Rainer Spanagel

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. doi request reprint New pharmacological treatment strategies for relapse prevention
    Rainer Spanagel
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Curr Top Behav Neurosci 13:583-609. 2013
  2. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
  3. doi request reprint Drugs for relapse prevention of alcoholism: ten years of progress
    Rainer Spanagel
    Department of Psychopharmacology and Department of Addictive Behaviour and Addiction Medicine at the Central Institute of Mental Health, Mannheim, Germany
    Trends Pharmacol Sci 29:109-15. 2008
  4. doi request reprint Alcoholism: a systems approach from molecular physiology to addictive behavior
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Physiol Rev 89:649-705. 2009
  5. ncbi request reprint Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice
    Tarek Zghoul
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159, Mannheim, Germany
    Psychopharmacology (Berl) 190:13-9. 2007
  6. doi request reprint Circadian regulation of central ethanol sensitivity by the mPer2 gene
    Stephanie Perreau-Lenz
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, Mannheim, Germany
    Addict Biol 14:253-9. 2009
  7. ncbi request reprint Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68072 Mannheim, Germany
    J Neurosci 26:1231-8. 2006
  8. ncbi request reprint The effects of lamotrigine on alcohol seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    Neuropharmacology 53:951-7. 2007
  9. pmc Ambiguous-cue interpretation is biased under stress- and depression-like states in rats
    Thomas Enkel
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 35:1008-15. 2010
  10. doi request reprint Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 205:389-97. 2009

Detail Information

Publications90

  1. doi request reprint New pharmacological treatment strategies for relapse prevention
    Rainer Spanagel
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Curr Top Behav Neurosci 13:583-609. 2013
    ..However, it will still be several years before the majority of the "treatment-seeking population" will benefit from those developments...
  2. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  3. doi request reprint Drugs for relapse prevention of alcoholism: ten years of progress
    Rainer Spanagel
    Department of Psychopharmacology and Department of Addictive Behaviour and Addiction Medicine at the Central Institute of Mental Health, Mannheim, Germany
    Trends Pharmacol Sci 29:109-15. 2008
    ..However, the heterogeneity in treatment response makes it necessary to characterize genetic and protein markers and endophenotypes for individualized pharmacotherapy...
  4. doi request reprint Alcoholism: a systems approach from molecular physiology to addictive behavior
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Physiol Rev 89:649-705. 2009
    ..As a subsequent consequence, alcohol-seeking responses ensue that can finally lead via complex environmental interactions to an addictive behavior...
  5. ncbi request reprint Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice
    Tarek Zghoul
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159, Mannheim, Germany
    Psychopharmacology (Berl) 190:13-9. 2007
    ..Objective To further complement the mPer2 study, our lab proceeded to assess mPer1's possible role on alcohol intake using operant and free choice two bottle paradigms...
  6. doi request reprint Circadian regulation of central ethanol sensitivity by the mPer2 gene
    Stephanie Perreau-Lenz
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, Mannheim, Germany
    Addict Biol 14:253-9. 2009
    ..The present study reveals a central role of the mPer2 gene in inhibiting alcohol sensitivity at the beginning of the inactive phase...
  7. ncbi request reprint Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68072 Mannheim, Germany
    J Neurosci 26:1231-8. 2006
    ..In conclusion, AMPA receptors seem to be involved in the neuroplastic changes underlying alcohol seeking behavior and relapse. Thus, AMPA receptors represent a novel therapeutic target in preventing relapse...
  8. ncbi request reprint The effects of lamotrigine on alcohol seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    Neuropharmacology 53:951-7. 2007
    ....
  9. pmc Ambiguous-cue interpretation is biased under stress- and depression-like states in rats
    Thomas Enkel
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 35:1008-15. 2010
    ..The behavioral paradigm described constitutes a useful tool to study the neuronal basis of decision making under ambiguous conditions and may promote innovative pharmaco- and psychotherapy for depression...
  10. doi request reprint Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
    Christoph von der Goltz
    Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 205:389-97. 2009
    ..The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval...
