Thomas G Schulze

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
  2. ncbi request reprint What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, 15, 68159 Mannheim, Germany
    Arch Gen Psychiatry 63:1368-76. 2006
  3. doi request reprint The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample
    Vanessa Nieratschker
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Schizophr Res 122:24-30. 2010
  4. doi request reprint Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin
    Frederike Schirmbeck
    Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    J Autism Dev Disord 38:1977-81. 2008
  5. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010
  6. doi request reprint Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorder
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 110:33-9. 2009
  7. ncbi request reprint No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sample
    Frederike Schirmbeck
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:127. 2007
  8. doi request reprint Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Neuropsychopharmacol 16:549-56. 2013
  9. ncbi request reprint Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample
    Alexander Georgi
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Psychiatr Genet 17:308-10. 2007
  10. doi request reprint G72 and its association with major depression and neuroticism in large population-based groups from Germany
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Psychiatry 165:753-62. 2008

Detail Information

Publications70

  1. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  2. ncbi request reprint What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, 15, 68159 Mannheim, Germany
    Arch Gen Psychiatry 63:1368-76. 2006
    ..Familial features of bipolar disorder should help define more homogeneous subtypes, but there are few data indicating which clinical features of bipolar disorder are the most familial...
  3. doi request reprint The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample
    Vanessa Nieratschker
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Schizophr Res 122:24-30. 2010
    ..Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population...
  4. doi request reprint Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin
    Frederike Schirmbeck
    Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    J Autism Dev Disord 38:1977-81. 2008
    ..Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA...
  5. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010
    ..In this HapMap-based study, we reappraised the association between Dysbindin and SCZ in a large sample of German ethnicity...
  6. doi request reprint Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorder
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 110:33-9. 2009
    ..It has been proposed as a predictor of clinical presentation and outcome, and may delineate a specific SZ phenotype for genetic and other biological studies. Research into PMA in BD has been scarce and inconclusive...
  7. ncbi request reprint No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sample
    Frederike Schirmbeck
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:127. 2007
  8. doi request reprint Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Neuropsychopharmacol 16:549-56. 2013
    ....
  9. ncbi request reprint Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample
    Alexander Georgi
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Psychiatr Genet 17:308-10. 2007
    ..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia...
  10. doi request reprint G72 and its association with major depression and neuroticism in large population-based groups from Germany
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Psychiatry 165:753-62. 2008
    ..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism...
  11. ncbi request reprint No association between the serine racemase gene (SRR) and schizophrenia in a German case-control sample
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:125. 2007
  12. ncbi request reprint Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol
    Nuran Tunc-Skarka
    Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty of Mannheim Heidelberg University, Germany
    NMR Biomed 27:228-34. 2014
    ..Our results corroborated the age-related changes in metabolite concentrations, and found evidence for a link between SCN1A and frontal white matter mI in healthy subjects...
  13. doi request reprint Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions
    Heike Tost
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Affect Disord 120:54-61. 2010
    ..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities...
  14. doi request reprint Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction
    Edda Bilek
    Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, 68159 Mannheim, Germany
    J Neurosci 33:7050-6. 2013
    ....
  15. doi request reprint SCN1A affects brain structure and the neural activity of the aging brain
    Sandra Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
    Biol Psychiatry 72:677-83. 2012
    ..rs10930201 was further observed to be related to differences in neural activity during a working memory task...
  16. ncbi request reprint Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 64:585-90. 2007
    ..Recent evidence suggests that gene x environment interactions could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with attention-deficit/hyperactivity disorder (ADHD)...
  17. ncbi request reprint Premorbid adjustment in schizophrenia--an important aspect of phenotype definition
    Christine Schmael
    Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D 68159 Mannheim, Germany
    Schizophr Res 92:50-62. 2007
    ..Studies of schizophrenia patients systematically assessed for PMA have used small patient samples and have rarely used controls...
  18. doi request reprint Induction and quantification of prefrontal cortical network plasticity using 5 Hz rTMS and fMRI
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Hum Brain Mapp 35:140-51. 2014
    ..In further studies this approach could be used to study pharmacological, genetic and disease-related alterations...
  19. pmc Association between a serotonin transporter length polymorphism and primary insomnia
    Michael Deuschle
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Sleep 33:343-7. 2010
    ..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia...
