Research Topics
Genomes and GenesSpecies | Thomas G SchulzeSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Publications
Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genomeThomas G Schulze
Dicvision of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health ZI, 68159 Mannheim, Germany
Hum Mol Genet 13:335-42. 2004..More information is needed to guide the choice of method, marker allele frequencies, and parameters in the development of a haplotype map...- Defining the phenotype in human genetic studies: forward genetics and reverse phenotypingThomas G Schulze
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Hum Hered 58:131-8. 2004..The stakes are high, since the success of gene mapping in genetically complex disorders hinges on the ability to delineate the target phenotype with accuracy and precision... - Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigreesThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
Biol Psychiatry 56:18-23. 2004.... - From degeneration to genetic susceptibility, from eugenics to genethics, from Bezugsziffer to LOD score: the history of psychiatric geneticsThomas G Schulze
Division of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Ruprecht Karls University of Heidelberg Mannheim, Germany
Int Rev Psychiatry 16:246-59. 2004..Finally, psychiatric genetic research should never again be performed in an environment void of ethical standards... - Genetic linkage and association studies in bipolar affective disorder: a time for optimismThomas G Schulze
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
Am J Med Genet C Semin Med Genet 123:36-47. 2003..Once these genes are identified, genetic mapping methods will yield to the other methods of 21st-century molecular biology as we begin to elucidate the pathophysiology of BPAD... 
The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sampleVanessa Nieratschker
Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Schizophr Res 122:24-30. 2010..Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population...- Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in DysbindinFrederike Schirmbeck
Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
J Autism Dev Disord 38:1977-81. 2008..Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA... 
A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestryJana Strohmaier
Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
Schizophr Res 118:98-105. 2010..In this HapMap-based study, we reappraised the association between Dysbindin and SCZ in a large sample of German ethnicity...- Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorderMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
Schizophr Res 110:33-9. 2009..It has been proposed as a predictor of clinical presentation and outcome, and may delineate a specific SZ phenotype for genetic and other biological studies. Research into PMA in BD has been scarce and inconclusive... - No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sampleFrederike Schirmbeck
Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 17:127. 2007 - Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sampleAlexander Georgi
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
Psychiatr Genet 17:308-10. 2007..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia... - Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorderSandra Meier
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Int J Neuropsychopharmacol 16:549-56. 2013.... - The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populationsJohannes Schumacher
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Hum Mol Genet 18:2719-27. 2009..Furthermore, our phenotype-genotype results--including the consideration of sex-specific effects--highlight the value of homogenous samples in mapping risk genes for schizophrenia in general, and at the DISC locus in particular... - No association between the serine racemase gene (SRR) and schizophrenia in a German case-control sampleJana Strohmaier
Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 17:125. 2007 - G72 and its association with major depression and neuroticism in large population-based groups from GermanyMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Am J Psychiatry 165:753-62. 2008..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism... - Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sampleManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Arch Gen Psychiatry 64:585-90. 2007..Recent evidence suggests that gene x environment interactions could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with attention-deficit/hyperactivity disorder (ADHD)... - Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoterJens Treutlein
Department of Genetic Epidemiology, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
Schizophr Res 111:123-30. 2009.... - SCN1A affects brain structure and the neural activity of the aging brainSandra Meier
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg, Germany
Biol Psychiatry 72:677-83. 2012..rs10930201 was further observed to be related to differences in neural activity during a working memory task... - Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1Francis J McMahon
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Nat Genet 42:128-31. 2010..83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD... - Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypesThomas G Schulze
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
Am J Psychiatry 162:2101-8. 2005.... - Premorbid adjustment in schizophrenia--an important aspect of phenotype definitionChristine Schmael
Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, J5, D 68159 Mannheim, Germany
Schizophr Res 92:50-62. 2007..Studies of schizophrenia patients systematically assessed for PMA have used small patient samples and have rarely used controls... - Association between a serotonin transporter length polymorphism and primary insomniaMichael Deuschle
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
Sleep 33:343-7. 2010..To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia... - What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristicsThomas G Schulze
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, 15, 68159 Mannheim, Germany