  11. doi request reprint Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  12. doi request reprint Stress triggers anhedonia in rats bred for learned helplessness
    Thomas Enkel
    Dept of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    Behav Brain Res 209:183-6. 2010
    ..These findings further add to the validity of congenitally learned helplessness as an animal model of depression, since gene-environment interactions are considered to play a role in the etiology of this disorder...
  13. pmc Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine
    Ainhoa Bilbao
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Proc Natl Acad Sci U S A 105:17549-54. 2008
    ..These findings reveal a critical role for CaMKIV in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription...
  14. ncbi request reprint The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Nat Med 11:35-42. 2005
    ..Collectively, these data establish glutamate as a link between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake...
  15. ncbi request reprint Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases
    Sören Siegmund
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 29:1139-45. 2005
    ..We investigated the magnitude of the effects of deprivation and stress on alcohol intake and the influence of these events on the alcohol drinking behavior across time...
  16. doi request reprint Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, PO Box 12 21 20, D 68072 Mannheim, Germany
    Eur J Neurosci 34:457-68. 2011
    ..We therefore conclude that perinatal ethanol toxicity alters the plasticity of neurodevelopment and the regulation of glutamatergic gene expression, which may result in specific hippocampus-dependent learning deficits in adulthood...
  17. ncbi request reprint The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    FASEB J 20:2223-33. 2006
    ..We therefore suggest that selective antagonists of this pharmacological target provide a specific treatment approach to reduce alcohol craving and relapse behavior...
  18. ncbi request reprint The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
    Neuropharmacology 48:822-9. 2005
    ..In summary, the results suggest that an inhibition of NMDAR function in general, rather than a particular interference with a specific binding site of this receptor, is sufficient for the reduction of relapse behavior...
  19. doi request reprint Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2
    Stephanie Perreau-Lenz
    Central Institute for Mental Health, Department of Psychopharmacology, CIMH, University of Heidelberg, Mannheim, Germany
    Eur Neuropsychopharmacol 20:509-17. 2010
    ..The Per2(Brdm1) mutant mice clearly developed less tolerance and showed attenuated withdrawal signs compared to WT. These results show that mPER2 is involved in morphine-induced tolerance and withdrawal...
  20. doi request reprint Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:13-6. 2010
    ..We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor...
  21. pmc Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence
    Marcus W Meinhardt
    Institute of Psychopharmacology at Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany
    J Neurosci 33:2794-806. 2013
    ..Normalization of mGluR(2) function within this brain circuit may be of therapeutic value...
  22. doi request reprint Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats
    Derik Hermann
    Department of Addiction Medicine, Central Institute for Mental Health, Mannheim, Germany
    Biol Psychiatry 71:1015-21. 2012
    ..Our understanding of this pathophysiological mechanism originates largely from animal studies, but human data are needed for translation into successful medication development...
  23. doi request reprint Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1
    Dragos Inta
    Department for Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany
    Behav Brain Res 228:328-32. 2012
    ..Our data may be important for a better understanding of the contribution of reduced VGLUT1-mediated presynaptic glutamatergic neurotransmission in the generation of several behavioural abnormalities associated with schizophrenia...
  24. ncbi request reprint Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats
    Marc W Füllgrabe
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
    Pharmacol Biochem Behav 86:320-6. 2007
    ..In conclusion, female rats that initiate alcohol consumption during adolescence might be more susceptible to stress-induced alcohol consumption. Adolescent alcohol drinking might also result in a reduced response to acamprosate...
  25. doi request reprint Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 68:704-11. 2010
    ..We therefore hypothesized that the blockade of glycine transporter 1 might interfere with compulsive alcohol consumption and relapse behavior...
  26. doi request reprint Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice
    Peter Gass
    RG Behavioral Biology, University of Heidelberg, Mannheim, Germany
    J Neurosci Res 86:3184-93. 2008
    ..This approach may also be useful to find new targets for pharmacotherapy in affective disorders...
  27. doi request reprint Perinatal exposure to alcohol reduces the expression of complexins I and II
    Mathias Zink
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, Mannheim, Germany
    Neurotoxicol Teratol 31:400-5. 2009
    ..Further investigations should focus on other synaptic vesicle protein genes in order to unravel the molecular basis of ethanol-induced neurocognitive disabilities...
  28. doi request reprint Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
    Behav Brain Res 208:466-72. 2010
    ....