  20. doi request reprint Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter
    Jens Treutlein
    Department of Genetic Epidemiology, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Schizophr Res 111:123-30. 2009
    ....
  21. ncbi request reprint Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Hum Hered 58:131-8. 2004
    ..The stakes are high, since the success of gene mapping in genetically complex disorders hinges on the ability to delineate the target phenotype with accuracy and precision...
  22. doi request reprint Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    Biol Psychiatry 68:578-85. 2010
    ..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression...
  23. pmc COMT val158met polymorphism and neural pain processing
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    PLoS ONE 7:e23658. 2012
    ....
  24. ncbi request reprint Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome
    Thomas G Schulze
    Dicvision of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health ZI, 68159 Mannheim, Germany
    Hum Mol Genet 13:335-42. 2004
    ..More information is needed to guide the choice of method, marker allele frequencies, and parameters in the development of a haplotype map...
  25. ncbi request reprint From degeneration to genetic susceptibility, from eugenics to genethics, from Bezugsziffer to LOD score: the history of psychiatric genetics
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Ruprecht Karls University of Heidelberg Mannheim, Germany
    Int Rev Psychiatry 16:246-59. 2004
    ..Finally, psychiatric genetic research should never again be performed in an environment void of ethical standards...
  26. doi request reprint Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion
    Stefan Wüst
    Department of Theoretical and Clinical Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 34:972-82. 2009
    ..Furthermore, the serotonergic system influences hypothalamus-pituitary-adrenal (HPA) axis activity, which, in turn, is related to psychiatric diseases...
  27. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  28. ncbi request reprint No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample
    Alexander Georgi
    Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 16:183-4. 2006
    ..This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population...
  29. ncbi request reprint No association between a common haplotype of the 6 and 10-repeat alleles in intron 8 and the 3'UTR of the DAT1 gene and adult attention deficit hyperactivity disorder
    Daniel Brüggemann
    Department of Genetic Epidemology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:121. 2007
  30. pmc Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1
    S Meier
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Transl Psychiatry 2:e165. 2012
    ..028, or=1.27)...
  31. ncbi request reprint Genetic linkage and association studies in bipolar affective disorder: a time for optimism
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Am J Med Genet C Semin Med Genet 123:36-47. 2003
    ..Once these genes are identified, genetic mapping methods will yield to the other methods of 21st-century molecular biology as we begin to elucidate the pathophysiology of BPAD...
  32. pmc Effects of age on the structure of functional connectivity networks during episodic and working memory demand
    Franziska Matthäus
    Center for Modeling and Simulation in the Biosciences BIOMS, University of Heidelberg, Heidelberg, Germany
    Brain Connect 2:113-24. 2012
    ..The chosen network approach is explorative and hypothesis-free. Our results extend seed-based and BOLD-signal intensity focused studies, and support present hypotheses like compensation and dedifferentiation...
  33. ncbi request reprint Neither single-marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorder
    Sridhar Prathikanti
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60615, USA
    Am J Med Genet B Neuropsychiatr Genet 131:10-5. 2004
    ..These results do not support an association between genetic variation near NOTCH4 and BPAD in this sample...
  34. ncbi request reprint Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population
    Sebastian Paus
    Department of Neurology, Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 14:233-4. 2004
    ..Our results suggest that the NMDAR1 subunit is not frequently involved in the development of schizophrenia in the German population...
  35. pmc The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 81:974-86. 2007
    ..Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies...
  36. ncbi request reprint Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Mol Genet 17:87-97. 2008
    ..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD...
  37. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004
  38. doi request reprint Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:199-203. 2008
    ..Based on the functional evidence and on the hypothesis that further genes, which are involved in the regulation of D-serine, could be involved in the disease aetiology, we considered VAMP2 and VAMP3 as candidate genes for BPAD...
  39. ncbi request reprint Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:79-81. 2004
    ..Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes...
  40. ncbi request reprint Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia
    Sibylle G Schwab
    Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Schizophr Res 65:19-25. 2003
    ..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]...
  41. pmc The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease
    Ann Van Den Bogaert
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 73:1438-43. 2003
    ..This would also explain the difficulty of replicating this association in consecutively ascertained case-control samples, which usually comprise only a small proportion of subjects with a family history of disease...
