Miriam Schneider

Summary

Affiliation: Central Institute of Mental Health
Country: Germany

Publications

  1. pmc Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling
    Theresa Brand
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 7:e31169. 2012
  2. pmc Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats
    Chris M Friemel
    Department of Psychopharmacology, Central Institute of Mental Health, Heidelberg University Mannheim, Germany
    Front Behav Neurosci 4:. 2010
  3. pmc AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity
    Matthias Klugmann
    Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales Sydney, NSW, Australia
    Front Behav Neurosci 5:37. 2011
  4. doi request reprint Adolescence as a vulnerable period to alter rodent behavior
    Miriam Schneider
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, J5, University of Heidelberg, 68159, Mannheim, Germany
    Cell Tissue Res 354:99-106. 2013
  5. doi request reprint Appetitive odor-cue conditioning attenuates the acoustic startle response in rats
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    Behav Brain Res 189:226-30. 2008
  6. doi request reprint Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats
    Miriam Schneider
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 13:345-57. 2008
  7. doi request reprint Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
    Addict Biol 13:253-63. 2008
  8. doi request reprint Cannabis use in pregnancy and early life and its consequences: animal models
    Miriam Schneider
    Department of Psychopharmacology, Central Institute of Mental Health ZI, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 259:383-93. 2009
  9. pmc Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    BMC Neurosci 8:105. 2007
  10. doi request reprint Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
    Behav Brain Res 208:466-72. 2010