  29. pmc Inhibition of the casein-kinase-1-epsilon/delta prevents relapse-like alcohol drinking
    Stephanie Perreau-Lenz
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:2121-31. 2012
    ..Our data suggest that CK1 inhibitors may be candidates for drug treatment development for alcoholism...
  30. ncbi request reprint Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 178:125-32. 2005
    ..A high comorbidity between depression and alcoholism has been reported in several studies, but the mechanisms underlying this relationship remain unknown...
  31. doi request reprint Appetitive odor-cue conditioning attenuates the acoustic startle response in rats
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    Behav Brain Res 189:226-30. 2008
    ..This odor conditioned "pleasure" attenuation of the startle response might, therefore, provide a new effective operational measure for the hedonic aspects of reward...
  32. ncbi request reprint Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, Germany
    Addict Biol 11:2-38. 2006
    ..In addition, comic strips that illustrate behavioural methods used in the drug abuse field are provided given for free download under http://www.zi-mannheim/psychopharmacology.de...
  33. doi request reprint Acamprosate: recent findings and future research directions
    Karl Mann
    The Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 32:1105-10. 2008
    ..Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy...
  34. ncbi request reprint Alcohol consumption and the body's biological clock
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Alcohol Clin Exp Res 29:1550-7. 2005
    ..Further steps in this pathologic chain are alterations in physiological and immune functions that are under circadian control, and, as a final consequence, addictive behavior might be triggered or sustained by this cascade...
  35. ncbi request reprint Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice
    Sabine Chourbaji
    Department of Behavioural Biology, Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Behav Brain Res 164:100-6. 2005
    ..These results suggest that housing conditions significantly influence the outcome of learned helplessness studies...
  36. doi request reprint Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism
    Ainhoa Bilbao
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty of Mannheim, University of Heidelberg, Germany
    Addict Biol 18:78-87. 2013
    ..However, further research is needed for the identification of the targets of OEA for its inhibitory action on cocaine-mediated responses...
  37. doi request reprint The effects of drugs of abuse on clock genes
    Stephanie Perreau-Lenz
    Central Institute of Mental Health CIMH, Department of Psychopharmacology, University of Heidelberg, Mannheim, Germany
    Drug News Perspect 21:211-7. 2008
    ..The present review summarizes these recent findings and reveals the complexity, as well as the specificity, of the interrelation between drugs of abuse and clock genes...
  38. doi request reprint A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption
    Cornelius R Pawlak
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, J 5, 68159, Mannheim, Germany
    Mamm Genome 19:77-84. 2008
    ..In accordance with the findings from knockout studies, we suggest that mainly recessive mutations contribute to an alcohol-drinking or alcohol-avoiding phenotype...
  39. ncbi request reprint Strain-specific responses of inbred mice to ethanol following food shortage
    Karl C Schroff
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, Mannheim, Germany
    Addict Biol 9:265-71. 2004
    ....
  40. doi request reprint Compulsive alcohol drinking in rodents
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Addict Biol 14:384-96. 2009
    ..In particular, hypofunctioning of monoaminergic systems and hyperfunctioning of glutamatergic systems may play a role in compulsive alcohol drinking...
  41. ncbi request reprint The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat
    Daniel Bachteler
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Neuropsychopharmacology 30:1104-10. 2005
    ..Treatment with neramexane that shares part of the pharmacological effects of acamprosate on NMDA receptors, however, resulted in a nonselective reduction of lever responding...
  42. doi request reprint D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 43:626-9. 2008
    ..The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour...
  43. pmc A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system
    Stefan M Berger
    Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:1986-98. 2012
    ....
  44. pmc Clock genes running amok. Clock genes and their role in drug addiction and depression
    Stephanie Perreau-Lenz
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    EMBO Rep 8:S20-3. 2007
  45. pmc Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling
    Theresa Brand
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 7:e31169. 2012
    ..The aim of the present study was to examine if differences in the endocannabinoid (ECB) system might be linked to strain specific variations in reward-related behavior in Fischer344 (Fischer) and Wistar rats...
  46. ncbi request reprint Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex
    Mathias Zink
    Department of Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroreport 16:377-80. 2005
    ..In summary, ethanol exposure of the developing cortex induces GABAergic genes, which might facilitate the excitatory functions of GABA during development...