  42. ncbi request reprint Age at onset in bipolar I affective disorder: further evidence for three subgroups
    Frank Bellivier
    Department of Psychiatry, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique Hopitaux de Paris, 51 avenue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Am J Psychiatry 160:999-1001. 2003
    ..Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup...
  43. ncbi request reprint Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, Illinois, USA
    Biol Psychiatry 53:239-43. 2003
    ..Here, we test for linkage in the same sample with a denser set of markers, now physically ordered according to the draft sequence of the human genome...
  44. ncbi request reprint Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet 114:1-11. 2002
    ..We present an overview of the development of genetic association tests, with practical guidelines on which test might be the most suitable for a given study...
  45. ncbi request reprint Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorder
    Esther Jahnes
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet 114:519-22. 2002
    ..For both BPAD and UPAD we could not detect a genetic association with either variant. Thus, our results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders...
  46. ncbi request reprint Can long-range microsatellite data be used to predict short-range linkage disequilibrium?
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 11:1363-72. 2002
    ....
  47. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  48. ncbi request reprint No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Psychiatr Genet 15:195-8. 2005
    ..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder...
  49. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  50. ncbi request reprint Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn
    Biol Psychiatry 58:307-14. 2005
    ....
  51. ncbi request reprint Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, R5 00, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Am J Med Genet B Neuropsychiatr Genet 141:71-5. 2006
    ..It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder...
  52. pmc Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24
    Johannes Schumacher
    Institute of Human Genetics, Life and Brain Center, University of Bonn, D 53105 Bonn, Germany
    Am J Hum Genet 77:1102-11. 2005
    ....
  53. ncbi request reprint Is there a phenotypic difference between probands in case-control versus family-based association studies?
    Thomas G Schulze
    Am J Med Genet B Neuropsychiatr Genet 118:25-6; author reply 27-8. 2003
  54. ncbi request reprint Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006
    ..Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population...
  55. ncbi request reprint Familial variation in episode frequency in bipolar affective disorder
    Maria E Fisfalen
    Department of Psychiatry, Mount Sinai Medical Center, Rosalind Franklin University of Medicine and Science, California at 15th Street, Chicago, IL 60608, USA
    Am J Psychiatry 162:1266-72. 2005
    ..The authors analyzed the recurrence frequency of affective episodes (episode frequency), along with associated clinical and demographic variables, in families with at least three members with a major affective disorder...
  56. ncbi request reprint No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample
    Markus H Skowronek
    Psychiatr Genet 16:233-4. 2006
    ..Allele and haplotype frequencies did not differ between cases and controls. Our results do not support an association of the ASCT1 gene with BD or SCZ in the German population...
  57. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  58. ncbi request reprint Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli Arabs
    Shirly Amar
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Schizophr Res 94:354-8. 2007
    ..However, mitochondrial DNA haplogroups are highly variable in human population and it will be necessary to replicate our results in other human ethnic groups...
  59. ncbi request reprint No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 17:43-5. 2007
    ....
  60. ncbi request reprint The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder
    Barbara Hoefgen
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 57:247-51. 2005
    ..Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant...
  61. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  62. ncbi request reprint Computer-assisted phenotype characterization for genetic research in psychiatry
    Heiner Fangerau
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Hum Hered 58:122-30. 2004
    ....
  63. ncbi request reprint Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder
    Daniel J Muller
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 114:74-8. 2002
    ..We observed a significantly increased frequency of genotypes homozygous for the C allele in females with BPAD in comparison with controls (P=0.017). Thus, our data strengthen the role of the SYBL1 gene as a candidate gene for BPAD...
  64. ncbi request reprint No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics bInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
    Psychiatr Genet 16:91. 2006
  65. ncbi request reprint Further evidence for age of onset being an indicator for severity in bipolar disorder
    Thomas G Schulze
    J Affect Disord 68:343-5. 2002
  66. pmc Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 77:140-8. 2005
    ..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA...
  67. ncbi request reprint Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
    Psychiatry Res 132:261-71. 2004
    ..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...
  68. ncbi request reprint No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis
    Roland Ivo
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 16:197-203. 2006
    ..In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin...
  69. ncbi request reprint [The 5 year Young Psychiatrist Program: A contribution for the young generation in psychiatry in Germany]
    Iris Tatjana Calliess
    Abteilung Sozialpsychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover
    Nervenarzt 77:1407-9. 2006
  70. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...