Wolfgang H Sommer

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, USA
    Hum Mutat 31:E1594-608. 2010
  2. pmc Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
  3. pmc Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
  4. doi request reprint Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Bethesda, MD, USA
    Int J Neuropsychopharmacol 13:583-93. 2010
  5. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
  6. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
  7. doi request reprint Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 68:704-11. 2010
  8. doi request reprint Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    J Psychopharmacol 25:1378-87. 2011
  9. doi request reprint The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus
    Smitha Sreedharan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    FEBS J 278:4881-94. 2011
  10. doi request reprint Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010

Detail Information

Publications12

  1. pmc Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, USA
    Hum Mutat 31:E1594-608. 2010
    ..Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function...
  2. pmc Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
    ..One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs...
  3. pmc Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
    ....
  4. doi request reprint Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Bethesda, MD, USA
    Int J Neuropsychopharmacol 13:583-93. 2010
    ..While suppression of hippocampal neurogenesis by alcohol dependence is transient, the suppression in the forebrain SVZ appears long-lasting...
  5. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
    ..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence...
  6. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  7. doi request reprint Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 68:704-11. 2010
    ..We therefore hypothesized that the blockade of glycine transporter 1 might interfere with compulsive alcohol consumption and relapse behavior...
  8. doi request reprint Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    J Psychopharmacol 25:1378-87. 2011
    ..These results indicate that the tropic hypothesis of depression has limitations and emphasize the need for validated disease models of depression to assess potential treatment targets...
  9. doi request reprint The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus
    Smitha Sreedharan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    FEBS J 278:4881-94. 2011
    ..This report provides the first detailed characterization of the evolution, expression and primary functional properties of the Gpr153 gene...
  10. doi request reprint Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010
    ..Here, we examined whether neuropeptide Y (NPY), an endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine...
  11. pmc Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex
    Olga Neznanova
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 12:275-80. 2009
    ..Together, these results identify candidate pathways for mediating high ethanol preference and emphasize the importance of the mPFC in controlling this behaviour...
  12. ncbi request reprint Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Neuropsychopharmacology 32:117-26. 2007
    ..These results show for the first time that impaired FAAH function may confer a phenotype of high voluntary alcohol intake, and point to a FAAH both as a potential susceptibility factor and a therapeutic target...