  47. doi request reprint Neurocircuitry for modeling drug effects
    Hamid R Noori
    Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Addict Biol 17:827-64. 2012
    ..We conclude that the present neurocircuitry provides a structural and dynamical framework for large-scale mathematical models and will help to predict chronic drug effects on brain function...
  48. pmc Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors
    Frauke Nees
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Neuropsychopharmacology 37:986-95. 2012
    ....
  49. doi request reprint Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge
    Peggy Schneider
    Central Institute of Mental Health, Institute of Psychopharmacology, 68159 Mannheim, Germany
    Brain Behav Immun 26:277-83. 2012
    ..The FACS analysis showed a significant increase in CD25(+) microglia in the hippocampus compared to controls. The results support the role of microglia as a mediator in the immune-CNS communication and the effects of peripheral IL-2...
  50. pmc Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    BMC Neurosci 8:105. 2007
    ..In the present study, we aimed at specifically dissecting the role of CaMKIV in the nucleus accumbens of adult mice...
  51. ncbi request reprint Alcohol addiction research: from animal models to clinics
    Rainer Spanagel
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, CIMH, J5, 68159, Mannheim, Germany
    Best Pract Res Clin Gastroenterol 17:507-18. 2003
    ..In conclusion, there appears to be a good correspondence between the events that induce relapse and loss of control over alcohol-taking behaviour in laboratory animals and those that provoke relapse and loss of control in humans...
  52. ncbi request reprint Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Alcohol Clin Exp Res 28:1752-7. 2004
    ..To further characterize the influence of chronic ethanol exposure on the developing brain, we assessed the transcriptional and translational regulation of glutamate transporters in a less artificial in vitro system...
  53. ncbi request reprint Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Neurosci Lett 416:275-8. 2007
    ..The results of the present study suggest that the alcohol effects abolished by the beta3(N265M) mutation do not play a dominant role in acute alcohol intoxication but influence ethanol tolerance and withdrawal...
  54. ncbi request reprint Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  55. ncbi request reprint Role of Fyn tyrosine kinase in ethanol consumption by mice
    Michael S Cowen
    Department of Psychopharmacology, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 27:1213-9. 2003
    ..To further study the involvement of Fyn in neurobehavioral effects of alcohol, we examined ethanol consumption and relapse drinking behavior in fynZ/fynZ mice...
  56. ncbi request reprint Candidate genes for alcohol dependence: animal studies
    Gunter Schumann
    Molecular Genetics Laboratory, Department of Psychiatry, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Alcohol Clin Exp Res 27:880-8. 2003
  57. ncbi request reprint The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    J Neurosci 22:8676-83. 2002
    ..In summary, the nNOS gene is critically involved in the regulation of neurobehavioral effects of alcohol...
  58. doi request reprint Why do we take drugs? From the drug-reinforcement theory to a novel concept of drug instrumentalization
    Rainer Spanagel
    Institute of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, 68159 Mannheim, Germany www zi mannheim de
    Behav Brain Sci 34:322. 2011
    ..The definition of drug instrumentalization goals will improve our understanding of individual drug-taking profiles...
  59. ncbi request reprint mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior
    Pia Bäckström
    National Public Health Institute, Helsinki, Finland
    Neuropsychopharmacology 29:921-8. 2004
    ..These results show in two commonly used models of relapse to ethanol that pharmacological targeting of mGlu5 receptors may be a promising approach for the treatment of alcoholism...
  60. ncbi request reprint Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning
    Barbara Vollmayr
    Department of Psychiatry, Central Institute of Mental Health J5, D 68159 Mannheim, Germany
    Behav Brain Res 150:217-21. 2004
    ....
  61. pmc Cocaine sensitization and reward are under the influence of circadian genes and rhythm
    Carolina Abarca
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Proc Natl Acad Sci U S A 99:9026-30. 2002
    ..In conclusion, we demonstrate that processes involved in cocaine addiction depend on the circadian rhythm and are modulated in an opposing manner by mPer1 and mPer2 genes...