Arch Gen Psychiatry 63:1368-76. 2006..Familial features of bipolar disorder should help define more homogeneous subtypes, but there are few data indicating which clinical features of bipolar disorder are the most familial... - Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusionsHeike Tost
Central Institute of Mental Health, 68159 Mannheim, Germany
J Affect Disord 120:54-61. 2010..We hypothesize that this discrepancy is related to the heterogeneity of BD, and examine the question of whether or not more homogeneous clinical subgroups display a more coherent pattern of morphometric abnormalities... - Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterizationThomas G Schulze
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD 20892 3719, USA
Psychiatr Clin North Am 33:67-82. 2010..It furthermore sketches out a potential research framework integrating various lines of research into the molecular biological basis of BD... - Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depressionMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
Biol Psychiatry 68:578-85. 2010..Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression... - COMT val158met polymorphism and neural pain processingChristian Schmahl
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
PLoS ONE 7:e23658. 2012.... - The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatmentThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Neuropsychobiology 62:72-8. 2010..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts... - No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sampleAlexander Georgi
Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 16:183-4. 2006..This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population... - Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretionStefan Wüst
Department of Theoretical and Clinical Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
Psychoneuroendocrinology 34:972-82. 2009..Furthermore, the serotonergic system influences hypothalamus-pituitary-adrenal (HPA) axis activity, which, in turn, is related to psychiatric diseases... - Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1S Meier
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Transl Psychiatry 2:e165. 2012..028, or=1.27)... - Application of High-Frequency Repetitive Transcranial Magnetic Stimulation to the DLPFC Alters Human Prefrontal-Hippocampal Functional InteractionEdda Bilek
Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, 68159 Mannheim, Germany
J Neurosci 33:7050-6. 2013.... - Effects of age on the structure of functional connectivity networks during episodic and working memory demandFranziska Matthäus
Center for Modeling and Simulation in the Biosciences BIOMS, University of Heidelberg, Heidelberg, Germany
Brain Connect 2:113-24. 2012..The chosen network approach is explorative and hypothesis-free. Our results extend seed-based and BOLD-signal intensity focused studies, and support present hypotheses like compensation and dedifferentiation... - No association between a common haplotype of the 6 and 10-repeat alleles in intron 8 and the 3'UTR of the DAT1 gene and adult attention deficit hyperactivity disorderDaniel Brüggemann
Department of Genetic Epidemology, Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 17:121. 2007 - The bipolar disorder phenome database: a resource for genetic studiesJames B Potash
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:1229-37. 2007..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies... - Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorderSven Cichon
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Hum Mol Genet 17:87-97. 2008..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD... - The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the diseaseAnn Van Den Bogaert
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Am J Hum Genet 73:1438-43. 2003..This would also explain the difficulty of replicating this association in consecutively ascertained case-control samples, which usually comprise only a small proportion of subjects with a family history of disease... - The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6qRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Hum Genet 81:974-86. 2007..Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies... - Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 18:199-203. 2008..Based on the functional evidence and on the hypothesis that further genes, which are involved in the regulation of D-serine, could be involved in the disease aetiology, we considered VAMP2 and VAMP3 as candidate genes for BPAD... - No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophreniaRami Abou Jamra
Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
Psychiatr Genet 17:43-5. 2007.... - No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sampleMarkus H Skowronek
Psychiatr Genet 16:233-4. 2006..Allele and haplotype frequencies did not differ between cases and controls. Our results do not support an association of the ASCT1 gene with BD or SCZ in the German population... - Computer-assisted phenotype characterization for genetic research in psychiatryHeiner Fangerau
Department of Psychiatry, University of Bonn, Bonn, Germany
Hum Hered 58:122-30. 2004.... - The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorderBarbara Hoefgen
Department of Psychiatry, University of Bonn, Germany
Biol Psychiatry 57:247-51. 2005..Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant... - Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German populationSebastian Paus
Department of Neurology, Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 14:233-4. 2004..Our results suggest that the NMDAR1 subunit is not frequently involved in the development of schizophrenia in the German population... - Neither single-marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorderSridhar Prathikanti
Department of Psychiatry, University of Chicago, Chicago, Illinois 60615, USA
Am J Med Genet B Neuropsychiatr Genet 131:10-5. 2004..These results do not support an association between genetic variation near NOTCH4 and BPAD in this sample... - Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European originSven Cichon
Nat Genet 36:783-4; author reply 784-5. 2004 - Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 126:79-81. 2004..Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes... - Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophreniaSibylle G Schwab
Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
Schizophr Res 65:19-25. 2003..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]... - Age at onset in bipolar I affective disorder: further evidence for three subgroupsFrank Bellivier
Department of Psychiatry, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique Hopitaux de Paris, 51 avenue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
Am J Psychiatry 160:999-1001. 2003..Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup... - Is there a phenotypic difference between probands in case-control versus family-based association studies?Thomas G Schulze
Am J Med Genet B Neuropsychiatr Genet 118:25-6; author reply 27-8. 2003 - Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22Thomas G Schulze
Department of Psychiatry, The University of Chicago, Chicago, Illinois, USA
Biol Psychiatry 53:239-43. 2003..Our data suggest that a dense set of markers, when physically ordered, can increase the informational value of genetic linkage signals... - Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorderEsther Jahnes
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet 114:519-22. 2002..For both BPAD and UPAD we could not detect a genetic association with either variant. Thus, our results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders... - Can long-range microsatellite data be used to predict short-range linkage disequilibrium?Thomas G Schulze
Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 11:1363-72. 2002.... - No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samplesBeate Glaser
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
Biol Psychiatry 58:78-80. 2005..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()... - Familial variation in episode frequency in bipolar affective disorderMaria E Fisfalen
Department of Psychiatry, Mount Sinai Medical Center, Rosalind Franklin University of Medicine and Science, California at 15th Street, Chicago, IL 60608, USA
Am J Psychiatry 162:1266-72. 2005..The authors analyzed the recurrence frequency of affective episodes (episode frequency), along with associated clinical and demographic variables, in families with at least three members with a major affective disorder... - Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli ArabsShirly Amar
Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
Schizophr Res 94:354-8. 2007..However, mitochondrial DNA haplogroups are highly variable in human population and it will be necessary to replicate our results in other human ethnic groups... - Disturbed frontal gyrification within families affected with schizophreniaPeter Falkai
Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
J Psychiatr Res 41:805-13. 2007.... - Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006..Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population... - Genetic association mapping at the crossroads: which test and why? Overview and practical guidelinesThomas G Schulze
Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet 114:1-11. 2002..We present an overview of the development of genetic association tests, with practical guidelines on which test might be the most suitable for a given study... - Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24Johannes Schumacher
Institute of Human Genetics, Life and Brain Center, University of Bonn, D-53105 Bonn, Germany
Am J Hum Genet 77:1102-11. 2005.... - Association study of a functional promoter polymorphism in the XBP1 gene and schizophreniaErik G Jonsson
Department of Clinical Neuroscience, Psychiatry Section, R5 00, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Am J Med Genet B Neuropsychiatr Genet 141:71-5. 2006..It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder... - No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
Psychiatr Genet 15:195-8. 2005..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder... - Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophreniaThomas Schneider-Axmann
Department of Psychiatry and Psychotherapy, University of Saarland, D-66421 Homburg/Saar, Germany
J Psychiatr Res 40:646-55. 2006..However, this correlation is independent of the factor diagnosis and is therefore not specific for schizophrenia... - Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depressionJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn
Biol Psychiatry 58:307-14. 2005.... - Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorderDaniel J Muller
Department of Psychiatry, University of Bonn, Bonn, Germany
Am J Med Genet 114:74-8. 2002..We observed a significantly increased frequency of genotypes homozygous for the C allele in females with BPAD in comparison with controls (P=0.017). Thus, our data strengthen the role of the SYBL1 gene as a candidate gene for BPAD... - Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopeciaAxel M Hillmer
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Am J Hum Genet 77:140-8. 2005..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA... - Further evidence for age of onset being an indicator for severity in bipolar disorderThomas G Schulze
J Affect Disord 68:343-5. 2002 - No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysisRoland Ivo
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 16:197-203. 2006..In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin... - [The 5 year Young Psychiatrist Program: A contribution for the young generation in psychiatry in Germany]Iris Tatjana Calliess
Abteilung Sozialpsychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover
Nervenarzt 77:1407-9. 2006 - Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal viewPeter Falkai
Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
Psychiatry Res 132:261-71. 2004..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder... - No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophreniaRami Abou Jamra
Institute of Human Genetics bInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Psychiatr Genet 16:91. 2006 - Reduction of the internal capsule in families affected with schizophreniaThomas Wobrock
Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
Biol Psychiatry 63:65-71. 2008..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...