Research Topics
Genomes and Genes | Miriam SchneiderSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Publications
Cannabis use in pregnancy and early life and its consequences: animal modelsMiriam Schneider
Department of Psychopharmacology, Central Institute of Mental Health ZI, J5, 68159 Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 259:383-93. 2009..The present review will summarize the possible residual behavioural effects of cannabinoid administration during pre- and perinatal as well as early postnatal development, derived from animal studies...- Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of rewardMiriam Schneider
Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
Behav Brain Res 208:466-72. 2010.... - Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult ratsMiriam Schneider
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
Addict Biol 13:345-57. 2008.... - Puberty as a highly vulnerable developmental period for the consequences of cannabis exposureMiriam Schneider
Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
Addict Biol 13:253-63. 2008.... - Appetitive odor-cue conditioning attenuates the acoustic startle response in ratsMiriam Schneider
Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
Behav Brain Res 189:226-30. 2008..This odor conditioned "pleasure" attenuation of the startle response might, therefore, provide a new effective operational measure for the hedonic aspects of reward... 
Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in miceMiriam Schneider
Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
BMC Neurosci 8:105. 2007..In the present study, we aimed at specifically dissecting the role of CaMKIV in the nucleus accumbens of adult mice...- Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1Dragos Inta
Department for Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany
Behav Brain Res 228:328-32. 2012..Our data may be important for a better understanding of the contribution of reduced VGLUT1-mediated presynaptic glutamatergic neurotransmission in the generation of several behavioural abnormalities associated with schizophrenia... - Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2Stephanie Perreau-Lenz
Central Institute for Mental Health, Department of Psychopharmacology, CIMH, University of Heidelberg, Mannheim, Germany
Eur Neuropsychopharmacol 20:509-17. 2010..The Per2(Brdm1) mutant mice clearly developed less tolerance and showed attenuated withdrawal signs compared to WT. These results show that mPER2 is involved in morphine-induced tolerance and withdrawal... - Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapineF Markus Leweke
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Int J Neuropsychopharmacol 14:43-51. 2011..Furthermore, the present data give further support and validity for the suitability of chronic pubertal cannabinoid administration as an animal model for aspects of schizophrenia... - Stress triggers anhedonia in rats bred for learned helplessnessThomas Enkel
Dept of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
Behav Brain Res 209:183-6. 2010..These findings further add to the validity of congenitally learned helplessness as an animal model of depression, since gene-environment interactions are considered to play a role in the etiology of this disorder... - Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypesRobert Waltereit
Department of Molecular Biology, Central Institute of Mental Health and Heidelberg University, Mannheim, Germany
FASEB J 26:4418-28. 2012..Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders... - Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signalingTheresa Brand
Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
PLoS ONE 7:e31169. 2012..The aim of the present study was to examine if differences in the endocannabinoid (ECB) system might be linked to strain specific variations in reward-related behavior in Fischer344 (Fischer) and Wistar rats... - Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaineAinhoa Bilbao
Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Proc Natl Acad Sci U S A 105:17549-54. 2008..These findings reveal a critical role for CaMKIV in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription... - Epilepsy and Tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in ratsRobert Waltereit
Department of Molecular Biology, Central Institute of Mental Health and University of Heidelberg, Mannheim, Germany
Behav Genet 41:364-72. 2011..The results suggest that the gene mutation may be sufficient to lead to some social deficits, and that seizures have a direct and additive effect to increase the likelihood and range of autistic-like behaviors... - Behavioral differences in three Wistar Han rat lines for emotional reactivity, cognitive processing and ethanol intakeAnja A Goepfrich
Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Physiol Behav 110:102-8. 2013.... - Reward sensitivity for a palatable food reward peaks during pubertal developmental in ratsChris M Friemel
Department of Psychopharmacology, Central Institute of Mental Health, Heidelberg University Mannheim, Germany
Front Behav Neurosci 4:. 2010..Therefore, higher reward sensitivity during pubertal maturation might contribute to the enhanced vulnerability of teenagers for the initiation of experimental drug use... - Lack of long-term behavioral alterations after early postnatal treatment with tropisetron: implications for developmental psychobiologyDragos Inta
Department for Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
Pharmacol Biochem Behav 99:35-41. 2011..These results may be of relevance regarding the possible protracted deleterious neuropsychiatric effects of tropisetron during early life... 
Deficient social and play behavior in juvenile and adult rats after neonatal cortical lesion: effects of chronic pubertal cannabinoid treatmentMiriam Schneider
Department of Neuropharmacology, Brain Research Institute, University of Bremen, Bremen, Germany
Neuropsychopharmacology 30:944-57. 2005..Therefore, we propose the combination of neonatal cortical lesions with chronic cannabinoid administration during puberty as an animal model for studying neuronal mechanisms of impaired social functioning in neuropsychiatric disorders...- Effects of the cannabinoid receptor agonist WIN 55,212-2 on operant behavior and locomotor activity in ratsEva Drews
Brain Research Institute, Department of Neuropharmacology, University of Bremen, P.O. Box 33 04 40, 28334 Bremen, Germany
Pharmacol Biochem Behav 80:145-50. 2005..We confirm previous findings of dose-dependent motor stimulating and inhibiting effects of cannabinoids, and show an impairment of a complex operant behavior at higher doses of WIN... - Behavioral and morphological alterations following neonatal excitotoxic lesions of the medial prefrontal cortex in ratsMiriam Schneider
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str. 62, 50924 Cologne, Germany
Exp Neurol 195:185-98. 2005..These data support the hypothesis that neonatal mPFC lesions lead to disruptions of neurodevelopmental processes in a cortico-limbic-striatal network, which are manifested in adult animals as morphological and behavioral disturbances... - The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesionMiriam Schneider
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Eur Neuropsychopharmacol 17:180-6. 2007..This study shows that behavioral deviations induced by neonatal mPFC lesions can be exacerbated by pubertal chronic cannabinoid treatment, leading to long-lasting impairments of mnemonic short-term information processing... - The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptorFernando Rodriguez de Fonseca
Addict Biol 13:143-6. 2008 - Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult ratsMiriam Schneider
Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany
Neuropsychopharmacology 28:1760-9. 2003.... - Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis useF Markus Leweke
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Res 94:29-36. 2007..In the present study we examined whether cannabis use may alter such a mechanism... - Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortexMichael Brecht
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
Nature 427:704-10. 2004..We conclude that in vibrissae motor cortex sparse AP activity can evoke movements...