  62. pmc The mGluR2/3 Agonist LY379268 Induced Anti-Reinstatement Effects in Rats Exhibiting Addiction-like Behavior
    Nazzareno Cannella
    Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Neuropsychopharmacology 38:2048-56. 2013
    ..These mice did not differ from controls in reinstatement, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior. ..
  63. pmc Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking
    Anna Molander
    Institute of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 37:1047-56. 2012
    ..We conclude that CRH/CRHR1 extra-HPA and HPA signaling may have opposing effects on stress-related alcohol consumption. CRHR1 does not have a role in basal alcohol intake or relapse-like drinking situations with a low stress load...
  64. doi request reprint Per1(Brdm1) mice self-administer cocaine and reinstate cocaine-seeking behaviour following extinction
    Briac Halbout
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Behav Pharmacol 22:76-80. 2011
    ..This study adds one further example to the notion that various behavioural tests usually used in addiction research rely on different neurobiological substrates...
  65. ncbi request reprint Addiction and its brain science
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Addiction 100:1813-22. 2005
    ..To illustrate how modern neurobiological approaches will help to identify the neurocircuits and genes involved in addictive behavior...
  66. ncbi request reprint Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
    Tatyana Strekalova
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 29:2007-17. 2004
    ..Thus, behavioral correlates of stress-induced anhedonia and of chronic stress alone can be separated in the present model...
  67. doi request reprint The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis
    Hamid R Noori
    Institute for Psychopharmacology, Central Institute for Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Synapse 66:893-901. 2012
    ..Our meta-analysis suggests the use of 0.1 μM neostigmine which produces an approximately 10-fold boost of brain baseline levels...
  68. ncbi request reprint A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 27:1048-54. 2003
    ..For the alcohol drinking procedure, a long-term model of alcohol self-administration originally developed for heterogeneous Wistar rats was used and was compared with different alcohol-preferring rat lines...
  69. doi request reprint Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis
    Stefanie Th Frank
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Synapse 62:243-52. 2008
    ..Finally, this study examplifies how meta- analyses may be applied to a wide range of data within the field of neurochemistry...
  70. pmc Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats
    Chris M Friemel
    Department of Psychopharmacology, Central Institute of Mental Health, Heidelberg University Mannheim, Germany
    Front Behav Neurosci 4:. 2010
    ..Therefore, higher reward sensitivity during pubertal maturation might contribute to the enhanced vulnerability of teenagers for the initiation of experimental drug use...
  71. doi request reprint Publication trends in addiction research
    Sandra Helinski
    Institute of Psychopharmacology, Central Institute of Mental Health, Germany
    Addict Biol 16:532-9. 2011
    ..There were also strongly increasing trends for genetic and imaging studies in the addiction field over time. These publication trends are also reflected to a certain degree by published studies in Addiction Biology...
  72. ncbi request reprint Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia
    Fernando Leonardi-Essmann
    Central Institute for Mental Health, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    J Neuroimmunol 160:92-101. 2005
    ..Two of them-integrin alpha(2) and integrin beta(5)-were upregulated as well. These data provide a much closer look into molecular mechanisms involved in apoptosis of neurons and their removal by microglia...
  73. ncbi request reprint Reduced sensitivity to reward in CB1 knockout mice
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute for Mental Health, CIMH, University of Heidelberg, 68159 Mannheim, Germany
    Psychopharmacology (Berl) 176:223-32. 2004
    ..Previous studies have demonstrated that the activation and blockade of the cannabinoid type 1 receptor (CB1) leads to an enhancement and decrease of the consumption of food and other orally ingested reinforcers, respectively...
  74. ncbi request reprint Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS
    Alexander Fleischmann
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Neurosci 23:9116-22. 2003
    ..In summary, our data suggest a role for c-Fos in hippocampus-dependent learning and memory as well as in NMDA receptor-dependent LTP formation...
  75. ncbi request reprint The glucocorticoid receptor as a potential target to reduce cocaine abuse
    Véronique Deroche-Gamonet
    Institut National de la Sante et de la Recherche Medicale, Unité 588, Bordeaux 33077, France
    J Neurosci 23:4785-90. 2003
    ..This suggests that targeting GR function in the brain could provide new therapeutic strategies to treat cocaine addiction for which there is no available treatment...
