol Clin Exp Res 37:E322-8. 2013..Here, we used a novel drinkometer system in combination with Fourier analysis to provide detailed information on drinking patterns...
The dopamine D3 receptor plays an essential role in alcohol-seeking and relapseValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
FASEB J 20:2223-33. 2006..We therefore suggest that selective antagonists of this pharmacological target provide a specific treatment approach to reduce alcohol craving and relapse behavior...- D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in ratsValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
Alcohol Alcohol 43:626-9. 2008..The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour... - The effects of lamotrigine on alcohol seeking and relapseValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
Neuropharmacology 53:951-7. 2007.... - Compulsive alcohol drinking in rodentsValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Addict Biol 14:384-96. 2009..In particular, hypofunctioning of monoaminergic systems and hyperfunctioning of glutamatergic systems may play a role in compulsive alcohol drinking... - Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in ratsValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Biol Psychiatry 68:704-11. 2010..We therefore hypothesized that the blockade of glycine transporter 1 might interfere with compulsive alcohol consumption and relapse behavior... - Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memoriesChristoph von der Goltz
Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Psychopharmacology (Berl) 205:389-97. 2009..The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval... - The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effectValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
Neuropharmacology 48:822-9. 2005..In summary, the results suggest that an inhibition of NMDAR function in general, rather than a particular interference with a specific binding site of this receptor, is sufficient for the reduction of relapse behavior... - Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapseCarles Sanchis-Segura
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68072 Mannheim, Germany
J Neurosci 26:1231-8. 2006..In conclusion, AMPA receptors seem to be involved in the neuroplastic changes underlying alcohol seeking behavior and relapse. Thus, AMPA receptors represent a novel therapeutic target in preventing relapse... - Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phasesSören Siegmund
Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
Alcohol Clin Exp Res 29:1139-45. 2005..We investigated the magnitude of the effects of deprivation and stress on alcohol intake and the influence of these events on the alcohol drinking behavior across time... - Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female ratsMarc W Füllgrabe
Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
Pharmacol Biochem Behav 86:320-6. 2007..In conclusion, female rats that initiate alcohol consumption during adolescence might be more susceptible to stress-induced alcohol consumption. Adolescent alcohol drinking might also result in a reduced response to acamprosate... 
Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinkingStephanie Perreau-Lenz
Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
Neuropsychopharmacology 37:2121-31. 2012..Our data suggest that CK1 inhibitors may be candidates for drug treatment development for alcoholism...- Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behaviorValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Psychopharmacology (Berl) 178:125-32. 2005..CONCLUSIONS: In summary, these data suggest that an inborn depressive-like behavior in female rats is associated with enhanced alcohol intake... - New pharmacological treatment strategies for relapse preventionRainer Spanagel
Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159 Mannheim, Germany
Curr Top Behav Neurosci 13:583-609. 2013..However, it will still be several years before the majority of the "treatment-seeking population" will benefit from those developments... - Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learningBarbara Vollmayr
Department of Psychiatry, Central Institute of Mental Health J5, D 68159 Mannheim, Germany
Behav Brain Res 150:217-21. 2004.... - Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice culturesMathias Zink
Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
Alcohol Clin Exp Res 28:1752-7. 2004..To further characterize the influence of chronic ethanol exposure on the developing brain, we assessed the transcriptional and translational regulation of glutamate transporters in a less artificial in vitro system... - A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intakeValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Alcohol Clin Exp Res 27:1048-54. 2003..For the alcohol drinking procedure, a long-term model of alcohol self-administration originally developed for heterogeneous Wistar rats was used and was compared with different alcohol-preferring rat lines... - Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinkingAnna Molander
Institute of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
Neuropsychopharmacology 37:1047-56. 2012..We conclude that CRH/CRHR1 extra-HPA and HPA signaling may have opposing effects on stress-related alcohol consumption. CRHR1 does not have a role in basal alcohol intake or relapse-like drinking situations with a low stress load... - The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine systemMichael S Cowen
Howard Florey Institute, University of Melbourne, Australia
Addict Biol 10:233-42. 2005....