Detail Information

Publications32

  1. pmc Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling
    Theresa Brand
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 7:e31169. 2012
    ..The aim of the present study was to examine if differences in the endocannabinoid (ECB) system might be linked to strain specific variations in reward-related behavior in Fischer344 (Fischer) and Wistar rats...
  2. pmc Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats
    Chris M Friemel
    Department of Psychopharmacology, Central Institute of Mental Health, Heidelberg University Mannheim, Germany
    Front Behav Neurosci 4:. 2010
    ..Therefore, higher reward sensitivity during pubertal maturation might contribute to the enhanced vulnerability of teenagers for the initiation of experimental drug use...
  3. pmc AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity
    Matthias Klugmann
    Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales Sydney, NSW, Australia
    Front Behav Neurosci 5:37. 2011
    ....
  4. doi request reprint Adolescence as a vulnerable period to alter rodent behavior
    Miriam Schneider
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, J5, University of Heidelberg, 68159, Mannheim, Germany
    Cell Tissue Res 354:99-106. 2013
    ....
  5. doi request reprint Appetitive odor-cue conditioning attenuates the acoustic startle response in rats
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    Behav Brain Res 189:226-30. 2008
    ..This odor conditioned "pleasure" attenuation of the startle response might, therefore, provide a new effective operational measure for the hedonic aspects of reward...
  6. doi request reprint Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats
    Miriam Schneider
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 13:345-57. 2008
    ....
  7. doi request reprint Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
    Addict Biol 13:253-63. 2008
    ....
  8. doi request reprint Cannabis use in pregnancy and early life and its consequences: animal models
    Miriam Schneider
    Department of Psychopharmacology, Central Institute of Mental Health ZI, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 259:383-93. 2009
    ..The present review will summarize the possible residual behavioural effects of cannabinoid administration during pre- and perinatal as well as early postnatal development, derived from animal studies...
  9. pmc Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    BMC Neurosci 8:105. 2007
    ..In the present study, we aimed at specifically dissecting the role of CaMKIV in the nucleus accumbens of adult mice...
  10. doi request reprint Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, Mannheim, Germany
    Behav Brain Res 208:466-72. 2010
    ....
  11. doi request reprint Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1
    Dragos Inta
    Department for Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany
    Behav Brain Res 228:328-32. 2012
    ..Our data may be important for a better understanding of the contribution of reduced VGLUT1-mediated presynaptic glutamatergic neurotransmission in the generation of several behavioural abnormalities associated with schizophrenia...
  12. doi request reprint Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels
    Matthias Klugmann
    Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Int J Neuropsychopharmacol 14:505-17. 2011
    ..In particular, augmented ethanol intake in pubertal cannabinoid-exposed animals might be related to some extent to increased emotional behaviour and in particular to enhanced NMDA and CB₁ receptor signalling...
  13. doi request reprint Behavioral differences in three Wistar Han rat lines for emotional reactivity, cognitive processing and ethanol intake
    Anja A Goepfrich
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Physiol Behav 110:102-8. 2013
    ....
  14. ncbi request reprint Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2
    Stephanie Perreau-Lenz
    Central Institute for Mental Health, Department of Psychopharmacology, CIMH, University of Heidelberg, Mannheim, Germany
    Eur Neuropsychopharmacol 20:509-17. 2010
    ..The Per2(Brdm1) mutant mice clearly developed less tolerance and showed attenuated withdrawal signs compared to WT. These results show that mPER2 is involved in morphine-induced tolerance and withdrawal...
  15. doi request reprint Stress triggers anhedonia in rats bred for learned helplessness
    Thomas Enkel
    Dept of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, 68159 Mannheim, Germany
    Behav Brain Res 209:183-6. 2010
    ..These findings further add to the validity of congenitally learned helplessness as an animal model of depression, since gene-environment interactions are considered to play a role in the etiology of this disorder...
  16. doi request reprint Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapine
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Int J Neuropsychopharmacol 14:43-51. 2011
    ..Furthermore, the present data give further support and validity for the suitability of chronic pubertal cannabinoid administration as an animal model for aspects of schizophrenia...
  17. ncbi request reprint Impact of pubertal stage at first drink on adult drinking behavior
    Dorothea Blomeyer
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 37:1804-11. 2013
    ..However, the influence of the pubertal phase at alcohol use initiation on subsequent drinking in later life has not been examined so far...
  18. doi request reprint Phenotype of mice with inducible ablation of GluA1 AMPA receptors during late adolescence: relevance for mental disorders
    Dragos Inta
    Department of Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
    Hippocampus 24:424-35. 2014
    ..Our data provide new insight into the role of deficient AMPA receptors specifically during late adolescence in inducing several cognitive and behavioral alterations with possible relevance for neuropsychiatric disorders...
  19. doi request reprint Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes
    Robert Waltereit
    Department of Molecular Biology, Central Institute of Mental Health and Heidelberg University, Mannheim, Germany
    FASEB J 26:4418-28. 2012
    ..Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders...
  20. pmc Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine
    Ainhoa Bilbao
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Proc Natl Acad Sci U S A 105:17549-54. 2008
    ..These findings reveal a critical role for CaMKIV in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription...
  21. doi request reprint Epilepsy and Tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in rats
    Robert Waltereit
    Department of Molecular Biology, Central Institute of Mental Health and University of Heidelberg, Mannheim, Germany
    Behav Genet 41:364-72. 2011
    ..The results suggest that the gene mutation may be sufficient to lead to some social deficits, and that seizures have a direct and additive effect to increase the likelihood and range of autistic-like behaviors...
  22. doi request reprint Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats
    Peggy Schneider
    Research Group Developmental Neuropsychopharmacology, Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Eur Neuropsychopharmacol 24:290-301. 2014
    ..The present animal model therefore represents a novel approach to assess the long-term consequences of peer-rejection during adolescence. ..
  23. ncbi request reprint Potential protective effects of cannabidiol on neuroanatomical alterations in cannabis users and psychosis: a critical review
    Derik Hermann
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany
    Curr Pharm Des 18:4897-905. 2012
    ..We will discuss here the mechanisms by which CBD may reduce brain volume loss, including antagonism of THC, interactions with endocannabinoids, and mechanisms that specifically underlie antipsychotic properties of CBD...
  24. doi request reprint Lack of long-term behavioral alterations after early postnatal treatment with tropisetron: implications for developmental psychobiology
    Dragos Inta
    Department for Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Pharmacol Biochem Behav 99:35-41. 2011
    ..These results may be of relevance regarding the possible protracted deleterious neuropsychiatric effects of tropisetron during early life...
  25. ncbi request reprint Deficient social and play behavior in juvenile and adult rats after neonatal cortical lesion: effects of chronic pubertal cannabinoid treatment
    Miriam Schneider
    Department of Neuropharmacology, Brain Research Institute, University of Bremen, Bremen, Germany
    Neuropsychopharmacology 30:944-57. 2005
    ..Therefore, we propose the combination of neonatal cortical lesions with chronic cannabinoid administration during puberty as an animal model for studying neuronal mechanisms of impaired social functioning in neuropsychiatric disorders...
  26. ncbi request reprint Effects of the cannabinoid receptor agonist WIN 55,212-2 on operant behavior and locomotor activity in rats
    Eva Drews
    Brain Research Institute, Department of Neuropharmacology, University of Bremen, P O Box 33 04 40, 28334 Bremen, Germany
    Pharmacol Biochem Behav 80:145-50. 2005
    ..We confirm previous findings of dose-dependent motor stimulating and inhibiting effects of cannabinoids, and show an impairment of a complex operant behavior at higher doses of WIN...
  27. ncbi request reprint Behavioral and morphological alterations following neonatal excitotoxic lesions of the medial prefrontal cortex in rats
    Miriam Schneider
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Exp Neurol 195:185-98. 2005
    ..These data support the hypothesis that neonatal mPFC lesions lead to disruptions of neurodevelopmental processes in a cortico-limbic-striatal network, which are manifested in adult animals as morphological and behavioral disturbances...
  28. ncbi request reprint The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion
    Miriam Schneider
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Eur Neuropsychopharmacol 17:180-6. 2007
    ..This study shows that behavioral deviations induced by neonatal mPFC lesions can be exacerbated by pubertal chronic cannabinoid treatment, leading to long-lasting impairments of mnemonic short-term information processing...
  29. doi request reprint The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor
    Fernando Rodriguez de Fonseca
    Addict Biol 13:143-6. 2008
  30. ncbi request reprint Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats
    Miriam Schneider
    Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany
    Neuropsychopharmacology 28:1760-9. 2003
    ....
  31. ncbi request reprint Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Res 94:29-36. 2007
    ..In the present study we examined whether cannabis use may alter such a mechanism...
  32. ncbi request reprint Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortex
    Michael Brecht
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 427:704-10. 2004
    ..We conclude that in vibrissae motor cortex sparse AP activity can evoke movements...