  76. ncbi request reprint Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol
    Claudia Werner
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    Eur J Neurosci 20:3498-506. 2004
    ..No taste differences to sweet solutions were observed compared to control animals. In summary, our data show that cGKII activity modulates anxiety-like behaviour and neurobehavioural effects of alcohol...
  77. doi request reprint Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior
    Gunter Schumann
    Interdisciplinary Research Group Addiction, MRC SGDP Center, Institute of Psychiatry at King s College, POB 080, London SE5 8AF, England
    Arch Gen Psychiatry 65:826-38. 2008
    ..Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models...
  78. ncbi request reprint Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors
    Inge Sillaber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Science 296:931-3. 2002
    ..Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism...
  79. ncbi request reprint Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior
    Markus S H Henniger
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 26:729-36. 2002
    ..It is concluded that, although such a relationship might exist in some individuals, increased levels of inborn anxiety and alcohol consumption are not necessarily related...
  80. pmc Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system
    Irene Brunk
    Institute for Integrative Neuroanatomy, Center for Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    FASEB J 22:3736-46. 2008
    ..We conclude that Go2alpha optimizes vesicular filling which is instrumental for normal dopamine functioning and for the development of drug-induced behavioral sensitization...
  81. ncbi request reprint [For and against: controlled drinking as useful and necessary treatment alternative]
    Joachim Körkel
    Ev Fachhochschule Nürnberg, Bärenschanzstrasse 4, 90429 Nürnberg
    Psychiatr Prax 32:324-6. 2005
  82. doi request reprint Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood
    Gabriele Hampp
    Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland
    Curr Biol 18:678-83. 2008
    ..These findings suggest a role of circadian-clock components in dopamine metabolism highlighting a role of the clock in regulating mood-related behaviors...
  83. doi request reprint Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administration
    Hanna Raeder
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Drug Alcohol Depend 96:16-21. 2008
    ..Our results demonstrate that long-term voluntary alcohol self-administration, affects the regulation of genes encoding the various subunits and splice variants of the NMDA receptor in a brain regional-specific manner...
  84. doi request reprint Glutamate receptors on dopamine neurons control the persistence of cocaine seeking
    David Engblom
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Neuron 59:497-508. 2008
    ..In conclusion, cocaine-evoked synaptic plasticity does not mediate concurrent short-term behavioral effects of the drug but may initiate adaptive changes eventually leading to the persistence of drug-seeking behavior...
  85. ncbi request reprint Effects of morphine withdrawal on micro-opioid receptor-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate autoradiography in rat brain
    Christian Kirschke
    Drug Abuse Research Group, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 446:43-51. 2002
    ....
  86. pmc Chronic intake of fermented floral nectar by wild treeshrews
    Frank Wiens
    Tierphysiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Proc Natl Acad Sci U S A 105:10426-31. 2008
    ..It is yet unclear to what extent treeshrews benefit from ingested alcohol per se and how they mitigate the risk of continuous high blood alcohol concentrations...
  87. ncbi request reprint Challenges to medications development in treating alcohol dependence: an international perspective
    John M Littleton
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Cooper and University Drives, Lexington 40546 0236, USA
    Alcohol Alcohol 39:271-5. 2004
    ..The investment risk to industry should be appraised not only in terms of the rather poor results of previous marketing efforts but with a view to the opportunity to penetrate a potentially enormous and largely untapped market...
  88. ncbi request reprint [One drink, one drunk--controlled drinking by alcoholics? 3-year-outcome after intensive outpatient treatment]
    Miriam Bottlender
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen
    Psychother Psychosom Med Psychol 57:32-8. 2007
    ..In the present study we examined in a sample of alcohol-dependent patients whether or not controlled drinking is possible during a three years period following treatment...
  89. ncbi request reprint cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise
    Derek Zieker
    Department of Transfusions Medicine, University of Tuebingen, Germany
    Physiol Genomics 23:287-94. 2005
    ..The study shows cDNA microarray expression analysis as a reliable systematic instrument to complete the list of candidate genes that may play a role in exhaustive exercise-induced modulation of the immune response...
  90. ncbi request reprint Measuring alcohol consumption in man--it is time for a change
    Falk Kiefer
    Addiction 101:1215-6; author reply 1216-7. 2006